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Protein

Syntaxin-1B

Gene

Stx1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNeurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-5682910 LGI-ADAM interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-1B
Gene namesi
Name:Stx1b
Synonyms:Stx1b1, Stx1b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1930705 Stx1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 264CytoplasmicSequence analysisAdd BLAST264
Transmembranei265 – 288Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002101931 – 288Syntaxin-1BAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CK2.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP61264
PaxDbiP61264
PeptideAtlasiP61264
PRIDEiP61264

PTM databases

iPTMnetiP61264
PhosphoSitePlusiP61264
SwissPalmiP61264

Expressioni

Gene expression databases

BgeeiENSMUSG00000030806 Expressed in 131 organ(s), highest expression level in cerebellum
ExpressionAtlasiP61264 baseline and differential
GenevisibleiP61264 MM

Interactioni

Subunit structurei

Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207850, 3 interactors
IntActiP61264, 6 interactors
MINTiP61264
STRINGi10090.ENSMUSP00000101874

Structurei

3D structure databases

ProteinModelPortaliP61264
SMRiP61264
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 253t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili29 – 104Sequence analysisAdd BLAST76

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
GeneTreeiENSGT00760000119200
HOGENOMiHOG000286023
HOVERGENiHBG000497
InParanoidiP61264
KOiK08486
OMAiGEHPDEE
OrthoDBiEOG091G0EUK
PhylomeDBiP61264
TreeFamiTF313763

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR037016 STX1B
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF76 PTHR19957:SF76, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P61264-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV
60 70 80 90 100
EQVKKQHSAI LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE
110 120 130 140 150
QEEGLNRSSA DLRIRKTQHS TLSRKFVEVM TEYNATQSKY RDRCKDRIQR
160 170 180 190 200
QLEITGRTTT NEELEDMLES GKLAIFTDDI KMDSQMTKQA LNEIETRHNE
210 220 230 240 250
IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV DYVERAVSDT
260 270 280
KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL
Length:288
Mass (Da):33,245
Last modified:May 10, 2004 - v1
Checksum:i2733497E02978BEB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RNT8A0A0U1RNT8_MOUSE
Syntaxin-1B
Stx1b
139Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3 – 4DR → EW in BAA25986 (Ref. 1) Curated2
Sequence conflicti8L → R in BAA25986 (Ref. 1) Curated1
Sequence conflicti26D → A in BAA25986 (Ref. 1) Curated1
Sequence conflicti30D → A in BAA25986 (Ref. 1) Curated1
Sequence conflicti51 – 55EQVKK → GRVGG in BAA25986 (Ref. 1) Curated5
Sequence conflicti65N → K in BAA25986 (Ref. 1) Curated1
Sequence conflicti98S → G in BAA25986 (Ref. 1) Curated1
Sequence conflicti114 – 116IRK → YRT in BAA25986 (Ref. 1) Curated3
Sequence conflicti122L → V in BAA25986 (Ref. 1) Curated1
Sequence conflicti125K → N in BAA25986 (Ref. 1) Curated1
Sequence conflicti137Q → K in BAA25986 (Ref. 1) Curated1
Sequence conflicti148I → L in BAA25986 (Ref. 1) Curated1
Sequence conflicti191L → R in BAA25986 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45207 mRNA Translation: BAA25986.1
D29743 mRNA Translation: BAA06162.1
AC149222 Genomic DNA No translation available.
BC132042 mRNA Translation: AAI32043.1
BC132068 mRNA Translation: AAI32069.1
CCDSiCCDS40146.1
RefSeqiNP_077725.1, NM_024414.2
UniGeneiMm.439759

Genome annotation databases

EnsembliENSMUST00000106267; ENSMUSP00000101874; ENSMUSG00000030806
GeneIDi56216
KEGGimmu:56216
UCSCiuc009jwx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSTX1B_MOUSE
AccessioniPrimary (citable) accession number: P61264
Secondary accession number(s): A2RSB4, O35525, P32853
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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