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Entry version 120 (02 Jun 2021)
Sequence version 1 (24 May 2004)
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Protein

Tudor domain-containing protein 6

Gene

Tdrd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation (PubMed:19345099, PubMed:27149095, PubMed:28263986) (By similarity).

Essential for RNA-dependent helicase UPF1 localization to chromatoid body, for UPF1-UPF2 and UPF1-DDX4 interactions which are required for mRNA degradation, using the extended 3' UTR-triggered nonsense-mediated mRNA decay (NMD) pathway (PubMed:27149095).

Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through interaction with arginine N-methyltransferase PRMT5 and symmetrically arginine dimethylated SNRPB (small nuclear ribonucleoprotein-associated protein) (PubMed:28263986).

By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Oogenesis, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tudor domain-containing protein 61 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tdrd61 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2679727, Tdrd6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Males are sterile (elongated spermatids are almost completely lacking), but viable (PubMed:19345099). Chromatoid body (CB) components mislocalize and CB architecture is distorted in round spermatids (PubMed:19345099). miRNA expression is altered (PubMed:19345099). Knockout spermatids are accompanied by distortion of chromatoid body structure, preventing UPF1-DDX4 and UPF1-UPF2 interactions, as well as disturbed association of several mRNAs with UPF1 and UPF2, and impaired long 3' UTR-triggered NMD (PubMed:27149095). Knockout diplotene spermatocytes display a reduction of PRMT5 association with SNRPB (also named SmB) and a reduction in arginine dimethylation of SNRPB, leading to an impairment in the assembly of spliceosomes (PubMed:28263986).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001831681 – 2134Tudor domain-containing protein 6Add BLAST2134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei292PhosphothreonineCombined sources1
Modified residuei1723PhosphoserineCombined sources1
Modified residuei1726PhosphoserineCombined sources1
Modified residuei1925PhosphoserineCombined sources1
Modified residuei1980PhosphoserineCombined sources1
Modified residuei2063PhosphoserineCombined sources1
Modified residuei2115PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Undergoes proteolytic cleavage near the C-terminal by an unknown protease during the transition from meiosis I to meiosis II in primary spermatocytes.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P61407

PRoteomics IDEntifications database

More...
PRIDEi
P61407

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
262747

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P61407

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P61407

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis specific. Expressed in primary spermatocytes at post natal (PN) day 17.5. Expressed in midpachytene stage of primary spermatocytes at PN16 and in round spermatids at PN22 (at protein level).3 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a mRNP complex (i.e. messenger ribonucleoproteins which correspond to mRNA with bound proteins), at least composed of TDRD1, TDRD6, TDRD7 and DDX4 (PubMed:17141210).

Found in a complex, at least composed of PIWIL1, PIWIL2, DDX4 and TDRD6 (PubMed:19345099, PubMed:19584108, PubMed:19926723).

Interacts with Tex19.1 and probably Tex19.2 (PubMed:28254886).

Interacts with PRMT5 (PubMed:28263986).

Interacts with SNRPB (when methylated); to trigger spliceosome formation (PubMed:28263986).

6 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
229157, 6 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000035338

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P61407, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P61407

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini309 – 368Tudor 1PROSITE-ProRule annotationAdd BLAST60
Domaini542 – 599Tudor 2PROSITE-ProRule annotationAdd BLAST58
Domaini820 – 879Tudor 3PROSITE-ProRule annotationAdd BLAST60
Domaini1038 – 1092Tudor 4PROSITE-ProRule annotationAdd BLAST55
Domaini1358 – 1417Tudor 5PROSITE-ProRule annotationAdd BLAST60
Domaini1570 – 1630Tudor 6PROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni287 – 315DisorderedSequence analysisAdd BLAST29
Regioni1271 – 1296DisorderedSequence analysisAdd BLAST26
Regioni1699 – 1733DisorderedSequence analysisAdd BLAST35
Regioni1860 – 1885DisorderedSequence analysisAdd BLAST26
Regioni1930 – 1987DisorderedSequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1699 – 1722Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1860 – 1874Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1938 – 1962Basic and acidic residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The tudor domains recognize and bind to proteins with dimethylated arginine residues.1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2039, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P61407

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P61407

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04508, TUDOR, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.90, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00567, TUDOR, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00333, TUDOR, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50304, TUDOR, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P61407-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSTPGLPTP GASLALRVSF VDVHPEVIPV QLWGLVGQRR EEYVRLSREI
60 70 80 90 100
QEAAATRGPW ALGGASASPG ELCLVQVGLM WHRCRVVSRQ AQDSRVFLLD
110 120 130 140 150
EGRTITAGAG SLAPGRSEFF HLPSEVLGCV LAGLVPAGGG GTGGGEPQQW
160 170 180 190 200
SPRAVDFLSN LQGKEVHGRV LDVLLLHRLV LLEVPVVSQQ MEELGLARQV
210 220 230 240 250
PDSLFCSLLK RYLTAAGQGS SGAPVLPRAA PKQEHPGLDY FYPQLQLGVT
260 270 280 290 300
EPVVVTQVCH PHRIHCQLRS LSQEIHRLSE SMAQVYRAPV GTDDEDSGSA
310 320 330 340 350
TWEEREESPD KPGSPCASCG LDGQWYRALL LETFRPQRCA QVLHVDYGRK
360 370 380 390 400
ELVSCSSLRY LLPEYFRMPV VTYPCALYGL WDCGRGWSRS QVGDLKALIL
410 420 430 440 450
GQAVNAKIEF YCSFEHMYYV TLYGEDGINL NSAFGVQSCC LADWFLQSQG
460 470 480 490 500
IEEEEEEDED EVEAAFQSQS PAEEMEAEVS LPSLRSIRLK MNTFYDAQVE
510 520 530 540 550
FVKSPSEFWI RLRKHKNTFS KLTKRMCSFY SSASKLDGVI LRPEPDDLCC
560 570 580 590 600
VKWKENGYYR ATVTRLDSKS VDVFLVDRGN SENVDWCDVR MLLPQFRQLP
610 620 630 640 650
ILALKCTLAD IWPLGKTWSQ EATSFFKKTV LHKELVVHVL DKQDHQYVIE
660 670 680 690 700
ILDESRMGEE NISKVIAQAG FAKFQEFETK ENIRLSAHSP GHVSGHFMAE
710 720 730 740 750
PSKITSAKKA EGDQRAKKDN KTLSVSEALA DTVSLSNLST AQDTEKVTSD
760 770 780 790 800
PSLLMLNFLK TKPDCCGKGE LEVGSTVEVK VSHIENPGSF WCQLMRNAQG
810 820 830 840 850
FRTLMCDIED YCKSSEPSPY EGDTRVCLAK RTASGRWSRA LISGAHSLEH
860 870 880 890 900
VRVVFVDYGD RDVVSTKDIL SVSDVFFQVR AQAFRCSLYN LIQPMGENPF
910 920 930 940 950
VWDEKAVQAF SGFIDSARQN NLELKCTVFA LASRHEEEWF NVVDLLTPFQ
960 970 980 990 1000
SACRFLVEKR LARPVKHQKP LEPSVQLHSY YYSTHDLKIG SEELVYVTHA
1010 1020 1030 1040 1050
DDPWTFYCQL ARNINVLEQL SYNIMQLSKA LLNLKASTLA PGTLCLARYT
1060 1070 1080 1090 1100
DGNWYRGIII EKEPSKVFFV DFGNTYIAVD HLLPIPRDAH DVLLLPMQAL
1110 1120 1130 1140 1150
KCSLSDIPHH IPEEVTAWFQ ETVLDKSLKA LVVAKDPDGR LIIELYDDSV
1160 1170 1180 1190 1200
QINASINEKL GLLGYKNRTR RKEKENEIIL HETKALEDKK ESVKPSLADY
1210 1220 1230 1240 1250
LGKPGESKAH SIEIMGESCK PKMGPACKEL RYLQGSAKAN LVPPYQDSVG
1260 1270 1280 1290 1300
NKNDGGFPLT REKKEDIFAS SPMSGTKLDS ALPERRMGEP SGRDLPPKFC
1310 1320 1330 1340 1350
EFPQKTIAPG FKTSVYVSHI NDLSDFYIQL IEDEAEINNL SERLNDVRTR
1360 1370 1380 1390 1400
PQYHTGPQWQ SGDVICAVFP EDNLWYRALV MEQQPNGLLS VQFIDYGNMS
1410 1420 1430 1440 1450
VVHTNRTGRL GPVDAVLPAL CLHCSLWGLS VPVCKEMVSY FSQRTDEAQI
1460 1470 1480 1490 1500
RCEFVKFQGT WEVILADEHG VIAEDMISRF PCNGNSQAGL TTQTMKGDCL
1510 1520 1530 1540 1550
KIANKPNTDT SVLLNWYNPK AKLIKAYATV IDGPEYFWCQ FADSEKLQYL
1560 1570 1580 1590 1600
ETEVQSAGKQ LSDRRSCTQC PQIGDPCIVR YREDGHYYRA LITNICDGEL
1610 1620 1630 1640 1650
ASVRLVDFGN AEDCVDAKEL WSIPSELLLV PMQAFPCCLA GFSVSGGVCP
1660 1670 1680 1690 1700
QEGNDYFYDI VTEDVLDITI LEIKRDVCNI PLAIVELRSK GENINEKMKK
1710 1720 1730 1740 1750
YAKTGVPKND LSSEKRGPER KGSLASPDLG LKKPSHKIAQ DKTFYGEARA
1760 1770 1780 1790 1800
SELSERLEKD LNIETKTSKF YERSTRSIFN AFENSCKGKM GSERLEGSMD
1810 1820 1830 1840 1850
YHFVDRAKFD NNYLITGFNP ILAHASEPKE LLELSSLEVP LSADNDDECK
1860 1870 1880 1890 1900
EFLELESIEL QHSPAGEEEK EELGLGSPMA PLSPGCQAGA TLESFMMQLP
1910 1920 1930 1940 1950
LDCEAEKQLE LKLPTPQLSL EDSISPLSAA VSQDIQGSRC SEDERKAGYM
1960 1970 1980 1990 2000
GSSDDDHSRS PLLQHGKGGN SPAHDGRNLS EEEFPQFESR DSAALLAPLF
2010 2020 2030 2040 2050
SEEEAREGRK CGSMVPAQLQ STYTLKGFSV GSKCVVWSSL RNTWSKCEIL
2060 2070 2080 2090 2100
ELAEEGTRVL NLSNGVEETV SPENVWNGIP KVDKRPSEAV FQTVGKDLPF
2110 2120 2130
MPSDDATTKG FSSVSEEEAC GGDADSLSTA KLNI
Length:2,134
Mass (Da):237,914
Last modified:May 24, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0862BA0B2F183C91
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B2W3Z0A0A3B2W3Z0_MOUSE
Tudor domain-containing protein 6
Tdrd6
1,941Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z429F2Z429_MOUSE
Tudor domain-containing protein 6
Tdrd6
2,135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PZ50E9PZ50_MOUSE
Tudor domain-containing protein 6
Tdrd6
2,134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB097085 mRNA Translation: BAD01486.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28797.1

NCBI Reference Sequences

More...
RefSeqi
NP_940810.2, NM_198418.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
210510

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:210510

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097085 mRNA Translation: BAD01486.1
CCDSiCCDS28797.1
RefSeqiNP_940810.2, NM_198418.2

3D structure databases

SMRiP61407
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi229157, 6 interactors
STRINGi10090.ENSMUSP00000035338

PTM databases

iPTMnetiP61407
PhosphoSitePlusiP61407

Proteomic databases

PaxDbiP61407
PRIDEiP61407
ProteomicsDBi262747

Genome annotation databases

GeneIDi210510
KEGGimmu:210510

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
221400
MGIiMGI:2679727, Tdrd6

Phylogenomic databases

eggNOGiKOG2039, Eukaryota
InParanoidiP61407
PhylomeDBiP61407

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
210510, 3 hits in 55 CRISPR screens

Protein Ontology

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PROi
PR:P61407
RNActiP61407, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Family and domain databases

CDDicd04508, TUDOR, 6 hits
Gene3Di2.40.50.90, 3 hits
InterProiView protein in InterPro
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor
PfamiView protein in Pfam
PF00567, TUDOR, 7 hits
SMARTiView protein in SMART
SM00333, TUDOR, 7 hits
PROSITEiView protein in PROSITE
PS50304, TUDOR, 6 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDRD6_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61407
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: June 2, 2021
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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