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Protein

Endogenous retrovirus group K member 24 Env polyprotein

Gene

ERVK-24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.
SU mediates receptor recognition.By similarity
TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).By similarity

Miscellaneous

This envelope protein is encoded by a human specific provirus.
Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.
Intergenic, closest flanking gene being PRODH.

Caution

No predictable signal peptide.Curated

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Endogenous retrovirus group K member 24 Env polyprotein
Alternative name(s):
Envelope polyprotein
HERV-K101 envelope protein
HERV-K_22q11.21 provirus ancestral Env polyprotein
Cleaved into the following 2 chains:
Surface protein
Short name:
SU
Transmembrane protein
Short name:
TM
Gene namesi
Name:ERVK-24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:39038 ERVK-24
neXtProtiNX_P61566

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei522 – 542HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane, Viral envelope protein, Virion

Pathology & Biotechi

Organism-specific databases

DisGeNETi100862684

Polymorphism and mutation databases

DMDMi47605617

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000085231 – 588Endogenous retrovirus group K member 24 Env polyproteinAdd BLAST588
ChainiPRO_00000085241 – 354Surface proteinBy similarityAdd BLAST354
ChainiPRO_0000008525355 – 588Transmembrane proteinBy similarityAdd BLAST234

Post-translational modificationi

Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei354 – 355CleavageBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP61566
ProteomicsDBi57305

PTM databases

iPTMnetiP61566
PhosphoSitePlusiP61566

Expressioni

Tissue specificityi

Expressed in teratocarcinoma cell line.1 Publication

Interactioni

Subunit structurei

The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity).By similarity

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni355 – 375Fusion peptideSequence analysisAdd BLAST21

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG051479
PhylomeDBiP61566

Family and domain databases

CDDicd09909 HIV-1-like_HR1-HR2, 1 hit
InterProiView protein in InterPro
IPR000328 GP41-like
IPR029104 HERV-K_env
PfamiView protein in Pfam
PF00517 GP41, 1 hit
PF13804 HERV-K_env_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

P61566-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTPVTWMDN PIEVYVNDSE WVPGPTDDRC PAKPEEEGMM INISIGYRYP
60 70 80 90 100
PICLGTAPGC LMPAVQNWLV EVPIVSPISR FTYHMVSGMS LRPRVNYLQD
110 120 130 140 150
FPYQRSLKFR PKGKPCPKEI PKESKNTEVL VWEECVANSA VILQNNEFGT
160 170 180 190 200
IIDWAPRGQF YHNCSGQTQS CPSAQVSPAV DSDLTESLDK HKHKKLQSFY
210 220 230 240 250
PWEWGEKGIS TPRPKIISPV SGPEHPELWR LTVASHHIRI WSGNQTLETR
260 270 280 290 300
DRKPFYTVDL NSSLTLPLQS CVKPPYMLVV GNIVIKPDSQ TITCENCRLL
310 320 330 340 350
TCIDSTFNWQ HRILLVRARE GVWILVSMDR PWEASPSVHI LTEVLKGVLN
360 370 380 390 400
RSKRFIFTLI AVIMGLIAVT ATGAVAGVAL HSSVQSVNFV NDWQKNSTRL
410 420 430 440 450
WNSQSSIDQK LANQINDLRQ TVIWMGDRLM SLEHRFQLQC DWNTSDFCIT
460 470 480 490 500
PQIYNESEHH WDMVRHHLQG REDNLTLDIS KLKEQIFEAS KAHLNLVPGT
510 520 530 540 550
EAIAGVADGL ANLNPVTWVK TIGSTTIINL ILILVCLFCL LLVCRCTQQL
560 570 580
RRDSDHRERA MMTMAVLSKR KGGNVGKSKR DQIVTVSV
Length:588
Mass (Da):66,585
Last modified:May 24, 2004 - v1
Checksum:i0C1ED9251CEB8656
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P63145GAK24_HUMAN
Endogenous retrovirus group K membe...
ERVK-24
666Annotation score:
P63129VPK24_HUMAN
Endogenous retrovirus group K membe...
ERVK-24
156Annotation score:
P61581NP24_HUMAN
Endogenous retrovirus group K membe...
ERVK-24
75Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164609 Genomic DNA No translation available.

Similar proteinsi

Entry informationi

Entry nameiENK24_HUMAN
AccessioniPrimary (citable) accession number: P61566
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: June 20, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, ERV, Reference proteome, Transposable element
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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