Insulin gene enhancer protein ISL-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• bHLH transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "ISL1 physically interacts with BETA2 to promote insulin gene transcriptional synergy in non-beta cells."
    Peng S.Y., Wang W.P., Meng J., Li T., Zhang H., Li Y.M., Chen P., Ma K.T., Zhou C.Y.
    Biochim. Biophys. Acta 1731:154-159(2005) [PubMed] [Europe PMC] [Abstract]
• chromatin binding Source: RGDInferred from sequence orthologyⁱ
  • "ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells."
    Pan L., Deng M., Xie X., Gan L.
    Development 135:1981-1990(2008) [PubMed] [Europe PMC] [Abstract]
  • "A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate."
    Kwon C., Qian L., Cheng P., Nigam V., Arnold J., Srivastava D.
    Nat. Cell Biol. 11:951-957(2009) [PubMed] [Europe PMC] [Abstract]
  • "Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation."
    Dykes I.M., Tempest L., Lee S.I., Turner E.E.
    J. Neurosci. 31:9789-9799(2011) [PubMed] [Europe PMC] [Abstract]
• cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2."
    Zhang H., Wang W.P., Guo T., Yang J.C., Chen P., Ma K.T., Guan Y.F., Zhou C.Y.
    J. Mol. Biol. 392:566-577(2009) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate."
    Kwon C., Qian L., Cheng P., Nigam V., Arnold J., Srivastava D.
    Nat. Cell Biol. 11:951-957(2009) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2."
    Zhang H., Wang W.P., Guo T., Yang J.C., Chen P., Ma K.T., Guan Y.F., Zhou C.Y.
    J. Mol. Biol. 392:566-577(2009) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2."
    Zhang H., Wang W.P., Guo T., Yang J.C., Chen P., Ma K.T., Guan Y.F., Zhou C.Y.
    J. Mol. Biol. 392:566-577(2009) [PubMed] [Europe PMC] [Abstract]
• estrogen receptor binding Source: BHF-UCLInferred from direct assayⁱ
  • "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions."
    Gay F., Anglade I., Gong Z., Salbert G.
    Mol. Endocrinol. 14:1627-1648(2000) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• nuclear receptor binding Source: BHF-UCLInferred from direct assayⁱ
  • "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions."
    Gay F., Anglade I., Gong Z., Salbert G.
    Mol. Endocrinol. 14:1627-1648(2000) [PubMed] [Europe PMC] [Abstract]
• promoter-specific chromatin binding Source: UniProtKB
• RNA polymerase II activating transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2."
    Zhang H., Wang W.P., Guo T., Yang J.C., Chen P., Ma K.T., Guan Y.F., Zhou C.Y.
    J. Mol. Biol. 392:566-577(2009) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • "The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2."
    Zhang H., Wang W.P., Guo T., Yang J.C., Chen P., Ma K.T., Guan Y.F., Zhou C.Y.
    J. Mol. Biol. 392:566-577(2009) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGDInferred from direct assayⁱ
  • Ref.3

    "Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain."
    Karlsson O., Thor S., Norberg T., Ohlsson H., Edlund T.
    Nature 344:879-882(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-316 (ISOFORM 1), DNA-BINDING, TISSUE SPECIFICITY.
  • "The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription."
    Wang M., Drucker D.J.
    J. Biol. Chem. 270:12646-12652(1995) [PubMed] [Europe PMC] [Abstract]
  • "Expression, purification and characterization of the homeodomain of rat ISL-1 protein."
    Behravan G., Lycksell P.O., Larsson G.
    Protein Eng. 10:1327-1331(1997) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator activity Source: RGDInferred from sequence orthologyⁱ
  • "The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities."
    Hao A., Novotny-Diermayr V., Bian W., Lin B., Lim C.P., Jing N., Cao X.
    Mol. Biol. Cell 16:1569-1583(2005) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• atrial septum morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis."
    Lin L., Cui L., Zhou W., Dufort D., Zhang X., Cai C.L., Bu L., Yang L., Martin J., Kemler R., Rosenfeld M.G., Chen J., Evans S.M.
    Proc. Natl. Acad. Sci. U.S.A. 104:9313-9318(2007) [PubMed] [Europe PMC] [Abstract]
• axonogenesis Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• axon regeneration Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Regulation of the LIM-type homeobox gene islet-1 during neuronal regeneration."
    Hol E.M., Schwaiger F.W., Werner A., Schmitt A., Raivich G., Kreutzberg G.W.
    Neuroscience 88:917-925(1999) [PubMed] [Europe PMC] [Abstract]
• cardiac cell fate determination Source: RGDInferred from sequence orthologyⁱ
  • "Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages."
    Bu L., Jiang X., Martin-Puig S., Caron L., Zhu S., Shao Y., Roberts D.J., Huang P.L., Domian I.J., Chien K.R.
    Nature 460:113-117(2009) [PubMed] [Europe PMC] [Abstract]
  • "A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate."
    Kwon C., Qian L., Cheng P., Nigam V., Arnold J., Srivastava D.
    Nat. Cell Biol. 11:951-957(2009) [PubMed] [Europe PMC] [Abstract]
• cardiac muscle cell myoblast differentiation Source: RGDInferred from sequence orthologyⁱ
  • "A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate."
    Kwon C., Qian L., Cheng P., Nigam V., Arnold J., Srivastava D.
    Nat. Cell Biol. 11:951-957(2009) [PubMed] [Europe PMC] [Abstract]
• cardiac right ventricle morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis."
    Lin L., Cui L., Zhou W., Dufort D., Zhang X., Cai C.L., Bu L., Yang L., Martin J., Kemler R., Rosenfeld M.G., Chen J., Evans S.M.
    Proc. Natl. Acad. Sci. U.S.A. 104:9313-9318(2007) [PubMed] [Europe PMC] [Abstract]
• cellular response to glucocorticoid stimulus Source: BHF-UCLInferred from expression patternⁱ
  • "The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2."
    Zhang H., Wang W.P., Guo T., Yang J.C., Chen P., Ma K.T., Guan Y.F., Zhou C.Y.
    J. Mol. Biol. 392:566-577(2009) [PubMed] [Europe PMC] [Abstract]
• endocardial cushion morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis."
    Lin L., Cui L., Zhou W., Dufort D., Zhang X., Cai C.L., Bu L., Yang L., Martin J., Kemler R., Rosenfeld M.G., Chen J., Evans S.M.
    Proc. Natl. Acad. Sci. U.S.A. 104:9313-9318(2007) [PubMed] [Europe PMC] [Abstract]
• heart development Source: UniProtKB
• heart morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis."
    Lin L., Bu L., Cai C.L., Zhang X., Evans S.
    Dev. Biol. 295:756-763(2006) [PubMed] [Europe PMC] [Abstract]
• innervation Source: RGDInferred from sequence orthologyⁱ
  • "A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs."
    Sun Y., Dykes I.M., Liang X., Eng S.R., Evans S.M., Turner E.E.
    Nat. Neurosci. 11:1283-1293(2008) [PubMed] [Europe PMC] [Abstract]
• mesenchymal cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells."
    Ahlgren U., Pfaff S.L., Jessell T.M., Edlund T., Edlund H.
    Nature 385:257-260(1997) [PubMed] [Europe PMC] [Abstract]
• negative regulation of canonical Wnt signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate."
    Kwon C., Qian L., Cheng P., Nigam V., Arnold J., Srivastava D.
    Nat. Cell Biol. 11:951-957(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of epithelial cell proliferation Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells."
    Bronnum H., Andersen D.C., Schneider M., Nossent A.Y., Nielsen S.B., Sheikh S.P.
    Exp. Cell Res. 319:424-435(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of inflammatory response Source: RGDInferred from sequence orthologyⁱ
  • "Islet-1 gene delivery improves myocardial performance after experimental infarction."
    Barzelay A., Hochhauser E., Entin-Meer M., Chepurko Y., Birk E., Afek A., Barshack I., Pinhas L., Rivo Y., Ben-Shoshan J., Maysel-Auslender S., Keren G., George J.
    Atherosclerosis 223:284-290(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of intracellular estrogen receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions."
    Gay F., Anglade I., Gong Z., Salbert G.
    Mol. Endocrinol. 14:1627-1648(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neuron apoptotic process Source: RGDInferred from sequence orthologyⁱ
  • "A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs."
    Sun Y., Dykes I.M., Liang X., Eng S.R., Evans S.M., Turner E.E.
    Nat. Neurosci. 11:1283-1293(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neuron differentiation Source: RGDInferred from sequence orthologyⁱ
  • "A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity."
    Thaler J.P., Koo S.J., Kania A., Lettieri K., Andrews S., Cox C., Jessell T.M., Pfaff S.L.
    Neuron 41:337-350(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein-containing complex assembly Source: BHF-UCLInferred from direct assayⁱ
  • "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions."
    Gay F., Anglade I., Gong Z., Salbert G.
    Mol. Endocrinol. 14:1627-1648(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs."
    Sun Y., Dykes I.M., Liang X., Eng S.R., Evans S.M., Turner E.E.
    Nat. Neurosci. 11:1283-1293(2008) [PubMed] [Europe PMC] [Abstract]
• neural crest cell migration Source: RGDInferred from sequence orthologyⁱ
  • "Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis."
    Lin L., Bu L., Cai C.L., Zhang X., Evans S.
    Dev. Biol. 295:756-763(2006) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: RGDInferred from sequence orthologyⁱ
  • "The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons."
    Elshatory Y., Gan L.
    J. Neurosci. 28:3291-3297(2008) [PubMed] [Europe PMC] [Abstract]
  • "Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy."
    Mak K.K., Kronenberg H.M., Chuang P.T., Mackem S., Yang Y.
    Development 135:1947-1956(2008) [PubMed] [Europe PMC] [Abstract]
  • "Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation."
    Pfaff S.L., Mendelsohn M., Stewart C.L., Edlund T., Jessell T.M.
    Cell 84:309-320(1996) [PubMed] [Europe PMC] [Abstract]
• neuron fate commitment Source: RGDInferred from sequence orthologyⁱ
  • "A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity."
    Thaler J.P., Koo S.J., Kania A., Lettieri K., Andrews S., Cox C., Jessell T.M., Pfaff S.L.
    Neuron 41:337-350(2004) [PubMed] [Europe PMC] [Abstract]
• neuron fate specification Source: RGDInferred from sequence orthologyⁱ
  • "A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs."
    Sun Y., Dykes I.M., Liang X., Eng S.R., Evans S.M., Turner E.E.
    Nat. Neurosci. 11:1283-1293(2008) [PubMed] [Europe PMC] [Abstract]
• outflow tract morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis."
    Lin L., Cui L., Zhou W., Dufort D., Zhang X., Cai C.L., Bu L., Yang L., Martin J., Kemler R., Rosenfeld M.G., Chen J., Evans S.M.
    Proc. Natl. Acad. Sci. U.S.A. 104:9313-9318(2007) [PubMed] [Europe PMC] [Abstract]
• outflow tract septum morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis."
    Lin L., Cui L., Zhou W., Dufort D., Zhang X., Cai C.L., Bu L., Yang L., Martin J., Kemler R., Rosenfeld M.G., Chen J., Evans S.M.
    Proc. Natl. Acad. Sci. U.S.A. 104:9313-9318(2007) [PubMed] [Europe PMC] [Abstract]
• pancreas development Source: RGDInferred from sequence orthologyⁱ
  • "Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells."
    Ahlgren U., Pfaff S.L., Jessell T.M., Edlund T., Edlund H.
    Nature 385:257-260(1997) [PubMed] [Europe PMC] [Abstract]
• peripheral nervous system neuron axonogenesis Source: RGDInferred from sequence orthologyⁱ
  • "A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs."
    Sun Y., Dykes I.M., Liang X., Eng S.R., Evans S.M., Turner E.E.
    Nat. Neurosci. 11:1283-1293(2008) [PubMed] [Europe PMC] [Abstract]
• peripheral nervous system neuron development Source: RGDInferred from sequence orthologyⁱ
  • "Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation."
    Dykes I.M., Tempest L., Lee S.I., Turner E.E.
    J. Neurosci. 31:9789-9799(2011) [PubMed] [Europe PMC] [Abstract]
• pharyngeal system development Source: RGDInferred from sequence orthologyⁱ
  • "Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis."
    Lin L., Cui L., Zhou W., Dufort D., Zhang X., Cai C.L., Bu L., Yang L., Martin J., Kemler R., Rosenfeld M.G., Chen J., Evans S.M.
    Proc. Natl. Acad. Sci. U.S.A. 104:9313-9318(2007) [PubMed] [Europe PMC] [Abstract]
• pituitary gland development Source: RGDInferred from sequence orthologyⁱ
  • "Formation of Rathke's pouch requires dual induction from the diencephalon."
    Takuma N., Sheng H.Z., Furuta Y., Ward J.M., Sharma K., Hogan B.L., Pfaff S.L., Westphal H., Kimura S., Mahon K.A.
    Development 125:4835-4840(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of angiogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Islet-1 gene delivery improves myocardial performance after experimental infarction."
    Barzelay A., Hochhauser E., Entin-Meer M., Chepurko Y., Birk E., Afek A., Barshack I., Pinhas L., Rivo Y., Ben-Shoshan J., Maysel-Auslender S., Keren G., George J.
    Atherosclerosis 223:284-290(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell differentiation Source: UniProtKB
• positive regulation of cell population proliferation Source: RGDInferred from sequence orthologyⁱ
  • "The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities."
    Hao A., Novotny-Diermayr V., Bian W., Lin B., Lim C.P., Jing N., Cao X.
    Mol. Biol. Cell 16:1569-1583(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities."
    Hao A., Novotny-Diermayr V., Bian W., Lin B., Lim C.P., Jing N., Cao X.
    Mol. Biol. Cell 16:1569-1583(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of epithelial to mesenchymal transition Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells."
    Bronnum H., Andersen D.C., Schneider M., Nossent A.Y., Nielsen S.B., Sheikh S.P.
    Exp. Cell Res. 319:424-435(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of granulocyte colony-stimulating factor production Source: RGDInferred from sequence orthologyⁱ
  • "Islet-1 gene delivery improves myocardial performance after experimental infarction."
    Barzelay A., Hochhauser E., Entin-Meer M., Chepurko Y., Birk E., Afek A., Barshack I., Pinhas L., Rivo Y., Ben-Shoshan J., Maysel-Auslender S., Keren G., George J.
    Atherosclerosis 223:284-290(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of granulocyte macrophage colony-stimulating factor production Source: RGDInferred from sequence orthologyⁱ
  • "Islet-1 gene delivery improves myocardial performance after experimental infarction."
    Barzelay A., Hochhauser E., Entin-Meer M., Chepurko Y., Birk E., Afek A., Barshack I., Pinhas L., Rivo Y., Ben-Shoshan J., Maysel-Auslender S., Keren G., George J.
    Atherosclerosis 223:284-290(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of histone acetylation Source: RGDInferred from sequence orthologyⁱ
  • "Islet-1 may function as an assistant factor for histone acetylation and regulation of cardiac development-related transcription factor Mef2c expression."
    Yu Z., Kong J., Pan B., Sun H., Lv T., Zhu J., Huang G., Tian J.
    PLoS ONE 8:e77690-e77690(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of insulin secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin."
    Kojima H., Nakamura T., Fujita Y., Kishi A., Fujimiya M., Yamada S., Kudo M., Nishio Y., Maegawa H., Haneda M., Yasuda H., Kojima I., Seno M., Wong N.C., Kikkawa R., Kashiwagi A.
    Diabetes 51:1398-1408(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interferon-gamma production Source: RGDInferred from sequence orthologyⁱ
  • "Islet-1 gene delivery improves myocardial performance after experimental infarction."
    Barzelay A., Hochhauser E., Entin-Meer M., Chepurko Y., Birk E., Afek A., Barshack I., Pinhas L., Rivo Y., Ben-Shoshan J., Maysel-Auslender S., Keren G., George J.
    Atherosclerosis 223:284-290(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-12 production Source: RGDInferred from sequence orthologyⁱ
  • "Islet-1 gene delivery improves myocardial performance after experimental infarction."
    Barzelay A., Hochhauser E., Entin-Meer M., Chepurko Y., Birk E., Afek A., Barshack I., Pinhas L., Rivo Y., Ben-Shoshan J., Maysel-Auslender S., Keren G., George J.
    Atherosclerosis 223:284-290(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-1 alpha production Source: RGDInferred from sequence orthologyⁱ
  • "Islet-1 gene delivery improves myocardial performance after experimental infarction."
    Barzelay A., Hochhauser E., Entin-Meer M., Chepurko Y., Birk E., Afek A., Barshack I., Pinhas L., Rivo Y., Ben-Shoshan J., Maysel-Auslender S., Keren G., George J.
    Atherosclerosis 223:284-290(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-1 beta production Source: RGDInferred from sequence orthologyⁱ
  • "Islet-1 gene delivery improves myocardial performance after experimental infarction."
    Barzelay A., Hochhauser E., Entin-Meer M., Chepurko Y., Birk E., Afek A., Barshack I., Pinhas L., Rivo Y., Ben-Shoshan J., Maysel-Auslender S., Keren G., George J.
    Atherosclerosis 223:284-290(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-6 production Source: RGDInferred from sequence orthologyⁱ
  • "Islet-1 gene delivery improves myocardial performance after experimental infarction."
    Barzelay A., Hochhauser E., Entin-Meer M., Chepurko Y., Birk E., Afek A., Barshack I., Pinhas L., Rivo Y., Ben-Shoshan J., Maysel-Auslender S., Keren G., George J.
    Atherosclerosis 223:284-290(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of macrophage colony-stimulating factor production Source: RGDInferred from sequence orthologyⁱ
  • "Islet-1 gene delivery improves myocardial performance after experimental infarction."
    Barzelay A., Hochhauser E., Entin-Meer M., Chepurko Y., Birk E., Afek A., Barshack I., Pinhas L., Rivo Y., Ben-Shoshan J., Maysel-Auslender S., Keren G., George J.
    Atherosclerosis 223:284-290(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from direct assayⁱ
  • "The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2."
    Zhang H., Wang W.P., Guo T., Yang J.C., Chen P., Ma K.T., Guan Y.F., Zhou C.Y.
    J. Mol. Biol. 392:566-577(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of tumor necrosis factor production Source: RGDInferred from sequence orthologyⁱ
  • "Islet-1 gene delivery improves myocardial performance after experimental infarction."
    Barzelay A., Hochhauser E., Entin-Meer M., Chepurko Y., Birk E., Afek A., Barshack I., Pinhas L., Rivo Y., Ben-Shoshan J., Maysel-Auslender S., Keren G., George J.
    Atherosclerosis 223:284-290(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of tyrosine phosphorylation of STAT protein Source: RGDInferred from sequence orthologyⁱ
  • "The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities."
    Hao A., Novotny-Diermayr V., Bian W., Lin B., Lim C.P., Jing N., Cao X.
    Mol. Biol. Cell 16:1569-1583(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of vascular endothelial growth factor production Source: RGDInferred from sequence orthologyⁱ
  • "Islet-1 gene delivery improves myocardial performance after experimental infarction."
    Barzelay A., Hochhauser E., Entin-Meer M., Chepurko Y., Birk E., Afek A., Barshack I., Pinhas L., Rivo Y., Ben-Shoshan J., Maysel-Auslender S., Keren G., George J.
    Atherosclerosis 223:284-290(2012) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity."
    Song M.R., Sun Y., Bryson A., Gill G.N., Evans S.M., Pfaff S.L.
    Development 136:2923-2932(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of secondary heart field cardioblast proliferation Source: RGDInferred from sequence orthologyⁱ
  • "A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate."
    Kwon C., Qian L., Cheng P., Nigam V., Arnold J., Srivastava D.
    Nat. Cell Biol. 11:951-957(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: RGDInferred from direct assayⁱ
  • "The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription."
    Wang M., Drucker D.J.
    J. Biol. Chem. 270:12646-12652(1995) [PubMed] [Europe PMC] [Abstract]
• retinal ganglion cell axon guidance Source: RGDInferred from sequence orthologyⁱ
  • "ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells."
    Pan L., Deng M., Xie X., Gan L.
    Development 135:1981-1990(2008) [PubMed] [Europe PMC] [Abstract]
• secondary heart field specification Source: RGDInferred from sequence orthologyⁱ
  • "Common variation in ISL1 confers genetic susceptibility for human congenital heart disease."
    Stevens K.N., Hakonarson H., Kim C.E., Doevendans P.A., Koeleman B.P., Mital S., Raue J., Glessner J.T., Coles J.G., Moreno V., Granger A., Gruber S.B., Gruber P.J.
    PLoS ONE 5:e10855-e10855(2010) [PubMed] [Europe PMC] [Abstract]
• sensory system development Source: RGDInferred from sequence orthologyⁱ
  • "A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs."
    Sun Y., Dykes I.M., Liang X., Eng S.R., Evans S.M., Turner E.E.
    Nat. Neurosci. 11:1283-1293(2008) [PubMed] [Europe PMC] [Abstract]
• spinal cord motor neuron cell fate specification Source: RGDInferred from sequence orthologyⁱ
  • "Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity."
    Song M.R., Sun Y., Bryson A., Gill G.N., Evans S.M., Pfaff S.L.
    Development 136:2923-2932(2009) [PubMed] [Europe PMC] [Abstract]
• spinal cord motor neuron differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation."
    Pfaff S.L., Mendelsohn M., Stewart C.L., Edlund T., Jessell T.M.
    Cell 84:309-320(1996) [PubMed] [Europe PMC] [Abstract]
• trigeminal nerve development Source: RGDInferred from sequence orthologyⁱ
  • "A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs."
    Sun Y., Dykes I.M., Liang X., Eng S.R., Evans S.M., Turner E.E.
    Nat. Neurosci. 11:1283-1293(2008) [PubMed] [Europe PMC] [Abstract]
• ventricular cardiac muscle tissue morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis."
    Lin L., Cui L., Zhou W., Dufort D., Zhang X., Cai C.L., Bu L., Yang L., Martin J., Kemler R., Rosenfeld M.G., Chen J., Evans S.M.
    Proc. Natl. Acad. Sci. U.S.A. 104:9313-9318(2007) [PubMed] [Europe PMC] [Abstract]
• visceral motor neuron differentiation Source: RGDInferred from sequence orthologyⁱ
  • "A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity."
    Thaler J.P., Koo S.J., Kania A., Lettieri K., Andrews S., Cox C., Jessell T.M., Pfaff S.L.
    Neuron 41:337-350(2004) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• bHLH transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "ISL1 physically interacts with BETA2 to promote insulin gene transcriptional synergy in non-beta cells."
    Peng S.Y., Wang W.P., Meng J., Li T., Zhang H., Li Y.M., Chen P., Ma K.T., Zhou C.Y.
    Biochim. Biophys. Acta 1731:154-159(2005) [PubMed] [Europe PMC] [Abstract]
• estrogen receptor binding Source: BHF-UCLInferred from direct assayⁱ
  • "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions."
    Gay F., Anglade I., Gong Z., Salbert G.
    Mol. Endocrinol. 14:1627-1648(2000) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor binding Source: BHF-UCLInferred from direct assayⁱ
  • "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions."
    Gay F., Anglade I., Gong Z., Salbert G.
    Mol. Endocrinol. 14:1627-1648(2000) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II activating transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2."
    Zhang H., Wang W.P., Guo T., Yang J.C., Chen P., Ma K.T., Guan Y.F., Zhou C.Y.
    J. Mol. Biol. 392:566-577(2009) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGDMGDPPKK KRLISLCVGC GNQIHDQYIL RVSPDLEWHA ACLKCAECNQ 
        60         70         80         90        100
YLDESCTCFV RDGKTYCKRD YIRLYGIKCA KCSIGFSKND FVMRARSKVY 
       110        120        130        140        150
HIECFRCVAC SRQLIPGDEF ALREDGLFCR ADHDVVERAS LGAGDPLSPL 
       160        170        180        190        200
HPARPLQMAA EPISARQPAL RPHVHKQPEK TTRVRTVLNE KQLHTLRTCY 
       210        220        230        240        250
AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKRS IMMKQLQQQQ 
       260        270        280        290        300
PNDKTNIQGM TGTPMVAASP ERHDGGLQAN PVEVQSYQPP WKVLSDFALQ 
       310        320        330        340 
SDIDQPAFQQ LVNFSEGGPG SNSTGSEVAS MSSQLPDTPN SMVASPIEA  

        10         20         30         40         50
MGDMGDPPKK KRLISLCVGC GNQIHDQYIL RVSPDLEWHA ACLKCAECNQ 
        60         70         80         90        100
YLDESCTCFV RDGKTYCKRD YIRLYGIKCA KCSIGFSKND FVMRARSKVY 
       110        120        130        140        150
HIECFRCVAC SRQLIPGDEF ALREDGLFCR ADHDVVERAS LGAGDPLSPL 
       160        170        180        190        200
HPARPLQMAA EPISARQPAL RPHVHKQPEK TTRVRTVLNE KQLHTLRTCY 
       210        220        230        240        250
AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKRS IMMKQLQQQQ 
       260        270        280        290        300
PNDKTANPVE VQSYQPPWKV LSDFALQSDI DQPAFQQLVN FSEGGPGSNS 
       310        320 
TGSEVASMSS QLPDTPNSMV ASPIEA                           

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ