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Protein

V-type proton ATPase subunit d 1

Gene

ATP6V0D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • brain development Source: Ensembl
  • cellular iron ion homeostasis Source: UniProtKB
  • cellular response to increased oxygen levels Source: UniProtKB
  • cilium assembly Source: UniProtKB
  • insulin receptor signaling pathway Source: Reactome
  • ion transmembrane transport Source: Reactome
  • IRE1-mediated unfolded protein response Source: Reactome
  • proton transmembrane transport Source: UniProtKB
  • regulation of macroautophagy Source: ParkinsonsUK-UCL
  • transferrin transport Source: Reactome
  • vacuolar acidification Source: GO_Central
  • vacuolar transport Source: GO_Central

Keywordsi

Biological processCilium biogenesis/degradation, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS08417-MONOMER
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-381038 XBP1(S) activates chaperone genes
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-983712 Ion channel transport

Protein family/group databases

TCDBi3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit d 1
Short name:
V-ATPase subunit d 1
Alternative name(s):
32 kDa accessory protein
V-ATPase 40 kDa accessory protein
V-ATPase AC39 subunit
Short name:
p39
Vacuolar proton pump subunit d 1
Gene namesi
Name:ATP6V0D1
Synonyms:ATP6D, VPATPD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000159720.11
HGNCiHGNC:13724 ATP6V0D1
MIMi607028 gene
neXtProtiNX_P61421

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9114
OpenTargetsiENSG00000159720
PharmGKBiPA25150

Polymorphism and mutation databases

BioMutaiATP6V0D1
DMDMi47606646

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001193501 – 351V-type proton ATPase subunit d 1Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270PhosphotyrosineBy similarity1
Modified residuei283PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP61421
MaxQBiP61421
PaxDbiP61421
PeptideAtlasiP61421
PRIDEiP61421
ProteomicsDBi57300

PTM databases

iPTMnetiP61421
PhosphoSitePlusiP61421
SwissPalmiP61421

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Gene expression databases

BgeeiENSG00000159720
CleanExiHS_ATP6V0D1
ExpressionAtlasiP61421 baseline and differential
GenevisibleiP61421 HS

Organism-specific databases

HPAiHPA016938

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Protein-protein interaction databases

BioGridi114564, 125 interactors
DIPiDIP-47435N
IntActiP61421, 45 interactors
MINTiP61421
STRINGi9606.ENSP00000290949

Structurei

3D structure databases

ProteinModelPortaliP61421
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase V0D/AC39 subunit family.Curated

Phylogenomic databases

eggNOGiKOG2957 Eukaryota
COG1527 LUCA
GeneTreeiENSGT00390000002200
HOGENOMiHOG000199065
HOVERGENiHBG018065
InParanoidiP61421
KOiK02146
PhylomeDBiP61421
TreeFamiTF300857

Family and domain databases

Gene3Di1.20.1690.10, 2 hits
InterProiView protein in InterPro
IPR036079 ATPase_su_C-like
IPR002843 ATPase_V0-cplx_csu/dsu
IPR016727 ATPase_V0-cplx_dsu
IPR035067 V-type_ATPase_suC
PANTHERiPTHR11028 PTHR11028, 1 hit
PfamiView protein in Pfam
PF01992 vATP-synt_AC39, 1 hit
PIRSFiPIRSF018497 V-ATP_synth_D, 1 hit
SUPFAMiSSF103486 SSF103486, 1 hit

Sequencei

Sequence statusi: Complete.

P61421-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFFPELYFN VDNGYLEGLV RGLKAGVLSQ ADYLNLVQCE TLEDLKLHLQ
60 70 80 90 100
STDYGNFLAN EASPLTVSVI DDRLKEKMVV EFRHMRNHAY EPLASFLDFI
110 120 130 140 150
TYSYMIDNVI LLITGTLHQR SIAELVPKCH PLGSFEQMEA VNIAQTPAEL
160 170 180 190 200
YNAILVDTPL AAFFQDCISE QDLDEMNIEI IRNTLYKAYL ESFYKFCTLL
210 220 230 240 250
GGTTADAMCP ILEFEADRRA FIITINSFGT ELSKEDRAKL FPHCGRLYPE
260 270 280 290 300
GLAQLARADD YEQVKNVADY YPEYKLLFEG AGSNPGDKTL EDRFFEHEVK
310 320 330 340 350
LNKLAFLNQF HFGVFYAFVK LKEQECRNIV WIAECIAQRH RAKIDNYIPI

F
Length:351
Mass (Da):40,329
Last modified:May 24, 2004 - v1
Checksum:iA720F8A87511203C
GO

Sequence cautioni

The sequence CAA50591 differs from that shown. Reason: Frameshift at positions 22, 25, 64 and 66.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27V → E in CAA50591 (PubMed:8250920).Curated1
Sequence conflicti266 – 267NV → KL in CAA50591 (PubMed:8250920).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71490 mRNA Translation: CAA50591.1 Frameshift.
BC008861 mRNA Translation: AAH08861.1
L05087 mRNA Translation: AAC15852.1
CCDSiCCDS10838.1
RefSeqiNP_004682.2, NM_004691.4
UniGeneiHs.106876

Genome annotation databases

EnsembliENST00000290949; ENSP00000290949; ENSG00000159720
GeneIDi9114
KEGGihsa:9114
UCSCiuc002ete.2 human

Similar proteinsi

Entry informationi

Entry nameiVA0D1_HUMAN
AccessioniPrimary (citable) accession number: P61421
Secondary accession number(s): P12953, Q02547
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: June 20, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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