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Protein

ADP-ribosylation factor-like protein 4A

Gene

Arl4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 34GTPBy similarity8
Nucleotide bindingi75 – 79GTPBy similarity5
Nucleotide bindingi134 – 137GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: MGI
  • GTP binding Source: UniProtKB

GO - Biological processi

  • brown fat cell differentiation Source: MGI
  • intracellular protein transport Source: GO_Central
  • vesicle-mediated transport Source: GO_Central

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 4A
Gene namesi
Name:Arl4a
Synonyms:Arl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:99437 Arl4a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074602 – 200ADP-ribosylation factor-like protein 4AAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Post-translational modificationi

Myristoylated.By similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP61213
PRIDEiP61213

PTM databases

PhosphoSitePlusiP61213

Expressioni

Tissue specificityi

Expressed strongly in testis and liver. Expressed slightly in heart, spleen, lung and kidney.1 Publication

Developmental stagei

Expressed strongly in embryo at 7 dpc. Expressed slightly in embryo at 11, 15 and 17 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000047446 Expressed in 290 organ(s), highest expression level in testis
CleanExiMM_ARL4A
ExpressionAtlasiP61213 baseline and differential
GenevisibleiP61213 MM

Interactioni

Subunit structurei

Interacts with CYTH2. Interacts with KPNA2; the interaction is direct. Does not interacts with ARL4A (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099013

Structurei

3D structure databases

ProteinModelPortaliP61213
SMRiP61213
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00930000150892
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiP61213
KOiK07945
OMAiCFHIVIL
OrthoDBiEOG091G0LK5
PhylomeDBiP61213
TreeFamiTF105464

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P61213-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNGLSDQTS ILSSLPSFQS FHIVILGLDC AGKTTVLYRL QFNEFVNTVP
60 70 80 90 100
TKGFNTEKIK VTLGNSKTVT FHFWDVGGQE KLRPLWKSYT RCTDGIVFVV
110 120 130 140 150
DSVDVERMEE AKTELHKITR ISENQGVPVL IVANKQDLRN SLSLSEIEKL
160 170 180 190 200
LAMGELSSST PWHLQPTCAI IGDGLKEGLE KLHDMIIKRR KMLRQQKKKR
Length:200
Mass (Da):22,588
Last modified:May 10, 2004 - v1
Checksum:i8D82542D0F5CEA22
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UVX1G3UVX1_MOUSE
ADP-ribosylation factor-like protei...
Arl4a mCG_5062
64Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76546 mRNA Translation: AAB18812.1
AK006286 mRNA Translation: BAB24505.1
AK048606 mRNA Translation: BAC33388.1
AK168618 mRNA Translation: BAE40483.1
BC029234 mRNA Translation: AAH29234.1
CCDSiCCDS25890.1
RefSeqiNP_001034604.1, NM_001039515.1
NP_031513.1, NM_007487.3
UniGeneiMm.12723

Genome annotation databases

EnsembliENSMUST00000101472; ENSMUSP00000099013; ENSMUSG00000047446
ENSMUST00000146905; ENSMUSP00000114458; ENSMUSG00000047446
GeneIDi11861
KEGGimmu:11861
UCSCiuc007nks.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76546 mRNA Translation: AAB18812.1
AK006286 mRNA Translation: BAB24505.1
AK048606 mRNA Translation: BAC33388.1
AK168618 mRNA Translation: BAE40483.1
BC029234 mRNA Translation: AAH29234.1
CCDSiCCDS25890.1
RefSeqiNP_001034604.1, NM_001039515.1
NP_031513.1, NM_007487.3
UniGeneiMm.12723

3D structure databases

ProteinModelPortaliP61213
SMRiP61213
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099013

PTM databases

PhosphoSitePlusiP61213

Proteomic databases

PaxDbiP61213
PRIDEiP61213

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101472; ENSMUSP00000099013; ENSMUSG00000047446
ENSMUST00000146905; ENSMUSP00000114458; ENSMUSG00000047446
GeneIDi11861
KEGGimmu:11861
UCSCiuc007nks.1 mouse

Organism-specific databases

CTDi10124
MGIiMGI:99437 Arl4a

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00930000150892
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiP61213
KOiK07945
OMAiCFHIVIL
OrthoDBiEOG091G0LK5
PhylomeDBiP61213
TreeFamiTF105464

Miscellaneous databases

PROiPR:P61213
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047446 Expressed in 290 organ(s), highest expression level in testis
CleanExiMM_ARL4A
ExpressionAtlasiP61213 baseline and differential
GenevisibleiP61213 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARL4A_MOUSE
AccessioniPrimary (citable) accession number: P61213
Secondary accession number(s): P41275, Q3TGR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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