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Protein

Somatostatin

Gene

SST

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Somatostatin inhibits the release of somatotropin.

GO - Molecular functioni

  • hormone activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP61278

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin
Alternative name(s):
Growth hormone release-inhibiting factor
Cleaved into the following 2 chains:
Gene namesi
Name:SST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000157005.3
HGNCiHGNC:11329 SST
MIMi182450 gene
neXtProtiNX_P61278

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

A synthetic analog known as octreotide or SMS 201-995 is available under the name Sandostatin (Novartis). It is used for the treatment of a variety of disorders including acromegaly and the symptomatic treatment of carcinoid tumors and vasoactive intestinal peptide tumors.

Organism-specific databases

DisGeNETi6750
OpenTargetsiENSG00000157005
PharmGKBiPA36153

Chemistry databases

ChEMBLiCHEMBL1795130
DrugBankiDB00847 Cysteamine

Polymorphism and mutation databases

BioMutaiSST
DMDMi47117741

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
PropeptideiPRO_000003308625 – 88Add BLAST64
PeptideiPRO_000003308789 – 116Somatostatin-28Add BLAST28
PeptideiPRO_0000033088103 – 116Somatostatin-14Add BLAST14

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi105 ↔ 116Combined sources

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP61278
PeptideAtlasiP61278
PRIDEiP61278
ProteomicsDBi57289

PTM databases

PhosphoSitePlusiP61278

Miscellaneous databases

PMAP-CutDBiP61278

Expressioni

Gene expression databases

BgeeiENSG00000157005 Expressed in 144 organ(s), highest expression level in islet of Langerhans
CleanExiHS_SST
GenevisibleiP61278 HS

Organism-specific databases

HPAiCAB000075
CAB034105
HPA019472

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112628, 2 interactors
STRINGi9606.ENSP00000287641

Chemistry databases

BindingDBiP61278

Structurei

Secondary structure

1116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP61278
SMRiP61278
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQ5 Eukaryota
ENOG4111WUI LUCA
GeneTreeiENSGT00510000047914
HOGENOMiHOG000036630
HOVERGENiHBG017816
InParanoidiP61278
KOiK05237
OMAiGEPEDIR
OrthoDBiEOG091G157X
PhylomeDBiP61278
TreeFamiTF333185

Family and domain databases

InterProiView protein in InterPro
IPR004250 Somatostatin
IPR018142 Somatostatin/Cortistatin_C
PANTHERiPTHR10558 PTHR10558, 1 hit
PfamiView protein in Pfam
PF03002 Somatostatin, 1 hit
PIRSFiPIRSF001814 Somatostatin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61278-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSCRLQCAL AALSIVLALG CVTGAPSDPR LRQFLQKSLA AAAGKQELAK
60 70 80 90 100
YFLAELLSEP NQTENDALEP EDLSQAAEQD EMRLELQRSA NSNPAMAPRE
110
RKAGCKNFFW KTFTSC
Length:116
Mass (Da):12,736
Last modified:July 21, 1986 - v1
Checksum:iAB49BB89DC9DD8DA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03449911A → V. Corresponds to variant dbSNP:rs35603672Ensembl.1
Natural variantiVAR_03450061N → T. Corresponds to variant dbSNP:rs33934967Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00306 Genomic DNA Translation: AAA60566.1
AK312177 mRNA Translation: BAG35110.1
CH471052 Genomic DNA Translation: EAW78145.1
BC032625 mRNA Translation: AAH32625.1
CCDSiCCDS3288.1
PIRiA43614 RIHUS1
RefSeqiNP_001039.1, NM_001048.3
UniGeneiHs.12409

Genome annotation databases

EnsembliENST00000287641; ENSP00000287641; ENSG00000157005
GeneIDi6750
KEGGihsa:6750
UCSCiuc003frn.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Somatostatin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00306 Genomic DNA Translation: AAA60566.1
AK312177 mRNA Translation: BAG35110.1
CH471052 Genomic DNA Translation: EAW78145.1
BC032625 mRNA Translation: AAH32625.1
CCDSiCCDS3288.1
PIRiA43614 RIHUS1
RefSeqiNP_001039.1, NM_001048.3
UniGeneiHs.12409

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P2Wmodel-A1-116[»]
2MI1NMR-A103-116[»]
ProteinModelPortaliP61278
SMRiP61278
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112628, 2 interactors
STRINGi9606.ENSP00000287641

Chemistry databases

BindingDBiP61278
ChEMBLiCHEMBL1795130
DrugBankiDB00847 Cysteamine

PTM databases

PhosphoSitePlusiP61278

Polymorphism and mutation databases

BioMutaiSST
DMDMi47117741

Proteomic databases

PaxDbiP61278
PeptideAtlasiP61278
PRIDEiP61278
ProteomicsDBi57289

Protocols and materials databases

DNASUi6750
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287641; ENSP00000287641; ENSG00000157005
GeneIDi6750
KEGGihsa:6750
UCSCiuc003frn.4 human

Organism-specific databases

CTDi6750
DisGeNETi6750
EuPathDBiHostDB:ENSG00000157005.3
GeneCardsiSST
HGNCiHGNC:11329 SST
HPAiCAB000075
CAB034105
HPA019472
MIMi182450 gene
neXtProtiNX_P61278
OpenTargetsiENSG00000157005
PharmGKBiPA36153
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXQ5 Eukaryota
ENOG4111WUI LUCA
GeneTreeiENSGT00510000047914
HOGENOMiHOG000036630
HOVERGENiHBG017816
InParanoidiP61278
KOiK05237
OMAiGEPEDIR
OrthoDBiEOG091G157X
PhylomeDBiP61278
TreeFamiTF333185

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP61278

Miscellaneous databases

ChiTaRSiSST human
GeneWikiiSomatostatin
GenomeRNAii6750
PMAP-CutDBiP61278
PROiPR:P61278
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157005 Expressed in 144 organ(s), highest expression level in islet of Langerhans
CleanExiHS_SST
GenevisibleiP61278 HS

Family and domain databases

InterProiView protein in InterPro
IPR004250 Somatostatin
IPR018142 Somatostatin/Cortistatin_C
PANTHERiPTHR10558 PTHR10558, 1 hit
PfamiView protein in Pfam
PF03002 Somatostatin, 1 hit
PIRSFiPIRSF001814 Somatostatin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSMS_HUMAN
AccessioniPrimary (citable) accession number: P61278
Secondary accession number(s): B2R5G3, P01166
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Pharmaceutical, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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