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Protein

Pterin-4-alpha-carbinolamine dehydratase

Gene

Pcbd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity).By similarity

Catalytic activityi

(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Lyase
Biological processTetrahydrobiopterin biosynthesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-71182 Phenylalanine and tyrosine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Pterin-4-alpha-carbinolamine dehydratase (EC:4.2.1.96)
Short name:
PHS
Alternative name(s):
4-alpha-hydroxy-tetrahydropterin dehydratase
Dimerization cofactor of hepatocyte nuclear factor 1-alpha
Short name:
DCoH
Short name:
Dimerization cofactor of HNF1
Phenylalanine hydroxylase-stimulating protein
Pterin carbinolamine dehydratase
Short name:
PCD
Gene namesi
Name:Pcbd1
Synonyms:Dcoh, Pcbd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:94873 Pcbd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000630532 – 104Pterin-4-alpha-carbinolamine dehydrataseAdd BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP61458
PaxDbiP61458
PeptideAtlasiP61458
PRIDEiP61458

PTM databases

iPTMnetiP61458
PhosphoSitePlusiP61458

Expressioni

Gene expression databases

BgeeiENSMUSG00000020098 Expressed in 226 organ(s), highest expression level in pancreas
ExpressionAtlasiP61458 baseline and differential
GenevisibleiP61458 MM

Interactioni

Subunit structurei

Homotetramer and homodimer. Heterotetramer with HNF1A; formed by a dimer of dimers (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199068, 18 interactors
IntActiP61458, 5 interactors
MINTiP61458
STRINGi10090.ENSMUSP00000020298

Structurei

3D structure databases

ProteinModelPortaliP61458
SMRiP61458
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 63Substrate bindingBy similarity3
Regioni78 – 81Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4073 Eukaryota
COG2154 LUCA
GeneTreeiENSGT00390000007221
HOGENOMiHOG000007680
HOVERGENiHBG000259
InParanoidiP61458
KOiK01724
OMAiAVGWNEV
OrthoDBiEOG091G120V
PhylomeDBiP61458
TreeFamiTF300188

Family and domain databases

Gene3Di3.30.1360.20, 1 hit
HAMAPiMF_00434 Pterin_4_alpha, 1 hit
InterProiView protein in InterPro
IPR036428 PCD_sf
IPR001533 Pterin_deHydtase
PfamiView protein in Pfam
PF01329 Pterin_4a, 1 hit
SUPFAMiSSF55248 SSF55248, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P61458-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGKAHRLSA EERDQLLPNL RAVGWNEVEG RDAIFKQFHF KDFNRAFGFM
60 70 80 90 100
TRVALQAEKL DHHPEWFNVY NKVHITLSTH ECAGLSERDI NLASFIEQVA

VSMT
Length:104
Mass (Da):11,986
Last modified:January 23, 2007 - v2
Checksum:i13C798C25D9117E9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P7A4A0A1W2P7A4_MOUSE
Pterin-4-alpha-carbinolamine dehydr...
Pcbd1
60Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83741 mRNA No translation available.
AK007401 mRNA Translation: BAB25014.1
BC024354 mRNA Translation: AAH24354.1
CCDSiCCDS35913.1
RefSeqiNP_079549.1, NM_025273.4
UniGeneiMm.39473

Genome annotation databases

EnsembliENSMUST00000020298; ENSMUSP00000020298; ENSMUSG00000020098
GeneIDi13180
KEGGimmu:13180
UCSCiuc007ffj.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83741 mRNA No translation available.
AK007401 mRNA Translation: BAB25014.1
BC024354 mRNA Translation: AAH24354.1
CCDSiCCDS35913.1
RefSeqiNP_079549.1, NM_025273.4
UniGeneiMm.39473

3D structure databases

ProteinModelPortaliP61458
SMRiP61458
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199068, 18 interactors
IntActiP61458, 5 interactors
MINTiP61458
STRINGi10090.ENSMUSP00000020298

PTM databases

iPTMnetiP61458
PhosphoSitePlusiP61458

Proteomic databases

MaxQBiP61458
PaxDbiP61458
PeptideAtlasiP61458
PRIDEiP61458

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020298; ENSMUSP00000020298; ENSMUSG00000020098
GeneIDi13180
KEGGimmu:13180
UCSCiuc007ffj.3 mouse

Organism-specific databases

CTDi5092
MGIiMGI:94873 Pcbd1

Phylogenomic databases

eggNOGiKOG4073 Eukaryota
COG2154 LUCA
GeneTreeiENSGT00390000007221
HOGENOMiHOG000007680
HOVERGENiHBG000259
InParanoidiP61458
KOiK01724
OMAiAVGWNEV
OrthoDBiEOG091G120V
PhylomeDBiP61458
TreeFamiTF300188

Enzyme and pathway databases

ReactomeiR-MMU-71182 Phenylalanine and tyrosine catabolism

Miscellaneous databases

PROiPR:P61458
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020098 Expressed in 226 organ(s), highest expression level in pancreas
ExpressionAtlasiP61458 baseline and differential
GenevisibleiP61458 MM

Family and domain databases

Gene3Di3.30.1360.20, 1 hit
HAMAPiMF_00434 Pterin_4_alpha, 1 hit
InterProiView protein in InterPro
IPR036428 PCD_sf
IPR001533 Pterin_deHydtase
PfamiView protein in Pfam
PF01329 Pterin_4a, 1 hit
SUPFAMiSSF55248 SSF55248, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHS_MOUSE
AccessioniPrimary (citable) accession number: P61458
Secondary accession number(s): P70519, P80095, Q9D930
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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