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Entry version 164 (07 Oct 2020)
Sequence version 1 (10 May 2004)
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Protein

Alpha-centractin

Gene

ACTR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P61163

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2132295, MHC class II antigen presentation
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-6807878, COPI-mediated anterograde transport
R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic
R-HSA-8854518, AURKA Activation by TPX2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P61163

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-centractin
Short name:
Centractin
Alternative name(s):
ARP1
Actin-RPV
Centrosome-associated actin homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACTR1A
Synonyms:CTRN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138107.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:167, ACTR1A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605143, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P61163

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10121

Open Targets

More...
OpenTargetsi
ENSG00000138107

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24486

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P61163, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ACTR1A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47117651

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000890581 – 376Alpha-centractinAdd BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P61163

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P61163

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P61163

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P61163

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P61163

PeptideAtlas

More...
PeptideAtlasi
P61163

PRoteomics IDEntifications database

More...
PRIDEi
P61163

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57270

2D gel databases

USC-OGP 2-DE database

More...
OGPi
P42024

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00029468

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P61163

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P61163

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
P61163

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P61163

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P61163

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138107, Expressed in cortical plate and 248 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P61163, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P61163, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000138107, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BCCIP (isoform 2/alpha).

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115425, 119 interactors

Protein interaction database and analysis system

More...
IntActi
P61163, 59 interactors

Molecular INTeraction database

More...
MINTi
P61163

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358921

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P61163, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P61163

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the actin family. ARP1 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0676, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155782

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027965_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P61163

KEGG Orthology (KO)

More...
KOi
K16575

Identification of Orthologs from Complete Genome Data

More...
OMAi
DWNDMEK

Database of Orthologous Groups

More...
OrthoDBi
649708at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P61163

TreeFam database of animal gene trees

More...
TreeFami
TF300420

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004000, Actin
IPR020902, Actin/actin-like_CS
IPR004001, Actin_CS
IPR043129, ATPase_NBD

The PANTHER Classification System

More...
PANTHERi
PTHR11937, PTHR11937, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00022, Actin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00190, ACTIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00268, ACTIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53067, SSF53067, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00432, ACTINS_2, 1 hit
PS01132, ACTINS_ACT_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P61163-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESYDVIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHVRVMAG
60 70 80 90 100
ALEGDIFIGP KAEEHRGLLS IRYPMEHGIV KDWNDMERIW QYVYSKDQLQ
110 120 130 140 150
TFSEEHPVLL TEAPLNPRKN RERAAEVFFE TFNVPALFIS MQAVLSLYAT
160 170 180 190 200
GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI MRIDIAGRDV SRFLRLYLRK
210 220 230 240 250
EGYDFHSSSE FEIVKAIKER ACYLSINPQK DETLETEKAQ YYLPDGSTIE
260 270 280 290 300
IGPSRFRAPE LLFRPDLIGE ESEGIHEVLV FAIQKSDMDL RRTLFSNIVL
310 320 330 340 350
SGGSTLFKGF GDRLLSEVKK LAPKDVKIRI SAPQERLYST WIGGSILASL
360 370
DTFKKMWVSK KEYEEDGARS IHRKTF
Length:376
Mass (Da):42,614
Last modified:May 10, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A978E7AB3739436
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GMT0R4GMT0_HUMAN
Alpha-centractin
ACTR1A
332Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVS3A0A1B0GVS3_HUMAN
Alpha-centractin
ACTR1A
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X82206 mRNA Translation: CAA57690.1
Z14978 mRNA Translation: CAA78701.1
AK312506 mRNA Translation: BAG35407.1
AL121928 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49685.1
BC000693 mRNA Translation: AAH00693.1
BC026016 mRNA Translation: AAH26016.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7536.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S29089

NCBI Reference Sequences

More...
RefSeqi
NP_005727.1, NM_005736.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369905; ENSP00000358921; ENSG00000138107

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10121

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10121

UCSC genome browser

More...
UCSCi
uc001kvv.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82206 mRNA Translation: CAA57690.1
Z14978 mRNA Translation: CAA78701.1
AK312506 mRNA Translation: BAG35407.1
AL121928 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49685.1
BC000693 mRNA Translation: AAH00693.1
BC026016 mRNA Translation: AAH26016.1
CCDSiCCDS7536.1
PIRiS29089
RefSeqiNP_005727.1, NM_005736.3

3D structure databases

SMRiP61163
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115425, 119 interactors
IntActiP61163, 59 interactors
MINTiP61163
STRINGi9606.ENSP00000358921

PTM databases

iPTMnetiP61163
MetOSiteiP61163
PhosphoSitePlusiP61163
SwissPalmiP61163

Polymorphism and mutation databases

BioMutaiACTR1A
DMDMi47117651

2D gel databases

OGPiP42024
REPRODUCTION-2DPAGEiIPI00029468
UCD-2DPAGEiP61163

Proteomic databases

EPDiP61163
jPOSTiP61163
MassIVEiP61163
MaxQBiP61163
PaxDbiP61163
PeptideAtlasiP61163
PRIDEiP61163
ProteomicsDBi57270

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31450, 257 antibodies

The DNASU plasmid repository

More...
DNASUi
10121

Genome annotation databases

EnsembliENST00000369905; ENSP00000358921; ENSG00000138107
GeneIDi10121
KEGGihsa:10121
UCSCiuc001kvv.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10121
DisGeNETi10121
EuPathDBiHostDB:ENSG00000138107.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ACTR1A
HGNCiHGNC:167, ACTR1A
HPAiENSG00000138107, Low tissue specificity
MIMi605143, gene
neXtProtiNX_P61163
OpenTargetsiENSG00000138107
PharmGKBiPA24486

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0676, Eukaryota
GeneTreeiENSGT00940000155782
HOGENOMiCLU_027965_0_1_1
InParanoidiP61163
KOiK16575
OMAiDWNDMEK
OrthoDBi649708at2759
PhylomeDBiP61163
TreeFamiTF300420

Enzyme and pathway databases

PathwayCommonsiP61163
ReactomeiR-HSA-2132295, MHC class II antigen presentation
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-6807878, COPI-mediated anterograde transport
R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic
R-HSA-8854518, AURKA Activation by TPX2
SignaLinkiP61163

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
10121, 486 hits in 886 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ACTR1A, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ACTR1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10121
PharosiP61163, Tbio

Protein Ontology

More...
PROi
PR:P61163
RNActiP61163, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138107, Expressed in cortical plate and 248 other tissues
ExpressionAtlasiP61163, baseline and differential
GenevisibleiP61163, HS

Family and domain databases

InterProiView protein in InterPro
IPR004000, Actin
IPR020902, Actin/actin-like_CS
IPR004001, Actin_CS
IPR043129, ATPase_NBD
PANTHERiPTHR11937, PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022, Actin, 1 hit
PRINTSiPR00190, ACTIN
SMARTiView protein in SMART
SM00268, ACTIN, 1 hit
SUPFAMiSSF53067, SSF53067, 2 hits
PROSITEiView protein in PROSITE
PS00432, ACTINS_2, 1 hit
PS01132, ACTINS_ACT_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACTZ_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61163
Secondary accession number(s): B2R6B0, P42024
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: October 7, 2020
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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