UniProtKB - P61177 (RL22_ECO57)
Protein
50S ribosomal protein L22
Gene
rplV
Organism
Escherichia coli O157:H7
Status
Functioni
This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).UniRule annotation
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.UniRule annotation
GO - Molecular functioni
- rRNA binding Source: UniProtKB-UniRule
- structural constituent of ribosome Source: InterPro
GO - Biological processi
- translation Source: UniProtKB-UniRule
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: 50S ribosomal protein L22UniRule annotation |
Gene namesi | Name:rplVUniRule annotation Ordered Locus Names:Z4686, ECs4180 |
Organismi | Escherichia coli O157:H7 |
Taxonomic identifieri | 83334 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125155 | 1 – 110 | 50S ribosomal protein L22Add BLAST | 110 |
Interactioni
Subunit structurei
Part of the 50S ribosomal subunit.
UniRule annotationProtein-protein interaction databases
STRINGi | 155864.EDL933_4532 |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uL22 family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0091, Bacteria |
HOGENOMi | CLU_083987_3_3_6 |
Family and domain databases
CDDi | cd00336, Ribosomal_L22, 1 hit |
Gene3Di | 3.90.470.10, 1 hit |
HAMAPi | MF_01331_B, Ribosomal_L22_B, 1 hit |
InterProi | View protein in InterPro IPR001063, Ribosomal_L22 IPR018260, Ribosomal_L22/L17_CS IPR036394, Ribosomal_L22/L17_sf IPR005727, Ribosomal_L22_bac/chlpt-type |
PANTHERi | PTHR13501, PTHR13501, 1 hit |
Pfami | View protein in Pfam PF00237, Ribosomal_L22, 1 hit |
SUPFAMi | SSF54843, SSF54843, 1 hit |
TIGRFAMsi | TIGR01044, rplV_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00464, RIBOSOMAL_L22, 1 hit |
i Sequence
Sequence statusi: Complete.
P61177-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METIAKHRHA RSSAQKVRLV ADLIRGKKVS QALDILTYTN KKAAVLVKKV
60 70 80 90 100
LESAIANAEH NDGADIDDLK VTKIFVDEGP SMKRIMPRAK GRADRILKRT
110
SHITVVVSDR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005174 Genomic DNA Translation: AAG58436.1 BA000007 Genomic DNA Translation: BAB37603.1 |
PIRi | D91151 H85996 |
RefSeqi | NP_312207.1, NC_002695.1 WP_000447529.1, NZ_SWKA01000005.1 |
Genome annotation databases
EnsemblBacteriai | AAG58436; AAG58436; Z4686 BAB37603; BAB37603; BAB37603 |
GeneIDi | 53886463 58463681 915968 |
KEGGi | ece:Z4686 ecs:ECs4180 |
PATRICi | fig|386585.9.peg.4363 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005174 Genomic DNA Translation: AAG58436.1 BA000007 Genomic DNA Translation: BAB37603.1 |
PIRi | D91151 H85996 |
RefSeqi | NP_312207.1, NC_002695.1 WP_000447529.1, NZ_SWKA01000005.1 |
3D structure databases
SMRi | P61177 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 155864.EDL933_4532 |
Chemistry databases
DrugBanki | DB01369, Quinupristin |
Genome annotation databases
EnsemblBacteriai | AAG58436; AAG58436; Z4686 BAB37603; BAB37603; BAB37603 |
GeneIDi | 53886463 58463681 915968 |
KEGGi | ece:Z4686 ecs:ECs4180 |
PATRICi | fig|386585.9.peg.4363 |
Phylogenomic databases
eggNOGi | COG0091, Bacteria |
HOGENOMi | CLU_083987_3_3_6 |
Family and domain databases
CDDi | cd00336, Ribosomal_L22, 1 hit |
Gene3Di | 3.90.470.10, 1 hit |
HAMAPi | MF_01331_B, Ribosomal_L22_B, 1 hit |
InterProi | View protein in InterPro IPR001063, Ribosomal_L22 IPR018260, Ribosomal_L22/L17_CS IPR036394, Ribosomal_L22/L17_sf IPR005727, Ribosomal_L22_bac/chlpt-type |
PANTHERi | PTHR13501, PTHR13501, 1 hit |
Pfami | View protein in Pfam PF00237, Ribosomal_L22, 1 hit |
SUPFAMi | SSF54843, SSF54843, 1 hit |
TIGRFAMsi | TIGR01044, rplV_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00464, RIBOSOMAL_L22, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL22_ECO57 | |
Accessioni | P61177Primary (citable) accession number: P61177 Secondary accession number(s): P02423 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | February 10, 2021 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Ribosomal proteins
Ribosomal proteins families and list of entries