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Protein

60S ribosomal protein L37a

Gene

Rpl37a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri39 – 60C4-typeAdd BLAST22

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L37a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rpl37a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:98068 Rpl37a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001398181 – 9260S ribosomal protein L37aAdd BLAST92

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P61514

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P61514

PeptideAtlas

More...
PeptideAtlasi
P61514

PRoteomics IDEntifications database

More...
PRIDEi
P61514

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P61514

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P61514

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P61514

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P61514

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000046330 Expressed in 92 organ(s), highest expression level in thymus

CleanEx database of gene expression profiles

More...
CleanExi
MM_RPL37A

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P61514 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P61514 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
202984, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P61514, 4 interactors

Molecular INTeraction database

More...
MINTi
P61514

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000058919

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P61514

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P61514

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri39 – 60C4-typeAdd BLAST22

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0402 Eukaryota
COG1997 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016988

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG056620

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P61514

KEGG Orthology (KO)

More...
KOi
K02921

Identification of Orthologs from Complete Genome Data

More...
OMAi
ISTGIWQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G107U

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P61514

TreeFam database of animal gene trees

More...
TreeFami
TF313068

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.25.30, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00327 Ribosomal_L37Ae, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002674 Ribosomal_L37ae
IPR011331 Ribosomal_L37ae/L37e
IPR011332 Ribosomal_zn-bd

The PANTHER Classification System

More...
PANTHERi
PTHR43931 PTHR43931, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01780 Ribosomal_L37ae, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57829 SSF57829, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00280 eL43_euk_arch, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P61514-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKRTKKVGI VGKYGTRYGA SLRKMVKKIE ISQHAKYTCS FCGKTKMKRR
60 70 80 90
AVGIWHCGSC MKTVAGGAWT YNTTSAVTVK SAIRRLKELK DQ
Length:92
Mass (Da):10,275
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7122AF87B0E24CF6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RL86A0A1D5RL86_MOUSE
60S ribosomal protein L37a
Rpl37a
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X73331 mRNA Translation: CAA51758.1
AK003501 mRNA Translation: BAB22825.1
AK011634 mRNA Translation: BAB27748.1
AK012396 mRNA Translation: BAB28213.1
AK012439 mRNA Translation: BAB28239.1
AK012655 mRNA Translation: BAB28386.1
AK014283 mRNA Translation: BAB29243.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35610.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S42109

NCBI Reference Sequences

More...
RefSeqi
NP_033110.1, NM_009084.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.21529
Mm.491227

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000059980; ENSMUSP00000058919; ENSMUSG00000046330

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
19981

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:19981

UCSC genome browser

More...
UCSCi
uc007bkv.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73331 mRNA Translation: CAA51758.1
AK003501 mRNA Translation: BAB22825.1
AK011634 mRNA Translation: BAB27748.1
AK012396 mRNA Translation: BAB28213.1
AK012439 mRNA Translation: BAB28239.1
AK012655 mRNA Translation: BAB28386.1
AK014283 mRNA Translation: BAB29243.1
CCDSiCCDS35610.1
PIRiS42109
RefSeqiNP_033110.1, NM_009084.4
UniGeneiMm.21529
Mm.491227

3D structure databases

ProteinModelPortaliP61514
SMRiP61514
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202984, 3 interactors
IntActiP61514, 4 interactors
MINTiP61514
STRINGi10090.ENSMUSP00000058919

PTM databases

iPTMnetiP61514
PhosphoSitePlusiP61514
SwissPalmiP61514

Proteomic databases

EPDiP61514
PaxDbiP61514
PeptideAtlasiP61514
PRIDEiP61514
TopDownProteomicsiP61514

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059980; ENSMUSP00000058919; ENSMUSG00000046330
GeneIDi19981
KEGGimmu:19981
UCSCiuc007bkv.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6168
MGIiMGI:98068 Rpl37a

Phylogenomic databases

eggNOGiKOG0402 Eukaryota
COG1997 LUCA
GeneTreeiENSGT00390000016988
HOVERGENiHBG056620
InParanoidiP61514
KOiK02921
OMAiISTGIWQ
OrthoDBiEOG091G107U
PhylomeDBiP61514
TreeFamiTF313068

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rpl37a mouse

Protein Ontology

More...
PROi
PR:P61514

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000046330 Expressed in 92 organ(s), highest expression level in thymus
CleanExiMM_RPL37A
ExpressionAtlasiP61514 baseline and differential
GenevisibleiP61514 MM

Family and domain databases

Gene3Di2.20.25.30, 1 hit
HAMAPiMF_00327 Ribosomal_L37Ae, 1 hit
InterProiView protein in InterPro
IPR002674 Ribosomal_L37ae
IPR011331 Ribosomal_L37ae/L37e
IPR011332 Ribosomal_zn-bd
PANTHERiPTHR43931 PTHR43931, 1 hit
PfamiView protein in Pfam
PF01780 Ribosomal_L37ae, 1 hit
SUPFAMiSSF57829 SSF57829, 1 hit
TIGRFAMsiTIGR00280 eL43_euk_arch, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL37A_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61514
Secondary accession number(s): P12751
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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