Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L37a

Gene

RPL37A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri39 – 60C4-typeAdd BLAST22

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L37a
Alternative name(s):
Large ribosomal subunit protein eL431 Publication
Gene namesi
Name:RPL37A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000197756.9
HGNCiHGNC:10348 RPL37A
MIMi613314 gene
neXtProtiNX_P61513

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6168
OpenTargetsiENSG00000197756
PharmGKBiPA34737

Polymorphism and mutation databases

BioMutaiRPL37A
DMDMi47606455

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001398171 – 9260S ribosomal protein L37aAdd BLAST92

Proteomic databases

EPDiP61513
MaxQBiP61513
PaxDbiP61513
PeptideAtlasiP61513
PRIDEiP61513
ProteomicsDBi57302
TopDownProteomicsiP61513

PTM databases

iPTMnetiP61513
PhosphoSitePlusiP61513
SwissPalmiP61513

Expressioni

Gene expression databases

BgeeiENSG00000197756 Expressed in 244 organ(s), highest expression level in cerebral cortex
CleanExiHS_RPL37A
ExpressionAtlasiP61513 baseline and differential
GenevisibleiP61513 HS

Organism-specific databases

HPAiHPA065327

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA6P433605EBI-356793,EBI-1045155

Protein-protein interaction databases

BioGridi112087, 238 interactors
CORUMiP61513
IntActiP61513, 31 interactors
MINTiP61513
STRINGi9606.ENSP00000418082

Structurei

3D structure databases

ProteinModelPortaliP61513
SMRiP61513
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri39 – 60C4-typeAdd BLAST22

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0402 Eukaryota
COG1997 LUCA
GeneTreeiENSGT00390000016988
HOGENOMiHOG000229493
HOVERGENiHBG056620
InParanoidiP61513
KOiK02921
OMAiISTGIWQ
OrthoDBiEOG091G107U
PhylomeDBiP61513
TreeFamiTF313068

Family and domain databases

Gene3Di2.20.25.30, 1 hit
HAMAPiMF_00327 Ribosomal_L37Ae, 1 hit
InterProiView protein in InterPro
IPR002674 Ribosomal_L37ae
IPR011331 Ribosomal_L37ae/L37e
IPR011332 Ribosomal_zn-bd
PANTHERiPTHR43931 PTHR43931, 1 hit
PfamiView protein in Pfam
PF01780 Ribosomal_L37ae, 1 hit
SUPFAMiSSF57829 SSF57829, 1 hit
TIGRFAMsiTIGR00280 eL43_euk_arch, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P61513-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKRTKKVGI VGKYGTRYGA SLRKMVKKIE ISQHAKYTCS FCGKTKMKRR
60 70 80 90
AVGIWHCGSC MKTVAGGAWT YNTTSAVTVK SAIRRLKELK DQ
Length:92
Mass (Da):10,275
Last modified:January 23, 2007 - v2
Checksum:i7122AF87B0E24CF6
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J4Z3C9J4Z3_HUMAN
60S ribosomal protein L37a
RPL37A hCG_16380
68Annotation score:
E9PEL3E9PEL3_HUMAN
60S ribosomal protein L37a
RPL37A
75Annotation score:
G5E9R3G5E9R3_HUMAN
60S ribosomal protein L37a
RPL37A hCG_16380
58Annotation score:
Q6P4E4Q6P4E4_HUMAN
60S ribosomal protein L37a
RPL37A
72Annotation score:
M0R0A1M0R0A1_HUMAN
60S ribosomal protein L37a
RPL37A
60Annotation score:
M0R2L6M0R2L6_HUMAN
60S ribosomal protein L37a
RPL37A
88Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06499 mRNA Translation: AAA60280.1
X66699 mRNA Translation: CAA47244.1
L22154 mRNA No translation available.
AK289472 mRNA Translation: BAF82161.1
CR542152 mRNA Translation: CAG46949.1
AC073321 Genomic DNA Translation: AAY15078.1
CH471063 Genomic DNA Translation: EAW70569.1
BC000555 mRNA Translation: AAH00555.2
BC014262 mRNA Translation: AAH14262.1
BC016748 mRNA Translation: AAH16748.1
BC067789 mRNA Translation: AAH67789.1
BC082239 mRNA Translation: AAH82239.1
CCDSiCCDS2404.1
PIRiJN0875
RefSeqiNP_000989.1, NM_000998.4
UniGeneiHs.433701

Genome annotation databases

EnsembliENST00000491306; ENSP00000418082; ENSG00000197756
GeneIDi6168
KEGGihsa:6168
UCSCiuc002vgf.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06499 mRNA Translation: AAA60280.1
X66699 mRNA Translation: CAA47244.1
L22154 mRNA No translation available.
AK289472 mRNA Translation: BAF82161.1
CR542152 mRNA Translation: CAG46949.1
AC073321 Genomic DNA Translation: AAY15078.1
CH471063 Genomic DNA Translation: EAW70569.1
BC000555 mRNA Translation: AAH00555.2
BC014262 mRNA Translation: AAH14262.1
BC016748 mRNA Translation: AAH16748.1
BC067789 mRNA Translation: AAH67789.1
BC082239 mRNA Translation: AAH82239.1
CCDSiCCDS2404.1
PIRiJN0875
RefSeqiNP_000989.1, NM_000998.4
UniGeneiHs.433701

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Lp1-92[»]
4V6Xelectron microscopy5.00Cp1-92[»]
5AJ0electron microscopy3.50Ap1-92[»]
5LKSelectron microscopy3.60Lp1-92[»]
5T2Celectron microscopy3.60j1-92[»]
6EK0electron microscopy2.90Lp1-92[»]
ProteinModelPortaliP61513
SMRiP61513
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112087, 238 interactors
CORUMiP61513
IntActiP61513, 31 interactors
MINTiP61513
STRINGi9606.ENSP00000418082

PTM databases

iPTMnetiP61513
PhosphoSitePlusiP61513
SwissPalmiP61513

Polymorphism and mutation databases

BioMutaiRPL37A
DMDMi47606455

Proteomic databases

EPDiP61513
MaxQBiP61513
PaxDbiP61513
PeptideAtlasiP61513
PRIDEiP61513
ProteomicsDBi57302
TopDownProteomicsiP61513

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000491306; ENSP00000418082; ENSG00000197756
GeneIDi6168
KEGGihsa:6168
UCSCiuc002vgf.4 human

Organism-specific databases

CTDi6168
DisGeNETi6168
EuPathDBiHostDB:ENSG00000197756.9
GeneCardsiRPL37A
HGNCiHGNC:10348 RPL37A
HPAiHPA065327
MIMi613314 gene
neXtProtiNX_P61513
OpenTargetsiENSG00000197756
PharmGKBiPA34737
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0402 Eukaryota
COG1997 LUCA
GeneTreeiENSGT00390000016988
HOGENOMiHOG000229493
HOVERGENiHBG056620
InParanoidiP61513
KOiK02921
OMAiISTGIWQ
OrthoDBiEOG091G107U
PhylomeDBiP61513
TreeFamiTF313068

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSiRPL37A human
GeneWikiiRPL37A
GenomeRNAii6168
PROiPR:P61513
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197756 Expressed in 244 organ(s), highest expression level in cerebral cortex
CleanExiHS_RPL37A
ExpressionAtlasiP61513 baseline and differential
GenevisibleiP61513 HS

Family and domain databases

Gene3Di2.20.25.30, 1 hit
HAMAPiMF_00327 Ribosomal_L37Ae, 1 hit
InterProiView protein in InterPro
IPR002674 Ribosomal_L37ae
IPR011331 Ribosomal_L37ae/L37e
IPR011332 Ribosomal_zn-bd
PANTHERiPTHR43931 PTHR43931, 1 hit
PfamiView protein in Pfam
PF01780 Ribosomal_L37ae, 1 hit
SUPFAMiSSF57829 SSF57829, 1 hit
TIGRFAMsiTIGR00280 eL43_euk_arch, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL37A_HUMAN
AccessioniPrimary (citable) accession number: P61513
Secondary accession number(s): P12751, Q6FGF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again