UniProtKB - P61421 (VA0D1_HUMAN)
Protein
V-type proton ATPase subunit d 1
Gene
ATP6V0D1
Organism
Homo sapiens (Human)
Status
Functioni
Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).By similarity1 Publication
GO - Molecular functioni
- protein-containing complex binding Source: Ensembl
- proton-exporting ATPase activity, phosphorylative mechanism Source: GO_Central
- proton-transporting ATPase activity, rotational mechanism Source: GO_Central
GO - Biological processi
- brain development Source: Ensembl
- cellular iron ion homeostasis Source: UniProtKB
- cellular response to increased oxygen levels Source: UniProtKB
- cilium assembly Source: UniProtKB
- insulin receptor signaling pathway Source: Reactome
- ion transmembrane transport Source: Reactome
- IRE1-mediated unfolded protein response Source: Reactome
- phagosome acidification Source: Reactome
- proton transmembrane transport Source: UniProtKB
- regulation of macroautophagy Source: ParkinsonsUK-UCL
- transferrin transport Source: Reactome
- vacuolar acidification Source: GO_Central
- vacuolar transport Source: GO_Central
Keywordsi
Biological process | Cilium biogenesis/degradation, Hydrogen ion transport, Ion transport, Transport |
Enzyme and pathway databases
BioCyci | MetaCyc:HS08417-MONOMER |
Reactomei | R-HSA-1222556 ROS and RNS production in phagocytes R-HSA-381038 XBP1(S) activates chaperone genes R-HSA-77387 Insulin receptor recycling R-HSA-917977 Transferrin endocytosis and recycling R-HSA-9639288 Amino acids regulate mTORC1 R-HSA-983712 Ion channel transport |
Protein family/group databases
TCDBi | 3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: V-type proton ATPase subunit d 1Short name: V-ATPase subunit d 1 Alternative name(s): 32 kDa accessory protein V-ATPase 40 kDa accessory protein V-ATPase AC39 subunit Short name: p39 Vacuolar proton pump subunit d 1 |
Gene namesi | Name:ATP6V0D1 Synonyms:ATP6D, VPATPD |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13724 ATP6V0D1 |
MIMi | 607028 gene |
neXtProti | NX_P61421 |
Subcellular locationi
Other locations
- Membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Note: Localizes to centrosome and the base of the cilium.
Endosome
- early endosome Source: GO_Central
- endosome membrane Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: Ensembl
- plasma membrane proton-transporting V-type ATPase complex Source: GO_Central
Other locations
- axon terminus Source: Ensembl
- cell Source: GOC
- membrane Source: UniProtKB
- phagocytic vesicle membrane Source: Reactome
- proton-transporting V-type ATPase, V0 domain Source: InterPro
- synaptic vesicle Source: Ensembl
- vacuolar proton-transporting V-type ATPase complex Source: UniProtKB
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 9114 |
OpenTargetsi | ENSG00000159720 |
PharmGKBi | PA25150 |
Miscellaneous databases
Pharosi | P61421 |
Polymorphism and mutation databases
BioMutai | ATP6V0D1 |
DMDMi | 47606646 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119350 | 1 – 351 | V-type proton ATPase subunit d 1Add BLAST | 351 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 270 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 283 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P61421 |
jPOSTi | P61421 |
MassIVEi | P61421 |
MaxQBi | P61421 |
PaxDbi | P61421 |
PeptideAtlasi | P61421 |
PRIDEi | P61421 |
ProteomicsDBi | 57300 |
PTM databases
iPTMneti | P61421 |
PhosphoSitePlusi | P61421 |
SwissPalmi | P61421 |
Expressioni
Tissue specificityi
Ubiquitous.2 Publications
Gene expression databases
Bgeei | ENSG00000159720 Expressed in 234 organ(s), highest expression level in Ammon's horn |
ExpressionAtlasi | P61421 baseline and differential |
Genevisiblei | P61421 HS |
Organism-specific databases
HPAi | HPA016938 |
Interactioni
Subunit structurei
V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d) (By similarity).
Interacts with PIP4P1 (PubMed:29644770).
By similarity1 PublicationProtein-protein interaction databases
BioGridi | 114564, 132 interactors |
CORUMi | P61421 |
DIPi | DIP-47435N |
IntActi | P61421, 89 interactors |
MINTi | P61421 |
STRINGi | 9606.ENSP00000290949 |
Family & Domainsi
Sequence similaritiesi
Belongs to the V-ATPase V0D/AC39 subunit family.Curated
Phylogenomic databases
eggNOGi | KOG2957 Eukaryota COG1527 LUCA |
GeneTreei | ENSGT00390000002200 |
HOGENOMi | HOG000199065 |
InParanoidi | P61421 |
KOi | K02146 |
OrthoDBi | 910004at2759 |
PhylomeDBi | P61421 |
TreeFami | TF300857 |
Family and domain databases
Gene3Di | 1.20.1690.10, 2 hits |
InterProi | View protein in InterPro IPR036079 ATPase_su_C-like IPR002843 ATPase_V0-cplx_csu/dsu IPR016727 ATPase_V0-cplx_dsu IPR035067 V-type_ATPase_suC |
PANTHERi | PTHR11028 PTHR11028, 1 hit |
Pfami | View protein in Pfam PF01992 vATP-synt_AC39, 1 hit |
PIRSFi | PIRSF018497 V-ATP_synth_D, 1 hit |
SUPFAMi | SSF103486 SSF103486, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
P61421-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFFPELYFN VDNGYLEGLV RGLKAGVLSQ ADYLNLVQCE TLEDLKLHLQ
60 70 80 90 100
STDYGNFLAN EASPLTVSVI DDRLKEKMVV EFRHMRNHAY EPLASFLDFI
110 120 130 140 150
TYSYMIDNVI LLITGTLHQR SIAELVPKCH PLGSFEQMEA VNIAQTPAEL
160 170 180 190 200
YNAILVDTPL AAFFQDCISE QDLDEMNIEI IRNTLYKAYL ESFYKFCTLL
210 220 230 240 250
GGTTADAMCP ILEFEADRRA FIITINSFGT ELSKEDRAKL FPHCGRLYPE
260 270 280 290 300
GLAQLARADD YEQVKNVADY YPEYKLLFEG AGSNPGDKTL EDRFFEHEVK
310 320 330 340 350
LNKLAFLNQF HFGVFYAFVK LKEQECRNIV WIAECIAQRH RAKIDNYIPI
F
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GYQ1 | F5GYQ1_HUMAN | V-type proton ATPase subunit | ATP6V0D1 | 392 | Annotation score: | ||
R4GN72 | R4GN72_HUMAN | V-type proton ATPase subunit d 1 | ATP6V0D1 | 274 | Annotation score: | ||
H3BQB4 | H3BQB4_HUMAN | V-type proton ATPase subunit d 1 | ATP6V0D1 | 113 | Annotation score: | ||
H3BSG7 | H3BSG7_HUMAN | V-type proton ATPase subunit d 1 | ATP6V0D1 | 115 | Annotation score: | ||
H3BQJ1 | H3BQJ1_HUMAN | V-type proton ATPase subunit d 1 | ATP6V0D1 | 227 | Annotation score: | ||
H3BUQ0 | H3BUQ0_HUMAN | V-type proton ATPase subunit d 1 | ATP6V0D1 | 47 | Annotation score: | ||
J3QL14 | J3QL14_HUMAN | V-type proton ATPase subunit d 1 | ATP6V0D1 | 232 | Annotation score: | ||
H3BTB5 | H3BTB5_HUMAN | V-type proton ATPase subunit d 1 | ATP6V0D1 | 57 | Annotation score: | ||
F8WEN9 | F8WEN9_HUMAN | V-type proton ATPase subunit d 1 | ATP6V0D1 | 58 | Annotation score: | ||
H3BPS0 | H3BPS0_HUMAN | V-type proton ATPase subunit d 1 | ATP6V0D1 | 71 | Annotation score: | ||
There is more potential isoformShow all |
Sequence cautioni
The sequence CAA50591 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 | V → E in CAA50591 (PubMed:8250920).Curated | 1 | |
Sequence conflicti | 266 – 267 | NV → KL in CAA50591 (PubMed:8250920).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71490 mRNA Translation: CAA50591.1 Frameshift. BC008861 mRNA Translation: AAH08861.1 L05087 mRNA Translation: AAC15852.1 |
CCDSi | CCDS10838.1 |
RefSeqi | NP_004682.2, NM_004691.4 |
Genome annotation databases
Ensembli | ENST00000290949; ENSP00000290949; ENSG00000159720 |
GeneIDi | 9114 |
KEGGi | hsa:9114 |
UCSCi | uc002ete.2 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71490 mRNA Translation: CAA50591.1 Frameshift. BC008861 mRNA Translation: AAH08861.1 L05087 mRNA Translation: AAC15852.1 |
CCDSi | CCDS10838.1 |
RefSeqi | NP_004682.2, NM_004691.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 114564, 132 interactors |
CORUMi | P61421 |
DIPi | DIP-47435N |
IntActi | P61421, 89 interactors |
MINTi | P61421 |
STRINGi | 9606.ENSP00000290949 |
Protein family/group databases
TCDBi | 3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
PTM databases
iPTMneti | P61421 |
PhosphoSitePlusi | P61421 |
SwissPalmi | P61421 |
Polymorphism and mutation databases
BioMutai | ATP6V0D1 |
DMDMi | 47606646 |
Proteomic databases
EPDi | P61421 |
jPOSTi | P61421 |
MassIVEi | P61421 |
MaxQBi | P61421 |
PaxDbi | P61421 |
PeptideAtlasi | P61421 |
PRIDEi | P61421 |
ProteomicsDBi | 57300 |
Protocols and materials databases
DNASUi | 9114 |
Genome annotation databases
Ensembli | ENST00000290949; ENSP00000290949; ENSG00000159720 |
GeneIDi | 9114 |
KEGGi | hsa:9114 |
UCSCi | uc002ete.2 human |
Organism-specific databases
CTDi | 9114 |
DisGeNETi | 9114 |
GeneCardsi | ATP6V0D1 |
HGNCi | HGNC:13724 ATP6V0D1 |
HPAi | HPA016938 |
MIMi | 607028 gene |
neXtProti | NX_P61421 |
OpenTargetsi | ENSG00000159720 |
PharmGKBi | PA25150 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2957 Eukaryota COG1527 LUCA |
GeneTreei | ENSGT00390000002200 |
HOGENOMi | HOG000199065 |
InParanoidi | P61421 |
KOi | K02146 |
OrthoDBi | 910004at2759 |
PhylomeDBi | P61421 |
TreeFami | TF300857 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS08417-MONOMER |
Reactomei | R-HSA-1222556 ROS and RNS production in phagocytes R-HSA-381038 XBP1(S) activates chaperone genes R-HSA-77387 Insulin receptor recycling R-HSA-917977 Transferrin endocytosis and recycling R-HSA-9639288 Amino acids regulate mTORC1 R-HSA-983712 Ion channel transport |
Miscellaneous databases
ChiTaRSi | ATP6V0D1 human |
GeneWikii | ATP6V0D1 |
GenomeRNAii | 9114 |
Pharosi | P61421 |
PROi | PR:P61421 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000159720 Expressed in 234 organ(s), highest expression level in Ammon's horn |
ExpressionAtlasi | P61421 baseline and differential |
Genevisiblei | P61421 HS |
Family and domain databases
Gene3Di | 1.20.1690.10, 2 hits |
InterProi | View protein in InterPro IPR036079 ATPase_su_C-like IPR002843 ATPase_V0-cplx_csu/dsu IPR016727 ATPase_V0-cplx_dsu IPR035067 V-type_ATPase_suC |
PANTHERi | PTHR11028 PTHR11028, 1 hit |
Pfami | View protein in Pfam PF01992 vATP-synt_AC39, 1 hit |
PIRSFi | PIRSF018497 V-ATP_synth_D, 1 hit |
SUPFAMi | SSF103486 SSF103486, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VA0D1_HUMAN | |
Accessioni | P61421Primary (citable) accession number: P61421 Secondary accession number(s): P12953, Q02547 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | May 24, 2004 | |
Last modified: | November 13, 2019 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot