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Protein

60S ribosomal protein L26

Gene

RPL26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.1 Publication

GO - Molecular functioni

  • mRNA 5'-UTR binding Source: CAFA
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • cellular response to gamma radiation Source: CAFA
  • cellular response to UV Source: CAFA
  • cytoplasmic translation Source: GO_Central
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: CAFA
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: CAFA
  • positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: CAFA
  • positive regulation of translation Source: CAFA
  • regulation of translation involved in cellular response to UV Source: CAFA
  • ribosomal large subunit biogenesis Source: UniProtKB
  • rRNA processing Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: ProtInc
  • translational initiation Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Protein family/group databases

MoonProtiP61254

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L26
Alternative name(s):
Large ribosomal subunit protein uL241 Publication
Gene namesi
Name:RPL26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000161970.12
HGNCiHGNC:10327 RPL26
MIMi603704 gene
neXtProtiNX_P61254

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 11 (DBA11)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:614900

Keywords - Diseasei

Diamond-Blackfan anemia

Organism-specific databases

DisGeNETi6154
GeneReviewsiRPL26
MalaCardsiRPL26
MIMi614900 phenotype
OpenTargetsiENSG00000161970
Orphaneti124 Blackfan-Diamond anemia
PharmGKBiPA34705

Polymorphism and mutation databases

BioMutaiRPL26
DMDMi47117765

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001307871 – 14560S ribosomal protein L26Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei139PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP61254
MaxQBiP61254
PaxDbiP61254
PeptideAtlasiP61254
PRIDEiP61254
ProteomicsDBi57287
TopDownProteomicsiP61254

PTM databases

iPTMnetiP61254
PhosphoSitePlusiP61254

Expressioni

Gene expression databases

BgeeiENSG00000161970
CleanExiHS_RPL26
ExpressionAtlasiP61254 baseline and differential

Organism-specific databases

HPAiCAB037301
HPA030449

Interactioni

Subunit structurei

Component of the large ribosomal subunit (Probable). Interacts with DHX33 (PubMed:26100019).1 Publication1 Publication

Protein-protein interaction databases

BioGridi112073, 103 interactors
CORUMiP61254
DIPiDIP-33198N
IntActiP61254, 49 interactors
MINTiP61254
STRINGi9606.ENSP00000293842

Structurei

3D structure databases

ProteinModelPortaliP61254
SMRiP61254
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3401 Eukaryota
COG0198 LUCA
GeneTreeiENSGT00390000014165
HOGENOMiHOG000216571
HOVERGENiHBG017293
InParanoidiP61254
KOiK02898
OMAiVRIMRGD
OrthoDBiEOG091G0TZX
PhylomeDBiP61254
TreeFamiTF300236

Family and domain databases

Gene3Di2.30.30.30, 1 hit
HAMAPiMF_01326_A Ribosomal_L24_A, 1 hit
InterProiView protein in InterPro
IPR005824 KOW
IPR014722 Rib_L2_dom2
IPR005825 Ribosomal_L24/26_CS
IPR005756 Ribosomal_L26/L24P_euk/arc
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11143 PTHR11143, 1 hit
PfamiView protein in Pfam
PF00467 KOW, 1 hit
PF16906 Ribosomal_L26, 1 hit
SMARTiView protein in SMART
SM00739 KOW, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
TIGRFAMsiTIGR01080 rplX_A_E, 1 hit
PROSITEiView protein in PROSITE
PS01108 RIBOSOMAL_L24, 1 hit

Sequencei

Sequence statusi: Complete.

P61254-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFNPFVTSD RSKNRKRHFN APSHIRRKIM SSPLSKELRQ KYNVRSMPIR
60 70 80 90 100
KDDEVQVVRG HYKGQQIGKV VQVYRKKYVI YIERVQREKA NGTTVHVGIH
110 120 130 140
PSKVVITRLK LDKDRKKILE RKAKSRQVGK EKGKYKEETI EKMQE
Length:145
Mass (Da):17,258
Last modified:May 10, 2004 - v1
Checksum:i049D53AB4E3F46B6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133G → S in AAA60279 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69392 mRNA Translation: CAA49189.1
L07287 Genomic DNA Translation: AAA60279.1
AB061829 Genomic DNA Translation: BAB79467.1
AK311804 mRNA Translation: BAG34747.1
CH471108 Genomic DNA Translation: EAW90053.1
CH471108 Genomic DNA Translation: EAW90054.1
CH471108 Genomic DNA Translation: EAW90057.1
BC071664 mRNA Translation: AAH71664.1
CCDSiCCDS11142.1
PIRiS33713
RefSeqiNP_000978.1, NM_000987.3
NP_001302459.1, NM_001315530.1
NP_001302460.1, NM_001315531.1
UniGeneiHs.482144
Hs.644794
Hs.744896

Genome annotation databases

EnsembliENST00000293842; ENSP00000293842; ENSG00000161970
ENST00000582556; ENSP00000463470; ENSG00000161970
ENST00000583011; ENSP00000462322; ENSG00000161970
ENST00000584164; ENSP00000463784; ENSG00000161970
GeneIDi6154
KEGGihsa:6154
UCSCiuc002glh.2 human

Similar proteinsi

Entry informationi

Entry nameiRL26_HUMAN
AccessioniPrimary (citable) accession number: P61254
Secondary accession number(s): B2R4F0
, D3DTR8, Q02877, Q6IPY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: July 18, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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