UniProtKB - P61202 (CSN2_MOUSE)
COP9 signalosome complex subunit 2
Cops2
Functioni
GO - Molecular functioni
- transcription corepressor activity Source: MGI
GO - Biological processi
- cell population proliferation Source: MGI
- inner cell mass cell proliferation Source: MGI
- negative regulation of nucleic acid-templated transcription Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- neuron differentiation Source: MGI
- protein deneddylation Source: Ensembl
- protein phosphorylation Source: Ensembl
- skeletal muscle cell differentiation Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-5696394, DNA Damage Recognition in GG-NER R-MMU-6781823, Formation of TC-NER Pre-Incision Complex R-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis R-MMU-8951664, Neddylation |
Names & Taxonomyi
Protein namesi | Recommended name: COP9 signalosome complex subunit 2Short name: SGN2 Short name: Signalosome subunit 2 Alternative name(s): Alien homolog JAB1-containing signalosome subunit 2 Thyroid receptor-interacting protein 15 Short name: TR-interacting protein 15 Short name: TRIP-15 |
Gene namesi | Name:Cops2 Synonyms:Csn2, Trip15 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1330276, Cops2 |
Subcellular locationi
Nucleus
- COP9 signalosome Source: MGI
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Nucleus, SignalosomePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000120969 | 1 – 443 | COP9 signalosome complex subunit 2Add BLAST | 443 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P61202 |
jPOSTi | P61202 |
MaxQBi | P61202 |
PaxDbi | P61202 |
PeptideAtlasi | P61202 |
PRIDEi | P61202 |
PTM databases
iPTMneti | P61202 |
PhosphoSitePlusi | P61202 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000027206, Expressed in ear vesicle and 323 other tissues |
ExpressionAtlasi | P61202, baseline and differential |
Genevisiblei | P61202, MM |
Interactioni
Subunit structurei
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS1, COPS4, COPS5, COPS6 and COPS7 (COPS7A or COPS7B) (PubMed:9707402). Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction.
Interacts with CUL1 and CUL2 (PubMed:11967155).
Interacts with IRF8/ICSBP1 and with nuclear receptors NR2F1 and NR0B1 (By similarity).
Interacts with NIF3L1 (PubMed:12522100).
By similarity3 PublicationsProtein-protein interaction databases
BioGRIDi | 198836, 42 interactors |
CORUMi | P61202 |
STRINGi | 10090.ENSMUSP00000106090 |
Miscellaneous databases
RNActi | P61202, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 254 – 416 | PCIPROSITE-ProRule annotationAdd BLAST | 163 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 275 | Mediates interaction with NIF3L1By similarityAdd BLAST | 275 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1464, Eukaryota |
GeneTreei | ENSGT00530000063301 |
HOGENOMi | CLU_028981_0_1_1 |
InParanoidi | P61202 |
OMAi | NMRTKGV |
TreeFami | TF105738 |
Family and domain databases
InterProi | View protein in InterPro IPR037750, COPS2 IPR000717, PCI_dom IPR011990, TPR-like_helical_dom_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10678:SF3, PTHR10678:SF3, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDMEDDFMC DDEEDYDLEY SEDSNSEPNV DLENQYYNSK ALKEDDPKAA
60 70 80 90 100
LSSFQKVLEL EGEKGEWGFK ALKQMIKINF KLTNFPEMMN RYKQLLTYIR
110 120 130 140 150
SAVTRNYSEK SINSILDYIS TSKQMDLLQE FYETTLEALK DAKNDRLWFK
160 170 180 190 200
TNTKLGKLYL EREEYGKLQK ILRQLHQSCQ TDDGEDDLKK GTQLLEIYAL
210 220 230 240 250
EIQMYTAQKN NKKLKALYEQ SLHIKSAIPH PLIMGVIREC GGKMHLREGE
260 270 280 290 300
FEKAHTDFFE AFKNYDESGS PRRTTCLKYL VLANMLMKSG INPFDSQEAK
310 320 330 340 350
PYKNDPEILA MTNLVSAYQN NDITEFEKIL KTNHSNIMDD PFIREHIEEL
360 370 380 390 400
LRNIRTQVLI KLIKPYTRIH IPFISKELNI DVADVESLLV QCILDNTIHG
410 420 430 440
RIDQVNQLLE LDHQKRGGAR YTALDKWTNQ LNSLNQAVVS KLA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2AQE4 | A2AQE4_MOUSE | COP9 signalosome complex subunit 2 | Cops2 | 402 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 40 | K → Y in BAB26900 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 52 | S → T in BAB26900 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 344 | R → K in AAH23096 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011885 | 124 | Q → QNSDFLCQ in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087688 mRNA Translation: AAC36309.1 AF114247 , AF114236, AF114237, AF114238, AF114239, AF114240, AF114241, AF114242, AF114244, AF114245, AF114246 Genomic DNA Translation: AAD26162.1 AK010383 mRNA Translation: BAB26900.1 AK084421 mRNA Translation: BAC39179.1 AK132207 mRNA Translation: BAE21033.1 BC023096 mRNA Translation: AAH23096.1 Different initiation. AF071312 mRNA Translation: AAC33899.1 |
CCDSi | CCDS16679.1 [P61202-1] CCDS71133.1 [P61202-2] |
RefSeqi | NP_001272441.1, NM_001285512.1 NP_034069.2, NM_009939.3 [P61202-1] |
Genome annotation databases
Ensembli | ENSMUST00000028635; ENSMUSP00000028635; ENSMUSG00000027206 [P61202-1] ENSMUST00000110463; ENSMUSP00000106090; ENSMUSG00000027206 [P61202-2] |
GeneIDi | 12848 |
KEGGi | mmu:12848 |
UCSCi | uc008mdb.2, mouse [P61202-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087688 mRNA Translation: AAC36309.1 AF114247 , AF114236, AF114237, AF114238, AF114239, AF114240, AF114241, AF114242, AF114244, AF114245, AF114246 Genomic DNA Translation: AAD26162.1 AK010383 mRNA Translation: BAB26900.1 AK084421 mRNA Translation: BAC39179.1 AK132207 mRNA Translation: BAE21033.1 BC023096 mRNA Translation: AAH23096.1 Different initiation. AF071312 mRNA Translation: AAC33899.1 |
CCDSi | CCDS16679.1 [P61202-1] CCDS71133.1 [P61202-2] |
RefSeqi | NP_001272441.1, NM_001285512.1 NP_034069.2, NM_009939.3 [P61202-1] |
3D structure databases
SMRi | P61202 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198836, 42 interactors |
CORUMi | P61202 |
STRINGi | 10090.ENSMUSP00000106090 |
PTM databases
iPTMneti | P61202 |
PhosphoSitePlusi | P61202 |
Proteomic databases
EPDi | P61202 |
jPOSTi | P61202 |
MaxQBi | P61202 |
PaxDbi | P61202 |
PeptideAtlasi | P61202 |
PRIDEi | P61202 |
Protocols and materials databases
Antibodypediai | 12106, 396 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000028635; ENSMUSP00000028635; ENSMUSG00000027206 [P61202-1] ENSMUST00000110463; ENSMUSP00000106090; ENSMUSG00000027206 [P61202-2] |
GeneIDi | 12848 |
KEGGi | mmu:12848 |
UCSCi | uc008mdb.2, mouse [P61202-1] |
Organism-specific databases
CTDi | 9318 |
MGIi | MGI:1330276, Cops2 |
Phylogenomic databases
eggNOGi | KOG1464, Eukaryota |
GeneTreei | ENSGT00530000063301 |
HOGENOMi | CLU_028981_0_1_1 |
InParanoidi | P61202 |
OMAi | NMRTKGV |
TreeFami | TF105738 |
Enzyme and pathway databases
Reactomei | R-MMU-5696394, DNA Damage Recognition in GG-NER R-MMU-6781823, Formation of TC-NER Pre-Incision Complex R-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis R-MMU-8951664, Neddylation |
Miscellaneous databases
BioGRID-ORCSi | 12848, 4 hits in 17 CRISPR screens |
ChiTaRSi | Cops2, mouse |
PROi | PR:P61202 |
RNActi | P61202, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027206, Expressed in ear vesicle and 323 other tissues |
ExpressionAtlasi | P61202, baseline and differential |
Genevisiblei | P61202, MM |
Family and domain databases
InterProi | View protein in InterPro IPR037750, COPS2 IPR000717, PCI_dom IPR011990, TPR-like_helical_dom_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10678:SF3, PTHR10678:SF3, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CSN2_MOUSE | |
Accessioni | P61202Primary (citable) accession number: P61202 Secondary accession number(s): O88950 Q9UNQ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | May 10, 2004 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families