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Protein

ATP-binding cassette sub-family E member 1

Gene

ABCE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.3 Publications

Miscellaneous

The ABC transporter domains seem not to be functional.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi110 – 117ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi379 – 386ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processHost-virus interaction
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family E member 1
Alternative name(s):
2'-5'-oligoadenylate-binding protein
HuHP68
RNase L inhibitor
Ribonuclease 4 inhibitor
Short name:
RNS4I
Gene namesi
Name:ABCE1
Synonyms:RLI, RNASEL1, RNASELI, RNS4I
ORF Names:OK/SW-cl.40
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000164163.10
HGNCiHGNC:69 ABCE1
MIMi601213 gene
neXtProtiNX_P61221

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi6059
OpenTargetsiENSG00000164163
PharmGKBiPA24404

Polymorphism and mutation databases

BioMutaiABCE1
DMDMi47117664

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933161 – 599ATP-binding cassette sub-family E member 1Add BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei417PhosphoserineCombined sources1
Modified residuei550PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP61221
MaxQBiP61221
PaxDbiP61221
PeptideAtlasiP61221
PRIDEiP61221
ProteomicsDBi57276

PTM databases

CarbonylDBiP61221
iPTMnetiP61221
PhosphoSitePlusiP61221
SwissPalmiP61221

Expressioni

Inductioni

Activated by encephalomyocarditis virus (EMCV) and HIV-1.2 Publications

Gene expression databases

BgeeiENSG00000164163
CleanExiHS_ABCE1
ExpressionAtlasiP61221 baseline and differential
GenevisibleiP61221 HS

Organism-specific databases

HPAiCAB012476
HPA036846

Interactioni

Subunit structurei

Probably heterodimerizes with RNASEL; this interaction inhibits the RNASEL.
(Microbial infection) Interacts with HIV-1 proteins Vif and Gag.1 Publication
(Microbial infection) Interacts with HIV-2 protein Gag.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111986, 242 interactors
IntActiP61221, 24 interactors
MINTiP61221
STRINGi9606.ENSP00000296577

Structurei

3D structure databases

ProteinModelPortaliP61221
SMRiP61221
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 374Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST31
Domaini46 – 754Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30
Domaini79 – 315ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini342 – 562ABC transporter 2PROSITE-ProRule annotationAdd BLAST221

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0063 Eukaryota
COG1245 LUCA
GeneTreeiENSGT00390000015089
HOVERGENiHBG050439
InParanoidiP61221
KOiK06174
OMAiTGCNTFL
OrthoDBiEOG091G038V
PhylomeDBiP61221
TreeFamiTF105206

Family and domain databases

CDDicd03236 ABC_RNaseL_inhibitor_domain1, 1 hit
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR013283 RLI1
IPR034348 RLI_dom_1
IPR007209 RNaseL-inhib_metal-bd_dom
PANTHERiPTHR19248 PTHR19248, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
PF00037 Fer4, 1 hit
PF04068 RLI, 1 hit
PRINTSiPR01868 ABCEFAMILY
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

P61221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKLTRIAI VNHDKCKPKK CRQECKKSCP VVRMGKLCIE VTPQSKIAWI
60 70 80 90 100
SETLCIGCGI CIKKCPFGAL SIVNLPSNLE KETTHRYCAN AFKLHRLPIP
110 120 130 140 150
RPGEVLGLVG TNGIGKSTAL KILAGKQKPN LGKYDDPPDW QEILTYFRGS
160 170 180 190 200
ELQNYFTKIL EDDLKAIIKP QYVDQIPKAA KGTVGSILDR KDETKTQAIV
210 220 230 240 250
CQQLDLTHLK ERNVEDLSGG ELQRFACAVV CIQKADIFMF DEPSSYLDVK
260 270 280 290 300
QRLKAAITIR SLINPDRYII VVEHDLSVLD YLSDFICCLY GVPSAYGVVT
310 320 330 340 350
MPFSVREGIN IFLDGYVPTE NLRFRDASLV FKVAETANEE EVKKMCMYKY
360 370 380 390 400
PGMKKKMGEF ELAIVAGEFT DSEIMVMLGE NGTGKTTFIR MLAGRLKPDE
410 420 430 440 450
GGEVPVLNVS YKPQKISPKS TGSVRQLLHE KIRDAYTHPQ FVTDVMKPLQ
460 470 480 490 500
IENIIDQEVQ TLSGGELQRV ALALCLGKPA DVYLIDEPSA YLDSEQRLMA
510 520 530 540 550
ARVVKRFILH AKKTAFVVEH DFIMATYLAD RVIVFDGVPS KNTVANSPQT
560 570 580 590
LLAGMNKFLS QLEITFRRDP NNYRPRINKL NSIKDVEQKK SGNYFFLDD
Length:599
Mass (Da):67,314
Last modified:May 10, 2004 - v1
Checksum:i5D582B62E95BC7A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118T → A in CAA53972 (PubMed:7539425).Curated1
Sequence conflicti174 – 179DQIPKA → ARFLRL in CAA53972 (PubMed:7539425).Curated6
Sequence conflicti471 – 473ALA → RLR in CAA53972 (PubMed:7539425).Curated3
Sequence conflicti471 – 473ALA → RLR in CAA52920 (PubMed:7539425).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068914489S → C Polymorphism; confirmed at protein level. 1 PublicationCorresponds to variant dbSNP:rs3816497Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76388 mRNA Translation: CAA53972.1
X74987 mRNA Translation: CAA52920.1
AB062293 mRNA Translation: BAB93476.1
BT009779 mRNA Translation: AAP88781.1
DQ148409 Genomic DNA Translation: AAZ38723.1
BC016283 mRNA Translation: AAH16283.1
BC016988 mRNA Translation: AAH16988.1
CCDSiCCDS34071.1
PIRiA57017
S63672
RefSeqiNP_001035809.1, NM_001040876.1
NP_002931.2, NM_002940.2
UniGeneiHs.12013

Genome annotation databases

EnsembliENST00000296577; ENSP00000296577; ENSG00000164163
GeneIDi6059
KEGGihsa:6059
UCSCiuc003ijy.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiABCE1_HUMAN
AccessioniPrimary (citable) accession number: P61221
Secondary accession number(s): O88793
, Q13181, Q13864, Q6NR76, Q96AL0, Q96B10, Q99K66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: July 18, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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