Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rap-1b

Gene

RAP1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.3 Publications

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by binding to the GTPase-activating protein RAP1GAP. Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 18GTP2 Publications9
Nucleotide bindingi57 – 61GTP2 Publications5
Nucleotide bindingi116 – 119GTP2 Publications4
Nucleotide bindingi147 – 149GTP2 Publications3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB
  • protein-containing complex binding Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins
R-HSA-392517 Rap1 signalling
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-6798695 Neutrophil degranulation
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-8875555 MET activates RAP1 and RAC1
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P61224

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P61224

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras-related protein Rap-1b
Alternative name(s):
GTP-binding protein smg p21B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAP1B
ORF Names:OK/SW-cl.11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000127314.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9857 RAP1B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
179530 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P61224

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi12G → V: Constitutively activated. 1
Mutagenesisi25Q → A: Impairs interaction with KRIT1. 1
Mutagenesisi32Y → A: 25-fold reduction in RAP1GAP-stimulated GTPase activity. 1 Publication1
Mutagenesisi32Y → F: 2-fold reduction in RAP1GAP-stimulated GTPase activity. 1 Publication1
Mutagenesisi37E → A: Strong reduction in nucleotide exchange with EPAC2. 1 Publication1
Mutagenesisi38D → A: Impairs interaction with KRIT1. 1
Mutagenesisi63Q → E: Abolishes complex formation with RAP1GAP. Loss GTPase activity. 1 Publication1
Mutagenesisi64F → A: Abolishes complex formation with RAP1GAP. Loss GTPase activity. 1 Publication1
Mutagenesisi179S → A: Abolishes phosphorylation by PKA. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5908

MalaCards human disease database

More...
MalaCardsi
RAP1B

Open Targets

More...
OpenTargetsi
ENSG00000127314

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2322 Kabuki syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34219

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RAP1B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47117723

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000302091 – 181Ras-related protein Rap-1bAdd BLAST181
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000030210182 – 184Removed in mature form3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei39ADP-ribosylserine; by botulinum toxin1 Publication1
Modified residuei179Phosphoserine; by PKA1 Publication1
Modified residuei181Cysteine methyl ester1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi181S-geranylgeranyl cysteine1 Publication1

Keywords - PTMi

ADP-ribosylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P61224

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P61224

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P61224

PeptideAtlas

More...
PeptideAtlasi
P61224

PRoteomics IDEntifications database

More...
PRIDEi
P61224

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57277

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P61224-1 [P61224-1]
P61224-2 [P61224-2]

2D gel databases

USC-OGP 2-DE database

More...
OGPi
P09526

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P61224

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P61224

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P61224

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000127314 Expressed in 94 organ(s), highest expression level in leukocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_RAP1B

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P61224 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P61224 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with RAP1GAP. Interacts with EPAC2, SGSM1, SGSM2 and SGSM3. Interacts with KRIT1.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111843, 76 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P61224

Database of interacting proteins

More...
DIPi
DIP-35407N

Protein interaction database and analysis system

More...
IntActi
P61224, 54 interactors

Molecular INTeraction database

More...
MINTi
P61224

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000250559

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P61224

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P61224

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P61224

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 67Interaction with KRIT11 PublicationAdd BLAST43

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi32 – 40Effector regionCurated9

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0395 Eukaryota
COG1100 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154429

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233973

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG009351

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P61224

KEGG Orthology (KO)

More...
KOi
K07836

Identification of Orthologs from Complete Genome Data

More...
OMAi
IDGRACD

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0OOG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P61224

TreeFam database of animal gene trees

More...
TreeFami
TF313014

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04175 Rap1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR038851 Rap1
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type

The PANTHER Classification System

More...
PANTHERi
PTHR24070 PTHR24070, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00071 Ras, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00231 small_GTP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51421 RAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 18 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P61224-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDAQQ
60 70 80 90 100
CMLEILDTAG TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI
110 120 130 140 150
LRVKDTDDVP MILVGNKCDL EDERVVGKEQ GQNLARQWNN CAFLESSAKS
160 170 180
KINVNEIFYD LVRQINRKTP VPGKARKKSS CQLL
Length:184
Mass (Da):20,825
Last modified:May 10, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE976895E5965224
GO
Isoform 2 (identifier: P61224-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-108: Missing.

Show »
Length:137
Mass (Da):15,356
Checksum:iA142020053FE1BC5
GO
Isoform 3 (identifier: P61224-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-61: Missing.

Show »
Length:165
Mass (Da):18,778
Checksum:i5F70CFF192C43A4A
GO
Isoform 4 (identifier: P61224-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-61: Missing.

Show »
Length:142
Mass (Da):16,033
Checksum:iEA48A041F34E0074
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 18 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZB78B7ZB78_HUMAN
cDNA, FLJ79442, highly similar to R...
RAP1B
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ESV4E7ESV4_HUMAN
Ras-related protein Rap-1b
RAP1B
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7Y6F5H7Y6_HUMAN
Ras-related protein Rap-1b
RAP1B
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H004F5H004_HUMAN
Ras-related protein Rap-1b
RAP1B
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H500F5H500_HUMAN
Ras-related protein Rap-1b
RAP1B
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZG1F5GZG1_HUMAN
Ras-related protein Rap-1b
RAP1B
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0B7F5H0B7_HUMAN
Ras-related protein Rap-1b
RAP1B
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H823F5H823_HUMAN
Ras-related protein Rap-1b
RAP1B
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GX62F5GX62_HUMAN
Ras-related protein Rap-1b
RAP1B
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWU8F5GWU8_HUMAN
Ras-related protein Rap-1b
RAP1B
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8V → F in AAH95467 (PubMed:15489334).Curated1
Sequence conflicti16K → N in AAH78173 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04530320 – 61Missing in isoform 4. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_04530443 – 61Missing in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_04530562 – 108Missing in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X08004 mRNA Translation: CAB46488.1
AL080212 mRNA Translation: CAB45777.1
AB062128 mRNA Translation: BAB93460.1
AF493913 mRNA Translation: AAM12627.1
AK298818 mRNA Translation: BAG60950.1
AK301401 mRNA Translation: BAG62936.1
AK301428 mRNA Translation: BAG62956.1
AK312371 mRNA Translation: BAG35289.1
CR407689 mRNA Translation: CAG28617.1
BT020093 mRNA Translation: AAV38896.1
EF581377 Genomic DNA Translation: ABQ52130.1
AC015550 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97189.1
BC000176 mRNA Translation: AAH00176.1
BC078173 mRNA Translation: AAH78173.1
BC095467 mRNA Translation: AAH95467.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58252.1 [P61224-2]
CCDS58253.1 [P61224-3]
CCDS58254.1 [P61224-4]
CCDS8984.1 [P61224-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
S01952 TVHUR1

NCBI Reference Sequences

More...
RefSeqi
NP_001010942.1, NM_001010942.2 [P61224-1]
NP_001238846.1, NM_001251917.1 [P61224-4]
NP_001238847.1, NM_001251918.1 [P61224-4]
NP_001238850.1, NM_001251921.1 [P61224-3]
NP_001238851.1, NM_001251922.1 [P61224-2]
NP_056461.1, NM_015646.5 [P61224-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.369920

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000250559; ENSP00000250559; ENSG00000127314 [P61224-1]
ENST00000341355; ENSP00000441275; ENSG00000127314 [P61224-1]
ENST00000393436; ENSP00000377085; ENSG00000127314 [P61224-1]
ENST00000450214; ENSP00000399986; ENSG00000127314 [P61224-4]
ENST00000537460; ENSP00000439966; ENSG00000127314 [P61224-1]
ENST00000539091; ENSP00000444830; ENSG00000127314 [P61224-4]
ENST00000540209; ENSP00000446318; ENSG00000127314 [P61224-3]
ENST00000542145; ENSP00000440014; ENSG00000127314 [P61224-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5908

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5908

UCSC genome browser

More...
UCSCi
uc001sub.5 human [P61224-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X08004 mRNA Translation: CAB46488.1
AL080212 mRNA Translation: CAB45777.1
AB062128 mRNA Translation: BAB93460.1
AF493913 mRNA Translation: AAM12627.1
AK298818 mRNA Translation: BAG60950.1
AK301401 mRNA Translation: BAG62936.1
AK301428 mRNA Translation: BAG62956.1
AK312371 mRNA Translation: BAG35289.1
CR407689 mRNA Translation: CAG28617.1
BT020093 mRNA Translation: AAV38896.1
EF581377 Genomic DNA Translation: ABQ52130.1
AC015550 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97189.1
BC000176 mRNA Translation: AAH00176.1
BC078173 mRNA Translation: AAH78173.1
BC095467 mRNA Translation: AAH95467.1
CCDSiCCDS58252.1 [P61224-2]
CCDS58253.1 [P61224-3]
CCDS58254.1 [P61224-4]
CCDS8984.1 [P61224-1]
PIRiS01952 TVHUR1
RefSeqiNP_001010942.1, NM_001010942.2 [P61224-1]
NP_001238846.1, NM_001251917.1 [P61224-4]
NP_001238847.1, NM_001251918.1 [P61224-4]
NP_001238850.1, NM_001251921.1 [P61224-3]
NP_001238851.1, NM_001251922.1 [P61224-2]
NP_056461.1, NM_015646.5 [P61224-1]
UniGeneiHs.369920

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BRWX-ray3.40D1-167[»]
3CF6X-ray2.20R1-167[»]
4DXAX-ray1.95A1-167[»]
4HDOX-ray1.67B1-167[»]
4HDQX-ray1.95B1-167[»]
4M8NX-ray3.29E/F/G/H1-166[»]
4MGIX-ray2.80R1-167[»]
4MGKX-ray2.70R1-167[»]
4MGYX-ray2.60R1-167[»]
4MGZX-ray3.00R1-167[»]
4MH0X-ray2.40R1-167[»]
5KHOX-ray2.78C/D1-167[»]
6AXFX-ray3.10B/D/F/H/J/L/N/P1-167[»]
6BA6NMR-B1-167[»]
ProteinModelPortaliP61224
SMRiP61224
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111843, 76 interactors
CORUMiP61224
DIPiDIP-35407N
IntActiP61224, 54 interactors
MINTiP61224
STRINGi9606.ENSP00000250559

PTM databases

iPTMnetiP61224
PhosphoSitePlusiP61224
SwissPalmiP61224

Polymorphism and mutation databases

BioMutaiRAP1B
DMDMi47117723

2D gel databases

OGPiP09526

Proteomic databases

EPDiP61224
MaxQBiP61224
PaxDbiP61224
PeptideAtlasiP61224
PRIDEiP61224
ProteomicsDBi57277
TopDownProteomicsiP61224-1 [P61224-1]
P61224-2 [P61224-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5908
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250559; ENSP00000250559; ENSG00000127314 [P61224-1]
ENST00000341355; ENSP00000441275; ENSG00000127314 [P61224-1]
ENST00000393436; ENSP00000377085; ENSG00000127314 [P61224-1]
ENST00000450214; ENSP00000399986; ENSG00000127314 [P61224-4]
ENST00000537460; ENSP00000439966; ENSG00000127314 [P61224-1]
ENST00000539091; ENSP00000444830; ENSG00000127314 [P61224-4]
ENST00000540209; ENSP00000446318; ENSG00000127314 [P61224-3]
ENST00000542145; ENSP00000440014; ENSG00000127314 [P61224-2]
GeneIDi5908
KEGGihsa:5908
UCSCiuc001sub.5 human [P61224-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5908
DisGeNETi5908
EuPathDBiHostDB:ENSG00000127314.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RAP1B

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0032084
HGNCiHGNC:9857 RAP1B
MalaCardsiRAP1B
MIMi179530 gene
neXtProtiNX_P61224
OpenTargetsiENSG00000127314
Orphaneti2322 Kabuki syndrome
PharmGKBiPA34219

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00940000154429
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiP61224
KOiK07836
OMAiIDGRACD
OrthoDBiEOG091G0OOG
PhylomeDBiP61224
TreeFamiTF313014

Enzyme and pathway databases

ReactomeiR-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins
R-HSA-392517 Rap1 signalling
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-6798695 Neutrophil degranulation
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-8875555 MET activates RAP1 and RAC1
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SignaLinkiP61224
SIGNORiP61224

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RAP1B human
EvolutionaryTraceiP61224

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RAP1B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5908

Protein Ontology

More...
PROi
PR:P61224

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000127314 Expressed in 94 organ(s), highest expression level in leukocyte
CleanExiHS_RAP1B
ExpressionAtlasiP61224 baseline and differential
GenevisibleiP61224 HS

Family and domain databases

CDDicd04175 Rap1, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR038851 Rap1
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAP1B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61224
Secondary accession number(s): B2R5Z2
, B4DQI8, B4DW74, B4DW94, P09526, Q502X3, Q5TZR4, Q6DCA1, Q6LES0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: December 5, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again