UniProtKB - P61601 (NCALD_HUMAN)
Protein
Neurocalcin-delta
Gene
NCALD
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 73 – 84 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 109 – 120 | 2PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 157 – 168 | 3PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- actin binding Source: UniProtKB
- calcium ion binding Source: InterPro
- clathrin binding Source: UniProtKB
- tubulin binding Source: UniProtKB
GO - Biological processi
- vesicle-mediated transport Source: UniProtKB
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P61601 |
Reactomei | R-HSA-451308, Activation of Ca-permeable Kainate Receptor |
Names & Taxonomyi
Protein namesi | Recommended name: Neurocalcin-delta |
Gene namesi | Name:NCALD |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7655, NCALD |
MIMi | 606722, gene |
neXtProti | NX_P61601 |
VEuPathDBi | HostDB:ENSG00000104490.17 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- clathrin coat of trans-Golgi network vesicle Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 83988 |
OpenTargetsi | ENSG00000104490 |
PharmGKBi | PA31458 |
Miscellaneous databases
Pharosi | P61601, Tbio |
Genetic variation databases
BioMutai | NCALD |
DMDMi | 47606440 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed | |||
ChainiPRO_0000073782 | 2 – 193 | Neurocalcin-deltaAdd BLAST | 192 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, MyristateProteomic databases
EPDi | P61601 |
jPOSTi | P61601 |
MassIVEi | P61601 |
MaxQBi | P61601 |
PaxDbi | P61601 |
PeptideAtlasi | P61601 |
PRIDEi | P61601 |
ProteomicsDBi | 57324 |
PTM databases
iPTMneti | P61601 |
PhosphoSitePlusi | P61601 |
Expressioni
Tissue specificityi
Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.
Gene expression databases
Bgeei | ENSG00000104490, Expressed in Brodmann (1909) area 10 and 202 other tissues |
ExpressionAtlasi | P61601, baseline and differential |
Genevisiblei | P61601, HS |
Organism-specific databases
HPAi | ENSG00000104490, Tissue enhanced (brain, salivary gland) |
Interactioni
Subunit structurei
Interacts with GUCY2D.
By similarityBinary interactionsi
Hide detailsP61601
GO - Molecular functioni
- actin binding Source: UniProtKB
- clathrin binding Source: UniProtKB
- tubulin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 123839, 40 interactors |
IntActi | P61601, 36 interactors |
MINTi | P61601 |
STRINGi | 9606.ENSP00000379256 |
Miscellaneous databases
RNActi | P61601, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 58 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 60 – 95 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 96 – 131 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 144 – 179 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the recoverin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0044, Eukaryota |
GeneTreei | ENSGT00940000158862 |
HOGENOMi | CLU_072366_1_0_1 |
InParanoidi | P61601 |
OMAi | CCNPIPS |
PhylomeDBi | P61601 |
TreeFami | TF300009 |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR028846, Recoverin |
PANTHERi | PTHR23055, PTHR23055, 1 hit |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 3 hits PS50222, EF_HAND_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 17 potential isoforms that are computationally mapped.Show allAlign All
P61601-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK
60 70 80 90 100
IYGNFFPYGD ASKFAEHVFR TFDANGDGTI DFREFIIALS VTSRGKLEQK
110 120 130 140 150
LKWAFSMYDL DGNGYISKAE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE
160 170 180 190
KIFRQMDTNR DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA GQF
Computationally mapped potential isoform sequencesi
There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RGA9 | E5RGA9_HUMAN | Neurocalcin-delta | NCALD | 194 | Annotation score: | ||
E5RI78 | E5RI78_HUMAN | Neurocalcin-delta | NCALD | 116 | Annotation score: | ||
E5RIA5 | E5RIA5_HUMAN | Neurocalcin-delta | NCALD | 152 | Annotation score: | ||
E5RIZ1 | E5RIZ1_HUMAN | Neurocalcin-delta | NCALD | 136 | Annotation score: | ||
E5RHC8 | E5RHC8_HUMAN | Neurocalcin-delta | NCALD | 120 | Annotation score: | ||
E5RHE8 | E5RHE8_HUMAN | Neurocalcin-delta | NCALD | 112 | Annotation score: | ||
E5RI95 | E5RI95_HUMAN | Neurocalcin-delta | NCALD | 105 | Annotation score: | ||
E5RIG4 | E5RIG4_HUMAN | Neurocalcin-delta | NCALD | 121 | Annotation score: | ||
E5RJJ6 | E5RJJ6_HUMAN | Neurocalcin-delta | NCALD | 85 | Annotation score: | ||
E5RGZ0 | E5RGZ0_HUMAN | Neurocalcin-delta | NCALD | 87 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 123 | E → V in CAB66547 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 166 | L → M in AAH36098 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF251061 mRNA Translation: AAK34951.1 AL136612 mRNA Translation: CAB66547.1 BC036098 mRNA Translation: AAH36098.1 BC063428 mRNA Translation: AAH63428.1 |
CCDSi | CCDS6292.1 |
RefSeqi | NP_001035714.1, NM_001040624.1 NP_001035715.1, NM_001040625.1 NP_001035716.1, NM_001040626.1 NP_001035717.1, NM_001040627.1 NP_001035718.1, NM_001040628.1 NP_001035719.1, NM_001040629.1 NP_001035720.1, NM_001040630.1 NP_114430.2, NM_032041.2 XP_011515634.1, XM_011517332.2 XP_011515635.1, XM_011517333.2 XP_011515636.1, XM_011517334.2 XP_011515637.1, XM_011517335.2 XP_016869390.1, XM_017013901.1 XP_016869391.1, XM_017013902.1 |
Genome annotation databases
Ensembli | ENST00000220931; ENSP00000220931; ENSG00000104490 ENST00000311028; ENSP00000310587; ENSG00000104490 ENST00000395923; ENSP00000379256; ENSG00000104490 ENST00000519508; ENSP00000430476; ENSG00000104490 ENST00000521599; ENSP00000428105; ENSG00000104490 |
GeneIDi | 83988 |
KEGGi | hsa:83988 |
UCSCi | uc003yke.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF251061 mRNA Translation: AAK34951.1 AL136612 mRNA Translation: CAB66547.1 BC036098 mRNA Translation: AAH36098.1 BC063428 mRNA Translation: AAH63428.1 |
CCDSi | CCDS6292.1 |
RefSeqi | NP_001035714.1, NM_001040624.1 NP_001035715.1, NM_001040625.1 NP_001035716.1, NM_001040626.1 NP_001035717.1, NM_001040627.1 NP_001035718.1, NM_001040628.1 NP_001035719.1, NM_001040629.1 NP_001035720.1, NM_001040630.1 NP_114430.2, NM_032041.2 XP_011515634.1, XM_011517332.2 XP_011515635.1, XM_011517333.2 XP_011515636.1, XM_011517334.2 XP_011515637.1, XM_011517335.2 XP_016869390.1, XM_017013901.1 XP_016869391.1, XM_017013902.1 |
3D structure databases
SMRi | P61601 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123839, 40 interactors |
IntActi | P61601, 36 interactors |
MINTi | P61601 |
STRINGi | 9606.ENSP00000379256 |
PTM databases
iPTMneti | P61601 |
PhosphoSitePlusi | P61601 |
Genetic variation databases
BioMutai | NCALD |
DMDMi | 47606440 |
Proteomic databases
EPDi | P61601 |
jPOSTi | P61601 |
MassIVEi | P61601 |
MaxQBi | P61601 |
PaxDbi | P61601 |
PeptideAtlasi | P61601 |
PRIDEi | P61601 |
ProteomicsDBi | 57324 |
Protocols and materials databases
Antibodypediai | 42836, 160 antibodies |
DNASUi | 83988 |
Genome annotation databases
Ensembli | ENST00000220931; ENSP00000220931; ENSG00000104490 ENST00000311028; ENSP00000310587; ENSG00000104490 ENST00000395923; ENSP00000379256; ENSG00000104490 ENST00000519508; ENSP00000430476; ENSG00000104490 ENST00000521599; ENSP00000428105; ENSG00000104490 |
GeneIDi | 83988 |
KEGGi | hsa:83988 |
UCSCi | uc003yke.4, human |
Organism-specific databases
CTDi | 83988 |
DisGeNETi | 83988 |
GeneCardsi | NCALD |
HGNCi | HGNC:7655, NCALD |
HPAi | ENSG00000104490, Tissue enhanced (brain, salivary gland) |
MIMi | 606722, gene |
neXtProti | NX_P61601 |
OpenTargetsi | ENSG00000104490 |
PharmGKBi | PA31458 |
VEuPathDBi | HostDB:ENSG00000104490.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0044, Eukaryota |
GeneTreei | ENSGT00940000158862 |
HOGENOMi | CLU_072366_1_0_1 |
InParanoidi | P61601 |
OMAi | CCNPIPS |
PhylomeDBi | P61601 |
TreeFami | TF300009 |
Enzyme and pathway databases
PathwayCommonsi | P61601 |
Reactomei | R-HSA-451308, Activation of Ca-permeable Kainate Receptor |
Miscellaneous databases
BioGRID-ORCSi | 83988, 8 hits in 994 CRISPR screens |
ChiTaRSi | NCALD, human |
GenomeRNAii | 83988 |
Pharosi | P61601, Tbio |
PROi | PR:P61601 |
RNActi | P61601, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104490, Expressed in Brodmann (1909) area 10 and 202 other tissues |
ExpressionAtlasi | P61601, baseline and differential |
Genevisiblei | P61601, HS |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR028846, Recoverin |
PANTHERi | PTHR23055, PTHR23055, 1 hit |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 3 hits PS50222, EF_HAND_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NCALD_HUMAN | |
Accessioni | P61601Primary (citable) accession number: P61601 Secondary accession number(s): P29554, Q8IYC3, Q9H0W2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families