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Protein

40S ribosomal protein S3a

Gene

RPS3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role during erythropoiesis through regulation of transcription factor DDIT3.UniRule annotation

GO - Molecular functioni

  • mRNA 5'-UTR binding Source: CAFA
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • cytoplasmic translation Source: GO_Central
  • negative regulation of apoptotic process Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: UniProtKB

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
Biological processDifferentiation

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S3aUniRule annotation
Alternative name(s):
Small ribosomal subunit protein eS11 Publication
v-fos transformation effector protein
Short name:
Fte-1
Gene namesi
Name:RPS3AUniRule annotation
Synonyms:FTE1, MFTL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000145425.9
HGNCiHGNC:10421 RPS3A
MIMi180478 gene
neXtProtiNX_P61247

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6189
OpenTargetsiENSG00000145425
PharmGKBiPA34830

Polymorphism and mutation databases

BioMutaiRPS3A
DMDMi47117764

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation1 Publication
ChainiPRO_00001535242 – 26440S ribosomal protein S3aAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34N6-acetyllysine; alternateCombined sources1
Cross-linki34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei56N6-acetyllysineBy similarity1
Modified residuei236PhosphoserineCombined sources1
Modified residuei237PhosphoserineBy similarity1
Modified residuei249N6-acetyllysine; alternateCombined sources1
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei256PhosphotyrosineCombined sources1
Modified residuei263PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP61247
MaxQBiP61247
PaxDbiP61247
PeptideAtlasiP61247
PRIDEiP61247
ProteomicsDBi57286
TopDownProteomicsiP61247

2D gel databases

SWISS-2DPAGEiP61247

PTM databases

CarbonylDBiP61247
iPTMnetiP61247
PhosphoSitePlusiP61247
SwissPalmiP61247

Miscellaneous databases

PMAP-CutDBiP61247

Expressioni

Gene expression databases

BgeeiENSG00000145425
CleanExiHS_RPS3A
ExpressionAtlasiP61247 baseline and differential
GenevisibleiP61247 HS

Organism-specific databases

HPAiHPA047100
HPA053454

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.UniRule annotation2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP90AA1P079003EBI-352378,EBI-296047

Protein-protein interaction databases

BioGridi112103, 253 interactors
CORUMiP61247
DIPiDIP-29408N
IntActiP61247, 52 interactors
MINTiP61247
STRINGi9606.ENSP00000346050

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SB1-264[»]
4V6Xelectron microscopy5.00AB1-264[»]
5A2Qelectron microscopy3.90B1-264[»]
5AJ0electron microscopy3.50BB1-264[»]
5FLXelectron microscopy3.90B1-264[»]
5LKSelectron microscopy3.60SB1-264[»]
5OA3electron microscopy4.30B1-264[»]
5T2Celectron microscopy3.60Ap1-264[»]
5VYCX-ray6.00B1/B2/B3/B4/B5/B61-264[»]
6EK0electron microscopy2.90SB1-264[»]
6FECelectron microscopy6.30i19-233[»]
ProteinModelPortaliP61247
SMRiP61247
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic ribosomal protein eS1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1628 Eukaryota
COG1890 LUCA
GeneTreeiENSGT00390000018433
HOGENOMiHOG000105220
HOVERGENiHBG000783
InParanoidiP61247
KOiK02984
OMAiMFEIMTR
OrthoDBiEOG091G0HTU
PhylomeDBiP61247
TreeFamiTF300037

Family and domain databases

HAMAPiMF_03122 Ribosomal_S3Ae_euk, 1 hit
InterProiView protein in InterPro
IPR027500 Ribosomal_S1/3_euk
IPR001593 Ribosomal_S3Ae
IPR018281 Ribosomal_S3Ae_CS
PfamiView protein in Pfam
PF01015 Ribosomal_S3Ae, 1 hit
SMARTiView protein in SMART
SM01397 Ribosomal_S3Ae, 1 hit
PROSITEiView protein in PROSITE
PS01191 RIBOSOMAL_S3AE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVGKNKRLT KGGKKGAKKK VVDPFSKKDW YDVKAPAMFN IRNIGKTLVT
60 70 80 90 100
RTQGTKIASD GLKGRVFEVS LADLQNDEVA FRKFKLITED VQGKNCLTNF
110 120 130 140 150
HGMDLTRDKM CSMVKKWQTM IEAHVDVKTT DGYLLRLFCV GFTKKRNNQI
160 170 180 190 200
RKTSYAQHQQ VRQIRKKMME IMTREVQTND LKEVVNKLIP DSIGKDIEKA
210 220 230 240 250
CQSIYPLHDV FVRKVKMLKK PKFELGKLME LHGEGSSSGK ATGDETGAKV
260
ERADGYEPPV QESV
Length:264
Mass (Da):29,945
Last modified:January 23, 2007 - v2
Checksum:i000037AE195F7A9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77234 mRNA Translation: AAA60290.1
M84711 mRNA Translation: AAA58487.1
L13802 mRNA Translation: AAA35682.1
X87373 Genomic DNA Translation: CAA60827.1
AC095055 Genomic DNA No translation available.
AK311788 mRNA Translation: BAG34731.1
CH471056 Genomic DNA Translation: EAX04991.1
CH471056 Genomic DNA Translation: EAX04995.1
BC000204 mRNA Translation: AAH00204.1
BC001708 mRNA Translation: AAH01708.1
BC004981 mRNA Translation: AAH04981.1
BC006298 mRNA Translation: AAH06298.1
BC009219 mRNA Translation: AAH09219.1
BC009404 mRNA Translation: AAH09404.1
BC017123 mRNA Translation: AAH17123.1
BC019072 mRNA Translation: AAH19072.1
BC030161 mRNA Translation: AAH30161.1
BC070211 mRNA Translation: AAH70211.1
BC071916 mRNA Translation: AAH71916.1
AB007148 Genomic DNA Translation: BAA25814.1
CCDSiCCDS3775.1
PIRiJC4662
RefSeqiNP_000997.1, NM_001006.4
UniGeneiHs.356572

Genome annotation databases

EnsembliENST00000274065; ENSP00000346050; ENSG00000145425
GeneIDi6189
KEGGihsa:6189
UCSCiuc003ilz.4 human

Similar proteinsi

Entry informationi

Entry nameiRS3A_HUMAN
AccessioniPrimary (citable) accession number: P61247
Secondary accession number(s): B2R4D4
, D3DP05, P33443, P49241
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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