Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP-ribosylation factor 3

Gene

Arf3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor 3
Alternative name(s):
Liver regeneration-related protein LRRG202
Gene namesi
Name:Arf3
ORF Names:Ac1-253
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621273 Arf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002073892 – 181ADP-ribosylation factor 3Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP61206
PRIDEiP61206

2D gel databases

World-2DPAGEi0004:P61206

PTM databases

iPTMnetiP61206
PhosphoSitePlusiP61206

Expressioni

Gene expression databases

BgeeiENSRNOG00000054775
ExpressionAtlasiP61206 baseline and differential
GenevisibleiP61206 RN

Interactioni

Subunit structurei

Interacts with PRKCABP. Interacts with PI4KB and NCS1/FREQ at the Golgi complex.By similarity

Protein-protein interaction databases

IntActiP61206, 2 interactors
STRINGi10116.ENSRNOP00000047811

Structurei

3D structure databases

ProteinModelPortaliP61206
SMRiP61206
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00530000062784
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiP61206
KOiK07938
PhylomeDBiP61206
TreeFamiTF300808

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR024156 Small_GTPase_ARF
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNIFGNLLK SLIGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG
60 70 80 90 100
FNVETVEYKN ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV
110 120 130 140 150
NEAREELMRM LAEDELRDAV LLVFANKQDL PNAMNAAEIT DKLGLHSLRH
160 170 180
RNWYIQATCA TSGDGLYEGL DWLANQLKNK K
Length:181
Mass (Da):20,601
Last modified:January 23, 2007 - v2
Checksum:iD6FA234DFAED3E5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12382 mRNA Translation: AAA40687.1
AY325223 mRNA Translation: AAP92624.1
BC088865 mRNA Translation: AAH88865.1
RefSeqiNP_543180.1, NM_080904.2
XP_006257382.1, XM_006257320.3
XP_017450124.1, XM_017594635.1
XP_017450125.1, XM_017594636.1
UniGeneiRn.106440

Genome annotation databases

EnsembliENSRNOT00000077884; ENSRNOP00000069538; ENSRNOG00000054775
GeneIDi140940
KEGGirno:140940
UCSCiRGD:621273 rat

Similar proteinsi

Entry informationi

Entry nameiARF3_RAT
AccessioniPrimary (citable) accession number: P61206
Secondary accession number(s): P16587
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health