Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 167 (13 Feb 2019)
Sequence version 1 (07 Jun 2004)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Lysozyme C

Gene

LYZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Miscellaneous

Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. EC:3.2.1.17

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei531
Active sitei711

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • lysozyme activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.1.17 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation
R-HSA-6803157 Antimicrobial peptides
R-HSA-977225 Amyloid fiber formation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P61626

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH22 Glycoside Hydrolase Family 22

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysozyme C (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LYZ
Synonyms:LZM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000090382.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6740 LYZ

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
153450 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P61626

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Amyloidosis 8 (AMYL8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.
See also OMIM:105200
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00428074I → T in AMYL8. 1 PublicationCorresponds to variant dbSNP:rs121913547EnsemblClinVar.1
Natural variantiVAR_00428185D → H in AMYL8. 1 PublicationCorresponds to variant dbSNP:rs121913548Ensembl.1

Keywords - Diseasei

Amyloidosis, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
4069

MalaCards human disease database

More...
MalaCardsi
LYZ
MIMi105200 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000090382

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
93561 ALys amyloidosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30503

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02159 (R)-Propylene glycol
DB03175 1-Proponol
DB03487 3-Aminosuccinimide
DB02759 4-Methylumbelliferyl Chitobiose
DB03006 Arsanilic acid
DB04194 Chitotriose
DB02250 Cu-Bicyclam
DB03189 Cu-Cyclam
DB03013 Di(N-Acetyl-D-Glucosamine)
DB03967 Dodecyl Sulfate
DB00128 L-Aspartic Acid
DB04268 Methylumbelliferyl Chitotriose
DB03120 Para-Toluene Sulfonate
DB02772 Sucrose

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LYZ

Domain mapping of disease mutations (DMDM)

More...
DMDMi
48428995

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 185 PublicationsAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001846719 – 148Lysozyme CAdd BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 146
Disulfide bondi48 ↔ 134
Disulfide bondi83 ↔ 99
Disulfide bondi95 ↔ 113

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P61626

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P61626

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P61626

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P61626

PeptideAtlas

More...
PeptideAtlasi
P61626

PRoteomics IDEntifications database

More...
PRIDEi
P61626

ProteomicsDB human proteome resource

More...
ProteomicsDBi
12683
57328

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P61626

2D gel databases

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P61626

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P61626

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P61626

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000090382 Expressed in 210 organ(s), highest expression level in nasal cavity mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P61626 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P61626 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000055
HPA048284
HPA066182

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-355360,EBI-355360

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110247, 42 interactors

Protein interaction database and analysis system

More...
IntActi
P61626, 12 interactors

Molecular INTeraction database

More...
MINTi
P61626

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261267

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
133LX-ray1.77A19-148[»]
134LX-ray1.77A19-148[»]
1B5UX-ray1.80A19-148[»]
1B5VX-ray2.17A19-148[»]
1B5WX-ray2.17A19-148[»]
1B5XX-ray2.00A19-148[»]
1B5YX-ray2.20A19-148[»]
1B5ZX-ray2.20A/B19-148[»]
1B7LX-ray1.80A19-148[»]
1B7MX-ray2.20A19-148[»]
1B7NX-ray1.80A19-148[»]
1B7OX-ray1.80A19-148[»]
1B7PX-ray2.00A19-148[»]
1B7QX-ray2.00A19-148[»]
1B7RX-ray1.80A19-148[»]
1B7SX-ray2.00A19-148[»]
1BB3X-ray1.80A/B19-148[»]
1BB4X-ray2.23A/B19-148[»]
1BB5X-ray1.80A/B19-148[»]
1C43X-ray1.80A19-148[»]
1C45X-ray1.80A19-148[»]
1C46X-ray2.20A19-148[»]
1C7PX-ray2.40A16-148[»]
1CJ6X-ray1.80A19-148[»]
1CJ7X-ray1.80A19-148[»]
1CJ8X-ray1.80A19-148[»]
1CJ9X-ray1.80A19-148[»]
1CKCX-ray1.80A19-148[»]
1CKDX-ray1.80A19-148[»]
1CKFX-ray1.80A19-148[»]
1CKGX-ray2.20A/B19-148[»]
1CKHX-ray2.00A19-148[»]
1D6PX-ray2.23A19-148[»]
1D6QX-ray1.96A19-148[»]
1DI3X-ray1.80A19-148[»]
1DI4X-ray2.00A19-148[»]
1DI5X-ray2.20A19-148[»]
1EQ4X-ray1.80A19-148[»]
1EQ5X-ray1.80A19-148[»]
1EQEX-ray1.80A19-148[»]
1GAYX-ray1.80A19-148[»]
1GAZX-ray1.80A19-148[»]
1GB0X-ray1.80A19-148[»]
1GB2X-ray1.80A19-148[»]
1GB3X-ray1.80A19-148[»]
1GB5X-ray1.80A19-148[»]
1GB6X-ray1.80A19-148[»]
1GB7X-ray1.80A19-148[»]
1GB8X-ray1.80A19-148[»]
1GB9X-ray1.80A19-148[»]
1GBOX-ray1.80A19-148[»]
1GBWX-ray1.80A19-148[»]
1GBXX-ray1.80A19-148[»]
1GBYX-ray1.80A19-148[»]
1GBZX-ray1.80A19-148[»]
1GDWX-ray1.80A19-148[»]
1GDXX-ray1.80A19-148[»]
1GE0X-ray1.80A19-148[»]
1GE1X-ray1.70A19-148[»]
1GE2X-ray2.00A19-148[»]
1GE3X-ray1.80A19-148[»]
1GE4X-ray1.80A19-148[»]
1GEVX-ray2.10A19-148[»]
1GEZX-ray1.80A19-148[»]
1GF0X-ray1.80A19-148[»]
1GF3X-ray1.80A19-148[»]
1GF4X-ray1.80A19-148[»]
1GF5X-ray1.80A19-148[»]
1GF6X-ray1.80A19-148[»]
1GF7X-ray1.80A19-148[»]
1GF8X-ray1.80A19-148[»]
1GF9X-ray1.80A19-148[»]
1GFAX-ray1.80A19-148[»]
1GFEX-ray1.80A19-148[»]
1GFGX-ray1.80A19-148[»]
1GFHX-ray1.80A19-148[»]
1GFJX-ray1.80A19-148[»]
1GFKX-ray1.80A19-148[»]
1GFRX-ray1.80A19-148[»]
1GFTX-ray1.80A19-148[»]
1GFUX-ray1.80A19-148[»]
1GFVX-ray1.80A19-148[»]
1HNLX-ray1.80A19-148[»]
1I1ZX-ray1.80A19-148[»]
1I20X-ray1.90A19-148[»]
1I22X-ray1.80A/B/C/D19-148[»]
1INUX-ray1.80A19-148[»]
1IOCX-ray2.40A19-148[»]
1IP1X-ray1.80A19-148[»]
1IP2X-ray1.80A19-148[»]
1IP3X-ray1.80A/B19-148[»]
1IP4X-ray1.80A19-148[»]
1IP5X-ray1.80A19-148[»]
1IP6X-ray1.80A19-148[»]
1IP7X-ray1.90A/B19-146[»]
1IWTX-ray1.40A19-148[»]
1IWUX-ray1.40A19-148[»]
1IWVX-ray1.40A19-148[»]
1IWWX-ray1.40A19-148[»]
1IWXX-ray1.40A19-148[»]
1IWYX-ray1.40A19-148[»]
1IWZX-ray1.48A19-148[»]
1IX0X-ray1.80A19-148[»]
1IY3NMR-A19-148[»]
1IY4NMR-A19-148[»]
1JKAX-ray1.66A19-148[»]
1JKBX-ray1.66A19-148[»]
1JKCX-ray1.60A19-148[»]
1JKDX-ray1.80A19-148[»]
1JSFX-ray1.15A19-148[»]
1JWRX-ray1.40A19-148[»]
1LAAX-ray1.77A19-148[»]
1LHHX-ray1.80A19-148[»]
1LHIX-ray1.80A19-148[»]
1LHJX-ray1.80A19-148[»]
1LHKX-ray1.80A19-148[»]
1LHLX-ray1.80A19-148[»]
1LHMX-ray1.80A19-148[»]
1LMTX-ray1.60A19-148[»]
1LOZX-ray1.80A19-148[»]
1LYYX-ray1.80A19-148[»]
1LZ1X-ray1.50A19-148[»]
1LZ4X-ray1.80A19-148[»]
1LZ5X-ray1.80A19-144[»]
1LZ6X-ray1.80A19-140[»]
1LZRX-ray1.50A19-148[»]
1LZSX-ray1.60A/B19-148[»]
1OP9X-ray1.86B19-148[»]
1OUAX-ray1.80A19-148[»]
1OUBX-ray1.80A19-148[»]
1OUCX-ray1.80A19-148[»]
1OUDX-ray1.80A19-148[»]
1OUEX-ray1.80A19-148[»]
1OUFX-ray1.80A19-147[»]
1OUGX-ray1.80A19-148[»]
1OUHX-ray1.80A19-148[»]
1OUIX-ray1.80A19-148[»]
1OUJX-ray1.80A19-148[»]
1QSWX-ray1.85A/B/C/D19-148[»]
1RE2X-ray2.30A19-148[»]
1REMX-ray2.10A19-148[»]
1REXX-ray1.50A19-148[»]
1REYX-ray1.70A19-148[»]
1REZX-ray1.70A19-148[»]
1TAYX-ray1.70A19-148[»]
1TBYX-ray1.77A19-148[»]
1TCYX-ray1.70A19-148[»]
1TDYX-ray1.70A19-148[»]
1UBZX-ray2.00A19-148[»]
1W08X-ray2.50A19-148[»]
1WQMX-ray1.80A19-148[»]
1WQNX-ray1.80A19-148[»]
1WQOX-ray1.80A19-148[»]
1WQPX-ray1.80A19-148[»]
1WQQX-ray1.80A19-148[»]
1WQRX-ray1.80A19-148[»]
1YAMX-ray1.80A19-148[»]
1YANX-ray1.80A19-148[»]
1YAOX-ray1.80A19-148[»]
1YAPX-ray1.80A19-148[»]
1YAQX-ray1.80A19-148[»]
207LX-ray1.80A19-148[»]
208LX-ray2.20A19-148[»]
2BQAX-ray1.80A19-148[»]
2BQBX-ray1.80A19-148[»]
2BQCX-ray1.80A19-148[»]
2BQDX-ray1.80A19-148[»]
2BQEX-ray1.80A19-148[»]
2BQFX-ray1.80A19-148[»]
2BQGX-ray1.80A19-148[»]
2BQHX-ray1.80A19-148[»]
2BQIX-ray1.80A19-148[»]
2BQJX-ray1.80A19-148[»]
2BQKX-ray1.80A19-147[»]
2BQLX-ray1.80A19-148[»]
2BQMX-ray1.80A19-148[»]
2BQNX-ray1.80A19-148[»]
2BQOX-ray1.80A19-148[»]
2HEAX-ray1.80A19-148[»]
2HEBX-ray2.20A19-148[»]
2HECX-ray1.80A19-148[»]
2HEDX-ray1.80A19-148[»]
2HEEX-ray1.80A19-148[»]
2HEFX-ray1.80A19-148[»]
2LHMX-ray1.80A19-148[»]
2MEAX-ray2.20A/B19-148[»]
2MEBX-ray1.80A19-148[»]
2MECX-ray2.20A/B19-148[»]
2MEDX-ray1.80A19-148[»]
2MEEX-ray1.80A19-148[»]
2MEFX-ray1.80A19-148[»]
2MEGX-ray1.80A19-148[»]
2MEHX-ray1.80A19-148[»]
2MEIX-ray1.80A19-148[»]
2NWDX-ray1.04X19-148[»]
2ZIJX-ray1.90A19-148[»]
2ZIKX-ray1.81A19-148[»]
2ZILX-ray1.80A19-148[»]
2ZWBneutron diffraction1.80A19-148[»]
3EBAX-ray1.85B19-148[»]
3FE0X-ray1.50A19-148[»]
3LHMX-ray1.80A19-148[»]
3LN2X-ray2.04A/B19-148[»]
4I0CX-ray1.95A/B19-148[»]
4ML7X-ray1.80A/C19-148[»]
4R0PX-ray1.52A74-79[»]
5LSHX-ray1.06A19-148[»]
5LVKX-ray2.49A/B19-148[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P61626

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P61626

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P61626

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXGD Eukaryota
ENOG4111QHM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153832

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000037357

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052297

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P61626

KEGG Orthology (KO)

More...
KOi
K13915

Identification of Orthologs from Complete Genome Data

More...
OMAi
KWESNYN

Database of Orthologous Groups

More...
OrthoDBi
1551203at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P61626

TreeFam database of animal gene trees

More...
TreeFami
TF324882

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00119 LYZ1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000974 Glyco_hydro_22_lys
IPR023346 Lysozyme-like_dom_sf
IPR030056 Lysozyme_C

The PANTHER Classification System

More...
PANTHERi
PTHR11407:SF28 PTHR11407:SF28, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00062 Lys, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00137 LYSOZYME
PR00135 LYZLACT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00263 LYZ1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53955 SSF53955, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P61626-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKALIVLGLV LLSVTVQGKV FERCELARTL KRLGMDGYRG ISLANWMCLA
60 70 80 90 100
KWESGYNTRA TNYNAGDRST DYGIFQINSR YWCNDGKTPG AVNACHLSCS
110 120 130 140
ALLQDNIADA VACAKRVVRD PQGIRAWVAW RNRCQNRDVR QYVQGCGV
Length:148
Mass (Da):16,537
Last modified:June 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8ECFD276BEB2678A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VV32F8VV32_HUMAN
Lysozyme
LYZ
104Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J259A0A0B4J259_HUMAN
Lysozyme
LYZ
137Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA32175 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10V → A in AAC63078 (Ref. 5) Curated1
Sequence conflicti41I → M in AAA36188 (PubMed:2971592).Curated1
Sequence conflicti111V → A in AAC63078 (Ref. 5) Curated1
Sequence conflicti124I → V in AAC63078 (Ref. 5) Curated1
Sequence conflicti128V → A in AAC63078 (Ref. 5) Curated1
Sequence conflicti136N → D in AAC63078 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00428074I → T in AMYL8. 1 PublicationCorresponds to variant dbSNP:rs121913547EnsemblClinVar.1
Natural variantiVAR_00428185D → H in AMYL8. 1 PublicationCorresponds to variant dbSNP:rs121913548Ensembl.1
Natural variantiVAR_01205088T → N. Corresponds to variant dbSNP:rs1800973EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M21119 mRNA Translation: AAA36188.1
J03801 mRNA Translation: AAA59535.1
M19045 mRNA Translation: AAA59536.1
X14008 Genomic DNA Translation: CAA32175.1 Different initiation.
U25677 mRNA Translation: AAC63078.1
BC004147 mRNA Translation: AAH04147.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8989.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S04938 LZHU

NCBI Reference Sequences

More...
RefSeqi
NP_000230.1, NM_000239.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.524579

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261267; ENSP00000261267; ENSG00000090382

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4069

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4069

UCSC genome browser

More...
UCSCi
uc001suw.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Lysozyme entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21119 mRNA Translation: AAA36188.1
J03801 mRNA Translation: AAA59535.1
M19045 mRNA Translation: AAA59536.1
X14008 Genomic DNA Translation: CAA32175.1 Different initiation.
U25677 mRNA Translation: AAC63078.1
BC004147 mRNA Translation: AAH04147.1
CCDSiCCDS8989.1
PIRiS04938 LZHU
RefSeqiNP_000230.1, NM_000239.2
UniGeneiHs.524579

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
133LX-ray1.77A19-148[»]
134LX-ray1.77A19-148[»]
1B5UX-ray1.80A19-148[»]
1B5VX-ray2.17A19-148[»]
1B5WX-ray2.17A19-148[»]
1B5XX-ray2.00A19-148[»]
1B5YX-ray2.20A19-148[»]
1B5ZX-ray2.20A/B19-148[»]
1B7LX-ray1.80A19-148[»]
1B7MX-ray2.20A19-148[»]
1B7NX-ray1.80A19-148[»]
1B7OX-ray1.80A19-148[»]
1B7PX-ray2.00A19-148[»]
1B7QX-ray2.00A19-148[»]
1B7RX-ray1.80A19-148[»]
1B7SX-ray2.00A19-148[»]
1BB3X-ray1.80A/B19-148[»]
1BB4X-ray2.23A/B19-148[»]
1BB5X-ray1.80A/B19-148[»]
1C43X-ray1.80A19-148[»]
1C45X-ray1.80A19-148[»]
1C46X-ray2.20A19-148[»]
1C7PX-ray2.40A16-148[»]
1CJ6X-ray1.80A19-148[»]
1CJ7X-ray1.80A19-148[»]
1CJ8X-ray1.80A19-148[»]
1CJ9X-ray1.80A19-148[»]
1CKCX-ray1.80A19-148[»]
1CKDX-ray1.80A19-148[»]
1CKFX-ray1.80A19-148[»]
1CKGX-ray2.20A/B19-148[»]
1CKHX-ray2.00A19-148[»]
1D6PX-ray2.23A19-148[»]
1D6QX-ray1.96A19-148[»]
1DI3X-ray1.80A19-148[»]
1DI4X-ray2.00A19-148[»]
1DI5X-ray2.20A19-148[»]
1EQ4X-ray1.80A19-148[»]
1EQ5X-ray1.80A19-148[»]
1EQEX-ray1.80A19-148[»]
1GAYX-ray1.80A19-148[»]
1GAZX-ray1.80A19-148[»]
1GB0X-ray1.80A19-148[»]
1GB2X-ray1.80A19-148[»]
1GB3X-ray1.80A19-148[»]
1GB5X-ray1.80A19-148[»]
1GB6X-ray1.80A19-148[»]
1GB7X-ray1.80A19-148[»]
1GB8X-ray1.80A19-148[»]
1GB9X-ray1.80A19-148[»]
1GBOX-ray1.80A19-148[»]
1GBWX-ray1.80A19-148[»]
1GBXX-ray1.80A19-148[»]
1GBYX-ray1.80A19-148[»]
1GBZX-ray1.80A19-148[»]
1GDWX-ray1.80A19-148[»]
1GDXX-ray1.80A19-148[»]
1GE0X-ray1.80A19-148[»]
1GE1X-ray1.70A19-148[»]
1GE2X-ray2.00A19-148[»]
1GE3X-ray1.80A19-148[»]
1GE4X-ray1.80A19-148[»]
1GEVX-ray2.10A19-148[»]
1GEZX-ray1.80A19-148[»]
1GF0X-ray1.80A19-148[»]
1GF3X-ray1.80A19-148[»]
1GF4X-ray1.80A19-148[»]
1GF5X-ray1.80A19-148[»]
1GF6X-ray1.80A19-148[»]
1GF7X-ray1.80A19-148[»]
1GF8X-ray1.80A19-148[»]
1GF9X-ray1.80A19-148[»]
1GFAX-ray1.80A19-148[»]
1GFEX-ray1.80A19-148[»]
1GFGX-ray1.80A19-148[»]
1GFHX-ray1.80A19-148[»]
1GFJX-ray1.80A19-148[»]
1GFKX-ray1.80A19-148[»]
1GFRX-ray1.80A19-148[»]
1GFTX-ray1.80A19-148[»]
1GFUX-ray1.80A19-148[»]
1GFVX-ray1.80A19-148[»]
1HNLX-ray1.80A19-148[»]
1I1ZX-ray1.80A19-148[»]
1I20X-ray1.90A19-148[»]
1I22X-ray1.80A/B/C/D19-148[»]
1INUX-ray1.80A19-148[»]
1IOCX-ray2.40A19-148[»]
1IP1X-ray1.80A19-148[»]
1IP2X-ray1.80A19-148[»]
1IP3X-ray1.80A/B19-148[»]
1IP4X-ray1.80A19-148[»]
1IP5X-ray1.80A19-148[»]
1IP6X-ray1.80A19-148[»]
1IP7X-ray1.90A/B19-146[»]
1IWTX-ray1.40A19-148[»]
1IWUX-ray1.40A19-148[»]
1IWVX-ray1.40A19-148[»]
1IWWX-ray1.40A19-148[»]
1IWXX-ray1.40A19-148[»]
1IWYX-ray1.40A19-148[»]
1IWZX-ray1.48A19-148[»]
1IX0X-ray1.80A19-148[»]
1IY3NMR-A19-148[»]
1IY4NMR-A19-148[»]
1JKAX-ray1.66A19-148[»]
1JKBX-ray1.66A19-148[»]
1JKCX-ray1.60A19-148[»]
1JKDX-ray1.80A19-148[»]
1JSFX-ray1.15A19-148[»]
1JWRX-ray1.40A19-148[»]
1LAAX-ray1.77A19-148[»]
1LHHX-ray1.80A19-148[»]
1LHIX-ray1.80A19-148[»]
1LHJX-ray1.80A19-148[»]
1LHKX-ray1.80A19-148[»]
1LHLX-ray1.80A19-148[»]
1LHMX-ray1.80A19-148[»]
1LMTX-ray1.60A19-148[»]
1LOZX-ray1.80A19-148[»]
1LYYX-ray1.80A19-148[»]
1LZ1X-ray1.50A19-148[»]
1LZ4X-ray1.80A19-148[»]
1LZ5X-ray1.80A19-144[»]
1LZ6X-ray1.80A19-140[»]
1LZRX-ray1.50A19-148[»]
1LZSX-ray1.60A/B19-148[»]
1OP9X-ray1.86B19-148[»]
1OUAX-ray1.80A19-148[»]
1OUBX-ray1.80A19-148[»]
1OUCX-ray1.80A19-148[»]
1OUDX-ray1.80A19-148[»]
1OUEX-ray1.80A19-148[»]
1OUFX-ray1.80A19-147[»]
1OUGX-ray1.80A19-148[»]
1OUHX-ray1.80A19-148[»]
1OUIX-ray1.80A19-148[»]
1OUJX-ray1.80A19-148[»]
1QSWX-ray1.85A/B/C/D19-148[»]
1RE2X-ray2.30A19-148[»]
1REMX-ray2.10A19-148[»]
1REXX-ray1.50A19-148[»]
1REYX-ray1.70A19-148[»]
1REZX-ray1.70A19-148[»]
1TAYX-ray1.70A19-148[»]
1TBYX-ray1.77A19-148[»]
1TCYX-ray1.70A19-148[»]
1TDYX-ray1.70A19-148[»]
1UBZX-ray2.00A19-148[»]
1W08X-ray2.50A19-148[»]
1WQMX-ray1.80A19-148[»]
1WQNX-ray1.80A19-148[»]
1WQOX-ray1.80A19-148[»]
1WQPX-ray1.80A19-148[»]
1WQQX-ray1.80A19-148[»]
1WQRX-ray1.80A19-148[»]
1YAMX-ray1.80A19-148[»]
1YANX-ray1.80A19-148[»]
1YAOX-ray1.80A19-148[»]
1YAPX-ray1.80A19-148[»]
1YAQX-ray1.80A19-148[»]
207LX-ray1.80A19-148[»]
208LX-ray2.20A19-148[»]
2BQAX-ray1.80A19-148[»]
2BQBX-ray1.80A19-148[»]
2BQCX-ray1.80A19-148[»]
2BQDX-ray1.80A19-148[»]
2BQEX-ray1.80A19-148[»]
2BQFX-ray1.80A19-148[»]
2BQGX-ray1.80A19-148[»]
2BQHX-ray1.80A19-148[»]
2BQIX-ray1.80A19-148[»]
2BQJX-ray1.80A19-148[»]
2BQKX-ray1.80A19-147[»]
2BQLX-ray1.80A19-148[»]
2BQMX-ray1.80A19-148[»]
2BQNX-ray1.80A19-148[»]
2BQOX-ray1.80A19-148[»]
2HEAX-ray1.80A19-148[»]
2HEBX-ray2.20A19-148[»]
2HECX-ray1.80A19-148[»]
2HEDX-ray1.80A19-148[»]
2HEEX-ray1.80A19-148[»]
2HEFX-ray1.80A19-148[»]
2LHMX-ray1.80A19-148[»]
2MEAX-ray2.20A/B19-148[»]
2MEBX-ray1.80A19-148[»]
2MECX-ray2.20A/B19-148[»]
2MEDX-ray1.80A19-148[»]
2MEEX-ray1.80A19-148[»]
2MEFX-ray1.80A19-148[»]
2MEGX-ray1.80A19-148[»]
2MEHX-ray1.80A19-148[»]
2MEIX-ray1.80A19-148[»]
2NWDX-ray1.04X19-148[»]
2ZIJX-ray1.90A19-148[»]
2ZIKX-ray1.81A19-148[»]
2ZILX-ray1.80A19-148[»]
2ZWBneutron diffraction1.80A19-148[»]
3EBAX-ray1.85B19-148[»]
3FE0X-ray1.50A19-148[»]
3LHMX-ray1.80A19-148[»]
3LN2X-ray2.04A/B19-148[»]
4I0CX-ray1.95A/B19-148[»]
4ML7X-ray1.80A/C19-148[»]
4R0PX-ray1.52A74-79[»]
5LSHX-ray1.06A19-148[»]
5LVKX-ray2.49A/B19-148[»]
ProteinModelPortaliP61626
SMRiP61626
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110247, 42 interactors
IntActiP61626, 12 interactors
MINTiP61626
STRINGi9606.ENSP00000261267

Chemistry databases

DrugBankiDB02159 (R)-Propylene glycol
DB03175 1-Proponol
DB03487 3-Aminosuccinimide
DB02759 4-Methylumbelliferyl Chitobiose
DB03006 Arsanilic acid
DB04194 Chitotriose
DB02250 Cu-Bicyclam
DB03189 Cu-Cyclam
DB03013 Di(N-Acetyl-D-Glucosamine)
DB03967 Dodecyl Sulfate
DB00128 L-Aspartic Acid
DB04268 Methylumbelliferyl Chitotriose
DB03120 Para-Toluene Sulfonate
DB02772 Sucrose

Protein family/group databases

CAZyiGH22 Glycoside Hydrolase Family 22

PTM databases

iPTMnetiP61626
PhosphoSitePlusiP61626

Polymorphism and mutation databases

BioMutaiLYZ
DMDMi48428995

2D gel databases

UCD-2DPAGEiP61626

Proteomic databases

EPDiP61626
jPOSTiP61626
MaxQBiP61626
PaxDbiP61626
PeptideAtlasiP61626
PRIDEiP61626
ProteomicsDBi12683
57328
TopDownProteomicsiP61626

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4069
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261267; ENSP00000261267; ENSG00000090382
GeneIDi4069
KEGGihsa:4069
UCSCiuc001suw.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4069
DisGeNETi4069
EuPathDBiHostDB:ENSG00000090382.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LYZ
HGNCiHGNC:6740 LYZ
HPAiCAB000055
HPA048284
HPA066182
MalaCardsiLYZ
MIMi105200 phenotype
153450 gene
neXtProtiNX_P61626
OpenTargetsiENSG00000090382
Orphaneti93561 ALys amyloidosis
PharmGKBiPA30503

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IXGD Eukaryota
ENOG4111QHM LUCA
GeneTreeiENSGT00940000153832
HOGENOMiHOG000037357
HOVERGENiHBG052297
InParanoidiP61626
KOiK13915
OMAiKWESNYN
OrthoDBi1551203at2759
PhylomeDBiP61626
TreeFamiTF324882

Enzyme and pathway databases

BRENDAi3.2.1.17 2681
ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-6803157 Antimicrobial peptides
R-HSA-977225 Amyloid fiber formation
SIGNORiP61626

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LYZ human
EvolutionaryTraceiP61626

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Lysozyme

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4069

Protein Ontology

More...
PROi
PR:P61626

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000090382 Expressed in 210 organ(s), highest expression level in nasal cavity mucosa
ExpressionAtlasiP61626 baseline and differential
GenevisibleiP61626 HS

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000974 Glyco_hydro_22_lys
IPR023346 Lysozyme-like_dom_sf
IPR030056 Lysozyme_C
PANTHERiPTHR11407:SF28 PTHR11407:SF28, 1 hit
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00137 LYSOZYME
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLYSC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61626
Secondary accession number(s): P00695, Q13170, Q9UCF8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 7, 2004
Last modified: February 13, 2019
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again