UniProtKB - P61509 (TX1F_APHSP)
Protein
Omega-theraphotoxin-Asp1f
Gene
N/A
Organism
Aphonopelma sp. (American tarantula)
Status
Functioni
Insecticidal toxin that is lethal to cockroaches (PubMed:2742756). Inhibits voltage-gated calcium channels (Cav) in rat cerebellar granule cells (By similarity).By similarity1 Publication
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Omega-theraphotoxin-Asp1fCuratedShort name: Omega-TRTX-Asp1fCurated Alternative name(s): Eurypelma spider toxin1 Publication Short name: ESTx1 Publication |
Organismi | Aphonopelma sp. (American tarantula) |
Taxonomic identifieri | 29932 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Araneae › Mygalomorphae › Theraphosidae › Aphonopelma |
Organism-specific databases
ArachnoServeri | AS000222 omega-theraphotoxin-Asp1f |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000044980 | 1 – 39 | Omega-theraphotoxin-Asp1f1 PublicationAdd BLAST | 39 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 4 ↔ 25 | By similarity | ||
Disulfide bondi | 8 ↔ 31 | By similarity | ||
Disulfide bondi | 17 ↔ 36 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Structurei
3D structure databases
ProteinModelPortali | P61509 |
SMRi | P61509 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
InterProi | View protein in InterPro IPR012625 Toxin_20 |
Pfami | View protein in Pfam PF08089 Toxin_20, 1 hit |
PROSITEi | View protein in PROSITE PS60022 HWTX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Similar proteinsi
Cross-referencesi
3D structure databases
ProteinModelPortali | P61509 |
SMRi | P61509 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Organism-specific databases
ArachnoServeri | AS000222 omega-theraphotoxin-Asp1f |
Family and domain databases
InterProi | View protein in InterPro IPR012625 Toxin_20 |
Pfami | View protein in Pfam PF08089 Toxin_20, 1 hit |
PROSITEi | View protein in PROSITE PS60022 HWTX_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | TX1F_APHSP | |
Accessioni | P61509Primary (citable) accession number: P61509 Secondary accession number(s): P18928 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | May 24, 2004 | |
Last modified: | June 20, 2018 | |
This is version 40 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families