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Protein

Protein mago nashi homolog

Gene

MAGOH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing, mRNA transport, Nonsense-mediated mRNA decay, Translation regulation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein mago nashi homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAGOH
Synonyms:MAGOHA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000162385.10

Human Gene Nomenclature Database

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HGNCi
HGNC:6815 MAGOH

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602603 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P61326

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi16 – 17KF → EA: Impaired nonsense-mediated decay activity. 1 Publication2
Mutagenesisi41 – 42KN → DA: Complete loss of nonsense-mediated decay activity. 1 Publication2
Mutagenesisi66 – 68DSE → RSR: Slightly reduced nonsense-mediated decay activity. 1 Publication3
Mutagenesisi68E → R: Abolishes interaction with PYM1 leading to increase EJC association with splices mRNAs; when associated with R-72; K-73 and R-117. 1 Publication1
Mutagenesisi72 – 73ED → RK: Fully active. 1 Publication2
Mutagenesisi72E → R: Abolishes interaction with PYM1 leading to increase EJC association with splices mRNAs; when associated with R-68; K-73 and R-117. 1 Publication1
Mutagenesisi73D → K: Abolishes interaction with PYM1 leading to increase EJC association with splices mRNAs; when associated with R-68; R-72 and R-117. 1 Publication1
Mutagenesisi85 – 87RQE → EQR: Fully active. 1 Publication3
Mutagenesisi117E → R: Abolishes interaction with PYM1 leading to increase EJC association with splices mRNAs; when associated with R-68; R-72 and K-73. 1 Publication1
Mutagenesisi130 – 134KCLVF → ECLVA: Complete loss of nonsense-mediated decay activity. 1 Publication5
Mutagenesisi136L → R: Complete loss of nonsense-mediated decay activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4116

Open Targets

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OpenTargetsi
ENSG00000162385

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30563

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAGOH

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47117708

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001741451 – 146Protein mago nashi homologAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P61326

MaxQB - The MaxQuant DataBase

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MaxQBi
P61326

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P61326

PeptideAtlas

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PeptideAtlasi
P61326

PRoteomics IDEntifications database

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PRIDEi
P61326

ProteomicsDB human proteome resource

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ProteomicsDBi
57294

Consortium for Top Down Proteomics

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TopDownProteomicsi
P61326-1 [P61326-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P61326

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P61326

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000162385 Expressed in 227 organ(s), highest expression level in oocyte

CleanEx database of gene expression profiles

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CleanExi
HS_MAGOH

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P61326 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB015425
HPA043036
HPA047754

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with RBM8A. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A. Interacts with PYM1; the interaction is direct and dissociates the EJC from spliced mRNAs. Identified in the spliceosome C complex.9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110290, 191 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1941 Exon junction core complex, MAGOH variant
CPX-1942 Exon junction subcomplex MAGOH-Y14

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P61326

Database of interacting proteins

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DIPi
DIP-33069N

Protein interaction database and analysis system

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IntActi
P61326, 141 interactors

Molecular INTeraction database

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MINTi
P61326

STRING: functional protein association networks

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STRINGi
9606.ENSP00000360525

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P61326

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P61326

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P61326

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mago nashi family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3392 Eukaryota
ENOG4111FJ7 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000003156

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000207428

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004353

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P61326

KEGG Orthology (KO)

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KOi
K12877

Identification of Orthologs from Complete Genome Data

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OMAi
EDDTNWP

Database of Orthologous Groups

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OrthoDBi
EOG091G0UKA

Database for complete collections of gene phylogenies

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PhylomeDBi
P61326

TreeFam database of animal gene trees

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TreeFami
TF300128

Family and domain databases

Conserved Domains Database

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CDDi
cd11295 Mago_nashi, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.1560.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004023 Mago_nashi
IPR036605 Mago_nashi_sf

The PANTHER Classification System

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PANTHERi
PTHR12638 PTHR12638, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02792 Mago_nashi, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF89817 SSF89817, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P61326-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESDFYLRYY VGHKGKFGHE FLEFEFRPDG KLRYANNSNY KNDVMIRKEA
60 70 80 90 100
YVHKSVMEEL KRIIDDSEIT KEDDALWPPP DRVGRQELEI VIGDEHISFT
110 120 130 140
TSKIGSLIDV NQSKDPEGLR VFYYLVQDLK CLVFSLIGLH FKIKPI
Length:146
Mass (Da):17,164
Last modified:May 10, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFAD0B075E045875
GO
Isoform 2 (identifier: P61326-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     50-86: Missing.

Note: No experimental confirmation available.
Show »
Length:109
Mass (Da):12,844
Checksum:iD232443C8370F0CF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05624650 – 86Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF035940 mRNA Translation: AAC39606.1
AF067173 mRNA Translation: AAD32457.1
AK297895 mRNA Translation: BAG60216.1
AK312113 mRNA Translation: BAG35049.1
AL606760 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06747.1
CH471059 Genomic DNA Translation: EAX06748.1
BC018211 mRNA Translation: AAH18211.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS577.1 [P61326-1]

NCBI Reference Sequences

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RefSeqi
NP_002361.1, NM_002370.3 [P61326-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.421576

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000371466; ENSP00000360521; ENSG00000162385 [P61326-2]
ENST00000371470; ENSP00000360525; ENSG00000162385 [P61326-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4116

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4116

UCSC genome browser

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UCSCi
uc001cvf.2 human [P61326-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035940 mRNA Translation: AAC39606.1
AF067173 mRNA Translation: AAD32457.1
AK297895 mRNA Translation: BAG60216.1
AK312113 mRNA Translation: BAG35049.1
AL606760 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06747.1
CH471059 Genomic DNA Translation: EAX06748.1
BC018211 mRNA Translation: AAH18211.1
CCDSiCCDS577.1 [P61326-1]
RefSeqiNP_002361.1, NM_002370.3 [P61326-1]
UniGeneiHs.421576

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P27X-ray2.00A/C2-145[»]
2HYIX-ray2.30A/G1-146[»]
2J0QX-ray3.20C/F1-146[»]
2J0SX-ray2.21C1-146[»]
2XB2X-ray3.40C/Y1-146[»]
3EX7X-ray2.30A/E1-146[»]
ProteinModelPortaliP61326
SMRiP61326
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110290, 191 interactors
ComplexPortaliCPX-1941 Exon junction core complex, MAGOH variant
CPX-1942 Exon junction subcomplex MAGOH-Y14
CORUMiP61326
DIPiDIP-33069N
IntActiP61326, 141 interactors
MINTiP61326
STRINGi9606.ENSP00000360525

Protein family/group databases

TCDBi3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

PTM databases

iPTMnetiP61326
PhosphoSitePlusiP61326

Polymorphism and mutation databases

BioMutaiMAGOH
DMDMi47117708

Proteomic databases

EPDiP61326
MaxQBiP61326
PaxDbiP61326
PeptideAtlasiP61326
PRIDEiP61326
ProteomicsDBi57294
TopDownProteomicsiP61326-1 [P61326-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4116
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371466; ENSP00000360521; ENSG00000162385 [P61326-2]
ENST00000371470; ENSP00000360525; ENSG00000162385 [P61326-1]
GeneIDi4116
KEGGihsa:4116
UCSCiuc001cvf.2 human [P61326-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4116
DisGeNETi4116
EuPathDBiHostDB:ENSG00000162385.10

GeneCards: human genes, protein and diseases

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GeneCardsi
MAGOH
HGNCiHGNC:6815 MAGOH
HPAiCAB015425
HPA043036
HPA047754
MIMi602603 gene
neXtProtiNX_P61326
OpenTargetsiENSG00000162385
PharmGKBiPA30563

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3392 Eukaryota
ENOG4111FJ7 LUCA
GeneTreeiENSGT00390000003156
HOGENOMiHOG000207428
HOVERGENiHBG004353
InParanoidiP61326
KOiK12877
OMAiEDDTNWP
OrthoDBiEOG091G0UKA
PhylomeDBiP61326
TreeFamiTF300128

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MAGOH human
EvolutionaryTraceiP61326

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MAGOH

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4116

Protein Ontology

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PROi
PR:P61326

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000162385 Expressed in 227 organ(s), highest expression level in oocyte
CleanExiHS_MAGOH
GenevisibleiP61326 HS

Family and domain databases

CDDicd11295 Mago_nashi, 1 hit
Gene3Di3.30.1560.10, 1 hit
InterProiView protein in InterPro
IPR004023 Mago_nashi
IPR036605 Mago_nashi_sf
PANTHERiPTHR12638 PTHR12638, 1 hit
PfamiView protein in Pfam
PF02792 Mago_nashi, 1 hit
SUPFAMiSSF89817 SSF89817, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMGN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61326
Secondary accession number(s): B1ARP8
, B2R5A2, O35169, P50606, Q5SW69
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: December 5, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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