UniProtKB - P61354 (RL27_RAT)
Protein
60S ribosomal protein L27
Gene
Rpl27
Organism
Rattus norvegicus (Rat)
Status
Functioni
Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity).By similarity
GO - Molecular functioni
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- response to aldosterone Source: RGD
- rRNA processing Source: UniProtKB
- translation Source: InterPro
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
Reactomei | R-RNO-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-RNO-1799339, SRP-dependent cotranslational protein targeting to membrane R-RNO-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-RNO-72689, Formation of a pool of free 40S subunits R-RNO-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-RNO-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-RNO-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L27 |
Gene namesi | Name:Rpl27 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621192, Rpl27 |
Subcellular locationi
Endoplasmic reticulum
- Rough endoplasmic reticulum By similarity
Cytosol
- cytosol By similarity
Other locations
- Cytoplasm By similarity
Note: Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).By similarity
Cytosol
- cytosolic large ribosomal subunit Source: RGD
Endoplasmic reticulum
- cytoplasmic side of rough endoplasmic reticulum membrane Source: UniProtKB
Other locations
- ribonucleoprotein complex Source: RGD
- ribosome Source: RGD
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulumPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000126079 | 1 – 136 | 60S ribosomal protein L27Add BLAST | 136 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 27 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 93 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | P61354 |
PaxDbi | P61354 |
PRIDEi | P61354 |
PTM databases
iPTMneti | P61354 |
PhosphoSitePlusi | P61354 |
SwissPalmi | P61354 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000020674, Expressed in female gonad and 21 other tissues |
Genevisiblei | P61354, RN |
Interactioni
Subunit structurei
Component of the large ribosomal subunit (By similarity).
Interacts with RRP1B (By similarity).
Component of the large ribosomal subunit.
Interacts with RRP1B.
Interacts with DHX33 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 249021, 5 interactors |
IntActi | P61354, 4 interactors |
STRINGi | 10116.ENSRNOP00000028060 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 40 | KOWAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the eukaryotic ribosomal protein eL27 family.Curated
Phylogenomic databases
eggNOGi | KOG3418, Eukaryota |
GeneTreei | ENSGT00390000010721 |
HOGENOMi | CLU_067359_0_1_1 |
InParanoidi | P61354 |
OMAi | KPHDEGT |
OrthoDBi | 1584965at2759 |
PhylomeDBi | P61354 |
TreeFami | TF314648 |
Family and domain databases
CDDi | cd06090, KOW_RPL27, 1 hit |
Gene3Di | 2.30.30.770, 1 hit |
InterProi | View protein in InterPro IPR005824, KOW IPR041991, KOW_RPL27 IPR038655, L27e_sf IPR001141, Ribosomal_L27e IPR018262, Ribosomal_L27e_CS IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR10497, PTHR10497, 1 hit |
Pfami | View protein in Pfam PF00467, KOW, 1 hit PF01777, Ribosomal_L27e, 1 hit |
SMARTi | View protein in SMART SM00739, KOW, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit |
PROSITEi | View protein in PROSITE PS01107, RIBOSOMAL_L27E, 1 hit |
i Sequence
Sequence statusi: Complete.
P61354-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKFMKPGKV VLVLAGRYSG RKAVIVKNID DGTSDRPYSH ALVAGIDRYP
60 70 80 90 100
RKVTAAMGKK KIAKRSKIKS FVKVYNYNHL MPTRYSVDIP LDKTVVNKDV
110 120 130
FRDPALKRKA RREAKVKFEE RYKTGKNKWF FQKLRF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X07424 mRNA Translation: CAA30313.1 BC058474 mRNA Translation: AAH58474.1 BC091566 mRNA Translation: AAH91566.1 |
PIRi | S00401, R5RT27 |
RefSeqi | NP_071959.1, NM_022514.1 |
Genome annotation databases
Ensembli | ENSRNOT00000028060; ENSRNOP00000028060; ENSRNOG00000020674 |
GeneIDi | 64306 |
KEGGi | rno:64306 |
UCSCi | RGD:621192, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X07424 mRNA Translation: CAA30313.1 BC058474 mRNA Translation: AAH58474.1 BC091566 mRNA Translation: AAH91566.1 |
PIRi | S00401, R5RT27 |
RefSeqi | NP_071959.1, NM_022514.1 |
3D structure databases
SMRi | P61354 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 249021, 5 interactors |
IntActi | P61354, 4 interactors |
STRINGi | 10116.ENSRNOP00000028060 |
PTM databases
iPTMneti | P61354 |
PhosphoSitePlusi | P61354 |
SwissPalmi | P61354 |
Proteomic databases
jPOSTi | P61354 |
PaxDbi | P61354 |
PRIDEi | P61354 |
Genome annotation databases
Ensembli | ENSRNOT00000028060; ENSRNOP00000028060; ENSRNOG00000020674 |
GeneIDi | 64306 |
KEGGi | rno:64306 |
UCSCi | RGD:621192, rat |
Organism-specific databases
CTDi | 6155 |
RGDi | 621192, Rpl27 |
Phylogenomic databases
eggNOGi | KOG3418, Eukaryota |
GeneTreei | ENSGT00390000010721 |
HOGENOMi | CLU_067359_0_1_1 |
InParanoidi | P61354 |
OMAi | KPHDEGT |
OrthoDBi | 1584965at2759 |
PhylomeDBi | P61354 |
TreeFami | TF314648 |
Enzyme and pathway databases
Reactomei | R-RNO-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-RNO-1799339, SRP-dependent cotranslational protein targeting to membrane R-RNO-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-RNO-72689, Formation of a pool of free 40S subunits R-RNO-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-RNO-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-RNO-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
PROi | PR:P61354 |
Gene expression databases
Bgeei | ENSRNOG00000020674, Expressed in female gonad and 21 other tissues |
Genevisiblei | P61354, RN |
Family and domain databases
CDDi | cd06090, KOW_RPL27, 1 hit |
Gene3Di | 2.30.30.770, 1 hit |
InterProi | View protein in InterPro IPR005824, KOW IPR041991, KOW_RPL27 IPR038655, L27e_sf IPR001141, Ribosomal_L27e IPR018262, Ribosomal_L27e_CS IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR10497, PTHR10497, 1 hit |
Pfami | View protein in Pfam PF00467, KOW, 1 hit PF01777, Ribosomal_L27e, 1 hit |
SMARTi | View protein in SMART SM00739, KOW, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit |
PROSITEi | View protein in PROSITE PS01107, RIBOSOMAL_L27E, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL27_RAT | |
Accessioni | P61354Primary (citable) accession number: P61354 Secondary accession number(s): P08526, Q5BJ97 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Ribosomal proteins
Ribosomal proteins families and list of entries