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Protein

Rho-related GTP-binding protein RhoE

Gene

RND3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 37GTPBy similarity8
Nucleotide bindingi77 – 81GTPBy similarity5
Nucleotide bindingi135 – 138GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: ProtInc

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

SIGNORiP61587

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoE
Alternative name(s):
Protein MemB
Rho family GTPase 3
Rho-related GTP-binding protein Rho8
Rnd3
Gene namesi
Name:RND3
Synonyms:ARHE, RHO8, RHOE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115963.13
HGNCiHGNC:671 RND3
MIMi602924 gene
neXtProtiNX_P61587

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi390
OpenTargetsiENSG00000115963
PharmGKBiPA24953

Chemistry databases

DrugBankiDB04137 Guanosine-5'-Triphosphate

Polymorphism and mutation databases

BioMutaiRND3
DMDMi47606459

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988781 – 241Rho-related GTP-binding protein RhoEAdd BLAST241
PropeptideiPRO_0000281230242 – 244Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei241Cysteine methyl esterBy similarity1
Lipidationi241S-farnesyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP61587
MaxQBiP61587
PaxDbiP61587
PeptideAtlasiP61587
PRIDEiP61587
ProteomicsDBi57322

PTM databases

iPTMnetiP61587
PhosphoSitePlusiP61587

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000115963 Expressed in 228 organ(s), highest expression level in amniotic fluid
CleanExiHS_RND3
ExpressionAtlasiP61587 baseline and differential
GenevisibleiP61587 HS

Organism-specific databases

HPAiHPA060504

Interactioni

Subunit structurei

Binds ROCK1 (By similarity). Interacts with UBXD5.By similarity2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi106883, 14 interactors
IntActiP61587, 7 interactors
MINTiP61587
STRINGi9606.ENSP00000263895

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP61587
SMRiP61587
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61587

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi52 – 60Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000119020
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiP61587
KOiK07859
OMAiERRPCQK
OrthoDBiEOG091G0M4M
PhylomeDBiP61587
TreeFamiTF330887

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

P61587-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE
60 70 80 90 100
NYVPTVFENY TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI
110 120 130 140 150
CFDISRPETL DSVLKKWKGE IQEFCPNTKM LLVGCKSDLR TDVSTLVELS
160 170 180 190 200
NHRQTPVSYD QGANMAKQIG AATYIECSAL QSENSVRDIF HVATLACVNK
210 220 230 240
TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS CTVM
Length:244
Mass (Da):27,368
Last modified:May 24, 2004 - v1
Checksum:iDD2D4021CD42BACC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q53RZ3Q53RZ3_HUMAN
Rho-related GTP-binding protein Rho...
RND3 ARHE
116Annotation score:
E9PFH1E9PFH1_HUMAN
Rho-related GTP-binding protein Rho...
RND3
115Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95282 mRNA Translation: CAA64603.1
X97758 mRNA Translation: CAA66352.1
AF498969 mRNA Translation: AAM21116.1
BT006769 mRNA Translation: AAP35415.1
CH471058 Genomic DNA Translation: EAX11524.1
CH471058 Genomic DNA Translation: EAX11526.1
BC012513 mRNA Translation: AAH12513.1
S82240 mRNA Translation: AAB47133.1
CCDSiCCDS2190.1
RefSeqiNP_001241667.1, NM_001254738.1
NP_005159.1, NM_005168.4
UniGeneiHs.6838
Hs.713765

Genome annotation databases

EnsembliENST00000263895; ENSP00000263895; ENSG00000115963
ENST00000375734; ENSP00000364886; ENSG00000115963
GeneIDi390
KEGGihsa:390
UCSCiuc002txe.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95282 mRNA Translation: CAA64603.1
X97758 mRNA Translation: CAA66352.1
AF498969 mRNA Translation: AAM21116.1
BT006769 mRNA Translation: AAP35415.1
CH471058 Genomic DNA Translation: EAX11524.1
CH471058 Genomic DNA Translation: EAX11526.1
BC012513 mRNA Translation: AAH12513.1
S82240 mRNA Translation: AAB47133.1
CCDSiCCDS2190.1
RefSeqiNP_001241667.1, NM_001254738.1
NP_005159.1, NM_005168.4
UniGeneiHs.6838
Hs.713765

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M7BX-ray2.00A19-200[»]
2V55X-ray3.70B/D1-200[»]
4BG6X-ray2.30Q/R232-241[»]
ProteinModelPortaliP61587
SMRiP61587
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106883, 14 interactors
IntActiP61587, 7 interactors
MINTiP61587
STRINGi9606.ENSP00000263895

Chemistry databases

DrugBankiDB04137 Guanosine-5'-Triphosphate

PTM databases

iPTMnetiP61587
PhosphoSitePlusiP61587

Polymorphism and mutation databases

BioMutaiRND3
DMDMi47606459

Proteomic databases

EPDiP61587
MaxQBiP61587
PaxDbiP61587
PeptideAtlasiP61587
PRIDEiP61587
ProteomicsDBi57322

Protocols and materials databases

DNASUi390
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263895; ENSP00000263895; ENSG00000115963
ENST00000375734; ENSP00000364886; ENSG00000115963
GeneIDi390
KEGGihsa:390
UCSCiuc002txe.4 human

Organism-specific databases

CTDi390
DisGeNETi390
EuPathDBiHostDB:ENSG00000115963.13
GeneCardsiRND3
HGNCiHGNC:671 RND3
HPAiHPA060504
MIMi602924 gene
neXtProtiNX_P61587
OpenTargetsiENSG00000115963
PharmGKBiPA24953
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000119020
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiP61587
KOiK07859
OMAiERRPCQK
OrthoDBiEOG091G0M4M
PhylomeDBiP61587
TreeFamiTF330887

Enzyme and pathway databases

SIGNORiP61587

Miscellaneous databases

ChiTaRSiRND3 human
EvolutionaryTraceiP61587
GeneWikiiRnd3
GenomeRNAii390
PROiPR:P61587
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115963 Expressed in 228 organ(s), highest expression level in amniotic fluid
CleanExiHS_RND3
ExpressionAtlasiP61587 baseline and differential
GenevisibleiP61587 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRND3_HUMAN
AccessioniPrimary (citable) accession number: P61587
Secondary accession number(s): D3DP95, P52199
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: September 12, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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