UniProtKB - P61244 (MAX_HUMAN)
Protein max
MAX
Functioni
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.
1 PublicationGO - Molecular functioni
- DNA binding Source: CAFA
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor binding Source: UniProtKB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: UniProtKB
- E-box binding Source: CAFA
- identical protein binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
- protein heterodimerization activity Source: InterPro
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- cellular response to peptide hormone stimulus Source: Ensembl
- cellular response to starvation Source: Ensembl
- negative regulation of gene expression Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- neuron apoptotic process Source: Ensembl
- positive regulation of transcription, DNA-templated Source: ComplexPortal
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- protein-containing complex assembly Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to axon injury Source: Ensembl
- response to insulin Source: Ensembl
- retina development in camera-type eye Source: Ensembl
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P61244 |
Reactomei | R-HSA-1362277, Transcription of E2F targets under negative control by DREAM complex R-HSA-69202, Cyclin E associated events during G1/S transition R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry R-HSA-8953750, Transcriptional Regulation by E2F6 |
SignaLinki | P61244 |
SIGNORi | P61244 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein maxCuratedAlternative name(s): Class D basic helix-loop-helix protein 4 Short name: bHLHd4 Myc-associated factor XImported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6913, MAX |
MIMi | 154950, gene |
neXtProti | NX_P61244 |
VEuPathDBi | HostDB:ENSG00000125952 |
Subcellular locationi
Nucleus
- Mad-Max complex Source: ComplexPortal
- MLL1 complex Source: UniProtKB
- Myc-Max complex Source: ComplexPortal
- nucleoplasm Source: Reactome
- nucleus Source: BHF-UCL
- PML body Source: Ensembl
- RNA polymerase II transcription regulator complex Source: NTNU_SB
Other locations
- chromatin Source: BHF-UCL
- cytoplasm Source: Ensembl
- dendrite Source: UniProtKB-SubCell
- protein-DNA complex Source: CAFA
Keywords - Cellular componenti
Cell projection, NucleusPathology & Biotechi
Involvement in diseasei
Pheochromocytoma (PCC)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079347 | 9 | V → L in PCC; does not repress MYC transcriptional activity. 2 PublicationsCorresponds to variant dbSNP:rs201743423EnsemblClinVar. | 1 | |
Natural variantiVAR_079348 | 23 | D → N in PCC; unknown pathological significance; does not affect MYC transcriptional activity. 2 Publications | 1 | |
Natural variantiVAR_079349 | 25 | R → W in PCC; does not repress MYC transcriptional activity. 2 Publications | 1 | |
Natural variantiVAR_079350 | 33 – 160 | Missing in PCC; does not repress MYC transcriptional activity. 3 PublicationsAdd BLAST | 128 | |
Natural variantiVAR_079351 | 35 | R → C in PCC; does not repress MYC transcriptional activity. 2 Publications | 1 | |
Natural variantiVAR_079352 | 47 – 52 | Missing in PCC; unknown pathological significance; somatic mutation. 1 Publication | 6 | |
Natural variantiVAR_079353 | 60 | R → W in PCC; does not repress MYC transcriptional activity. 2 Publications | 1 | |
Natural variantiVAR_079354 | 71 | I → S in PCC; does not repress MYC transcriptional activity. 2 Publications | 1 | |
Natural variantiVAR_079355 | 74 | M → V in PCC; does not repress MYC transcriptional activity. 2 Publications | 1 | |
Natural variantiVAR_079356 | 75 – 160 | Missing in PCC; unknown pathological significance. 2 PublicationsAdd BLAST | 86 | |
Natural variantiVAR_079357 | 82 – 160 | Missing in PCC; unknown pathological significance. 1 PublicationAdd BLAST | 79 | |
Natural variantiVAR_079358 | 90 | R → P in PCC; does not repress MYC transcriptional activity. 2 Publications | 1 | |
Natural variantiVAR_079359 | 94 | L → P in PCC; does not repress MYC transcriptional activity. 2 Publications | 1 | |
Natural variantiVAR_079360 | 102 | L → P in PCC; does not repress MYC transcriptional activity. 2 Publications | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 66 | K → Q: Kept nuclear localization. Loss of nuclear localization; when associated with Q-153 and Q-154. 1 Publication | 1 | |
Mutagenesisi | 66 | K → R: Loss of acetylation, kept nuclear localization; when associated with R-153 and R-154. 1 Publication | 1 | |
Mutagenesisi | 153 | K → Q: Loss of nuclear localization; when associated with Q-66 and Q-154. Kept nuclear localization; when associated with Q-154. 1 Publication | 1 | |
Mutagenesisi | 153 | K → R: Loss of acetylation, kept nuclear localization; when associated with R-66 and R-154. 1 Publication | 1 | |
Mutagenesisi | 154 | K → Q: Loss of nuclear localization; when associated with Q-66 and Q-153. Kept nuclear localization; when associated with Q-153. 1 Publication | 1 | |
Mutagenesisi | 154 | K → R: Loss of acetylation, kept nuclear localization; when associated with R-66 and R-153. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 4149 |
GeneReviewsi | MAX |
MalaCardsi | MAX |
MIMi | 171300, phenotype |
OpenTargetsi | ENSG00000125952 |
Orphaneti | 29072, Hereditary pheochromocytoma-paraganglioma |
PharmGKBi | PA30656 |
Miscellaneous databases
Pharosi | P61244, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1250363 |
Genetic variation databases
BioMutai | MAX |
DMDMi | 47117704 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | ||||
ChainiPRO_0000127269 | 2 – 160 | Protein maxAdd BLAST | 159 | ||
Isoform 2 (identifier: P61244-2) | |||||
Initiator methioninei | RemovedCombined sources |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | ||
Modified residuei | 2 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 11 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 66 | N6-acetyllysine1 Publication | 1 | ||
Modified residuei | 107 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 153 | N6-acetyllysine1 Publication | 1 | ||
Modified residuei | 154 | N6-acetyllysine1 Publication | 1 | ||
Isoform 2 (identifier: P61244-2) | |||||
Modified residuei | 2 | N-acetylserineCombined sources | 1 | ||
Modified residuei | 2 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 11 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P61244 |
jPOSTi | P61244 |
MassIVEi | P61244 |
MaxQBi | P61244 |
PaxDbi | P61244 |
PeptideAtlasi | P61244 |
PRIDEi | P61244 |
ProteomicsDBi | 1183 57281 57282 [P61244-2] 57283 [P61244-3] 57284 [P61244-4] 57285 [P61244-5] |
PTM databases
iPTMneti | P61244 |
PhosphoSitePlusi | P61244 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000125952, Expressed in monocyte and 253 other tissues |
ExpressionAtlasi | P61244, baseline and differential |
Genevisiblei | P61244, HS |
Organism-specific databases
HPAi | ENSG00000125952, Low tissue specificity |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2.
Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.
Interacts with SPAG9. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity.
2 PublicationsBinary interactionsi
P61244
Isoform 2 [P61244-2]
With | #Exp. | IntAct |
---|---|---|
MXI1 [P50539] | 3 | EBI-10218525,EBI-752241 |
UNC45A [Q9H3U1] | 3 | EBI-10218525,EBI-1048763 |
Isoform 4 [P61244-4]
GO - Molecular functioni
- DNA-binding transcription factor binding Source: UniProtKB
- identical protein binding Source: Ensembl
- protein heterodimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 110319, 204 interactors |
ComplexPortali | CPX-104, Transcriptional repressor Mad-Max complex CPX-91, Transcriptional activator Myc-Max complex |
CORUMi | P61244 |
DIPi | DIP-28145N |
IntActi | P61244, 116 interactors |
MINTi | P61244 |
STRINGi | 9606.ENSP00000351490 |
Chemistry databases
BindingDBi | P61244 |
Miscellaneous databases
RNActi | P61244, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P61244 |
SASBDBi | P61244 |
SMRi | P61244 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P61244 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 74 | bHLHPROSITE-ProRule annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 40 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 81 – 102 | Leucine-zipperAdd BLAST | 22 | |
Regioni | 103 – 160 | DisorderedSequence analysisAdd BLAST | 58 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 152 – 156 | Nuclear localization signal | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 13 – 40 | Basic and acidic residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 103 – 144 | Polar residuesSequence analysisAdd BLAST | 42 | |
Compositional biasi | 145 – 160 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2483, Eukaryota |
GeneTreei | ENSGT00530000064011 |
HOGENOMi | CLU_2541927_0_0_1 |
InParanoidi | P61244 |
OMAi | QIQTNYS |
OrthoDBi | 1545748at2759 |
PhylomeDBi | P61244 |
TreeFami | TF318841 |
Family and domain databases
DisProti | DP00084 DP01097 [P61244-2] |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR037933, MAX |
PANTHERi | PTHR10328, PTHR10328, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDNDDIEVE SDEEQPRFQS AADKRAHHNA LERKRRDHIK DSFHSLRDSV
60 70 80 90 100
PSLQGEKASR AQILDKATEY IQYMRRKNHT HQQDIDDLKR QNALLEQQVR
110 120 130 140 150
ALEKARSSAQ LQTNYPSSDN SLYTNAKGST ISAFDGGSDS SSESEPEEPQ
160
SRKKLRMEAS
The sequence of this isoform differs from the canonical sequence as follows:
99-160: VRALEKARSSAQLQTNYPSSDNSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS → GESES
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V2R5 | G3V2R5_HUMAN | Myc-associated factor X | MAX | 125 | Annotation score: | ||
G3V563 | G3V563_HUMAN | Myc-associated factor X | MAX | 121 | Annotation score: | ||
Q6V3B1 | Q6V3B1_HUMAN | Myc-associated factor X | MAX | 94 | Annotation score: | ||
A0A494C130 | A0A494C130_HUMAN | Myc-associated factor X | MAX | 48 | Annotation score: | ||
G3V5L1 | G3V5L1_HUMAN | Protein max | MAX | 124 | Annotation score: | ||
G3V302 | G3V302_HUMAN | Protein max | MAX | 97 | Annotation score: | ||
G3V2N4 | G3V2N4_HUMAN | Protein max | MAX | 82 | Annotation score: | ||
G3V570 | G3V570_HUMAN | Protein max | MAX | 43 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079347 | 9 | V → L in PCC; does not repress MYC transcriptional activity. 2 PublicationsCorresponds to variant dbSNP:rs201743423EnsemblClinVar. | 1 | |
Natural variantiVAR_079348 | 23 | D → N in PCC; unknown pathological significance; does not affect MYC transcriptional activity. 2 Publications | 1 | |
Natural variantiVAR_079349 | 25 | R → W in PCC; does not repress MYC transcriptional activity. 2 Publications | 1 | |
Natural variantiVAR_079350 | 33 – 160 | Missing in PCC; does not repress MYC transcriptional activity. 3 PublicationsAdd BLAST | 128 | |
Natural variantiVAR_079351 | 35 | R → C in PCC; does not repress MYC transcriptional activity. 2 Publications | 1 | |
Natural variantiVAR_079352 | 47 – 52 | Missing in PCC; unknown pathological significance; somatic mutation. 1 Publication | 6 | |
Natural variantiVAR_079353 | 60 | R → W in PCC; does not repress MYC transcriptional activity. 2 Publications | 1 | |
Natural variantiVAR_079354 | 71 | I → S in PCC; does not repress MYC transcriptional activity. 2 Publications | 1 | |
Natural variantiVAR_079355 | 74 | M → V in PCC; does not repress MYC transcriptional activity. 2 Publications | 1 | |
Natural variantiVAR_079356 | 75 – 160 | Missing in PCC; unknown pathological significance. 2 PublicationsAdd BLAST | 86 | |
Natural variantiVAR_079357 | 82 – 160 | Missing in PCC; unknown pathological significance. 1 PublicationAdd BLAST | 79 | |
Natural variantiVAR_079358 | 90 | R → P in PCC; does not repress MYC transcriptional activity. 2 Publications | 1 | |
Natural variantiVAR_079359 | 94 | L → P in PCC; does not repress MYC transcriptional activity. 2 Publications | 1 | |
Natural variantiVAR_079360 | 102 | L → P in PCC; does not repress MYC transcriptional activity. 2 Publications | 1 | |
Natural variantiVAR_079361 | 114 | N → T Does not affect MYC transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs772912674EnsemblClinVar. | 1 | |
Natural variantiVAR_079362 | 142 | S → L Does not affect MYC transcriptional activity. 2 PublicationsCorresponds to variant dbSNP:rs760147253EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002117 | 13 – 21 | Missing in isoform 2. 3 Publications | 9 | |
Alternative sequenceiVSP_043430 | 58 – 160 | ASRAQ…RMEAS → LYFLFWKLCTPVLHRQSLMQ KCHTFISSYQVHKKKECKI in isoform 5. 1 PublicationAdd BLAST | 103 | |
Alternative sequenceiVSP_047661 | 58 – 160 | ASRAQ…RMEAS → GTKMKLTLPPVFPYEHLPFP TVFCHG in isoform 6. CuratedAdd BLAST | 103 | |
Alternative sequenceiVSP_002118 | 99 – 160 | VRALE…RMEAS → GESES in isoform 3. 2 PublicationsAdd BLAST | 62 | |
Alternative sequenceiVSP_043183 | 99 – 160 | VRALE…RMEAS → GEHPSSWGSWPCCAPARSGF GTWACRVRASHGVCAQ in isoform 4. 1 PublicationAdd BLAST | 62 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AN2 | X-ray | 2.90 | A | 22-107 | [»] | |
1HLO | X-ray | 2.80 | A/B | 4-92 | [»] | |
1NKP | X-ray | 1.80 | B/E | 23-102 | [»] | |
1NLW | X-ray | 2.00 | B/E | 24-99 | [»] | |
1R05 | NMR | - | A/B | 22-103 | [»] | |
5EYO | X-ray | 2.39 | A/C | 22-107 | [»] | |
6G6J | X-ray | 2.25 | B/D | 22-103 | [»] | |
6G6K | X-ray | 1.35 | B/D | 22-103 | [»] | |
6G6L | X-ray | 2.20 | B/D/F/H | 22-103 | [»] | |
BMRBi | P61244 | |||||
SASBDBi | P61244 | |||||
SMRi | P61244 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110319, 204 interactors |
ComplexPortali | CPX-104, Transcriptional repressor Mad-Max complex CPX-91, Transcriptional activator Myc-Max complex |
CORUMi | P61244 |
DIPi | DIP-28145N |
IntActi | P61244, 116 interactors |
MINTi | P61244 |
STRINGi | 9606.ENSP00000351490 |
Chemistry databases
BindingDBi | P61244 |
ChEMBLi | CHEMBL1250363 |
PTM databases
iPTMneti | P61244 |
PhosphoSitePlusi | P61244 |
Genetic variation databases
BioMutai | MAX |
DMDMi | 47117704 |
Proteomic databases
EPDi | P61244 |
jPOSTi | P61244 |
MassIVEi | P61244 |
MaxQBi | P61244 |
PaxDbi | P61244 |
PeptideAtlasi | P61244 |
PRIDEi | P61244 |
ProteomicsDBi | 1183 57281 57282 [P61244-2] 57283 [P61244-3] 57284 [P61244-4] 57285 [P61244-5] |
Protocols and materials databases
Antibodypediai | 159, 565 antibodies from 39 providers |
DNASUi | 4149 |
Genome annotation databases
Organism-specific databases
CTDi | 4149 |
DisGeNETi | 4149 |
GeneCardsi | MAX |
GeneReviewsi | MAX |
HGNCi | HGNC:6913, MAX |
HPAi | ENSG00000125952, Low tissue specificity |
MalaCardsi | MAX |
MIMi | 154950, gene 171300, phenotype |
neXtProti | NX_P61244 |
OpenTargetsi | ENSG00000125952 |
Orphaneti | 29072, Hereditary pheochromocytoma-paraganglioma |
PharmGKBi | PA30656 |
VEuPathDBi | HostDB:ENSG00000125952 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2483, Eukaryota |
GeneTreei | ENSGT00530000064011 |
HOGENOMi | CLU_2541927_0_0_1 |
InParanoidi | P61244 |
OMAi | QIQTNYS |
OrthoDBi | 1545748at2759 |
PhylomeDBi | P61244 |
TreeFami | TF318841 |
Enzyme and pathway databases
PathwayCommonsi | P61244 |
Reactomei | R-HSA-1362277, Transcription of E2F targets under negative control by DREAM complex R-HSA-69202, Cyclin E associated events during G1/S transition R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry R-HSA-8953750, Transcriptional Regulation by E2F6 |
SignaLinki | P61244 |
SIGNORi | P61244 |
Miscellaneous databases
BioGRID-ORCSi | 4149, 550 hits in 1081 CRISPR screens |
ChiTaRSi | MAX, human |
EvolutionaryTracei | P61244 |
GeneWikii | MAX_(gene) |
GenomeRNAii | 4149 |
Pharosi | P61244, Tbio |
PROi | PR:P61244 |
RNActi | P61244, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125952, Expressed in monocyte and 253 other tissues |
ExpressionAtlasi | P61244, baseline and differential |
Genevisiblei | P61244, HS |
Family and domain databases
DisProti | DP00084 DP01097 [P61244-2] |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR037933, MAX |
PANTHERi | PTHR10328, PTHR10328, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MAX_HUMAN | |
Accessioni | P61244Primary (citable) accession number: P61244 Secondary accession number(s): A6NH73 Q96CY8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | May 10, 2004 | |
Last modified: | February 23, 2022 | |
This is version 195 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families