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Entry version 168 (13 Nov 2019)
Sequence version 2 (23 Jan 2007)
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Protein

40S ribosomal protein S3a

Gene

RPS3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role during erythropoiesis through regulation of transcription factor DDIT3.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
Biological processDifferentiation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
40S ribosomal protein S3aUniRule annotation
Alternative name(s):
Small ribosomal subunit protein eS11 Publication
v-fos transformation effector protein
Short name:
Fte-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPS3AUniRule annotation
Synonyms:FTE1, MFTL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10421 RPS3A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
180478 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P61247

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6189

Open Targets

More...
OpenTargetsi
ENSG00000145425

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34830

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P61247

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPS3A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47117764

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedUniRule annotation1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001535242 – 26440S ribosomal protein S3aAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei34N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei56N6-acetyllysineBy similarity1
Modified residuei236PhosphoserineCombined sources1
Modified residuei237PhosphoserineBy similarity1
Modified residuei249N6-acetyllysine; alternateCombined sources1
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei256PhosphotyrosineCombined sources1
Modified residuei263PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P61247

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P61247

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P61247

MaxQB - The MaxQuant DataBase

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MaxQBi
P61247

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P61247

PeptideAtlas

More...
PeptideAtlasi
P61247

PRoteomics IDEntifications database

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PRIDEi
P61247

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
57286

Consortium for Top Down Proteomics

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TopDownProteomicsi
P61247

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P61247

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P61247

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P61247

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P61247

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P61247

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P61247

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145425 Expressed in 92 organ(s), highest expression level in ectocervix

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P61247 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P61247 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047100
HPA053454

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4.

Interacts with DDIT3.

UniRule annotation2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112103, 296 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P61247

Database of interacting proteins

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DIPi
DIP-29408N

Protein interaction database and analysis system

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IntActi
P61247, 102 interactors

Molecular INTeraction database

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MINTi
P61247

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000346050

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P61247

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic ribosomal protein eS1 family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1628 Eukaryota
COG1890 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000018433

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000105220

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P61247

KEGG Orthology (KO)

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KOi
K02984

Identification of Orthologs from Complete Genome Data

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OMAi
FTRKEWY

Database of Orthologous Groups

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OrthoDBi
1207239at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P61247

TreeFam database of animal gene trees

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TreeFami
TF300037

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_03122 Ribosomal_S3Ae_euk, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027500 Ribosomal_S1/3_euk
IPR001593 Ribosomal_S3Ae
IPR018281 Ribosomal_S3Ae_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01015 Ribosomal_S3Ae, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01397 Ribosomal_S3Ae, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01191 RIBOSOMAL_S3AE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

P61247-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVGKNKRLT KGGKKGAKKK VVDPFSKKDW YDVKAPAMFN IRNIGKTLVT
60 70 80 90 100
RTQGTKIASD GLKGRVFEVS LADLQNDEVA FRKFKLITED VQGKNCLTNF
110 120 130 140 150
HGMDLTRDKM CSMVKKWQTM IEAHVDVKTT DGYLLRLFCV GFTKKRNNQI
160 170 180 190 200
RKTSYAQHQQ VRQIRKKMME IMTREVQTND LKEVVNKLIP DSIGKDIEKA
210 220 230 240 250
CQSIYPLHDV FVRKVKMLKK PKFELGKLME LHGEGSSSGK ATGDETGAKV
260
ERADGYEPPV QESV
Length:264
Mass (Da):29,945
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i000037AE195F7A9D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RAT0D6RAT0_HUMAN
40S ribosomal protein S3a
RPS3A
227Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PFI5E9PFI5_HUMAN
40S ribosomal protein S3a
RPS3A
205Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9Y4H0Y9Y4_HUMAN
40S ribosomal protein S3a
RPS3A
208Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RG13D6RG13_HUMAN
40S ribosomal protein S3a
RPS3A
223Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB09D6RB09_HUMAN
40S ribosomal protein S3a
RPS3A
193Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8L7H0Y8L7_HUMAN
40S ribosomal protein S3a
RPS3A
190Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9B6D6R9B6_HUMAN
40S ribosomal protein S3a
RPS3A hCG_2026261
145Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAS7D6RAS7_HUMAN
40S ribosomal protein S3a
RPS3A
125Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RED7D6RED7_HUMAN
40S ribosomal protein S3a
RPS3A
101Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RI02D6RI02_HUMAN
40S ribosomal protein S3a
RPS3A
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M77234 mRNA Translation: AAA60290.1
M84711 mRNA Translation: AAA58487.1
L13802 mRNA Translation: AAA35682.1
X87373 Genomic DNA Translation: CAA60827.1
AC095055 Genomic DNA No translation available.
AK311788 mRNA Translation: BAG34731.1
CH471056 Genomic DNA Translation: EAX04991.1
CH471056 Genomic DNA Translation: EAX04995.1
BC000204 mRNA Translation: AAH00204.1
BC001708 mRNA Translation: AAH01708.1
BC004981 mRNA Translation: AAH04981.1
BC006298 mRNA Translation: AAH06298.1
BC009219 mRNA Translation: AAH09219.1
BC009404 mRNA Translation: AAH09404.1
BC017123 mRNA Translation: AAH17123.1
BC019072 mRNA Translation: AAH19072.1
BC030161 mRNA Translation: AAH30161.1
BC070211 mRNA Translation: AAH70211.1
BC071916 mRNA Translation: AAH71916.1
AB007148 Genomic DNA Translation: BAA25814.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3775.1

Protein sequence database of the Protein Information Resource

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PIRi
JC4662

NCBI Reference Sequences

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RefSeqi
NP_000997.1, NM_001006.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000274065; ENSP00000346050; ENSG00000145425

Database of genes from NCBI RefSeq genomes

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GeneIDi
6189

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6189

UCSC genome browser

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UCSCi
uc003ilz.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77234 mRNA Translation: AAA60290.1
M84711 mRNA Translation: AAA58487.1
L13802 mRNA Translation: AAA35682.1
X87373 Genomic DNA Translation: CAA60827.1
AC095055 Genomic DNA No translation available.
AK311788 mRNA Translation: BAG34731.1
CH471056 Genomic DNA Translation: EAX04991.1
CH471056 Genomic DNA Translation: EAX04995.1
BC000204 mRNA Translation: AAH00204.1
BC001708 mRNA Translation: AAH01708.1
BC004981 mRNA Translation: AAH04981.1
BC006298 mRNA Translation: AAH06298.1
BC009219 mRNA Translation: AAH09219.1
BC009404 mRNA Translation: AAH09404.1
BC017123 mRNA Translation: AAH17123.1
BC019072 mRNA Translation: AAH19072.1
BC030161 mRNA Translation: AAH30161.1
BC070211 mRNA Translation: AAH70211.1
BC071916 mRNA Translation: AAH71916.1
AB007148 Genomic DNA Translation: BAA25814.1
CCDSiCCDS3775.1
PIRiJC4662
RefSeqiNP_000997.1, NM_001006.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SB1-264[»]
4V6Xelectron microscopy5.00AB1-264[»]
5A2Qelectron microscopy3.90B1-264[»]
5AJ0electron microscopy3.50BB1-264[»]
5FLXelectron microscopy3.90B1-264[»]
5LKSelectron microscopy3.60SB1-264[»]
5OA3electron microscopy4.30B1-264[»]
5T2Celectron microscopy3.60Ap1-264[»]
5VYCX-ray6.00B1/B2/B3/B4/B5/B61-264[»]
6EK0electron microscopy2.90SB1-264[»]
6FECelectron microscopy6.30i19-233[»]
6G18electron microscopy3.60B1-264[»]
6G4Selectron microscopy4.00B1-264[»]
6G4Welectron microscopy4.50B1-264[»]
6G51electron microscopy4.10B1-264[»]
6G53electron microscopy4.50B1-264[»]
6G5Helectron microscopy3.60B1-264[»]
6G5Ielectron microscopy3.50B1-264[»]
6IP5electron microscopy3.902o1-264[»]
6IP6electron microscopy4.502o1-264[»]
6IP8electron microscopy3.902o1-264[»]
6OLEelectron microscopy3.10SB21-234[»]
6OLFelectron microscopy3.90SB21-234[»]
6OLGelectron microscopy3.40BB22-233[»]
6OLIelectron microscopy3.50SB21-234[»]
6OLZelectron microscopy3.90BB22-233[»]
6OM0electron microscopy3.10SB21-234[»]
6OM7electron microscopy3.70SB21-234[»]
6QZPelectron microscopy2.90SB21-234[»]
SMRiP61247
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112103, 296 interactors
CORUMiP61247
DIPiDIP-29408N
IntActiP61247, 102 interactors
MINTiP61247
STRINGi9606.ENSP00000346050

PTM databases

CarbonylDBiP61247
iPTMnetiP61247
PhosphoSitePlusiP61247
SwissPalmiP61247

Polymorphism and mutation databases

BioMutaiRPS3A
DMDMi47117764

2D gel databases

SWISS-2DPAGEiP61247

Proteomic databases

EPDiP61247
jPOSTiP61247
MassIVEiP61247
MaxQBiP61247
PaxDbiP61247
PeptideAtlasiP61247
PRIDEiP61247
ProteomicsDBi57286
TopDownProteomicsiP61247

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6189

Genome annotation databases

EnsembliENST00000274065; ENSP00000346050; ENSG00000145425
GeneIDi6189
KEGGihsa:6189
UCSCiuc003ilz.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6189
DisGeNETi6189

GeneCards: human genes, protein and diseases

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GeneCardsi
RPS3A
HGNCiHGNC:10421 RPS3A
HPAiHPA047100
HPA053454
MIMi180478 gene
neXtProtiNX_P61247
OpenTargetsiENSG00000145425
PharmGKBiPA34830

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1628 Eukaryota
COG1890 LUCA
GeneTreeiENSGT00390000018433
HOGENOMiHOG000105220
InParanoidiP61247
KOiK02984
OMAiFTRKEWY
OrthoDBi1207239at2759
PhylomeDBiP61247
TreeFamiTF300037

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPS3A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RPS3A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6189
PharosiP61247
PMAP-CutDBiP61247

Protein Ontology

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PROi
PR:P61247

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145425 Expressed in 92 organ(s), highest expression level in ectocervix
ExpressionAtlasiP61247 baseline and differential
GenevisibleiP61247 HS

Family and domain databases

HAMAPiMF_03122 Ribosomal_S3Ae_euk, 1 hit
InterProiView protein in InterPro
IPR027500 Ribosomal_S1/3_euk
IPR001593 Ribosomal_S3Ae
IPR018281 Ribosomal_S3Ae_CS
PfamiView protein in Pfam
PF01015 Ribosomal_S3Ae, 1 hit
SMARTiView protein in SMART
SM01397 Ribosomal_S3Ae, 1 hit
PROSITEiView protein in PROSITE
PS01191 RIBOSOMAL_S3AE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRS3A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61247
Secondary accession number(s): B2R4D4
, D3DP05, P33443, P49241
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: November 13, 2019
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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