UniProtKB - P61202 (CSN2_MOUSE)

BLAST

>sp|P61202|CSN2_MOUSE COP9 signalosome complex subunit 2 OS=Mus musculus OX=10090 GN=Cops2 PE=1 SV=1
MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLEL
EGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYIS
TSKQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQ
TDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIREC
GGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAK
PYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLI
KLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGAR
YTALDKWTNQLNSLNQAVVSKLA

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History
Entry version 133 (07 Nov 2018)
Sequence version 1 (10 May 2004)
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Protein

COP9 signalosome complex subunit 2

Gene

Cops2

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.3 Publications

GO - Molecular functionⁱ

transcription corepressor activity
Source: MGI
Inferred from direct assayⁱ
- 15062575

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 12972599
negative regulation of nucleic acid-templated transcription Source: MGI
negative regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 15062575
negative regulation of transcription by RNA polymerase II Source: MGI
neuron differentiation Source: MGI
protein deneddylation Source: Ensembl
protein phosphorylation Source: Ensembl
skeletal muscle cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 22147266

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5696394 DNA Damage Recognition in GG-NER R-MMU-6781823 Formation of TC-NER Pre-Incision Complex R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis R-MMU-8951664 Neddylation

Reactomeⁱ

R-MMU-5696394 DNA Damage Recognition in GG-NER
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8951664 Neddylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: COP9 signalosome complex subunit 2 Short name: SGN2 Short name: Signalosome subunit 2 Alternative name(s): Alien homolog JAB1-containing signalosome subunit 2 Thyroid receptor-interacting protein 15 Short name: TR-interacting protein 15 Short name: TRIP-15
Gene namesⁱ	Name:Cops2 Synonyms:Csn2, Trip15
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:1330276 Cops2

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus, Signalosome

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Its absence causes arrest of embryo development at the peri-implantation stage. Blastocysts without Cops2 fail to outgrow in culture and exhibit a cell proliferation defect in inner cell mass, accompanied by a slight decrease in Oct4. In addition, lack of Cops2 disrupts the CSN complex and results in a drastic increase in cyclin E. It also induces elevated levels of p53 and p21, which may contribute to premature cell cycle arrest of the mutant.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000120969	1 – 443	COP9 signalosome complex subunit 2Add BLAST		443

Post-translational modificationⁱ

Phosphorylated by CK2 and PKD kinases.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P61202
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P61202
PaxDbⁱ	P61202
PeptideAtlas More...PeptideAtlasⁱ	P61202
PRIDEⁱ	P61202

PTM databases

iPTMnetⁱ	P61202
PhosphoSitePlusⁱ	P61202

Expressionⁱ

Tissue specificityⁱ

Widely expressed in embryonic, fetal and adult tissues, except cartilage and smooth muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000027206 Expressed in 310 organ(s), highest expression level in ear vesicle
CleanExⁱ	MM_CSN2
ExpressionAtlasⁱ	P61202 baseline and differential
Genevisibleⁱ	P61202 MM

Interactionⁱ

Subunit structureⁱ

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS1, COPS4, COPS5, COPS6 and COPS7 (COPS7A or COPS7B) (PubMed:9707402). Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction. Interacts with CUL1 and CUL2 (PubMed:11967155). Interacts with IRF8/ICSBP1 and with nuclear receptors NR2F1 and NR0B1 (By similarity). Interacts with NIF3L1 (PubMed:12522100).By similarity3 Publications

Protein-protein interaction databases

BioGridⁱ	198836, 24 interactors
CORUMⁱ	P61202
STRINGⁱ	10090.ENSMUSP00000028635

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P61202
SMRⁱ	P61202
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	254 – 416	PCIPROSITE-ProRule annotationAdd BLAST		163

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 275	Mediates interaction with NIF3L1By similarityAdd BLAST		275

Sequence similaritiesⁱ

Belongs to the CSN2 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1464 Eukaryota COG5159 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063301
HOVERGENⁱ	HBG003924
InParanoidⁱ	P61202
KEGG Orthology (KO) More...KOⁱ	K12176
OMAⁱ	NMRTKGV
TreeFamⁱ	TF105738

Family and domain databases

InterProⁱ	View protein in InterPro IPR037750 COPS2 IPR000717 PCI_dom IPR011990 TPR-like_helical_dom_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR10678:SF3 PTHR10678:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01399 PCI, 1 hit
SMARTⁱ	View protein in SMART SM00088 PINT, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF48452 SSF48452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50250 PCI, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P61202-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDMEDDFMC DDEEDYDLEY SEDSNSEPNV DLENQYYNSK ALKEDDPKAA 
        60         70         80         90        100
LSSFQKVLEL EGEKGEWGFK ALKQMIKINF KLTNFPEMMN RYKQLLTYIR 
       110        120        130        140        150
SAVTRNYSEK SINSILDYIS TSKQMDLLQE FYETTLEALK DAKNDRLWFK 
       160        170        180        190        200
TNTKLGKLYL EREEYGKLQK ILRQLHQSCQ TDDGEDDLKK GTQLLEIYAL 
       210        220        230        240        250
EIQMYTAQKN NKKLKALYEQ SLHIKSAIPH PLIMGVIREC GGKMHLREGE 
       260        270        280        290        300
FEKAHTDFFE AFKNYDESGS PRRTTCLKYL VLANMLMKSG INPFDSQEAK 
       310        320        330        340        350
PYKNDPEILA MTNLVSAYQN NDITEFEKIL KTNHSNIMDD PFIREHIEEL 
       360        370        380        390        400
LRNIRTQVLI KLIKPYTRIH IPFISKELNI DVADVESLLV QCILDNTIHG 
       410        420        430        440 
RIDQVNQLLE LDHQKRGGAR YTALDKWTNQ LNSLNQAVVS KLA

Length:443

Mass (Da):51,597

Last modified:May 10, 2004 - v1

Checksum:ⁱ1DB6FA774C13BC59

Isoform 2 (identifier: P61202-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
124-124: Q → QNSDFLCQ

« Hide

        10         20         30         40         50
MSDMEDDFMC DDEEDYDLEY SEDSNSEPNV DLENQYYNSK ALKEDDPKAA 
        60         70         80         90        100
LSSFQKVLEL EGEKGEWGFK ALKQMIKINF KLTNFPEMMN RYKQLLTYIR 
       110        120        130        140        150
SAVTRNYSEK SINSILDYIS TSKQNSDFLC QMDLLQEFYE TTLEALKDAK 
       160        170        180        190        200
NDRLWFKTNT KLGKLYLERE EYGKLQKILR QLHQSCQTDD GEDDLKKGTQ 
       210        220        230        240        250
LLEIYALEIQ MYTAQKNNKK LKALYEQSLH IKSAIPHPLI MGVIRECGGK 
       260        270        280        290        300
MHLREGEFEK AHTDFFEAFK NYDESGSPRR TTCLKYLVLA NMLMKSGINP 
       310        320        330        340        350
FDSQEAKPYK NDPEILAMTN LVSAYQNNDI TEFEKILKTN HSNIMDDPFI 
       360        370        380        390        400
REHIEELLRN IRTQVLIKLI KPYTRIHIPF ISKELNIDVA DVESLLVQCI 
       410        420        430        440        450
LDNTIHGRID QVNQLLELDH QKRGGARYTA LDKWTNQLNS LNQAVVSKLA

Show »

Length:450

Mass (Da):52,405

Checksum:ⁱ581DE764677E90C0

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A2AQE4	A2AQE4_MOUSE		COP9 signalosome complex subunit 2 COP9 signalosome complex subunit 2	Cops2	402	Annotation score:

Sequence cautionⁱ

The sequence AAH23096 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	40	K → Y in BAB26900 (PubMed:16141072).Curated	1
Sequence conflictⁱ	52	S → T in BAB26900 (PubMed:16141072).Curated	1
Sequence conflictⁱ	344	R → K in AAH23096 (PubMed:15489334).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_011885	124	Q → QNSDFLCQ in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF087688 mRNA Translation: AAC36309.1 AF114247 AF114246 Genomic DNA Translation: AAD26162.1 AK010383 mRNA Translation: BAB26900.1 AK084421 mRNA Translation: BAC39179.1 AK132207 mRNA Translation: BAE21033.1 BC023096 mRNA Translation: AAH23096.1 Different initiation. AF071312 mRNA Translation: AAC33899.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16679.1 [P61202-1] CCDS71133.1 [P61202-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001272441.1, NM_001285512.1 NP_034069.2, NM_009939.3 [P61202-1]
UniGeneⁱ	Mm.3596

Genome annotation databases

Ensemblⁱ	ENSMUST00000028635; ENSMUSP00000028635; ENSMUSG00000027206 [P61202-1] ENSMUST00000110463; ENSMUSP00000106090; ENSMUSG00000027206 [P61202-2]
GeneIDⁱ	12848
KEGGⁱ	mmu:12848
UCSC genome browser More...UCSCⁱ	uc008mdb.2 mouse [P61202-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P61202	COP9 signalosome complex subunit 2	)	HUMAN		443	UniRef100_P61201
COP9 signalosome complex subunit 2		RAT		443
COPS2 isoform 5 (Fragment)		PONAB		263
COPS2 isoform 6 (Fragment)		PANTR		263
COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) (Fragment)		Iconisemion striatum		376
+33
P61202-2	Uncharacterized protein		MOUSE		450	UniRef100_Q3V3N6
COP9 signalosome complex subunit 2 isoform 2		MACMU		450
COP9 signalosome complex subunit 2 isoform 2		CALJA		450
COP9 constitutive photomorphogenic homolog subunit 2		PANTR		450
Brain cDNA, clone: QnpA-16974, similar to human thyroid receptor interacting protein 15 (TRIP15)		MACFA		450
+44

Protein	Similar proteins		Species	Score	Length	Source
P61202	COP9 signalosome complex subunit 2	)	HUMAN		443	UniRef90_P61201
COP9 signalosome complex subunit 2		RAT		443
COPS2 isoform 5 (Fragment)		PONAB		263
COPS2 isoform 6 (Fragment)		PANTR		263
COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) (Fragment)		Iconisemion striatum		376
+106

Protein	Similar proteins		Species	Score	Length	Source
P61202	COP9 signalosome complex subunit 2	)	HUMAN		443	UniRef50_P61201
COP9 signalosome complex subunit 2		RAT		443
COPS2 isoform 5 (Fragment)		PONAB		263
COPS2 isoform 6 (Fragment)		PANTR		263
COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) (Fragment)		Iconisemion striatum		376
+108

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF087688 mRNA Translation: AAC36309.1 AF114247 AF114246 Genomic DNA Translation: AAD26162.1 AK010383 mRNA Translation: BAB26900.1 AK084421 mRNA Translation: BAC39179.1 AK132207 mRNA Translation: BAE21033.1 BC023096 mRNA Translation: AAH23096.1 Different initiation. AF071312 mRNA Translation: AAC33899.1
CCDSⁱ	CCDS16679.1 [P61202-1] CCDS71133.1 [P61202-2]
RefSeqⁱ	NP_001272441.1, NM_001285512.1 NP_034069.2, NM_009939.3 [P61202-1]
UniGeneⁱ	Mm.3596

3D structure databases

ProteinModelPortalⁱ	P61202
SMRⁱ	P61202
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198836, 24 interactors
CORUMⁱ	P61202
STRINGⁱ	10090.ENSMUSP00000028635

PTM databases

iPTMnetⁱ	P61202
PhosphoSitePlusⁱ	P61202

Proteomic databases

EPDⁱ	P61202
MaxQBⁱ	P61202
PaxDbⁱ	P61202
PeptideAtlasⁱ	P61202
PRIDEⁱ	P61202

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000028635; ENSMUSP00000028635; ENSMUSG00000027206 [P61202-1] ENSMUST00000110463; ENSMUSP00000106090; ENSMUSG00000027206 [P61202-2]
GeneIDⁱ	12848
KEGGⁱ	mmu:12848
UCSCⁱ	uc008mdb.2 mouse [P61202-1]

Organism-specific databases

CTDⁱ	9318
MGIⁱ	MGI:1330276 Cops2

Phylogenomic databases

eggNOGⁱ	KOG1464 Eukaryota COG5159 LUCA
GeneTreeⁱ	ENSGT00530000063301
HOVERGENⁱ	HBG003924
InParanoidⁱ	P61202
KOⁱ	K12176
OMAⁱ	NMRTKGV
TreeFamⁱ	TF105738

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5696394 DNA Damage Recognition in GG-NER R-MMU-6781823 Formation of TC-NER Pre-Incision Complex R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis R-MMU-8951664 Neddylation

Reactomeⁱ

R-MMU-5696394 DNA Damage Recognition in GG-NER
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8951664 Neddylation

Miscellaneous databases

ChiTaRSⁱ	Cops2 mouse
Protein Ontology More...PROⁱ	PR:P61202
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000027206 Expressed in 310 organ(s), highest expression level in ear vesicle
CleanExⁱ	MM_CSN2
ExpressionAtlasⁱ	P61202 baseline and differential
Genevisibleⁱ	P61202 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR037750 COPS2 IPR000717 PCI_dom IPR011990 TPR-like_helical_dom_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR10678:SF3 PTHR10678:SF3, 1 hit
Pfamⁱ	View protein in Pfam PF01399 PCI, 1 hit
SMARTⁱ	View protein in SMART SM00088 PINT, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF48452 SSF48452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50250 PCI, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CSN2_MOUSE
Accessionⁱ	P61202Primary (citable) accession number: P61202 Secondary accession number(s): O88950 Q9UNQ5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
	Last sequence update:	May 10, 2004
	Last modified:	November 7, 2018
	This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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Supporting data

UniProtKB - P61202 (CSN2_MOUSE)

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COP9 signalosome complex subunit 2

Cops2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ