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Protein

10 kDa heat shock protein, mitochondrial

Gene

HSPE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:7912672, PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable).1 Publication3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: InterPro
  • chaperone binding Source: UniProtKB
  • metal ion binding Source: GO_Central
  • RNA binding Source: UniProtKB
  • unfolded protein binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processStress response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
10 kDa heat shock protein, mitochondrial
Short name:
Hsp10
Alternative name(s):
10 kDa chaperonin
Chaperonin 10
Short name:
CPN10
Early-pregnancy factor
Short name:
EPF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HSPE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000115541.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5269 HSPE1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600141 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P61604

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3336

Open Targets

More...
OpenTargetsi
ENSG00000115541

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29535

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HSPE1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47606335

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001749172 – 10210 kDa heat shock protein, mitochondrialAdd BLAST101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei8N6-acetyllysineBy similarity1
Modified residuei28N6-succinyllysineBy similarity1
Modified residuei40N6-acetyllysine; alternateBy similarity1
Modified residuei40N6-malonyllysine; alternate1 Publication1
Modified residuei40N6-succinyllysine; alternateBy similarity1
Modified residuei54N6-malonyllysine; alternate1 Publication1
Modified residuei54N6-succinyllysine; alternateBy similarity1
Modified residuei56N6-acetyllysine; alternateCombined sources1
Modified residuei56N6-malonyllysine; alternate1 Publication1
Modified residuei56N6-succinyllysine; alternateBy similarity1
Modified residuei66N6-acetyllysine; alternateBy similarity1
Modified residuei66N6-succinyllysine; alternateBy similarity1
Modified residuei70N6-acetyllysine; alternateBy similarity1
Modified residuei70N6-succinyllysine; alternateBy similarity1
Modified residuei79PhosphothreonineCombined sources1
Modified residuei80N6-acetyllysine; alternateBy similarity1
Modified residuei80N6-succinyllysine; alternateBy similarity1
Modified residuei86N6-acetyllysine; alternateCombined sources1
Modified residuei86N6-succinyllysine; alternateBy similarity1
Modified residuei99N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P61604

MaxQB - The MaxQuant DataBase

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MaxQBi
P61604

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P61604

PeptideAtlas

More...
PeptideAtlasi
P61604

PRoteomics IDEntifications database

More...
PRIDEi
P61604

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57325

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P61604

2D gel databases

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P61604

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P61604

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P61604

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By stress.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115541 Expressed in 89 organ(s), highest expression level in right adrenal gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_HSPE1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P61604 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P61604 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017366
HPA038755
HPA048272

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homoheptamer arranged in a ring structure (PubMed:25918392). 2 heptameric Hsp10 rings interact with a Hsp60 tetradecamer in the structure of a back-to-back double heptameric ring to form the symmetrical football complex (PubMed:25918392).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109568, 126 interactors

Protein interaction database and analysis system

More...
IntActi
P61604, 39 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000233893

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1102
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P61604

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P61604

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GroES chaperonin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1641 Eukaryota
COG0234 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006350

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000133897

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000385

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P61604

KEGG Orthology (KO)

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KOi
K04078

Identification of Orthologs from Complete Genome Data

More...
OMAi
PGRIDDN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0ZIY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P61604

TreeFam database of animal gene trees

More...
TreeFami
TF313814

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00320 cpn10, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.33.40, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00580 CH10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020818 Chaperonin_GroES
IPR037124 Chaperonin_GroES_sf
IPR018369 Chaprnonin_Cpn10_CS
IPR011032 GroES-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10772 PTHR10772, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00166 Cpn10, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00297 CHAPERONIN10

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00883 Cpn10, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50129 SSF50129, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00681 CHAPERONINS_CPN10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P61604-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGQAFRKFL PLFDRVLVER SAAETVTKGG IMLPEKSQGK VLQATVVAVG
60 70 80 90 100
SGSKGKGGEI QPVSVKVGDK VLLPEYGGTK VVLDDKDYFL FRDGDILGKY

VD
Length:102
Mass (Da):10,932
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F3192C81F6EDB78
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZL8B8ZZL8_HUMAN
10 kDa heat shock protein, mitochon...
HSPE1 hCG_21429
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8ZZ54B8ZZ54_HUMAN
10 kDa heat shock protein, mitochon...
HSPE1 hCG_21429
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 10843.5±0.2 Da from positions 2 - 102. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X75821 mRNA Translation: CAA53455.1
U07550 mRNA Translation: AAA50953.1
AJ250915 Genomic DNA Translation: CAB75425.1
AK312104 mRNA Translation: BAG35040.1
CR407688 mRNA Translation: CAG28616.1
AC020550 Genomic DNA Translation: AAX93146.1
CH471063 Genomic DNA Translation: EAW70163.1
BC023518 mRNA Translation: AAH23518.1
AH007060 Genomic DNA Translation: AAC95387.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2320.1

Protein sequence database of the Protein Information Resource

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PIRi
S47532

NCBI Reference Sequences

More...
RefSeqi
NP_002148.1, NM_002157.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.1197

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000233893; ENSP00000233893; ENSG00000115541

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3336

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3336

UCSC genome browser

More...
UCSCi
uc002uul.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75821 mRNA Translation: CAA53455.1
U07550 mRNA Translation: AAA50953.1
AJ250915 Genomic DNA Translation: CAB75425.1
AK312104 mRNA Translation: BAG35040.1
CR407688 mRNA Translation: CAG28616.1
AC020550 Genomic DNA Translation: AAX93146.1
CH471063 Genomic DNA Translation: EAW70163.1
BC023518 mRNA Translation: AAH23518.1
AH007060 Genomic DNA Translation: AAC95387.1
CCDSiCCDS2320.1
PIRiS47532
RefSeqiNP_002148.1, NM_002157.2
UniGeneiHs.1197

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PJ1X-ray3.151/2/O/P/Q/R/S/T/U/V/W/X/Y/Z1-102[»]
ProteinModelPortaliP61604
SMRiP61604
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109568, 126 interactors
IntActiP61604, 39 interactors
STRINGi9606.ENSP00000233893

PTM databases

iPTMnetiP61604
PhosphoSitePlusiP61604

Polymorphism and mutation databases

BioMutaiHSPE1
DMDMi47606335

2D gel databases

UCD-2DPAGEiP61604

Proteomic databases

EPDiP61604
MaxQBiP61604
PaxDbiP61604
PeptideAtlasiP61604
PRIDEiP61604
ProteomicsDBi57325
TopDownProteomicsiP61604

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3336
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233893; ENSP00000233893; ENSG00000115541
GeneIDi3336
KEGGihsa:3336
UCSCiuc002uul.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3336
DisGeNETi3336
EuPathDBiHostDB:ENSG00000115541.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HSPE1
HGNCiHGNC:5269 HSPE1
HPAiCAB017366
HPA038755
HPA048272
MIMi600141 gene
neXtProtiNX_P61604
OpenTargetsiENSG00000115541
PharmGKBiPA29535

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1641 Eukaryota
COG0234 LUCA
GeneTreeiENSGT00390000006350
HOGENOMiHOG000133897
HOVERGENiHBG000385
InParanoidiP61604
KOiK04078
OMAiPGRIDDN
OrthoDBiEOG091G0ZIY
PhylomeDBiP61604
TreeFamiTF313814

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HSPE1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GroES

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3336

Protein Ontology

More...
PROi
PR:P61604

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115541 Expressed in 89 organ(s), highest expression level in right adrenal gland
CleanExiHS_HSPE1
ExpressionAtlasiP61604 baseline and differential
GenevisibleiP61604 HS

Family and domain databases

CDDicd00320 cpn10, 1 hit
Gene3Di2.30.33.40, 1 hit
HAMAPiMF_00580 CH10, 1 hit
InterProiView protein in InterPro
IPR020818 Chaperonin_GroES
IPR037124 Chaperonin_GroES_sf
IPR018369 Chaprnonin_Cpn10_CS
IPR011032 GroES-like_sf
PANTHERiPTHR10772 PTHR10772, 1 hit
PfamiView protein in Pfam
PF00166 Cpn10, 1 hit
PRINTSiPR00297 CHAPERONIN10
SMARTiView protein in SMART
SM00883 Cpn10, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
PROSITEiView protein in PROSITE
PS00681 CHAPERONINS_CPN10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCH10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61604
Secondary accession number(s): O95421
, Q04984, Q53X54, Q9UDH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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