D(2) dopamine receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• dopamine binding Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Decreased [3H] YM-09151-2 binding to dopamine D2 receptors in the hypothalamus, brainstem and pancreatic islets of streptozotocin-induced diabetic rats."
    Shankar P.N., Joseph A., Paulose C.S.
    Eur J Pharmacol 557:99-105(2007) [PubMed] [Europe PMC] [Abstract]
• dopamine neurotransmitter receptor activity Source: RGD
• dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Activation of heterologously expressed D3 dopamine receptors: comparison with D2 dopamine receptors."
    Chio C.L., Lajiness M.E., Huff R.M.
    Mol Pharmacol 45:51-60(1994) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor activity Source: RGD
• heterocyclic compound binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Dopamine receptor contribution to the action of PCP, LSD and ketamine psychotomimetics."
    Seeman P., Ko F., Tallerico T.
    Mol Psychiatry 10:877-883(2005) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: RGDInferred from physical interactionⁱ
  • "Schizophrenia, amphetamine-induced sensitized state and acute amphetamine exposure all show a common alteration: increased dopamine D2 receptor dimerization."
    Wang M., Pei L., Fletcher P.J., Kapur S., Seeman P., Liu F.
    Mol Brain 3:25-25(2010) [PubMed] [Europe PMC] [Abstract]
• ionotropic glutamate receptor binding Source: RGDInferred from physical interactionⁱ
  • "Modulation of D2R-NR2B interactions in response to cocaine."
    Liu X.Y., Chu X.P., Mao L.M., Wang M., Lan H.X., Li M.H., Zhang G.C., Parelkar N.K., Fibuch E.E., Haines M., Neve K.A., Liu F., Xiong Z.G., Wang J.Q.
    Neuron 52:897-909(2006) [PubMed] [Europe PMC] [Abstract]
• organic cyclic compound binding Source: RGDInferred from physical interactionⁱ
  • "Dopamine receptor contribution to the action of PCP, LSD and ketamine psychotomimetics."
    Seeman P., Ko F., Tallerico T.
    Mol Psychiatry 10:877-883(2005) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGDInferred from physical interactionⁱ
  • "Reduced striatal dopamine D1-D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats."
    Perreault M.L., Hasbi A., Alijaniaram M., O'Dowd B.F., George S.R.
    Neuroscience 225:130-139(2012) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: RGDInferred from physical interactionⁱ
  • "Modulation of D2R-NR2B interactions in response to cocaine."
    Liu X.Y., Chu X.P., Mao L.M., Wang M., Lan H.X., Li M.H., Zhang G.C., Parelkar N.K., Fibuch E.E., Haines M., Neve K.A., Liu F., Xiong Z.G., Wang J.Q.
    Neuron 52:897-909(2006) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• acid secretion Source: BHF-UCLInferred from direct assayⁱ
  • "Activation of heterologously expressed D3 dopamine receptors: comparison with D2 dopamine receptors."
    Chio C.L., Lajiness M.E., Huff R.M.
    Mol Pharmacol 45:51-60(1994) [PubMed] [Europe PMC] [Abstract]
• activation of protein kinase activity Source: RGDInferred from direct assayⁱ
  • "betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption."
    Yao L., Arolfo M.P., Dohrman D.P., Jiang Z., Fan P., Fuchs S., Janak P.H., Gordon A.S., Diamond I.
    Cell 109:733-743(2002) [PubMed] [Europe PMC] [Abstract]
• adenohypophysis development Source: RGD
• adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Characterization of dopamine receptors mediating inhibition of adenylate cyclase activity in rat striatum."
    Onali P., Olianas M.C., Gessa G.L.
    Mol Pharmacol 28:138-145(1985) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: RGDInferred from direct assayⁱ
  • "betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption."
    Yao L., Arolfo M.P., Dohrman D.P., Jiang Z., Fan P., Fuchs S., Janak P.H., Gordon A.S., Diamond I.
    Cell 109:733-743(2002) [PubMed] [Europe PMC] [Abstract]
• adult behavior Source: RGD
• adult walking behavior Source: RGD
• arachidonic acid secretion Source: RGD
• associative learning Source: RGD
• auditory behavior Source: RGDInferred from mutant phenotypeⁱ
  • "Sound sequence discrimination learning motivated by reward requires dopaminergic D2 receptor activation in the rat auditory cortex."
    Kudoh M., Shibuki K.
    Learn Mem 13:690-698(2006) [PubMed] [Europe PMC] [Abstract]
• autophagy Source: RGDInferred from direct assayⁱ
  • "A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation."
    Wang J.D., Cao Y.L., Li Q., Yang Y.P., Jin M., Chen D., Wang F., Wang G.H., Qin Z.H., Hu L.F., Liu C.F.
    Autophagy 11:2057-2073(2015) [PubMed] [Europe PMC] [Abstract]
• axonogenesis Source: RGD
• behavioral response to cocaine Source: RGD
• behavioral response to ethanol Source: RGD
• branching morphogenesis of a nerve Source: RGD
• cellular potassium ion homeostasis Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "Differential coupling of dopaminergic D2 receptors expressed in different cell types. Stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis in LtK- fibroblasts, hyperpolarization, and cytosolic-free Ca2+ concentration decrease in GH4C1 cells."
    Vallar L., Muca C., Magni M., Albert P., Bunzow J., Meldolesi J., Civelli O.
    J Biol Chem 265:10320-10326(1990) [PubMed] [Europe PMC] [Abstract]
• cerebral cortex GABAergic interneuron migration Source: RGD
• circadian regulation of gene expression Source: RGD
• dopamine metabolic process Source: RGD
• dopamine receptor signaling pathway Source: RGDInferred from direct assayⁱ
  • "Activation of Go-coupled dopamine D2 receptors inhibits ERK1/ERK2 in pituitary cells. A key step in the transcriptional suppression of the prolactin gene."
    Liu J.C., Baker R.E., Sun C., Sundmark V.C., Elsholtz H.P.
    J Biol Chem 277:35819-35825(2002) [PubMed] [Europe PMC] [Abstract]
• drinking behavior Source: RGDInferred from direct assayⁱ
  • "Wake-promoting actions of dopamine D1 and D2 receptor stimulation."
    Isaac S.O., Berridge C.W.
    J Pharmacol Exp Ther 307:386-394(2003) [PubMed] [Europe PMC] [Abstract]
• feeding behavior Source: RGD
• forebrain development Source: RGDInferred from mutant phenotypeⁱ
  • "Effects of risperidone on dopamine receptor subtypes in developing rat brain."
    Moran-Gates T., Grady C., Shik Park Y., Baldessarini R.J., Tarazi F.I.
    Eur Neuropsychopharmacol 17:448-455(2007) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor internalization Source: RGDInferred from direct assayⁱ
  • "Interactions of GIPC with dopamine D2, D3 but not D4 receptors define a novel mode of regulation of G protein-coupled receptors."
    Jeanneteau F., Diaz J., Sokoloff P., Griffon N.
    Mol Biol Cell 15:696-705(2004) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway Source: RGD
• grooming behavior Source: RGD
• hyaloid vascular plexus regression Source: UniProtKB
• locomotory behavior Source: RGDInferred from mutant phenotypeⁱ
  • "Conditioned locomotion induced by unilateral intrastriatal administration of apomorphine: D(2) receptor activation is critical but not the expression of the unconditioned response."
    Dias F.R., Carey R.J., Carrera M.P.
    Brain Res 1083:85-95(2006) [PubMed] [Europe PMC] [Abstract]
• long-term memory Source: RGDInferred from mutant phenotypeⁱ
  • "Microinjections of the dopamine D2 receptor antagonist sulpiride into the medial prefrontal cortex attenuate glucocorticoid-induced impairment of long-term memory retrieval in rats."
    Pakdel R., Rashidy-Pour A.
    Neurobiol Learn Mem 87:385-390(2007) [PubMed] [Europe PMC] [Abstract]
• modulation of chemical synaptic transmission Source: RGD
• negative regulation of adenylate cyclase activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of blood pressure Source: RGD
• negative regulation of cell death Source: RGDInferred from direct assayⁱ
  • "Modulation of Postnatal Neurogenesis by Perinatal Asphyxia: Effect of D₁ and D₂ Dopamine Receptor Agonists."
    Tapia-Bustos A., Perez-Lobos R., Vio V., Lespay-Rebolledo C., Palacios E., Chiti-Morales A., Bustamante D., Herrera-Marschitz M., Morales P.
    Neurotox Res 31:109-121(2017) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell migration Source: RGD
• negative regulation of cell population proliferation Source: RGD
• negative regulation of circadian sleep/wake cycle, sleep Source: RGDInferred from direct assayⁱ
  • "Wake-promoting actions of dopamine D1 and D2 receptor stimulation."
    Isaac S.O., Berridge C.W.
    J Pharmacol Exp Ther 307:386-394(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cytosolic calcium ion concentration Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine D2 receptor modulation of carotid body type 1 cell intracellular calcium in developing rats."
    Carroll J.L., Boyle K.M., Wasicko M.J., Sterni L.M.
    Am J Physiol Lung Cell Mol Physiol 288:L910-6(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of dopamine receptor signaling pathway Source: RGD
• negative regulation of dopamine secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine D3 receptor modulation of dopamine efflux in the rat nucleus accumbens."
    Roberts C., Cummins R., Gnoffo Z., Kew J.N.
    Eur J Pharmacol 534:108-114(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of innate immune response Source: RGD
• negative regulation of insulin secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Identification of glucose-dependant insulin secretion targets in pancreatic beta cells by combining defined-mechanism compound library screening and siRNA gene silencing."
    Wu W., Shang J., Feng Y., Thompson C.M., Horwitz S., Thompson J.R., MacIntyre E.D., Thornberry N.A., Chapman K., Zhou Y.P., Howard A.D., Li J.
    J Biomol Screen 13:128-134(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein kinase B signaling Source: RGD
• negative regulation of protein phosphorylation Source: RGDInferred from mutant phenotypeⁱ
  • "Dopaminergic and cholinergic regulation of Fyn tyrosine kinase phosphorylation in the rat striatum in vivo."
    Mao L.M., Wang J.Q.
    Neuropharmacology 99:491-499(2015) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein secretion Source: RGD
• negative regulation of synaptic transmission Source: RGDInferred from direct assayⁱ
  • "Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway."
    Floresco S.B., Tse M.T.
    J Neurosci 27:2045-2057(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of synaptic transmission, glutamatergic Source: RGD
• negative regulation of voltage-gated calcium channel activity Source: BHF-UCLInferred from direct assayⁱ
  • "Differential coupling of dopaminergic D2 receptors expressed in different cell types. Stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis in LtK- fibroblasts, hyperpolarization, and cytosolic-free Ca2+ concentration decrease in GH4C1 cells."
    Vallar L., Muca C., Magni M., Albert P., Bunzow J., Meldolesi J., Civelli O.
    J Biol Chem 265:10320-10326(1990) [PubMed] [Europe PMC] [Abstract]
• nervous system process involved in regulation of systemic arterial blood pressure Source: RGD
• neuron-neuron synaptic transmission Source: RGD
• orbitofrontal cortex development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Expression and function of dopamine receptors in the developing medial frontal cortex and striatum of the rat."
    Sillivan S.E., Konradi C.
    Neuroscience 199:501-514(2011) [PubMed] [Europe PMC] [Abstract]
• peristalsis Source: RGD
• phospholipase C-activating dopamine receptor signaling pathway Source: RGD
• pigmentation Source: RGD
• positive regulation of cytokinesis Source: RGD
• positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of dopamine uptake involved in synaptic transmission Source: RGD
• positive regulation of ERK1 and ERK2 cascade Source: RGDInferred from mutant phenotypeⁱ
  • "A dopamine D2 receptor mutant capable of G protein-mediated signaling but deficient in arrestin binding."
    Lan H., Liu Y., Bell M.I., Gurevich V.V., Neve K.A.
    Mol Pharmacol 75:113-123(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of glial cell-derived neurotrophic factor production Source: RGD
• positive regulation of G protein-coupled receptor signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • "A dopamine D2 receptor mutant capable of G protein-mediated signaling but deficient in arrestin binding."
    Lan H., Liu Y., Bell M.I., Gurevich V.V., Neve K.A.
    Mol Pharmacol 75:113-123(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of growth hormone secretion Source: RGD
• positive regulation of long-term synaptic potentiation Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine receptor mechanisms mediate corticotropin-releasing factor-induced long-term potentiation in the rat amygdala following cocaine withdrawal."
    Krishnan B., Centeno M., Pollandt S., Fu Y., Genzer K., Liu J., Gallagher J.P., Shinnick-Gallagher P.
    Eur J Neurosci 31:1027-1042(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mitotic nuclear division Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Activation of heterologously expressed D3 dopamine receptors: comparison with D2 dopamine receptors."
    Chio C.L., Lajiness M.E., Huff R.M.
    Mol Pharmacol 45:51-60(1994) [PubMed] [Europe PMC] [Abstract]
• positive regulation of multicellular organism growth Source: RGD
• positive regulation of neuroblast proliferation Source: RGD
• positive regulation of neurogenesis Source: RGDInferred from direct assayⁱ
  • "Modulation of Postnatal Neurogenesis by Perinatal Asphyxia: Effect of D₁ and D₂ Dopamine Receptor Agonists."
    Tapia-Bustos A., Perez-Lobos R., Vio V., Lespay-Rebolledo C., Palacios E., Chiti-Morales A., Bustamante D., Herrera-Marschitz M., Morales P.
    Neurotox Res 31:109-121(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of receptor internalization Source: RGDInferred from mutant phenotypeⁱ
  • "A dopamine D2 receptor mutant capable of G protein-mediated signaling but deficient in arrestin binding."
    Lan H., Liu Y., Bell M.I., Gurevich V.V., Neve K.A.
    Mol Pharmacol 75:113-123(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of renal sodium excretion Source: RGD
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from direct assayⁱ
  • "Substrate-dependent regulation of MAO-A in rat mesangial cells: involvement of dopamine D2-like receptors."
    Pizzinat N., Marchal-Victorion S., Maurel A., Ordener C., Bompart G., Parini A.
    Am J Physiol Renal Physiol 284:F167-74(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of urine volume Source: RGD
• postsynaptic modulation of chemical synaptic transmission Source: SynGOInferred from direct assayⁱ
  • "Dopamine-glutamate interactions controlling prefrontal cortical pyramidal cell excitability involve multiple signaling mechanisms."
    Tseng K.Y., O'Donnell P.
    J Neurosci 24:5131-5139(2004) [PubMed] [Europe PMC] [Abstract]
• prepulse inhibition Source: RGD
• protein localization Source: RGD
• regulation of dopamine secretion Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of dopamine uptake involved in synaptic transmission Source: RGD
• regulation of heart rate Source: RGD
• regulation of locomotion involved in locomotory behavior Source: RGDInferred from mutant phenotypeⁱ
  • "Lentiviral-mediated gene delivery reveals distinct roles of nucleus accumbens dopamine D2 and D3 receptors in novelty- and light-induced locomotor activity."
    Fernandes A.R., Easton A.C., De Souza Silva M.A., Schumann G., Muller C.P., Desrivieres S.
    Eur J Neurosci 35:1344-1353(2012) [PubMed] [Europe PMC] [Abstract]
• regulation of long-term neuronal synaptic plasticity Source: RGD
• regulation of MAPK cascade Source: RGDInferred from direct assayⁱ
  • "Activation of Go-coupled dopamine D2 receptors inhibits ERK1/ERK2 in pituitary cells. A key step in the transcriptional suppression of the prolactin gene."
    Liu J.C., Baker R.E., Sun C., Sundmark V.C., Elsholtz H.P.
    J Biol Chem 277:35819-35825(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of neurotransmitter uptake Source: RGD
• regulation of phosphoprotein phosphatase activity Source: RGDInferred from mutant phenotypeⁱ
  • "Inhibition of protein tyrosine/mitogen-activated protein kinase phosphatase activity is associated with D2 dopamine receptor supersensitivity in a rat model of Parkinson's disease."
    Zhen X., Torres C., Cai G., Friedman E.
    Mol Pharmacol 62:1356-1363(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of potassium ion transport Source: BHF-UCLInferred from direct assayⁱ
  • "Differential coupling of dopaminergic D2 receptors expressed in different cell types. Stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis in LtK- fibroblasts, hyperpolarization, and cytosolic-free Ca2+ concentration decrease in GH4C1 cells."
    Vallar L., Muca C., Magni M., Albert P., Bunzow J., Meldolesi J., Civelli O.
    J Biol Chem 265:10320-10326(1990) [PubMed] [Europe PMC] [Abstract]
  • "Transfected D2 short dopamine receptors inhibit voltage-dependent potassium current in neuroblastoma x glioma hybrid (NG108-15) cells."
    Castellano M.A., Liu L.X., Monsma F.J. Jr., Sibley D.R., Kapatos G., Chiodo L.A.
    Mol Pharmacol 44:649-656(1993) [PubMed] [Europe PMC] [Abstract]
• regulation of sodium ion transport Source: RGD
• regulation of synapse structural plasticity Source: RGDInferred from direct assayⁱ
  • "Polysialic acid is required for dopamine D2 receptor-mediated plasticity involving inhibitory circuits of the rat medial prefrontal cortex."
    Castillo-Gomez E., Varea E., Blasco-Ibanez J.M., Crespo C., Nacher J.
    PLoS One 6:e29516-e29516(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of synaptic transmission, GABAergic Source: RGD
• regulation of synaptic vesicle exocytosis Source: RGD
• release of sequestered calcium ion into cytosol Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Transfected D2 short dopamine receptors inhibit voltage-dependent potassium current in neuroblastoma x glioma hybrid (NG108-15) cells."
    Castellano M.A., Liu L.X., Monsma F.J. Jr., Sibley D.R., Kapatos G., Chiodo L.A.
    Mol Pharmacol 44:649-656(1993) [PubMed] [Europe PMC] [Abstract]
• response to amphetamine Source: RGDInferred from expression patternⁱ
  • "Amphetamine-induced changes in dopamine receptors in early postnatal rat brain."
    Mukda S., Kaewsuk S., Ebadi M., Govitrapong P.
    Dev Neurosci 31:193-201(2009) [PubMed] [Europe PMC] [Abstract]
• response to axon injury Source: RGDInferred from expression patternⁱ
  • "Developmental changes in the mRNA expression of neuropeptides and dopamine and glutamate receptors in neonates and adult rats after ventral hippocampal lesion."
    El-Rawas R., Saade N.E., Thiriet N., Atweh S., Jaber M., Al-Amin H.A.
    Schizophr Res 113:298-307(2009) [PubMed] [Europe PMC] [Abstract]
• response to cocaine Source: RGD
• response to ethanol Source: RGDInferred from expression patternⁱ
  • "Enhanced dopamine D2 receptor function in hypothalamus and corpus striatum: their role in liver, plasma and in vitro hepatocyte ALDH regulation in ethanol treated rats."
    Akash K.G., Anju T.R., Peeyush K.T., Paulose C.S.
    J Biomed Sci 15:623-631(2008) [PubMed] [Europe PMC] [Abstract]
• response to histamine Source: RGD
• response to hypoxia Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine D2 receptor modulation of carotid body type 1 cell intracellular calcium in developing rats."
    Carroll J.L., Boyle K.M., Wasicko M.J., Sterni L.M.
    Am J Physiol Lung Cell Mol Physiol 288:L910-6(2005) [PubMed] [Europe PMC] [Abstract]
• response to inactivity Source: RGDInferred from expression patternⁱ
  • "Effects of immobilization stress on neurochemical markers in the motivational system of the male rat."
    Lucas L.R., Wang C.J., McCall T.J., McEwen B.S.
    Brain Res 1155:108-115(2007) [PubMed] [Europe PMC] [Abstract]
• response to iron ion Source: RGDInferred from expression patternⁱ
  • "Dopamine D2 receptor expression is altered by changes in cellular iron levels in PC12 cells and rat brain tissue."
    Unger E.L., Wiesinger J.A., Hao L., Beard J.L.
    J Nutr 138:2487-2494(2008) [PubMed] [Europe PMC] [Abstract]
• response to light stimulus Source: RGD
• response to morphine Source: RGD
• response to nicotine Source: RGDInferred from expression patternⁱ
  • "Nicotine tolerance to PC12 cell line: acute and chronic exposures modulate dopamine D2 receptor and tyrosine hydroxylase expression."
    Naha N., Lee H.Y., Hwang J.S., Bahk J.Y., Park M.S., Lee S.Y., Kim S.H., Kim M.O.
    Neurol Res 31:289-299(2009) [PubMed] [Europe PMC] [Abstract]
• response to toxic substance Source: RGDInferred from expression patternⁱ
  • "Changes in neurotransmitter receptor expression levels in rat brain after 4-week exposure to 1-bromopropane."
    Mohideen S.S., Ichihara S., Banu S., Liu F., Kitoh J., Ichihara G.
    Neurotoxicology 30:1078-1083(2009) [PubMed] [Europe PMC] [Abstract]
• response to xenobiotic stimulus Source: BHF-UCLInferred from direct assayⁱ
  • "Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics."
    Sokoloff P., Giros B., Martres M.-P., Bouthenet M.-L., Schwartz J.-C.
    Nature 347:146-151(1990) [PubMed] [Europe PMC] [Abstract]
• sensory perception of smell Source: RGD
• startle response Source: RGD
• striatum development Source: RGDInferred from expression patternⁱ
  • "Expression and function of dopamine receptors in the developing medial frontal cortex and striatum of the rat."
    Sillivan S.E., Konradi C.
    Neuroscience 199:501-514(2011) [PubMed] [Europe PMC] [Abstract]
• synapse assembly Source: BHF-UCLInferred from expression patternⁱ
  • "D1- and D2-like dopamine receptors are co-localized on the presynaptic varicosities of striatal and nucleus accumbens neurons in vitro."
    Wong A.C., Shetreat M.E., Clarke J.O., Rayport S.
    Neuroscience 89:221-233(1999) [PubMed] [Europe PMC] [Abstract]
• temperature homeostasis Source: RGD
• visual learning Source: RGD
• Wnt signaling pathway Source: RGDInferred from direct assayⁱ
  • "Activation of the canonical Wnt pathway by the antipsychotics haloperidol and clozapine involves dishevelled-3."
    Sutton L.P., Honardoust D., Mouyal J., Rajakumar N., Rushlow W.J.
    J Neurochem 102:153-169(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: RGDInferred from physical interactionⁱ
  • "Schizophrenia, amphetamine-induced sensitized state and acute amphetamine exposure all show a common alteration: increased dopamine D2 receptor dimerization."
    Wang M., Pei L., Fletcher P.J., Kapur S., Seeman P., Liu F.
    Mol Brain 3:25-25(2010) [PubMed] [Europe PMC] [Abstract]
• ionotropic glutamate receptor binding Source: RGDInferred from physical interactionⁱ
  • "Modulation of D2R-NR2B interactions in response to cocaine."
    Liu X.Y., Chu X.P., Mao L.M., Wang M., Lan H.X., Li M.H., Zhang G.C., Parelkar N.K., Fibuch E.E., Haines M., Neve K.A., Liu F., Xiong Z.G., Wang J.Q.
    Neuron 52:897-909(2006) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: RGDInferred from physical interactionⁱ
  • "Modulation of D2R-NR2B interactions in response to cocaine."
    Liu X.Y., Chu X.P., Mao L.M., Wang M., Lan H.X., Li M.H., Zhang G.C., Parelkar N.K., Fibuch E.E., Haines M., Neve K.A., Liu F., Xiong Z.G., Wang J.Q.
    Neuron 52:897-909(2006) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDPLNLSWYD DDLERQNWSR PFNGSEGKAD RPHYNYYAML LTLLIFIIVF 
        60         70         80         90        100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW 
       110        120        130        140        150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR 
       160        170        180        190        200
RVTVMIAIVW VLSFTISCPL LFGLNNTDQN ECIIANPAFV VYSSIVSFYV 
       210        220        230        240        250
PFIVTLLVYI KIYIVLRKRR KRVNTKRSSR AFRANLKTPL KGNCTHPEDM 
       260        270        280        290        300
KLCTVIMKSN GSFPVNRRRM DAARRAQELE MEMLSSTSPP ERTRYSPIPP 
       310        320        330        340        350
SHHQLTLPDP SHHGLHSNPD SPAKPEKNGH AKIVNPRIAK FFEIQTMPNG 
       360        370        380        390        400
KTRTSLKTMS RRKLSQQKEK KATQMLAIVL GVFIICWLPF FITHILNIHC 
       410        420        430        440 
DCNIPPVLYS AFTWLGYVNS AVNPIIYTTF NIEFRKAFMK ILHC       

        10         20         30         40         50
MDPLNLSWYD DDLERQNWSR PFNGSEGKAD RPHYNYYAML LTLLIFIIVF 
        60         70         80         90        100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW 
       110        120        130        140        150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR 
       160        170        180        190        200
RVTVMIAIVW VLSFTISCPL LFGLNNTDQN ECIIANPAFV VYSSIVSFYV 
       210        220        230        240        250
PFIVTLLVYI KIYIVLRKRR KRVNTKRSSR AFRANLKTPL KDAARRAQEL 
       260        270        280        290        300
EMEMLSSTSP PERTRYSPIP PSHHQLTLPD PSHHGLHSNP DSPAKPEKNG 
       310        320        330        340        350
HAKIVNPRIA KFFEIQTMPN GKTRTSLKTM SRRKLSQQKE KKATQMLAIV 
       360        370        380        390        400
LGVFIICWLP FFITHILNIH CDCNIPPVLY SAFTWLGYVN SAVNPIIYTT 
       410 
FNIEFRKAFM KILHC                                       

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. SIMILARITY comments
   Index of protein domains and families