D(2) dopamine receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• dopamine binding Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 17174299
• dopamine neurotransmitter receptor activity Source: RGDInferred from mutant phenotypeⁱ
  • 16490190
• dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 8302280
• drug binding Source: BHF-UCLInferred from direct assayⁱ
  • 1975644
• ionotropic glutamate receptor binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 17145509
• protein heterodimerization activity Source: RGDInferred from physical interactionⁱ
  • 22986162
• protein homodimerization activity Source: RGDInferred from direct assayⁱ
  • 20813060
• signaling receptor binding Source: RGDInferred from physical interactionⁱ
  • 17145509

GO - Biological processⁱ

• acid secretion Source: BHF-UCLInferred from direct assayⁱ
  • 8302280
• activation of protein kinase activity Source: RGDInferred from direct assayⁱ
  • 12086672
• adenohypophysis development Source: Ensembl
• adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • 2410769
• adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGDInferred from direct assayⁱ
  • 12086672
• adrenergic receptor signaling pathway Source: GOC
• adult walking behavior Source: Ensembl
• arachidonic acid secretion Source: Ensembl
• auditory behavior Source: RGDInferred from mutant phenotypeⁱ
  • 17142301
• autophagy Source: RGDInferred from direct assayⁱ
  • 26649942
• axonogenesis Source: Ensembl
• behavioral response to cocaine Source: GO_Central
• behavioral response to ethanol Source: GO_Central
• branching morphogenesis of a nerve Source: Ensembl
• cellular potassium ion homeostasis Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence <br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • 2162345
• cerebral cortex GABAergic interneuron migration Source: Ensembl
• circadian regulation of gene expression Source: Ensembl
• dopamine metabolic process Source: Ensembl
• dopamine receptor signaling pathway Source: RGDInferred from direct assayⁱ
  • 12121979
  • 17314300
• drinking behavior Source: RGDInferred from direct assayⁱ
  • 12944496
• forebrain development Source: RGDInferred from mutant phenotypeⁱ
  • 17175142
• G-protein coupled receptor internalization Source: RGDInferred from direct assayⁱ
  • 14617818
• grooming behavior Source: Ensembl
• locomotory behavior Source: RGDInferred from mutant phenotypeⁱ
  • 16530737
• long-term memory Source: RGDInferred from mutant phenotypeⁱ
  • 17118678
• modulation of chemical synaptic transmission Source: RGDInferred from direct assayⁱ
  • 17314300
• negative regulation of blood pressure Source: Ensembl
• negative regulation of cell death Source: RGDInferred from direct assayⁱ
  • 27638511
• negative regulation of cell migration Source: Ensembl
• negative regulation of cell proliferation Source: Ensembl
• negative regulation of circadian sleep/wake cycle, sleep Source: RGDInferred from direct assayⁱ
  • 12944496
• negative regulation of cytosolic calcium ion concentration Source: RGDInferred from mutant phenotypeⁱ
  • 15681393
• negative regulation of dopamine receptor signaling pathway Source: Ensembl
• negative regulation of dopamine secretion Source: RGDInferred from mutant phenotypeⁱ
  • 16490190
• negative regulation of innate immune response Source: Ensembl
• negative regulation of insulin secretion Source: RGDInferred from mutant phenotypeⁱ
  • 18216393
• negative regulation of protein kinase B signaling Source: Ensembl
• negative regulation of protein phosphorylation Source: RGDInferred from mutant phenotypeⁱ
  • 26277342
• negative regulation of synaptic transmission, glutamatergic Source: GO_Central
• negative regulation of voltage-gated calcium channel activity Source: BHF-UCLInferred from direct assayⁱ
  • 2162345
• neurological system process involved in regulation of systemic arterial blood pressure Source: Ensembl
• neuron-neuron synaptic transmission Source: Ensembl
• orbitofrontal cortex development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 22015925
• peristalsis Source: Ensembl
• phospholipase C-activating dopamine receptor signaling pathway Source: GO_Central
• pigmentation Source: Ensembl
• positive regulation of cytokinesis Source: Ensembl
• positive regulation of dopamine uptake involved in synaptic transmission Source: Ensembl
• positive regulation of ERK1 and ERK2 cascade Source: RGDInferred from mutant phenotypeⁱ
  • 18809670
• positive regulation of glial cell-derived neurotrophic factor secretion Source: Ensembl
• positive regulation of G-protein coupled receptor protein signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • 18809670
• positive regulation of growth hormone secretion Source: Ensembl
• positive regulation of long-term synaptic potentiation Source: RGDInferred from mutant phenotypeⁱ
  • 20377617
• positive regulation of mitotic nuclear division Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 8302280
• positive regulation of multicellular organism growth Source: Ensembl
• positive regulation of neuroblast proliferation Source: Ensembl
• positive regulation of neurogenesis Source: RGDInferred from direct assayⁱ
  • 27638511
• positive regulation of receptor internalization Source: RGDInferred from mutant phenotypeⁱ
  • 18809670
• positive regulation of renal sodium excretion Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from direct assayⁱ
  • 12388421
• positive regulation of urine volume Source: Ensembl
• prepulse inhibition Source: Ensembl
• protein localization Source: Ensembl
• regulation of heart rate Source: Ensembl
• regulation of locomotion involved in locomotory behavior Source: RGDInferred from mutant phenotypeⁱ
  • 22394078
• regulation of long-term neuronal synaptic plasticity Source: Ensembl
• regulation of MAPK cascade Source: RGDInferred from direct assayⁱ
  • 12121979
• regulation of phosphoprotein phosphatase activity Source: RGDInferred from mutant phenotypeⁱ
  • 12435803
• regulation of potassium ion transport Source: BHF-UCLInferred from direct assayⁱ
  • 2162345
  • 8371717
• regulation of sodium ion transport Source: Ensembl
• regulation of synapse structural plasticity Source: RGDInferred from direct assayⁱ
  • 22216301
• regulation of synaptic transmission, GABAergic Source: Ensembl
• regulation of synaptic vesicle exocytosis Source: Ensembl
• release of sequestered calcium ion into cytosol Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 8371717
• response to amphetamine Source: RGDInferred from expression patternⁱ
  • 19145071
• response to axon injury Source: RGDInferred from expression patternⁱ
  • 19500946
• response to drug Source: BHF-UCLInferred from direct assayⁱ
  • 1975644
• response to ethanol Source: RGDInferred from expression patternⁱ
  • 18536982
• response to histamine Source: Ensembl
• response to hypoxia Source: RGDInferred from mutant phenotypeⁱ
  • 15681393
• response to inactivity Source: RGDInferred from expression patternⁱ
  • 17511973
• response to iron ion Source: RGDInferred from expression patternⁱ
  • 19022977
• response to morphine Source: Ensembl
• response to nicotine Source: RGDInferred from expression patternⁱ
  • 19406037
• response to toxic substance Source: RGDInferred from expression patternⁱ
  • 19576243
• sensory perception of smell Source: Ensembl
• striatum development Source: RGDInferred from expression patternⁱ
  • 22015925
• synapse assembly Source: BHF-UCLInferred from expression patternⁱ
  • 10051231
• synaptic transmission, dopaminergic Source: RGDInferred from direct assayⁱ
  • 17314300
• temperature homeostasis Source: Ensembl
• visual learning Source: Ensembl
• Wnt signaling pathway Source: RGDInferred from direct assayⁱ
  • 17472703

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• ionotropic glutamate receptor binding Source: RGDInferred from physical interactionⁱ
  • 17145509
• protein heterodimerization activity Source: RGDInferred from physical interactionⁱ
  • 22986162
• protein homodimerization activity Source: RGDInferred from direct assayⁱ
  • 20813060
• signaling receptor binding Source: RGDInferred from physical interactionⁱ
  • 17145509

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDPLNLSWYD DDLERQNWSR PFNGSEGKAD RPHYNYYAML LTLLIFIIVF 
        60         70         80         90        100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW 
       110        120        130        140        150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR 
       160        170        180        190        200
RVTVMIAIVW VLSFTISCPL LFGLNNTDQN ECIIANPAFV VYSSIVSFYV 
       210        220        230        240        250
PFIVTLLVYI KIYIVLRKRR KRVNTKRSSR AFRANLKTPL KGNCTHPEDM 
       260        270        280        290        300
KLCTVIMKSN GSFPVNRRRM DAARRAQELE MEMLSSTSPP ERTRYSPIPP 
       310        320        330        340        350
SHHQLTLPDP SHHGLHSNPD SPAKPEKNGH AKIVNPRIAK FFEIQTMPNG 
       360        370        380        390        400
KTRTSLKTMS RRKLSQQKEK KATQMLAIVL GVFIICWLPF FITHILNIHC 
       410        420        430        440 
DCNIPPVLYS AFTWLGYVNS AVNPIIYTTF NIEFRKAFMK ILHC       

        10         20         30         40         50
MDPLNLSWYD DDLERQNWSR PFNGSEGKAD RPHYNYYAML LTLLIFIIVF 
        60         70         80         90        100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW 
       110        120        130        140        150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR 
       160        170        180        190        200
RVTVMIAIVW VLSFTISCPL LFGLNNTDQN ECIIANPAFV VYSSIVSFYV 
       210        220        230        240        250
PFIVTLLVYI KIYIVLRKRR KRVNTKRSSR AFRANLKTPL KDAARRAQEL 
       260        270        280        290        300
EMEMLSSTSP PERTRYSPIP PSHHQLTLPD PSHHGLHSNP DSPAKPEKNG 
       310        320        330        340        350
HAKIVNPRIA KFFEIQTMPN GKTRTSLKTM SRRKLSQQKE KKATQMLAIV 
       360        370        380        390        400
LGVFIICWLP FFITHILNIH CDCNIPPVLY SAFTWLGYVN SAVNPIIYTT 
       410 
FNIEFRKAFM KILHC                                       

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries