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Protein

60S ribosomal protein L15

Gene

RPL15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L15
Alternative name(s):
Large ribosomal subunit protein eL151 Publication
Gene namesi
Name:RPL15
Synonyms:EC45
ORF Names:TCBAP0781
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000174748.18
HGNCiHGNC:10306 RPL15
MIMi604174 gene
neXtProtiNX_P61313

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 12 (DBA12)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:615550

Keywords - Diseasei

Diamond-Blackfan anemia

Organism-specific databases

DisGeNETi6138
GeneReviewsiRPL15
MalaCardsiRPL15
MIMi615550 phenotype
OpenTargetsiENSG00000174748
Orphaneti124 Blackfan-Diamond anemia
PharmGKBiPA34674

Chemistry databases

DrugBankiDB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB07374 Anisomycin
DB08437 Puromycin

Polymorphism and mutation databases

BioMutaiRPL15
DMDMi47117726

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001275272 – 20460S ribosomal protein L15Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei34PhosphoserineBy similarity1
Cross-linki83Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei97PhosphoserineCombined sources1
Modified residuei100PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP61313
MaxQBiP61313
PaxDbiP61313
PeptideAtlasiP61313
PRIDEiP61313
ProteomicsDBi57293
TopDownProteomicsiP61313-1 [P61313-1]

2D gel databases

SWISS-2DPAGEiP61313

PTM databases

iPTMnetiP61313
PhosphoSitePlusiP61313
SwissPalmiP61313

Expressioni

Gene expression databases

BgeeiENSG00000174748
CleanExiHS_RPL15
ExpressionAtlasiP61313 baseline and differential
GenevisibleiP61313 HS

Interactioni

Subunit structurei

Interacts with IFIT1 (via TPR repeats 1-4).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2P502225EBI-443462,EBI-748397

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112058, 197 interactors
CORUMiP61313
IntActiP61313, 30 interactors
MINTiP61313
STRINGi9606.ENSP00000309334

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LN1-204[»]
4V6Xelectron microscopy5.00CN1-204[»]
5AJ0electron microscopy3.50AN1-204[»]
5LKSelectron microscopy3.60LN1-204[»]
5T2Celectron microscopy3.60t1-204[»]
6EK0electron microscopy2.90LN1-204[»]
ProteinModelPortaliP61313
SMRiP61313
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1678 Eukaryota
COG1632 LUCA
GeneTreeiENSGT00910000144184
HOGENOMiHOG000229584
HOVERGENiHBG000443
InParanoidiP61313
KOiK02877
OMAiYWVAQDS
OrthoDBiEOG091G0LFF
PhylomeDBiP61313
TreeFamiTF300050

Family and domain databases

Gene3Di3.40.1120.10, 1 hit
InterProiView protein in InterPro
IPR024794 Rbsml_L15e_core_dom_sf
IPR000439 Ribosomal_L15e
IPR020925 Ribosomal_L15e_CS
IPR012678 Ribosomal_L23/L15e_core_dom_sf
PANTHERiPTHR11847 PTHR11847, 1 hit
PfamiView protein in Pfam
PF00827 Ribosomal_L15e, 1 hit
SMARTiView protein in SMART
SM01384 Ribosomal_L15e, 1 hit
SUPFAMiSSF54189 SSF54189, 1 hit
PROSITEiView protein in PROSITE
PS01194 RIBOSOMAL_L15E, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P61313-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAYKYIQEL WRKKQSDVMR FLLRVRCWQY RQLSALHRAP RPTRPDKARR
60 70 80 90 100
LGYKAKQGYV IYRIRVRRGG RKRPVPKGAT YGKPVHHGVN QLKFARSLQS
110 120 130 140 150
VAEERAGRHC GALRVLNSYW VGEDSTYKFF EVILIDPFHK AIRRNPDTQW
160 170 180 190 200
ITKPVHKHRE MRGLTSAGRK SRGLGKGHKF HHTIGGSRRA AWRRRNTLQL

HRYR
Length:204
Mass (Da):24,146
Last modified:January 23, 2007 - v2
Checksum:iA6E3AD1A76C9506F
GO
Isoform 2 (identifier: P61313-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-204: VGEDSTYKFF...RNTLQLHRYR → MESHSHSGGSAVGQSRLTATSVSRV

Show »
Length:145
Mass (Da):16,717
Checksum:i0195D5816021FCC4
GO

Sequence cautioni

The sequence AAA36583 differs from that shown. Reason: Frameshift at position 199.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101V → L in AAG44837 (Ref. 5) Curated1
Sequence conflicti129F → A in AAA36583 (Ref. 1) Curated1
Sequence conflicti129F → A in BAB79461 (Ref. 3) Curated1
Sequence conflicti155V → D in AAA36583 (Ref. 1) Curated1
Sequence conflicti180F → S in AAH14837 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045144121 – 204VGEDS…LHRYR → MESHSHSGGSAVGQSRLTAT SVSRV in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25899 mRNA Translation: AAA36583.1 Frameshift.
AF279903 mRNA Translation: AAG44837.1
AB061823 Genomic DNA Translation: BAB79461.1
AY347528 mRNA Translation: AAQ24859.1
AF283772 mRNA Translation: AAG15591.1
AK290694 mRNA Translation: BAF83383.1
AK292000 mRNA Translation: BAF84689.1
BT019672 mRNA Translation: AAV38478.1
AC124914 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64338.1
BC081565 mRNA Translation: AAH81565.1
BC014837 mRNA Translation: AAH14837.1
BC068198 mRNA Translation: AAH68198.1
BC070328 mRNA Translation: AAH70328.1
BC071672 mRNA Translation: AAH71672.1
CCDSiCCDS2640.1 [P61313-1]
CCDS58818.1 [P61313-2]
RefSeqiNP_001240308.1, NM_001253379.1 [P61313-1]
NP_001240309.1, NM_001253380.1 [P61313-1]
NP_001240311.1, NM_001253382.1 [P61313-1]
NP_001240312.1, NM_001253383.1 [P61313-1]
NP_001240313.1, NM_001253384.1 [P61313-2]
NP_002939.2, NM_002948.3 [P61313-1]
UniGeneiHs.381219
Hs.592455

Genome annotation databases

EnsembliENST00000307839; ENSP00000309334; ENSG00000174748 [P61313-1]
ENST00000354811; ENSP00000346867; ENSG00000174748 [P61313-1]
ENST00000413699; ENSP00000416692; ENSG00000174748 [P61313-1]
ENST00000415719; ENSP00000388529; ENSG00000174748 [P61313-1]
ENST00000435882; ENSP00000390193; ENSG00000174748 [P61313-1]
ENST00000456530; ENSP00000398788; ENSG00000174748 [P61313-2]
ENST00000611050; ENSP00000483260; ENSG00000174748 [P61313-1]
ENST00000644185; ENSP00000493759; ENSG00000174748 [P61313-1]
GeneIDi6138
KEGGihsa:6138
UCSCiuc003ccn.4 human [P61313-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRL15_HUMAN
AccessioniPrimary (citable) accession number: P61313
Secondary accession number(s): P39030
, P41051, Q5U0C0, Q642I1, Q6IPX6, Q8WYP2, Q96C44, Q9H2E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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