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Protein

60S ribosomal protein L27

Gene

RPL27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902).1 Publication4 Publications

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • response to aldosterone Source: Ensembl
  • rRNA processing Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L27
Alternative name(s):
Large ribosomal subunit protein eL271 Publication
Gene namesi
Name:RPL27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000131469.12
HGNCiHGNC:10328 RPL27
MIMi607526 gene
neXtProtiNX_P61353

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 16 (DBA16)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:617408

Keywords - Diseasei

Diamond-Blackfan anemia

Organism-specific databases

DisGeNETi6155
MalaCardsiRPL27
MIMi617408 phenotype
OpenTargetsiENSG00000131469
PharmGKBiPA34707

Polymorphism and mutation databases

BioMutaiRPL27
DMDMi47117772

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001260772 – 13660S ribosomal protein L27Add BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27N6-acetyllysineCombined sources1
Modified residuei93N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61353
MaxQBiP61353
PaxDbiP61353
PeptideAtlasiP61353
PRIDEiP61353
ProteomicsDBi57297
TopDownProteomicsiP61353

2D gel databases

SWISS-2DPAGEiP61353

PTM databases

iPTMnetiP61353
PhosphoSitePlusiP61353
SwissPalmiP61353

Expressioni

Gene expression databases

BgeeiENSG00000131469
CleanExiHS_RPL27
ExpressionAtlasiP61353 baseline and differential
GenevisibleiP61353 HS

Organism-specific databases

HPAiHPA002649

Interactioni

Subunit structurei

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). Interacts with RRP1B (PubMed:20926688). Interacts with DHX33 (PubMed:26100019).1 Publication5 Publications

Protein-protein interaction databases

BioGridi112074, 157 interactors
CORUMiP61353
IntActiP61353, 33 interactors
MINTiP61353
STRINGi9606.ENSP00000253788

Structurei

3D structure databases

ProteinModelPortaliP61353
SMRiP61353
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 40KOWAdd BLAST36

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3418 Eukaryota
COG2163 LUCA
GeneTreeiENSGT00390000010721
HOGENOMiHOG000210138
HOVERGENiHBG050005
InParanoidiP61353
KOiK02901
OMAiRYPRKVH
PhylomeDBiP61353

Family and domain databases

Gene3Di2.30.30.770, 1 hit
InterProiView protein in InterPro
IPR005824 KOW
IPR038655 L27e_sf
IPR001141 Ribosomal_L27e
IPR018262 Ribosomal_L27e_CS
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR10497 PTHR10497, 1 hit
PfamiView protein in Pfam
PF00467 KOW, 1 hit
PF01777 Ribosomal_L27e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009396 Ribosomal_L27e, 1 hit
SMARTiView protein in SMART
SM00739 KOW, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
PROSITEiView protein in PROSITE
PS01107 RIBOSOMAL_L27E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKFMKPGKV VLVLAGRYSG RKAVIVKNID DGTSDRPYSH ALVAGIDRYP
60 70 80 90 100
RKVTAAMGKK KIAKRSKIKS FVKVYNYNHL MPTRYSVDIP LDKTVVNKDV
110 120 130
FRDPALKRKA RREAKVKFEE RYKTGKNKWF FQKLRF
Length:136
Mass (Da):15,798
Last modified:January 23, 2007 - v2
Checksum:i73F4151495029A32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19527 mRNA Translation: AAA19815.1
AB061851 Genomic DNA Translation: BAB79492.1
L05094 mRNA Translation: AAC15857.1
BC001700 mRNA Translation: AAH01700.1
BC002588 mRNA Translation: AAH02588.1
BC007273 mRNA Translation: AAH07273.1
BC010026 mRNA Translation: AAH10026.1
BC098560 mRNA Translation: AAH98560.1
CCDSiCCDS11449.1
PIRiS43505
RefSeqiNP_000979.1, NM_000988.3
UniGeneiHs.514196
Hs.660076
Hs.731595

Genome annotation databases

EnsembliENST00000253788; ENSP00000253788; ENSG00000131469
ENST00000589037; ENSP00000467587; ENSG00000131469
ENST00000589913; ENSP00000464813; ENSG00000131469
GeneIDi6155
KEGGihsa:6155
UCSCiuc002icj.4 human

Similar proteinsi

Entry informationi

Entry nameiRL27_HUMAN
AccessioniPrimary (citable) accession number: P61353
Secondary accession number(s): P08526, Q4G0A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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