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Protein

ATP-binding cassette sub-family E member 1

Gene

ABCE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.3 Publications

Miscellaneous

The ABC transporter domains seem not to be functional.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi110 – 117ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi379 – 386ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity Source: InterPro
  • ATP binding Source: GO_Central
  • endoribonuclease inhibitor activity Source: GO_Central
  • iron ion binding Source: GO_Central
  • ribosomal small subunit binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processHost-virus interaction
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8983711 OAS antiviral response
R-HSA-909733 Interferon alpha/beta signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family E member 1
Alternative name(s):
2'-5'-oligoadenylate-binding protein
HuHP68
RNase L inhibitor
Ribonuclease 4 inhibitor
Short name:
RNS4I
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCE1
Synonyms:RLI, RNASEL1, RNASELI, RNS4I
ORF Names:OK/SW-cl.40
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164163.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:69 ABCE1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601213 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P61221

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6059

Open Targets

More...
OpenTargetsi
ENSG00000164163

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24404

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABCE1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47117664

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933161 – 599ATP-binding cassette sub-family E member 1Add BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei417PhosphoserineCombined sources1
Modified residuei550PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P61221

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P61221

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P61221

PeptideAtlas

More...
PeptideAtlasi
P61221

PRoteomics IDEntifications database

More...
PRIDEi
P61221

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57276

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P61221

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P61221

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P61221

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P61221

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Activated by encephalomyocarditis virus (EMCV) and HIV-1.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164163 Expressed in 226 organ(s), highest expression level in female gonad

CleanEx database of gene expression profiles

More...
CleanExi
HS_ABCE1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P61221 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P61221 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB012476
HPA036846

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probably heterodimerizes with RNASEL; this interaction inhibits the RNASEL.
(Microbial infection) Interacts with HIV-1 proteins Vif and Gag.1 Publication
(Microbial infection) Interacts with HIV-2 protein Gag.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111986, 244 interactors

Protein interaction database and analysis system

More...
IntActi
P61221, 25 interactors

Molecular INTeraction database

More...
MINTi
P61221

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000296577

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P61221

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P61221

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 374Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST31
Domaini46 – 754Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30
Domaini79 – 315ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini342 – 562ABC transporter 2PROSITE-ProRule annotationAdd BLAST221

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0063 Eukaryota
COG1245 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015089

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050439

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P61221

KEGG Orthology (KO)

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KOi
K06174

Identification of Orthologs from Complete Genome Data

More...
OMAi
GQYFFLE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G038V

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P61221

TreeFam database of animal gene trees

More...
TreeFami
TF105206

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03236 ABC_RNaseL_inhibitor_domain1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR013283 RLI1
IPR034348 RLI_dom_1
IPR007209 RNaseL-inhib_metal-bd_dom

The PANTHER Classification System

More...
PANTHERi
PTHR19248 PTHR19248, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005 ABC_tran, 2 hits
PF00037 Fer4, 1 hit
PF04068 RLI, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01868 ABCEFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P61221-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADKLTRIAI VNHDKCKPKK CRQECKKSCP VVRMGKLCIE VTPQSKIAWI
60 70 80 90 100
SETLCIGCGI CIKKCPFGAL SIVNLPSNLE KETTHRYCAN AFKLHRLPIP
110 120 130 140 150
RPGEVLGLVG TNGIGKSTAL KILAGKQKPN LGKYDDPPDW QEILTYFRGS
160 170 180 190 200
ELQNYFTKIL EDDLKAIIKP QYVDQIPKAA KGTVGSILDR KDETKTQAIV
210 220 230 240 250
CQQLDLTHLK ERNVEDLSGG ELQRFACAVV CIQKADIFMF DEPSSYLDVK
260 270 280 290 300
QRLKAAITIR SLINPDRYII VVEHDLSVLD YLSDFICCLY GVPSAYGVVT
310 320 330 340 350
MPFSVREGIN IFLDGYVPTE NLRFRDASLV FKVAETANEE EVKKMCMYKY
360 370 380 390 400
PGMKKKMGEF ELAIVAGEFT DSEIMVMLGE NGTGKTTFIR MLAGRLKPDE
410 420 430 440 450
GGEVPVLNVS YKPQKISPKS TGSVRQLLHE KIRDAYTHPQ FVTDVMKPLQ
460 470 480 490 500
IENIIDQEVQ TLSGGELQRV ALALCLGKPA DVYLIDEPSA YLDSEQRLMA
510 520 530 540 550
ARVVKRFILH AKKTAFVVEH DFIMATYLAD RVIVFDGVPS KNTVANSPQT
560 570 580 590
LLAGMNKFLS QLEITFRRDP NNYRPRINKL NSIKDVEQKK SGNYFFLDD
Length:599
Mass (Da):67,314
Last modified:May 10, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D582B62E95BC7A6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9I9D6R9I9_HUMAN
ATP-binding cassette sub-family E m...
ABCE1
421Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGF4D6RGF4_HUMAN
ATP-binding cassette sub-family E m...
ABCE1
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y990H0Y990_HUMAN
ATP-binding cassette sub-family E m...
ABCE1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti118T → A in CAA53972 (PubMed:7539425).Curated1
Sequence conflicti174 – 179DQIPKA → ARFLRL in CAA53972 (PubMed:7539425).Curated6
Sequence conflicti471 – 473ALA → RLR in CAA53972 (PubMed:7539425).Curated3
Sequence conflicti471 – 473ALA → RLR in CAA52920 (PubMed:7539425).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_068914489S → C Polymorphism; confirmed at protein level. 1 PublicationCorresponds to variant dbSNP:rs3816497Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X76388 mRNA Translation: CAA53972.1
X74987 mRNA Translation: CAA52920.1
AB062293 mRNA Translation: BAB93476.1
BT009779 mRNA Translation: AAP88781.1
DQ148409 Genomic DNA Translation: AAZ38723.1
BC016283 mRNA Translation: AAH16283.1
BC016988 mRNA Translation: AAH16988.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34071.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A57017
S63672

NCBI Reference Sequences

More...
RefSeqi
NP_001035809.1, NM_001040876.1
NP_002931.2, NM_002940.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.12013

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296577; ENSP00000296577; ENSG00000164163

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6059

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6059

UCSC genome browser

More...
UCSCi
uc003ijy.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs
ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76388 mRNA Translation: CAA53972.1
X74987 mRNA Translation: CAA52920.1
AB062293 mRNA Translation: BAB93476.1
BT009779 mRNA Translation: AAP88781.1
DQ148409 Genomic DNA Translation: AAZ38723.1
BC016283 mRNA Translation: AAH16283.1
BC016988 mRNA Translation: AAH16988.1
CCDSiCCDS34071.1
PIRiA57017
S63672
RefSeqiNP_001035809.1, NM_001040876.1
NP_002931.2, NM_002940.2
UniGeneiHs.12013

3D structure databases

ProteinModelPortaliP61221
SMRiP61221
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111986, 244 interactors
IntActiP61221, 25 interactors
MINTiP61221
STRINGi9606.ENSP00000296577

PTM databases

CarbonylDBiP61221
iPTMnetiP61221
PhosphoSitePlusiP61221
SwissPalmiP61221

Polymorphism and mutation databases

BioMutaiABCE1
DMDMi47117664

Proteomic databases

EPDiP61221
MaxQBiP61221
PaxDbiP61221
PeptideAtlasiP61221
PRIDEiP61221
ProteomicsDBi57276

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6059
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296577; ENSP00000296577; ENSG00000164163
GeneIDi6059
KEGGihsa:6059
UCSCiuc003ijy.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6059
DisGeNETi6059
EuPathDBiHostDB:ENSG00000164163.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ABCE1
HGNCiHGNC:69 ABCE1
HPAiCAB012476
HPA036846
MIMi601213 gene
neXtProtiNX_P61221
OpenTargetsiENSG00000164163
PharmGKBiPA24404

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0063 Eukaryota
COG1245 LUCA
GeneTreeiENSGT00390000015089
HOVERGENiHBG050439
InParanoidiP61221
KOiK06174
OMAiGQYFFLE
OrthoDBiEOG091G038V
PhylomeDBiP61221
TreeFamiTF105206

Enzyme and pathway databases

ReactomeiR-HSA-8983711 OAS antiviral response
R-HSA-909733 Interferon alpha/beta signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ABCE1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6059

Protein Ontology

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PROi
PR:P61221

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000164163 Expressed in 226 organ(s), highest expression level in female gonad
CleanExiHS_ABCE1
ExpressionAtlasiP61221 baseline and differential
GenevisibleiP61221 HS

Family and domain databases

CDDicd03236 ABC_RNaseL_inhibitor_domain1, 1 hit
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR013283 RLI1
IPR034348 RLI_dom_1
IPR007209 RNaseL-inhib_metal-bd_dom
PANTHERiPTHR19248 PTHR19248, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
PF00037 Fer4, 1 hit
PF04068 RLI, 1 hit
PRINTSiPR01868 ABCEFAMILY
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCE1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61221
Secondary accession number(s): O88793
, Q13181, Q13864, Q6NR76, Q96AL0, Q96B10, Q99K66
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: December 5, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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