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Protein

COP9 signalosome complex subunit 2

Gene

COPS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.5 Publications

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8951664 Neddylation
SignaLinkiP61201

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 2
Short name:
SGN2
Short name:
Signalosome subunit 2
Alternative name(s):
Alien homolog
JAB1-containing signalosome subunit 2
Thyroid receptor-interacting protein 15
Short name:
TR-interacting protein 15
Short name:
TRIP-15
Gene namesi
Name:COPS2
Synonyms:CSN2, TRIP15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000166200.14
HGNCiHGNC:30747 COPS2
MIMi604508 gene
neXtProtiNX_P61201

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi9318
OpenTargetsiENSG00000166200
PharmGKBiPA134952445

Polymorphism and mutation databases

BioMutaiCOPS2
DMDMi47117681

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001209681 – 443COP9 signalosome complex subunit 2Add BLAST443

Post-translational modificationi

Phosphorylated by CK2 and PKD kinases.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP61201
MaxQBiP61201
PaxDbiP61201
PeptideAtlasiP61201
PRIDEiP61201
ProteomicsDBi57272
57273 [P61201-2]

PTM databases

iPTMnetiP61201
PhosphoSitePlusiP61201
SwissPalmiP61201

Expressioni

Gene expression databases

BgeeiENSG00000166200
CleanExiHS_COPS2
HS_CSN2
ExpressionAtlasiP61201 baseline and differential
GenevisibleiP61201 HS

Organism-specific databases

HPAiHPA016867
HPA018271
HPA061071

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS1, COPS4, COPS5, COPS6 and COPS7 (COPS7A or COPS7B) (PubMed:11337588, PubMed:18850735). Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction (By similarity). Interacts with CUL1 and CUL2 (PubMed:11337588). Interacts with IRF8/ICSBP1 and with nuclear receptors NR2F1 and NR0B1 (PubMed:10207062, PubMed:10713076, PubMed:10991940). Interacts with NIF3L1 (By similarity).By similarity6 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114729, 128 interactors
ComplexPortaliCPX-1870 COP9 signalosome variant 1
CPX-1871 COP9 signalosome variant 2
CORUMiP61201
DIPiDIP-42076N
IntActiP61201, 37 interactors
MINTiP61201
STRINGi9606.ENSP00000299259

Structurei

3D structure databases

ProteinModelPortaliP61201
SMRiP61201
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini254 – 416PCIPROSITE-ProRule annotationAdd BLAST163

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 275Mediates interaction with NIF3L1By similarityAdd BLAST275

Sequence similaritiesi

Belongs to the CSN2 family.Curated

Phylogenomic databases

eggNOGiKOG1464 Eukaryota
COG5159 LUCA
GeneTreeiENSGT00530000063301
HOVERGENiHBG003924
InParanoidiP61201
KOiK12176
OMAiEDYGFDY
OrthoDBiEOG091G07D9
PhylomeDBiP61201
TreeFamiTF105738

Family and domain databases

InterProiView protein in InterPro
IPR000717 PCI_dom
IPR011990 TPR-like_helical_dom_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P61201-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDMEDDFMC DDEEDYDLEY SEDSNSEPNV DLENQYYNSK ALKEDDPKAA
60 70 80 90 100
LSSFQKVLEL EGEKGEWGFK ALKQMIKINF KLTNFPEMMN RYKQLLTYIR
110 120 130 140 150
SAVTRNYSEK SINSILDYIS TSKQMDLLQE FYETTLEALK DAKNDRLWFK
160 170 180 190 200
TNTKLGKLYL EREEYGKLQK ILRQLHQSCQ TDDGEDDLKK GTQLLEIYAL
210 220 230 240 250
EIQMYTAQKN NKKLKALYEQ SLHIKSAIPH PLIMGVIREC GGKMHLREGE
260 270 280 290 300
FEKAHTDFFE AFKNYDESGS PRRTTCLKYL VLANMLMKSG INPFDSQEAK
310 320 330 340 350
PYKNDPEILA MTNLVSAYQN NDITEFEKIL KTNHSNIMDD PFIREHIEEL
360 370 380 390 400
LRNIRTQVLI KLIKPYTRIH IPFISKELNI DVADVESLLV QCILDNTIHG
410 420 430 440
RIDQVNQLLE LDHQKRGGAR YTALDKWTNQ LNSLNQAVVS KLA
Length:443
Mass (Da):51,597
Last modified:May 10, 2004 - v1
Checksum:i1DB6FA774C13BC59
GO
Isoform 2 (identifier: P61201-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-124: Q → QNSDFLCQ

Show »
Length:450
Mass (Da):52,405
Checksum:i581DE764677E90C0
GO

Sequence cautioni

The sequence AAD30269 differs from that shown. Reason: Frameshift at position 304.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36Y → N in CAG46860 (Ref. 3) Curated1
Sequence conflicti151T → A in AAD43026 (PubMed:10931946).Curated1
Sequence conflicti211N → T in CAG46860 (Ref. 3) Curated1
Sequence conflicti352R → Q (PubMed:10207062).Curated1
Sequence conflicti392C → S (PubMed:10207062).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011884124Q → QNSDFLCQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084260 mRNA Translation: AAC34122.1
AF100762 mRNA Translation: AAD43026.1
AF212227 mRNA Translation: AAK26250.1
CR542063 mRNA Translation: CAG46860.1
BC012629 mRNA Translation: AAH12629.1
L40388 mRNA Translation: AAC41734.1
AF120268 mRNA Translation: AAD30269.1 Frameshift.
CCDSiCCDS32235.1 [P61201-1]
CCDS45257.1 [P61201-2]
RefSeqiNP_001137359.1, NM_001143887.1 [P61201-2]
NP_004227.1, NM_004236.3 [P61201-1]
UniGeneiHs.369614

Genome annotation databases

EnsembliENST00000299259; ENSP00000299259; ENSG00000166200 [P61201-2]
ENST00000388901; ENSP00000373553; ENSG00000166200 [P61201-1]
GeneIDi9318
KEGGihsa:9318
UCSCiuc001zxf.4 human [P61201-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCSN2_HUMAN
AccessioniPrimary (citable) accession number: P61201
Secondary accession number(s): O88950
, Q15647, Q6FGP4, Q9BY54, Q9R249, Q9UNI2, Q9UNQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: July 18, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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