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Entry version 162 (16 Oct 2019)
Sequence version 2 (23 Jan 2007)
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Protein

60S ribosomal protein L15

Gene

RPL15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L15
Alternative name(s):
Large ribosomal subunit protein eL151 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPL15
Synonyms:EC45
ORF Names:TCBAP0781
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10306 RPL15

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604174 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P61313

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diamond-Blackfan anemia 12 (DBA12)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
Related information in OMIM

Keywords - Diseasei

Diamond-Blackfan anemia

Organism-specific databases

DisGeNET

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DisGeNETi
6138

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
RPL15

MalaCards human disease database

More...
MalaCardsi
RPL15
MIMi615550 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000174748

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
124 Blackfan-Diamond anemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34674

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P61313

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB07374 Anisomycin
DB08437 Puromycin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPL15

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001275272 – 20460S ribosomal protein L15Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei34PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki83Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei97PhosphoserineCombined sources1
Modified residuei100PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P61313

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P61313

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P61313

MaxQB - The MaxQuant DataBase

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MaxQBi
P61313

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P61313

PeptideAtlas

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PeptideAtlasi
P61313

PRoteomics IDEntifications database

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PRIDEi
P61313

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
57293 [P61313-1]
65913

Consortium for Top Down Proteomics

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TopDownProteomicsi
P61313-1 [P61313-1]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P61313

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P61313

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P61313

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P61313

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000174748 Expressed in 241 organ(s), highest expression level in cerebellar hemisphere

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P61313 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P61313 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with IFIT1 (via TPR repeats 1-4).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2P502223EBI-443462,EBI-748397

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112058, 224 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P61313

Protein interaction database and analysis system

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IntActi
P61313, 75 interactors

Molecular INTeraction database

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MINTi
P61313

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000309334

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P61313

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1678 Eukaryota
COG1632 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00910000144184

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000229584

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P61313

KEGG Orthology (KO)

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KOi
K02877

Identification of Orthologs from Complete Genome Data

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OMAi
YWVAQDS

Database of Orthologous Groups

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OrthoDBi
664798at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P61313

TreeFam database of animal gene trees

More...
TreeFami
TF300050

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.1120.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024794 Rbsml_L15e_core_dom_sf
IPR000439 Ribosomal_L15e
IPR020925 Ribosomal_L15e_CS
IPR012678 Ribosomal_L23/L15e_core_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR11847 PTHR11847, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00827 Ribosomal_L15e, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01384 Ribosomal_L15e, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54189 SSF54189, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS01194 RIBOSOMAL_L15E, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P61313-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAYKYIQEL WRKKQSDVMR FLLRVRCWQY RQLSALHRAP RPTRPDKARR
60 70 80 90 100
LGYKAKQGYV IYRIRVRRGG RKRPVPKGAT YGKPVHHGVN QLKFARSLQS
110 120 130 140 150
VAEERAGRHC GALRVLNSYW VGEDSTYKFF EVILIDPFHK AIRRNPDTQW
160 170 180 190 200
ITKPVHKHRE MRGLTSAGRK SRGLGKGHKF HHTIGGSRRA AWRRRNTLQL

HRYR
Length:204
Mass (Da):24,146
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6E3AD1A76C9506F
GO
Isoform 2 (identifier: P61313-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-204: VGEDSTYKFF...RNTLQLHRYR → MESHSHSGGSAVGQSRLTATSVSRV

Show »
Length:145
Mass (Da):16,717
Checksum:i0195D5816021FCC4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ERA2E7ERA2_HUMAN
Ribosomal protein L15
RPL15
44Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQV9E7EQV9_HUMAN
Ribosomal protein L15
RPL15
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ENU7E7ENU7_HUMAN
Ribosomal protein L15
RPL15
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EX53E7EX53_HUMAN
Ribosomal protein L15
RPL15
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y738A0A2R8Y738_HUMAN
Ribosomal protein L15
RPL15
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YEM3A0A2R8YEM3_HUMAN
Ribosomal protein L15
RPL15
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA36583 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti101V → L in AAG44837 (Ref. 5) Curated1
Sequence conflicti129F → A in AAA36583 (Ref. 1) Curated1
Sequence conflicti129F → A in BAB79461 (Ref. 3) Curated1
Sequence conflicti155V → D in AAA36583 (Ref. 1) Curated1
Sequence conflicti180F → S in AAH14837 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045144121 – 204VGEDS…LHRYR → MESHSHSGGSAVGQSRLTAT SVSRV in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L25899 mRNA Translation: AAA36583.1 Frameshift.
AF279903 mRNA Translation: AAG44837.1
AB061823 Genomic DNA Translation: BAB79461.1
AY347528 mRNA Translation: AAQ24859.1
AF283772 mRNA Translation: AAG15591.1
AK290694 mRNA Translation: BAF83383.1
AK292000 mRNA Translation: BAF84689.1
BT019672 mRNA Translation: AAV38478.1
AC124914 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64338.1
BC081565 mRNA Translation: AAH81565.1
BC014837 mRNA Translation: AAH14837.1
BC068198 mRNA Translation: AAH68198.1
BC070328 mRNA Translation: AAH70328.1
BC071672 mRNA Translation: AAH71672.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2640.1 [P61313-1]
CCDS58818.1 [P61313-2]

NCBI Reference Sequences

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RefSeqi
NP_001240308.1, NM_001253379.1 [P61313-1]
NP_001240309.1, NM_001253380.1 [P61313-1]
NP_001240311.1, NM_001253382.1 [P61313-1]
NP_001240312.1, NM_001253383.1 [P61313-1]
NP_001240313.1, NM_001253384.1 [P61313-2]
NP_002939.2, NM_002948.3 [P61313-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000307839; ENSP00000309334; ENSG00000174748 [P61313-1]
ENST00000354811; ENSP00000346867; ENSG00000174748 [P61313-1]
ENST00000413699; ENSP00000416692; ENSG00000174748 [P61313-1]
ENST00000415719; ENSP00000388529; ENSG00000174748 [P61313-1]
ENST00000456530; ENSP00000398788; ENSG00000174748 [P61313-2]
ENST00000611050; ENSP00000483260; ENSG00000174748 [P61313-1]
ENST00000644185; ENSP00000493759; ENSG00000174748 [P61313-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6138

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6138

UCSC genome browser

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UCSCi
uc003ccn.4 human [P61313-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25899 mRNA Translation: AAA36583.1 Frameshift.
AF279903 mRNA Translation: AAG44837.1
AB061823 Genomic DNA Translation: BAB79461.1
AY347528 mRNA Translation: AAQ24859.1
AF283772 mRNA Translation: AAG15591.1
AK290694 mRNA Translation: BAF83383.1
AK292000 mRNA Translation: BAF84689.1
BT019672 mRNA Translation: AAV38478.1
AC124914 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64338.1
BC081565 mRNA Translation: AAH81565.1
BC014837 mRNA Translation: AAH14837.1
BC068198 mRNA Translation: AAH68198.1
BC070328 mRNA Translation: AAH70328.1
BC071672 mRNA Translation: AAH71672.1
CCDSiCCDS2640.1 [P61313-1]
CCDS58818.1 [P61313-2]
RefSeqiNP_001240308.1, NM_001253379.1 [P61313-1]
NP_001240309.1, NM_001253380.1 [P61313-1]
NP_001240311.1, NM_001253382.1 [P61313-1]
NP_001240312.1, NM_001253383.1 [P61313-1]
NP_001240313.1, NM_001253384.1 [P61313-2]
NP_002939.2, NM_002948.3 [P61313-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LN1-204[»]
4V6Xelectron microscopy5.00CN1-204[»]
5AJ0electron microscopy3.50AN1-204[»]
5LKSelectron microscopy3.60LN1-204[»]
5T2Celectron microscopy3.60t1-204[»]
6EK0electron microscopy2.90LN1-204[»]
6IP5electron microscopy3.902H1-204[»]
6IP6electron microscopy4.502H1-204[»]
6IP8electron microscopy3.902H1-204[»]
6OLEelectron microscopy3.10O2-204[»]
6OLFelectron microscopy3.90O2-204[»]
6OLGelectron microscopy3.40AN2-204[»]
6OLIelectron microscopy3.50O2-204[»]
6OLZelectron microscopy3.90AN2-204[»]
6OM0electron microscopy3.10O2-204[»]
6OM7electron microscopy3.70O2-204[»]
6QZPelectron microscopy2.90LN2-204[»]
SMRiP61313
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112058, 224 interactors
CORUMiP61313
IntActiP61313, 75 interactors
MINTiP61313
STRINGi9606.ENSP00000309334

Chemistry databases

DrugBankiDB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB07374 Anisomycin
DB08437 Puromycin

PTM databases

iPTMnetiP61313
PhosphoSitePlusiP61313
SwissPalmiP61313

Polymorphism and mutation databases

BioMutaiRPL15

2D gel databases

SWISS-2DPAGEiP61313

Proteomic databases

EPDiP61313
jPOSTiP61313
MassIVEiP61313
MaxQBiP61313
PaxDbiP61313
PeptideAtlasiP61313
PRIDEiP61313
ProteomicsDBi57293 [P61313-1]
65913
TopDownProteomicsiP61313-1 [P61313-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6138

Genome annotation databases

EnsembliENST00000307839; ENSP00000309334; ENSG00000174748 [P61313-1]
ENST00000354811; ENSP00000346867; ENSG00000174748 [P61313-1]
ENST00000413699; ENSP00000416692; ENSG00000174748 [P61313-1]
ENST00000415719; ENSP00000388529; ENSG00000174748 [P61313-1]
ENST00000456530; ENSP00000398788; ENSG00000174748 [P61313-2]
ENST00000611050; ENSP00000483260; ENSG00000174748 [P61313-1]
ENST00000644185; ENSP00000493759; ENSG00000174748 [P61313-1]
GeneIDi6138
KEGGihsa:6138
UCSCiuc003ccn.4 human [P61313-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6138
DisGeNETi6138

GeneCards: human genes, protein and diseases

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GeneCardsi
RPL15
GeneReviewsiRPL15
HGNCiHGNC:10306 RPL15
MalaCardsiRPL15
MIMi604174 gene
615550 phenotype
neXtProtiNX_P61313
OpenTargetsiENSG00000174748
Orphaneti124 Blackfan-Diamond anemia
PharmGKBiPA34674

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1678 Eukaryota
COG1632 LUCA
GeneTreeiENSGT00910000144184
HOGENOMiHOG000229584
InParanoidiP61313
KOiK02877
OMAiYWVAQDS
OrthoDBi664798at2759
PhylomeDBiP61313
TreeFamiTF300050

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPL15 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RPL15

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6138
PharosiP61313

Protein Ontology

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PROi
PR:P61313

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000174748 Expressed in 241 organ(s), highest expression level in cerebellar hemisphere
ExpressionAtlasiP61313 baseline and differential
GenevisibleiP61313 HS

Family and domain databases

Gene3Di3.40.1120.10, 1 hit
InterProiView protein in InterPro
IPR024794 Rbsml_L15e_core_dom_sf
IPR000439 Ribosomal_L15e
IPR020925 Ribosomal_L15e_CS
IPR012678 Ribosomal_L23/L15e_core_dom_sf
PANTHERiPTHR11847 PTHR11847, 1 hit
PfamiView protein in Pfam
PF00827 Ribosomal_L15e, 1 hit
SMARTiView protein in SMART
SM01384 Ribosomal_L15e, 1 hit
SUPFAMiSSF54189 SSF54189, 1 hit
PROSITEiView protein in PROSITE
PS01194 RIBOSOMAL_L15E, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL15_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61313
Secondary accession number(s): P39030
, P41051, Q5U0C0, Q642I1, Q6IPX6, Q8WYP2, Q96C44, Q9H2E5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
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