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Entry version 153 (18 Sep 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Protein transport protein Sec61 subunit alpha isoform 1

Gene

SEC61A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:22375059, PubMed:28782633, PubMed:29719251). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (PubMed:22375059, PubMed:29719251). Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (PubMed:28782633). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.5.9.1 the general secretory pathway (sec) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein transport protein Sec61 subunit alpha isoform 1
Short name:
Sec61 alpha-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC61A1
Synonyms:SEC61A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18276 SEC61A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609213 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P61619

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei34 – 53HelicalSequence analysisAdd BLAST20
Topological domaini54 – 76LumenalSequence analysisAdd BLAST23
Transmembranei77 – 96HelicalSequence analysisAdd BLAST20
Topological domaini97 – 117CytoplasmicSequence analysisAdd BLAST21
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 144LumenalSequence analysis6
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 172CytoplasmicSequence analysis7
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 240LumenalSequence analysisAdd BLAST47
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 288CytoplasmicSequence analysisAdd BLAST27
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 354LumenalSequence analysisAdd BLAST45
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 420CytoplasmicSequence analysisAdd BLAST45
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21
Topological domaini442 – 445LumenalSequence analysis4
Transmembranei446 – 462HelicalSequence analysisAdd BLAST17
Topological domaini463 – 476CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Familial juvenile hyperuricemic nephropathy 4 (HNFJ4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant renal disorder characterized by progressive chronic kidney disease, anemia, elevated serum creatinine levels, and hyperuricemia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07705967V → G in HNFJ4; decreases in protein stability; partly confers novel Golgi subcellular location. 1 PublicationCorresponds to variant dbSNP:rs752745051EnsemblClinVar.1
Natural variantiVAR_077060185T → A in HNFJ4; decreases in protein stability; partly confers novel Golgi subcellular location. 1 PublicationCorresponds to variant dbSNP:rs879255648EnsemblClinVar.1
Defects in SEC61A1 may be a cause of autosomal dominant hypogammaglobulinemia, resulting in severe recurrent infections, mainly of the respiratory tract. Disease onset is mostly in the first year of life. Affected subjects manifest reduced antibodies production by plasma cells, in the presence of normal subpopulations of B and T cells in the peripheral blood. Patients respond well to immunoglobulin replacement therapy.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi344Y → H: Reduces cotranslational translocation of APLN precursor/preproapelin. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
29927

MalaCards human disease database

More...
MalaCardsi
SEC61A1
MIMi617056 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000058262

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134901772

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SEC61A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
48429109

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001317911 – 476Protein transport protein Sec61 subunit alpha isoform 1Add BLAST476

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P61619

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P61619

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P61619

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P61619

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P61619

PeptideAtlas

More...
PeptideAtlasi
P61619

PRoteomics IDEntifications database

More...
PRIDEi
P61619

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57326 [P61619-1]
57327 [P61619-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P61619

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P61619

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P61619

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in proximal and distal tubules in kidney (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000058262 Expressed in 219 organ(s), highest expression level in body of pancreas

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P61619 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P61619 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB022076

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The ER translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
118968, 88 interactors

Protein interaction database and analysis system

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IntActi
P61619, 44 interactors

Molecular INTeraction database

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MINTi
P61619

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000243253

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1373 Eukaryota
COG0201 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003721

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P61619

KEGG Orthology (KO)

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KOi
K10956

Database of Orthologous Groups

More...
OrthoDBi
482911at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P61619

TreeFam database of animal gene trees

More...
TreeFami
TF300348

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3370.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002208 SecY/SEC61-alpha
IPR030659 SecY_CS
IPR023201 SecY_dom_sf
IPR019561 Translocon_Sec61/SecY_plug_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10906 PTHR10906, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10559 Plug_translocon, 1 hit
PF00344 SecY, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF004557 SecY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103491 SSF103491, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00967 3a0501s007, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00755 SECY_1, 1 hit
PS00756 SECY_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P61619-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL
60 70 80 90 100
FGIMSSDSAD PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII
110 120 130 140 150
EVGDTPKDRA LFNGAQKLFG MIITIGQSIV YVMTGMYGDP SEMGAGICLL
160 170 180 190 200
ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS LFIATNICET IVWKAFSPTT
210 220 230 240 250
VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP NLMNLIATIF
260 270 280 290 300
VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN
310 320 330 340 350
LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARAYPVGG LCYYLSPPES
360 370 380 390 400
FGSVLEDPVH AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV
410 420 430 440 450
MRGHRETSMV HELNRYIPTA AAFGGLCIGA LSVLADFLGA IGSGTGILLA
460 470
VTIIYQYFEI FVKEQSEVGS MGALLF
Length:476
Mass (Da):52,265
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44A9B7B37C7C82E4
GO
Isoform 3 (identifier: P61619-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.

Note: No experimental confirmation available.
Show »
Length:356
Mass (Da):38,849
Checksum:i51804242521CDA10
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DR61B4DR61_HUMAN
Protein transport protein Sec61 sub...
SEC61A1
482Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JXC6C9JXC6_HUMAN
Protein transport protein Sec61 sub...
SEC61A1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11283 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11434 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti135G → W in AAD27765 (Ref. 1) Curated1
Sequence conflicti234F → L in BAC11298 (PubMed:14702039).Curated1
Sequence conflicti278T → S in AAD27765 (Ref. 1) Curated1
Sequence conflicti310A → V in AAD27765 (Ref. 1) Curated1
Sequence conflicti316L → F in AAD27765 (Ref. 1) Curated1
Sequence conflicti319S → N in AAD27765 (Ref. 1) Curated1
Sequence conflicti323 – 329TWSDTSS → QWADVSG in AAD27765 (Ref. 1) Curated7
Sequence conflicti335A → S in AAD27765 (Ref. 1) Curated1
Sequence conflicti351 – 355FGSVL → MGAIF in AAD27765 (Ref. 1) Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07705967V → G in HNFJ4; decreases in protein stability; partly confers novel Golgi subcellular location. 1 PublicationCorresponds to variant dbSNP:rs752745051EnsemblClinVar.1
Natural variantiVAR_08023185V → D Probable disease-associated mutation found in a family with hypogammaglobulinemia; decreased function in cotranslational protein targeting to endoplasmic reticulum. 1 PublicationCorresponds to variant dbSNP:rs1553721236EnsemblClinVar.1
Natural variantiVAR_077060185T → A in HNFJ4; decreases in protein stability; partly confers novel Golgi subcellular location. 1 PublicationCorresponds to variant dbSNP:rs879255648EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0137471 – 120Missing in isoform 3. 1 PublicationAdd BLAST120

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF077032 mRNA Translation: AAD27765.1
AF084458 mRNA Translation: AAD39847.1
AF346602 mRNA Translation: AAK29083.1
AK074907 mRNA Translation: BAC11283.1 Different initiation.
AK074928 mRNA Translation: BAC11298.1
AK075148 mRNA Translation: BAC11434.1 Different initiation.
AL831940 mRNA Translation: CAD38592.1
AL832821 mRNA Translation: CAI46127.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3046.1 [P61619-1]

NCBI Reference Sequences

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RefSeqi
NP_037468.1, NM_013336.3 [P61619-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000243253; ENSP00000243253; ENSG00000058262 [P61619-1]
ENST00000424880; ENSP00000411445; ENSG00000058262 [P61619-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
29927

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:29927

UCSC genome browser

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UCSCi
uc003ekb.4 human [P61619-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077032 mRNA Translation: AAD27765.1
AF084458 mRNA Translation: AAD39847.1
AF346602 mRNA Translation: AAK29083.1
AK074907 mRNA Translation: BAC11283.1 Different initiation.
AK074928 mRNA Translation: BAC11298.1
AK075148 mRNA Translation: BAC11434.1 Different initiation.
AL831940 mRNA Translation: CAD38592.1
AL832821 mRNA Translation: CAI46127.1
CCDSiCCDS3046.1 [P61619-1]
RefSeqiNP_037468.1, NM_013336.3 [P61619-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi118968, 88 interactors
IntActiP61619, 44 interactors
MINTiP61619
STRINGi9606.ENSP00000243253

Protein family/group databases

TCDBi3.A.5.9.1 the general secretory pathway (sec) family

PTM databases

iPTMnetiP61619
PhosphoSitePlusiP61619
SwissPalmiP61619

Polymorphism and mutation databases

BioMutaiSEC61A1
DMDMi48429109

Proteomic databases

EPDiP61619
jPOSTiP61619
MassIVEiP61619
MaxQBiP61619
PaxDbiP61619
PeptideAtlasiP61619
PRIDEiP61619
ProteomicsDBi57326 [P61619-1]
57327 [P61619-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
29927
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243253; ENSP00000243253; ENSG00000058262 [P61619-1]
ENST00000424880; ENSP00000411445; ENSG00000058262 [P61619-3]
GeneIDi29927
KEGGihsa:29927
UCSCiuc003ekb.4 human [P61619-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
29927
DisGeNETi29927

GeneCards: human genes, protein and diseases

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GeneCardsi
SEC61A1
HGNCiHGNC:18276 SEC61A1
HPAiCAB022076
MalaCardsiSEC61A1
MIMi609213 gene
617056 phenotype
neXtProtiNX_P61619
OpenTargetsiENSG00000058262
PharmGKBiPA134901772

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1373 Eukaryota
COG0201 LUCA
GeneTreeiENSGT00390000003721
InParanoidiP61619
KOiK10956
OrthoDBi482911at2759
PhylomeDBiP61619
TreeFamiTF300348

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SEC61A1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Sec61_alpha_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29927

Pharos

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Pharosi
P61619

Protein Ontology

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PROi
PR:P61619

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000058262 Expressed in 219 organ(s), highest expression level in body of pancreas
ExpressionAtlasiP61619 baseline and differential
GenevisibleiP61619 HS

Family and domain databases

Gene3Di1.10.3370.10, 1 hit
InterProiView protein in InterPro
IPR002208 SecY/SEC61-alpha
IPR030659 SecY_CS
IPR023201 SecY_dom_sf
IPR019561 Translocon_Sec61/SecY_plug_dom
PANTHERiPTHR10906 PTHR10906, 1 hit
PfamiView protein in Pfam
PF10559 Plug_translocon, 1 hit
PF00344 SecY, 1 hit
PIRSFiPIRSF004557 SecY, 1 hit
SUPFAMiSSF103491 SSF103491, 1 hit
TIGRFAMsiTIGR00967 3a0501s007, 1 hit
PROSITEiView protein in PROSITE
PS00755 SECY_1, 1 hit
PS00756 SECY_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS61A1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61619
Secondary accession number(s): P38378
, P57726, Q5JPF8, Q8N0Z4, Q8N3U3, Q8NC71, Q9BU16, Q9Y2R3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: September 18, 2019
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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