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Protein

Holliday junction ATP-dependent DNA helicase RuvB

Gene

ruvB

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 66ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase
Biological processDNA damage, DNA recombination, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSUL243231:G1G0I-1129-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvBUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvBUniRule annotation
Ordered Locus Names:GSU1077
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000000577 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001655341 – 338Holliday junction ATP-dependent DNA helicase RuvBAdd BLAST338

Interactioni

Subunit structurei

Forms a complex with RuvA.UniRule annotation

Protein-protein interaction databases

STRINGi243231.GSU1077

Structurei

3D structure databases

ProteinModelPortaliP61532
SMRiP61532
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKJ Bacteria
COG2255 LUCA
HOGENOMiHOG000218623
InParanoidiP61532
KOiK03551
OMAiDEIHRMS
OrthoDBiPOG091H00GH

Family and domain databases

Gene3Di1.10.10.10, 1 hit
HAMAPiMF_00016 DNA_helic_RuvB, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR004605 DNA_helicase_Holl-junc_RuvB
IPR008823 DNA_helicase_Holl-junc_RuvB_C
IPR027417 P-loop_NTPase
IPR008824 RuvB_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR42848 PTHR42848, 1 hit
PfamiView protein in Pfam
PF05491 RuvB_C, 1 hit
PF05496 RuvB_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005323 DNA_helicase_Holl-junc_RuvB_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00635 ruvB, 1 hit

Sequencei

Sequence statusi: Complete.

P61532-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTRTISPEK TDDDYVESSL RPRALEDYIG QEKAKGNLRV FIDAARKRGE
60 70 80 90 100
ALDHVLLYGP PGLGKTTLAN IIACEMGVNI KSTSGPVIER PGDLAAILTN
110 120 130 140 150
LEPHDVLFID EIHRLSHVVE EILYPAMEDF QLDIIIGQGP SARTIKLDLP
160 170 180 190 200
RFTLVGATTR AGLLSSPLRD RFGVISRLEF YTDAELSTIV TRSAHILDIQ
210 220 230 240 250
IEPDGARELA RRSRGTPRIA NRLLRRVRDF AQVRADGVIS AQVVDESLKL
260 270 280 290 300
LEIDEKGFDQ MDRTIMLTII DKFGGGPVGL DTIAAAIGEE RDTIEDVYEP
310 320 330
FLIQHGFINR TPRGRVATKS AYEHFGRIAP APGQGALF
Length:338
Mass (Da):37,350
Last modified:May 24, 2004 - v1
Checksum:i857EA1AA4FDAE2B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA Translation: AAR34403.1
RefSeqiNP_952130.1, NC_002939.5
WP_010941738.1, NC_002939.5

Genome annotation databases

EnsemblBacteriaiAAR34403; AAR34403; GSU1077
GeneIDi2686958
KEGGigsu:GSU1077
PATRICifig|243231.5.peg.1075

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA Translation: AAR34403.1
RefSeqiNP_952130.1, NC_002939.5
WP_010941738.1, NC_002939.5

3D structure databases

ProteinModelPortaliP61532
SMRiP61532
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243231.GSU1077

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAR34403; AAR34403; GSU1077
GeneIDi2686958
KEGGigsu:GSU1077
PATRICifig|243231.5.peg.1075

Phylogenomic databases

eggNOGiENOG4105CKJ Bacteria
COG2255 LUCA
HOGENOMiHOG000218623
InParanoidiP61532
KOiK03551
OMAiDEIHRMS
OrthoDBiPOG091H00GH

Enzyme and pathway databases

BioCyciGSUL243231:G1G0I-1129-MONOMER

Family and domain databases

Gene3Di1.10.10.10, 1 hit
HAMAPiMF_00016 DNA_helic_RuvB, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR004605 DNA_helicase_Holl-junc_RuvB
IPR008823 DNA_helicase_Holl-junc_RuvB_C
IPR027417 P-loop_NTPase
IPR008824 RuvB_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR42848 PTHR42848, 1 hit
PfamiView protein in Pfam
PF05491 RuvB_C, 1 hit
PF05496 RuvB_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005323 DNA_helicase_Holl-junc_RuvB_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00635 ruvB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRUVB_GEOSL
AccessioniPrimary (citable) accession number: P61532
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: October 10, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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