UniProtKB - P61236 (YPEL3_HUMAN)
Protein
Protein yippee-like 3
Gene
YPEL3
Organism
Homo sapiens (Human)
Status
Functioni
Involved in proliferation and apoptosis in myeloid precursor cells.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 23 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 26 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 79 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 82 | ZincPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- positive regulation of cellular senescence Source: HGNC
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P61236 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein yippee-like 3 |
Gene namesi | Name:YPEL3 ORF Names:FKSG5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000090238.11 |
HGNCi | HGNC:18327, YPEL3 |
MIMi | 609724, gene |
neXtProti | NX_P61236 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 83719 |
OpenTargetsi | ENSG00000090238 |
PharmGKBi | PA134985092 |
Miscellaneous databases
Pharosi | P61236, Tbio |
Polymorphism and mutation databases
BioMutai | YPEL3 |
DMDMi | 47117782 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212389 | 1 – 119 | Protein yippee-like 3Add BLAST | 119 |
Post-translational modificationi
Probably ubiquitinated leading to its degradation by the proteasome.By similarity
Keywords - PTMi
Ubl conjugationProteomic databases
MassIVEi | P61236 |
PaxDbi | P61236 |
PeptideAtlasi | P61236 |
PRIDEi | P61236 |
ProteomicsDBi | 57279 [P61236-1] 57280 [P61236-2] |
Expressioni
Tissue specificityi
Widely expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000090238, Expressed in blood and 210 other tissues |
ExpressionAtlasi | P61236, baseline and differential |
Genevisiblei | P61236, HS |
Organism-specific databases
HPAi | ENSG00000090238, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123740, 122 interactors |
IntActi | P61236, 4 interactors |
STRINGi | 9606.ENSP00000381821 |
Miscellaneous databases
RNActi | P61236, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 116 | YippeePROSITE-ProRule annotationAdd BLAST | 98 |
Sequence similaritiesi
Belongs to the yippee family.Curated
Phylogenomic databases
eggNOGi | KOG3399, Eukaryota |
GeneTreei | ENSGT00940000161514 |
HOGENOMi | CLU_043857_5_2_1 |
InParanoidi | P61236 |
OMAi | MHAVSDI |
OrthoDBi | 1431042at2759 |
PhylomeDBi | P61236 |
TreeFami | TF313936 |
Family and domain databases
InterProi | View protein in InterPro IPR034751, Yippee IPR004910, Yippee/Mis18/Cereblon IPR039058, Yippee_fam |
PANTHERi | PTHR13848, PTHR13848, 1 hit |
Pfami | View protein in Pfam PF03226, Yippee-Mis18, 1 hit |
PROSITEi | View protein in PROSITE PS51792, YIPPEE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P61236-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVRISKPKTF QAYLDDCHRR YSCAHCRAHL ANHDDLISKS FQGSQGRAYL
60 70 80 90 100
FNSVVNVGCG PAEERVLLTG LHAVADIHCE NCKTTLGWKY EQAFESSQKY
110
KEGKYIIELN HMIKDNGWD
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BME7 | H3BME7_HUMAN | Protein yippee-like | YPEL3 YPEL | 103 | Annotation score: | ||
A0A0B4J290 | A0A0B4J290_HUMAN | Protein yippee-like | YPEL3 YPEL | 137 | Annotation score: | ||
H3BUE2 | H3BUE2_HUMAN | Protein yippee-like 3 | YPEL3 | 75 | Annotation score: | ||
H3BNP5 | H3BNP5_HUMAN | Protein yippee-like 3 | YPEL3 | 31 | Annotation score: | ||
H3BRF0 | H3BRF0_HUMAN | Protein yippee-like 3 | YPEL3 | 54 | Annotation score: |
Sequence cautioni
The sequence EAW79925 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037276 | 1 | M → MCVAQVLTAHLLPPRQALGS LCSPWAAPRVGPLPPAPAM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB098737 Genomic DNA Translation: BAD51378.1 AF305622 mRNA Translation: AAL09365.1 AC012645 Genomic DNA No translation available. CH471238 Genomic DNA Translation: EAW79925.1 Different initiation. BC005009 mRNA Translation: AAH05009.3 BC050664 mRNA Translation: AAH50664.2 |
CCDSi | CCDS42147.1 [P61236-2] CCDS45459.1 [P61236-1] |
RefSeqi | NP_001138996.1, NM_001145524.1 [P61236-1] NP_113665.3, NM_031477.4 [P61236-2] |
Genome annotation databases
Ensembli | ENST00000398838; ENSP00000381818; ENSG00000090238 [P61236-1] ENST00000398841; ENSP00000381821; ENSG00000090238 [P61236-2] ENST00000563788; ENSP00000457976; ENSG00000090238 [P61236-1] ENST00000566595; ENSP00000456427; ENSG00000090238 [P61236-1] |
GeneIDi | 83719 |
KEGGi | hsa:83719 |
UCSCi | uc002dwl.3, human [P61236-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB098737 Genomic DNA Translation: BAD51378.1 AF305622 mRNA Translation: AAL09365.1 AC012645 Genomic DNA No translation available. CH471238 Genomic DNA Translation: EAW79925.1 Different initiation. BC005009 mRNA Translation: AAH05009.3 BC050664 mRNA Translation: AAH50664.2 |
CCDSi | CCDS42147.1 [P61236-2] CCDS45459.1 [P61236-1] |
RefSeqi | NP_001138996.1, NM_001145524.1 [P61236-1] NP_113665.3, NM_031477.4 [P61236-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123740, 122 interactors |
IntActi | P61236, 4 interactors |
STRINGi | 9606.ENSP00000381821 |
Polymorphism and mutation databases
BioMutai | YPEL3 |
DMDMi | 47117782 |
Proteomic databases
MassIVEi | P61236 |
PaxDbi | P61236 |
PeptideAtlasi | P61236 |
PRIDEi | P61236 |
ProteomicsDBi | 57279 [P61236-1] 57280 [P61236-2] |
Protocols and materials databases
Antibodypediai | 27015, 71 antibodies |
Genome annotation databases
Ensembli | ENST00000398838; ENSP00000381818; ENSG00000090238 [P61236-1] ENST00000398841; ENSP00000381821; ENSG00000090238 [P61236-2] ENST00000563788; ENSP00000457976; ENSG00000090238 [P61236-1] ENST00000566595; ENSP00000456427; ENSG00000090238 [P61236-1] |
GeneIDi | 83719 |
KEGGi | hsa:83719 |
UCSCi | uc002dwl.3, human [P61236-1] |
Organism-specific databases
CTDi | 83719 |
DisGeNETi | 83719 |
EuPathDBi | HostDB:ENSG00000090238.11 |
GeneCardsi | YPEL3 |
HGNCi | HGNC:18327, YPEL3 |
HPAi | ENSG00000090238, Low tissue specificity |
MIMi | 609724, gene |
neXtProti | NX_P61236 |
OpenTargetsi | ENSG00000090238 |
PharmGKBi | PA134985092 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3399, Eukaryota |
GeneTreei | ENSGT00940000161514 |
HOGENOMi | CLU_043857_5_2_1 |
InParanoidi | P61236 |
OMAi | MHAVSDI |
OrthoDBi | 1431042at2759 |
PhylomeDBi | P61236 |
TreeFami | TF313936 |
Enzyme and pathway databases
PathwayCommonsi | P61236 |
Miscellaneous databases
BioGRID-ORCSi | 83719, 23 hits in 845 CRISPR screens |
GenomeRNAii | 83719 |
Pharosi | P61236, Tbio |
PROi | PR:P61236 |
RNActi | P61236, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000090238, Expressed in blood and 210 other tissues |
ExpressionAtlasi | P61236, baseline and differential |
Genevisiblei | P61236, HS |
Family and domain databases
InterProi | View protein in InterPro IPR034751, Yippee IPR004910, Yippee/Mis18/Cereblon IPR039058, Yippee_fam |
PANTHERi | PTHR13848, PTHR13848, 1 hit |
Pfami | View protein in Pfam PF03226, Yippee-Mis18, 1 hit |
PROSITEi | View protein in PROSITE PS51792, YIPPEE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YPEL3_HUMAN | |
Accessioni | P61236Primary (citable) accession number: P61236 Secondary accession number(s): Q65Z99 Q9CQB6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | May 10, 2004 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM