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Protein

Alpha-centractin

Gene

ACTR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-8854518 AURKA Activation by TPX2
SignaLinkiP61163

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-centractin
Short name:
Centractin
Alternative name(s):
ARP1
Actin-RPV
Centrosome-associated actin homolog
Gene namesi
Name:ACTR1A
Synonyms:CTRN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000138107.11
HGNCiHGNC:167 ACTR1A
MIMi605143 gene
neXtProtiNX_P61163

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi10121
OpenTargetsiENSG00000138107
PharmGKBiPA24486

Polymorphism and mutation databases

BioMutaiACTR1A
DMDMi47117651

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000890581 – 376Alpha-centractinAdd BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61163
MaxQBiP61163
PaxDbiP61163
PeptideAtlasiP61163
PRIDEiP61163
ProteomicsDBi57270

2D gel databases

OGPiP42024
REPRODUCTION-2DPAGEiIPI00029468
UCD-2DPAGEiP61163

PTM databases

iPTMnetiP61163
PhosphoSitePlusiP61163
SwissPalmiP61163

Expressioni

Gene expression databases

BgeeiENSG00000138107
CleanExiHS_ACTR1A
ExpressionAtlasiP61163 baseline and differential
GenevisibleiP61163 HS

Organism-specific databases

HPAiCAB037193
HPA047443

Interactioni

Subunit structurei

Interacts with BCCIP (isoform 2/alpha).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DCTN1Q142034EBI-774234,EBI-724352

Protein-protein interaction databases

BioGridi115425, 84 interactors
CORUMiP61163
IntActiP61163, 32 interactors
MINTiP61163
STRINGi9606.ENSP00000358921

Structurei

3D structure databases

ProteinModelPortaliP61163
SMRiP61163
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiP61163
KOiK16575
OMAiKIKYPME
OrthoDBiEOG091G08LD
PhylomeDBiP61163
TreeFamiTF300420

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
IPR029909 Arp1
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF195 PTHR11937:SF195, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

P61163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESYDVIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHVRVMAG
60 70 80 90 100
ALEGDIFIGP KAEEHRGLLS IRYPMEHGIV KDWNDMERIW QYVYSKDQLQ
110 120 130 140 150
TFSEEHPVLL TEAPLNPRKN RERAAEVFFE TFNVPALFIS MQAVLSLYAT
160 170 180 190 200
GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI MRIDIAGRDV SRFLRLYLRK
210 220 230 240 250
EGYDFHSSSE FEIVKAIKER ACYLSINPQK DETLETEKAQ YYLPDGSTIE
260 270 280 290 300
IGPSRFRAPE LLFRPDLIGE ESEGIHEVLV FAIQKSDMDL RRTLFSNIVL
310 320 330 340 350
SGGSTLFKGF GDRLLSEVKK LAPKDVKIRI SAPQERLYST WIGGSILASL
360 370
DTFKKMWVSK KEYEEDGARS IHRKTF
Length:376
Mass (Da):42,614
Last modified:May 10, 2004 - v1
Checksum:i4A978E7AB3739436
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82206 mRNA Translation: CAA57690.1
Z14978 mRNA Translation: CAA78701.1
AK312506 mRNA Translation: BAG35407.1
AL121928 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49685.1
BC000693 mRNA Translation: AAH00693.1
BC026016 mRNA Translation: AAH26016.1
CCDSiCCDS7536.1
PIRiS29089
RefSeqiNP_005727.1, NM_005736.3
UniGeneiHs.153961

Genome annotation databases

EnsembliENST00000369905; ENSP00000358921; ENSG00000138107
GeneIDi10121
KEGGihsa:10121
UCSCiuc001kvv.4 human

Similar proteinsi

Entry informationi

Entry nameiACTZ_HUMAN
AccessioniPrimary (citable) accession number: P61163
Secondary accession number(s): B2R6B0, P42024
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: July 18, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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