Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription initiation factor TFIID subunit 13

Gene

Taf13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the DNA-binding general RNA polymerase II transcription factor IID complex (TFIID). TFIID plays a critical role in the regulation of gene transcription in eukaryotic cells (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: MGI
  • protein C-terminus binding Source: MGI
  • protein heterodimerization activity Source: InterPro
  • transcription coregulator activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 13By similarity
Alternative name(s):
Transcription initiation factor TFIID 18 kDa subunitBy similarity
Short name:
TAF(II)18By similarity
Short name:
TAFII-18By similarity
Short name:
TAFII18By similarity
Gene namesi
Name:Taf13Imported
Synonyms:Taf2kBy similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1913500 Taf13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189111 – 124Transcription initiation factor TFIID subunit 13Add BLAST124

Proteomic databases

EPDiP61216
MaxQBiP61216
PaxDbiP61216
PeptideAtlasiP61216
PRIDEiP61216

PTM databases

iPTMnetiP61216
PhosphoSitePlusiP61216

Expressioni

Gene expression databases

BgeeiENSMUSG00000048100 Expressed in 28 organ(s), highest expression level in zone of skin
GenevisibleiP61216 MM

Interactioni

Subunit structurei

TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TBP, and more strongly with TAF10 and TAF11 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221311, 3 interactors
ComplexPortaliCPX-932 General transcription factor complex TFIID
CPX-959 General transcription factor complex TFIID, Taf4b variant
IntActiP61216, 1 interactor
MINTiP61216
STRINGi10090.ENSMUSP00000121346

Structurei

3D structure databases

ProteinModelPortaliP61216
SMRiP61216
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 74Histone-foldCuratedAdd BLAST43

Domaini

The binding of TAF10 and TAF11 requires distinct domains of TAF13.By similarity

Sequence similaritiesi

Belongs to the TAF13 family.Curated

Phylogenomic databases

eggNOGiKOG3901 Eukaryota
COG5248 LUCA
GeneTreeiENSGT00390000012981
HOGENOMiHOG000237827
HOVERGENiHBG055385
InParanoidiP61216
KOiK03127
OMAiMTHKAME
OrthoDBiEOG091G0VJ8
PhylomeDBiP61216
TreeFamiTF323609

Family and domain databases

CDDicd07978 TAF13, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR003195 TFIID_TAF13
PANTHERiPTHR11380 PTHR11380, 1 hit
PfamiView protein in Pfam
PF02269 TFIID-18kDa, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequencei

Sequence statusi: Complete.

P61216-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADEEEDPTF EEENEEIGGG AEGGQGKRKR LFSKELRCMM YGFGDDQNPY
60 70 80 90 100
TESVDILEDL VIEFITEMTH KAMSIGRQGR VQVEDIVFLI RKDPRKFARV
110 120
KDLLTMNEEL KRARKAFDEA NYGS
Length:124
Mass (Da):14,287
Last modified:May 10, 2004 - v1
Checksum:i98B62FF1BC8E7B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007339 mRNA Translation: BAB24972.1
AK076595 mRNA Translation: BAC36408.1
AK160171 mRNA Translation: BAE35671.1
BC021447 mRNA Translation: AAH21447.1
CCDSiCCDS17764.1
RefSeqiNP_079720.1, NM_025444.2
UniGeneiMm.24431

Genome annotation databases

EnsembliENSMUST00000143054; ENSMUSP00000121346; ENSMUSG00000048100
GeneIDi99730
KEGGimmu:99730
UCSCiuc008qzh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007339 mRNA Translation: BAB24972.1
AK076595 mRNA Translation: BAC36408.1
AK160171 mRNA Translation: BAE35671.1
BC021447 mRNA Translation: AAH21447.1
CCDSiCCDS17764.1
RefSeqiNP_079720.1, NM_025444.2
UniGeneiMm.24431

3D structure databases

ProteinModelPortaliP61216
SMRiP61216
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221311, 3 interactors
ComplexPortaliCPX-932 General transcription factor complex TFIID
CPX-959 General transcription factor complex TFIID, Taf4b variant
IntActiP61216, 1 interactor
MINTiP61216
STRINGi10090.ENSMUSP00000121346

PTM databases

iPTMnetiP61216
PhosphoSitePlusiP61216

Proteomic databases

EPDiP61216
MaxQBiP61216
PaxDbiP61216
PeptideAtlasiP61216
PRIDEiP61216

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000143054; ENSMUSP00000121346; ENSMUSG00000048100
GeneIDi99730
KEGGimmu:99730
UCSCiuc008qzh.1 mouse

Organism-specific databases

CTDi6884
MGIiMGI:1913500 Taf13

Phylogenomic databases

eggNOGiKOG3901 Eukaryota
COG5248 LUCA
GeneTreeiENSGT00390000012981
HOGENOMiHOG000237827
HOVERGENiHBG055385
InParanoidiP61216
KOiK03127
OMAiMTHKAME
OrthoDBiEOG091G0VJ8
PhylomeDBiP61216
TreeFamiTF323609

Enzyme and pathway databases

ReactomeiR-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

PROiPR:P61216
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048100 Expressed in 28 organ(s), highest expression level in zone of skin
GenevisibleiP61216 MM

Family and domain databases

CDDicd07978 TAF13, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR003195 TFIID_TAF13
PANTHERiPTHR11380 PTHR11380, 1 hit
PfamiView protein in Pfam
PF02269 TFIID-18kDa, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAF13_MOUSE
AccessioniPrimary (citable) accession number: P61216
Secondary accession number(s): Q3TVE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again