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Protein

Syntaxin-1B

Gene

Stx1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones (PubMed:7901002). May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei252 – 253(Microbial infection) Cleavage; by C.botulinum neurotoxin type C (BoNT/C)1 Publication2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNeurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-5682910 LGI-ADAM interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-1B
Alternative name(s):
P35B
Syntaxin-1B2
Gene namesi
Name:Stx1b
Synonyms:Stx1b2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3784 Stx1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 264CytoplasmicSequence analysisAdd BLAST264
Transmembranei265 – 288Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002101941 – 288Syntaxin-1BAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Modified residuei14PhosphoserineCombined sources1 Publication1

Post-translational modificationi

Phosphorylated by CK2.1 Publication
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type C (BoNT/C), which hydrolyzes the 252-Lys-|-Ala-253 bond (PubMed:7737992). Cleavage inhibits neurotransmitter release (PubMed:7901002).2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP61265
PRIDEiP61265

PTM databases

iPTMnetiP61265
PhosphoSitePlusiP61265
SwissPalmiP61265

Expressioni

Tissue specificityi

Cerebral cortex, hippocampus, cerebellum, and adrenal medulla.

Gene expression databases

BgeeiENSRNOG00000019193 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiP61265 RN

Interactioni

Subunit structurei

Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Rnf40Q8CJB94EBI-2255905,EBI-6110162

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247029, 4 interactors
CORUMiP61265
IntActiP61265, 1 interactor
STRINGi10116.ENSRNOP00000026063

Structurei

3D structure databases

ProteinModelPortaliP61265
SMRiP61265
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 253t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili29 – 104Sequence analysisAdd BLAST76

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
GeneTreeiENSGT00760000119200
HOGENOMiHOG000286023
HOVERGENiHBG000497
InParanoidiP61265
KOiK08486
OMAiGEHPDEE
OrthoDBiEOG091G0EUK
PhylomeDBiP61265
TreeFamiTF313763

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR037016 STX1B
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF76 PTHR19957:SF76, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

P61265-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV
60 70 80 90 100
EQVKKQHSAI LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE
110 120 130 140 150
QEEGLNRSSA DLRIRKTQHS TLSRKFVEVM TEYNATQSKY RDRCKDRIQR
160 170 180 190 200
QLEITGRTTT NEELEDMLES GKLAIFTDDI KMDSQMTKQA LNEIETRHNE
210 220 230 240 250
IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV DYVERAVSDT
260 270 280
KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL
Length:288
Mass (Da):33,245
Last modified:May 10, 2004 - v1
Checksum:i2733497E02978BEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95735 mRNA Translation: AAA42197.1
PIRiB48213
RefSeqiNP_036832.1, NM_012700.2
UniGeneiRn.98793

Genome annotation databases

EnsembliENSRNOT00000026063; ENSRNOP00000026063; ENSRNOG00000019193
GeneIDi24923
KEGGirno:24923
UCSCiRGD:3784 rat

Similar proteinsi

Entry informationi

Entry nameiSTX1B_RAT
AccessioniPrimary (citable) accession number: P61265
Secondary accession number(s): P32853
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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