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Protein

Actin-related protein 2

Gene

ACTR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi160 – 162ATPBy similarity3
Nucleotide bindingi214 – 218ATPBy similarity5
Nucleotide bindingi305 – 310ATPBy similarity6

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • ATP binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionActin-binding
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-6798695 Neutrophil degranulation
R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkiP61160
SIGNORiP61160

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2
Alternative name(s):
Actin-like protein 2
Gene namesi
Name:ACTR2
Synonyms:ARP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000138071.13
HGNCiHGNC:169 ACTR2
MIMi604221 gene
neXtProtiNX_P61160

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi10097
OpenTargetsiENSG00000138071
PharmGKBiPA24488

Chemistry databases

ChEMBLiCHEMBL6090
DrugBankiDB08235 N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide

Polymorphism and mutation databases

BioMutaiACTR2
DMDMi47117648

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000890671 – 394Actin-related protein 2Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei299N6-acetyllysineCombined sources1
Modified residuei322N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61160
MaxQBiP61160
PaxDbiP61160
PeptideAtlasiP61160
PRIDEiP61160
ProteomicsDBi57269

2D gel databases

SWISS-2DPAGEiP61160

PTM databases

iPTMnetiP61160
PhosphoSitePlusiP61160
SwissPalmiP61160

Expressioni

Gene expression databases

BgeeiENSG00000138071 Expressed in 243 organ(s), highest expression level in blood
CleanExiHS_ACTR2
ExpressionAtlasiP61160 baseline and differential
GenevisibleiP61160 HS

Organism-specific databases

HPAiCAB005083
HPA015050

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115404, 148 interactors
CORUMiP61160
DIPiDIP-33165N
IntActiP61160, 87 interactors
MINTiP61160
STRINGi9606.ENSP00000367220

Structurei

3D structure databases

ProteinModelPortaliP61160
SMRiP61160
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP2 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0677 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00910000144135
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiP61160
KOiK17260
OMAiHLVDVEQ
OrthoDBiEOG091G08WH
PhylomeDBiP61160
TreeFamiTF300467

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR027306 Arp2
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF149 PTHR11937:SF149, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P61160-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSQGRKVVV CDNGTGFVKC GYAGSNFPEH IFPALVGRPI IRSTTKVGNI
60 70 80 90 100
EIKDLMVGDE ASELRSMLEV NYPMENGIVR NWDDMKHLWD YTFGPEKLNI
110 120 130 140 150
DTRNCKILLT EPPMNPTKNR EKIVEVMFET YQFSGVYVAI QAVLTLYAQG
160 170 180 190 200
LLTGVVVDSG DGVTHICPVY EGFSLPHLTR RLDIAGRDIT RYLIKLLLLR
210 220 230 240 250
GYAFNHSADF ETVRMIKEKL CYVGYNIEQE QKLALETTVL VESYTLPDGR
260 270 280 290 300
IIKVGGERFE APEALFQPHL INVEGVGVAE LLFNTIQAAD IDTRSEFYKH
310 320 330 340 350
IVLSGGSTMY PGLPSRLERE LKQLYLERVL KGDVEKLSKF KIRIEDPPRR
360 370 380 390
KHMVFLGGAV LADIMKDKDN FWMTRQEYQE KGVRVLEKLG VTVR
Length:394
Mass (Da):44,761
Last modified:May 10, 2004 - v1
Checksum:i1BFA6B442ED1A797
GO
Isoform 2 (identifier: P61160-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-53: K → KNNKKM

Note: No experimental confirmation available.
Show »
Length:399
Mass (Da):45,377
Checksum:iCF06512483DAD60A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H6T1F5H6T1_HUMAN
ARP2 actin-related protein 2 homolo...
ACTR2 hCG_21224
339Annotation score:
A0A1B0GWD0A0A1B0GWD0_HUMAN
Actin-related protein 2
ACTR2
53Annotation score:
A0A1B0GWH0A0A1B0GWH0_HUMAN
Actin-related protein 2
ACTR2
65Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67M → T in AAH14546 (PubMed:15489334).Curated1
Sequence conflicti172G → S in AAH14546 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04617853K → KNNKKM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006082 mRNA Translation: AAB64187.1
AK315205 mRNA Translation: BAG37642.1
BX649080 mRNA No translation available.
AC007318 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99908.1
CH471053 Genomic DNA Translation: EAW99910.1
CH471053 Genomic DNA Translation: EAW99912.1
CH471053 Genomic DNA Translation: EAW99913.1
BC014546 mRNA Translation: AAH14546.1
CCDSiCCDS1881.1 [P61160-1]
CCDS46307.1 [P61160-2]
RefSeqiNP_001005386.1, NM_001005386.2 [P61160-2]
NP_005713.1, NM_005722.3 [P61160-1]
UniGeneiHs.643727
Hs.744913

Genome annotation databases

EnsembliENST00000260641; ENSP00000260641; ENSG00000138071 [P61160-1]
ENST00000377982; ENSP00000367220; ENSG00000138071 [P61160-2]
GeneIDi10097
KEGGihsa:10097
UCSCiuc002sdp.4 human [P61160-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006082 mRNA Translation: AAB64187.1
AK315205 mRNA Translation: BAG37642.1
BX649080 mRNA No translation available.
AC007318 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99908.1
CH471053 Genomic DNA Translation: EAW99910.1
CH471053 Genomic DNA Translation: EAW99912.1
CH471053 Genomic DNA Translation: EAW99913.1
BC014546 mRNA Translation: AAH14546.1
CCDSiCCDS1881.1 [P61160-1]
CCDS46307.1 [P61160-2]
RefSeqiNP_001005386.1, NM_001005386.2 [P61160-2]
NP_005713.1, NM_005722.3 [P61160-1]
UniGeneiHs.643727
Hs.744913

3D structure databases

ProteinModelPortaliP61160
SMRiP61160
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115404, 148 interactors
CORUMiP61160
DIPiDIP-33165N
IntActiP61160, 87 interactors
MINTiP61160
STRINGi9606.ENSP00000367220

Chemistry databases

ChEMBLiCHEMBL6090
DrugBankiDB08235 N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide

PTM databases

iPTMnetiP61160
PhosphoSitePlusiP61160
SwissPalmiP61160

Polymorphism and mutation databases

BioMutaiACTR2
DMDMi47117648

2D gel databases

SWISS-2DPAGEiP61160

Proteomic databases

EPDiP61160
MaxQBiP61160
PaxDbiP61160
PeptideAtlasiP61160
PRIDEiP61160
ProteomicsDBi57269

Protocols and materials databases

DNASUi10097
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260641; ENSP00000260641; ENSG00000138071 [P61160-1]
ENST00000377982; ENSP00000367220; ENSG00000138071 [P61160-2]
GeneIDi10097
KEGGihsa:10097
UCSCiuc002sdp.4 human [P61160-1]

Organism-specific databases

CTDi10097
DisGeNETi10097
EuPathDBiHostDB:ENSG00000138071.13
GeneCardsiACTR2
HGNCiHGNC:169 ACTR2
HPAiCAB005083
HPA015050
MIMi604221 gene
neXtProtiNX_P61160
OpenTargetsiENSG00000138071
PharmGKBiPA24488
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0677 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00910000144135
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiP61160
KOiK17260
OMAiHLVDVEQ
OrthoDBiEOG091G08WH
PhylomeDBiP61160
TreeFamiTF300467

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-6798695 Neutrophil degranulation
R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkiP61160
SIGNORiP61160

Miscellaneous databases

ChiTaRSiACTR2 human
GeneWikiiACTR2
GenomeRNAii10097
PROiPR:P61160
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138071 Expressed in 243 organ(s), highest expression level in blood
CleanExiHS_ACTR2
ExpressionAtlasiP61160 baseline and differential
GenevisibleiP61160 HS

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR027306 Arp2
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF149 PTHR11937:SF149, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS01132 ACTINS_ACT_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARP2_HUMAN
AccessioniPrimary (citable) accession number: P61160
Secondary accession number(s): B2RCP5
, D6W5F4, E9PF41, O15142, Q96C82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 12, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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