D(2) dopamine receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• adrenergic receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• dopamine binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 15716360
• dopamine neurotransmitter receptor activity Source: MGIInferred from direct assayⁱ
  • 18671743
• dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: MGIInferred from direct assayⁱ
  • 11015197
  • 12930822
  • 1980140
  • 7566118
  • 8001143
  • 8294904
  • 8836575
  • 11069937
  • 12476322
  • 1991517
  • 7706278
• drug binding Source: MGI
• G protein-coupled receptor activity Source: MGIInferred from direct assayⁱ
  • 14712229
• identical protein binding Source: MGI
• ionotropic glutamate receptor binding Source: MGI
• protein heterodimerization activity Source: MGI
• protein homodimerization activity Source: MGI
• signaling receptor binding Source: MGI

GO - Biological processⁱ

• acid secretion Source: MGI
• activation of protein kinase activity Source: MGI
• adenohypophysis development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 9140068
• adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: MGIInferred from direct assayⁱ
  • 12665504
• adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: MGI
• adult behavior Source: MGIInferred from mutant phenotypeⁱ
  • 11303741
• adult walking behavior Source: MGIInferred from mutant phenotypeⁱ
  • 7566118
• arachidonic acid secretion Source: MGI
• associative learning Source: MGIInferred from mutant phenotypeⁱ
  • 12084937
  • 12182883
  • 15061865
• auditory behavior Source: MGI
• autophagy Source: MGI
• axonogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 11438590
• behavioral response to cocaine Source: MGIInferred from mutant phenotypeⁱ
  • 17426149
• behavioral response to ethanol Source: MGIInferred from mutant phenotypeⁱ
  • 11105945
  • 11166059
  • 12837020
• branching morphogenesis of a nerve Source: MGIInferred from mutant phenotypeⁱ
  • 11438590
• cerebral cortex GABAergic interneuron migration Source: MGIInferred from mutant phenotypeⁱ
  • 17409246
• circadian regulation of gene expression Source: MGIInferred from mutant phenotypeⁱ
  • 16606840
• dopamine metabolic process Source: MGIInferred from mutant phenotypeⁱ
  • 7925842
• dopamine receptor signaling pathway Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 11089973
• drinking behavior Source: MGI
• feeding behavior Source: MGIInferred from genetic interactionⁱ
  • 15272078
• forebrain development Source: MGI
• G protein-coupled receptor internalization Source: MGI
• G protein-coupled receptor signaling pathway Source: MGIInferred from direct assayⁱ
  • 14712229
• grooming behavior Source: MGIInferred from mutant phenotypeⁱ
  • 10698004
• intracellular signal transduction Source: MGI
• locomotory behavior Source: MGIInferred from mutant phenotypeⁱ
  • 10471093
  • 10698004
  • 11166059
  • 11557166
  • 12084937
  • 12175868
  • 12185400
  • 12837020
  • 15080900
  • 9547254
  • 11069937
• long-term memory Source: MGI
• modulation of chemical synaptic transmission Source: MGIInferred from mutant phenotypeⁱ
  • 10974427
• negative regulation of adenylate cyclase activity Source: MGI
• negative regulation of blood pressure Source: MGIInferred from mutant phenotypeⁱ
  • 11566895
• negative regulation of cell death Source: MGI
• negative regulation of cell migration Source: MGIInferred from mutant phenotypeⁱ
  • 17409246
• negative regulation of cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • 10537166
  • 9140068
  • 9247267
  • 9247268
  • 9717839
• negative regulation of circadian sleep/wake cycle, sleep Source: MGI
• negative regulation of cytosolic calcium ion concentration Source: MGI
• negative regulation of dopamine receptor signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • 11089973
• negative regulation of dopamine secretion Source: MGI
• negative regulation of innate immune response Source: CACAOInferred from mutant phenotypeⁱ
  • 23242137
• negative regulation of insulin secretion Source: MGI
• negative regulation of protein kinase B signaling Source: MGIInferred from mutant phenotypeⁱ
  • 17251429
• negative regulation of protein phosphorylation Source: MGI
• negative regulation of protein secretion Source: MGI
• negative regulation of synaptic transmission, glutamatergic Source: MGIInferred from mutant phenotypeⁱ
  • 11160501
  • 15489038
• negative regulation of voltage-gated calcium channel activity Source: MGI
• neurological system process involved in regulation of systemic arterial blood pressure Source: MGIInferred from mutant phenotypeⁱ
  • 11566895
• neuron-neuron synaptic transmission Source: MGIInferred from mutant phenotypeⁱ
  • 12084937
• orbitofrontal cortex development Source: Ensembl
• peristalsis Source: MGIInferred from mutant phenotypeⁱ
  • 16525059
• phospholipase C-activating dopamine receptor signaling pathway Source: MGIInferred from direct assayⁱ
  • 15016423
• pigmentation Source: MGIInferred from mutant phenotypeⁱ
  • 9140068
• positive regulation of cytokinesis Source: MGI
• positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: MGI
• positive regulation of dopamine uptake involved in synaptic transmission Source: MGIInferred from mutant phenotypeⁱ
  • 9886065
• positive regulation of ERK1 and ERK2 cascade Source: MGI
• positive regulation of glial cell-derived neurotrophic factor secretion Source: MGI
• positive regulation of G protein-coupled receptor signaling pathway Source: MGI
• positive regulation of growth hormone secretion Source: MGIInferred from mutant phenotypeⁱ
  • 11897683
• positive regulation of long-term synaptic potentiation Source: MGI
• positive regulation of multicellular organism growth Source: MGIInferred from mutant phenotypeⁱ
  • 11897683
• positive regulation of neuroblast proliferation Source: MGIInferred from direct assayⁱ
  • 17426594
• positive regulation of neurogenesis Source: MGI
• positive regulation of receptor internalization Source: MGI
• positive regulation of renal sodium excretion Source: MGIInferred from mutant phenotypeⁱ
  • 11566895
• positive regulation of transcription by RNA polymerase II Source: MGI
• positive regulation of urine volume Source: MGIInferred from mutant phenotypeⁱ
  • 11566895
• postsynaptic modulation of chemical synaptic transmission Source: MGI
• prepulse inhibition Source: MGIInferred from mutant phenotypeⁱ
  • 10341260
  • 12417685
  • 17712281
  • 12476322
• protein localization Source: MGIInferred from mutant phenotypeⁱ
  • 10828532
• regulation of dopamine secretion Source: MGIInferred from mutant phenotypeⁱ
  • 11943831
• regulation of dopamine uptake involved in synaptic transmission Source: MGIInferred from mutant phenotypeⁱ
  • 12223553
• regulation of heart rate Source: MGIInferred from mutant phenotypeⁱ
  • 11566895
• regulation of locomotion involved in locomotory behavior Source: MGI
• regulation of long-term neuronal synaptic plasticity Source: MGIInferred from mutant phenotypeⁱ
  • 9169514
• regulation of MAPK cascade Source: MGI
• regulation of neurotransmitter uptake Source: SynGOInferred from direct assayⁱ
  • 12223553
• regulation of phosphoprotein phosphatase activity Source: MGI
• regulation of potassium ion transport Source: MGIInferred from mutant phenotypeⁱ
  • 11566895
• regulation of sodium ion transport Source: MGIInferred from mutant phenotypeⁱ
  • 11566895
• regulation of synapse structural plasticity Source: MGI
• regulation of synaptic transmission, GABAergic Source: MGIInferred from mutant phenotypeⁱ
  • 15080900
  • 15489038
• regulation of synaptic vesicle exocytosis Source: SynGOInferred from direct assayⁱ
  • 22586226
  • 12223553
• release of sequestered calcium ion into cytosol Source: MGI
• response to amphetamine Source: MGIInferred from mutant phenotypeⁱ
  • 18486343
  • 12476322
• response to axon injury Source: Ensembl
• response to cocaine Source: MGIInferred from direct assayⁱ
  • 18671743
• response to drug Source: MGIInferred from direct assayⁱ
  • 7549459
• response to histamine Source: MGI
• response to hypoxia Source: MGI
• response to inactivity Source: Ensembl
• response to iron ion Source: Ensembl
• response to light stimulus Source: MGIInferred from mutant phenotypeⁱ
  • 16715079
• response to morphine Source: MGIInferred from mutant phenotypeⁱ
  • 11264672
  • 11567069
  • 12182883
  • 9252189
  • 11943831
• response to nicotine Source: Ensembl
• sensory perception of smell Source: MGIInferred from mutant phenotypeⁱ
  • 16765459
• startle response Source: MGIInferred from mutant phenotypeⁱ
  • 17712281
• striatum development Source: Ensembl
• synapse assembly Source: Ensembl
• synaptic transmission, dopaminergic Source: MGI
• temperature homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • 10471093
  • 18486343
• visual learning Source: MGIInferred from mutant phenotypeⁱ
  • 12097513
• Wnt signaling pathway Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• identical protein binding Source: MGI
• ionotropic glutamate receptor binding Source: MGI
• protein heterodimerization activity Source: MGI
• protein homodimerization activity Source: MGI
• signaling receptor binding Source: MGI

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDPLNLSWYD DDLERQNWSR PFNGSEGKPD RPHYNYYAML LTLLIFIIVF 
        60         70         80         90        100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW 
       110        120        130        140        150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR 
       160        170        180        190        200
RVTVMIAIVW VLSFTISCPL LFGLNNTDQN ECIIANPAFV VYSSIVSFYV 
       210        220        230        240        250
PFIVTLLVYI KIYIVLRKRR KRVNTKRSSR AFRANLKTPL KGNCTHPEDM 
       260        270        280        290        300
KLCTVIMKSN GSFPVNRRRM DAARRAQELE MEMLSSTSPP ERTRYSPIPP 
       310        320        330        340        350
SHHQLTLPDP SHHGLHSNPD SPAKPEKNGH AKIVNPRIAK FFEIQTMPNG 
       360        370        380        390        400
KTRTSLKTMS RRKLSQQKEK KATQMLAIVL GVFIICWLPF FITHILNIHC 
       410        420        430        440 
DCNIPPVLYS AFTWLGYVNS AVNPIIYTTF NIEFRKAFMK ILHC       

        10         20         30         40         50
MDPLNLSWYD DDLERQNWSR PFNGSEGKPD RPHYNYYAML LTLLIFIIVF 
        60         70         80         90        100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW 
       110        120        130        140        150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR 
       160        170        180        190        200
RVTVMIAIVW VLSFTISCPL LFGLNNTDQN ECIIANPAFV VYSSIVSFYV 
       210        220        230        240        250
PFIVTLLVYI KIYIVLRKRR KRVNTKRSSR AFRANLKTPL KDAARRAQEL 
       260        270        280        290        300
EMEMLSSTSP PERTRYSPIP PSHHQLTLPD PSHHGLHSNP DSPAKPEKNG 
       310        320        330        340        350
HAKIVNPRIA KFFEIQTMPN GKTRTSLKTM SRRKLSQQKE KKATQMLAIV 
       360        370        380        390        400
LGVFIICWLP FFITHILNIH CDCNIPPVLY SAFTWLGYVN SAVNPIIYTT 
       410 
FNIEFRKAFM KILHC                                       

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
3. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries