UniProtKB - P61149 (FGF1_RAT)
Fibroblast growth factor 1
Fgf1
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 33 | HeparinBy similarity | 1 |
GO - Molecular functioni
- fibroblast growth factor receptor binding Source: UniProtKB
- growth factor activity Source: RGD
- heparin binding Source: UniProtKB
- Hsp70 protein binding Source: RGD
- integrin binding Source: UniProtKB
- S100 protein binding Source: UniProtKB
GO - Biological processi
- activation of MAPK activity Source: UniProtKB
- activation of protein kinase B activity Source: UniProtKB
- angiogenesis Source: UniProtKB-KW
- animal organ morphogenesis Source: GO_Central
- branch elongation involved in ureteric bud branching Source: UniProtKB
- cell differentiation Source: GO_Central
- cellular response to heat Source: UniProtKB
- fibroblast growth factor receptor signaling pathway Source: UniProtKB
- lung development Source: RGD
- mesonephric epithelium development Source: UniProtKB
- organ induction Source: RGD
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of cell division Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of cholesterol biosynthetic process Source: UniProtKB
- positive regulation of endothelial cell migration Source: UniProtKB
- positive regulation of epithelial cell proliferation Source: RGD
- positive regulation of gene expression Source: GO_Central
- positive regulation of hepatocyte proliferation Source: UniProtKB
- positive regulation of intracellular signal transduction Source: UniProtKB
- positive regulation of MAP kinase activity Source: RGD
- positive regulation of protein phosphorylation Source: RGD
- positive regulation of sprouting angiogenesis Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of cell migration Source: GO_Central
- regulation of endothelial cell chemotaxis to fibroblast growth factor Source: RGD
- regulation of endothelial tube morphogenesis Source: UniProtKB
- wound healing Source: RGD
Keywordsi
Molecular function | Developmental protein, Growth factor, Heparin-binding, Mitogen |
Biological process | Angiogenesis, Differentiation |
Enzyme and pathway databases
Reactomei | R-RNO-109704, PI3K Cascade R-RNO-1257604, PIP3 activates AKT signaling R-RNO-190322, FGFR4 ligand binding and activation R-RNO-190370, FGFR1b ligand binding and activation R-RNO-190371, FGFR3b ligand binding and activation R-RNO-190372, FGFR3c ligand binding and activation R-RNO-190373, FGFR1c ligand binding and activation R-RNO-190375, FGFR2c ligand binding and activation R-RNO-190377, FGFR2b ligand binding and activation R-RNO-5654219, Phospholipase C-mediated cascade: FGFR1 R-RNO-5654221, Phospholipase C-mediated cascade, FGFR2 R-RNO-5654227, Phospholipase C-mediated cascade, FGFR3 R-RNO-5654228, Phospholipase C-mediated cascade, FGFR4 R-RNO-5654687, Downstream signaling of activated FGFR1 R-RNO-5654688, SHC-mediated cascade:FGFR1 R-RNO-5654689, PI-3K cascade:FGFR1 R-RNO-5654693, FRS-mediated FGFR1 signaling R-RNO-5654695, PI-3K cascade:FGFR2 R-RNO-5654699, SHC-mediated cascade:FGFR2 R-RNO-5654700, FRS-mediated FGFR2 signaling R-RNO-5654704, SHC-mediated cascade:FGFR3 R-RNO-5654706, FRS-mediated FGFR3 signaling R-RNO-5654710, PI-3K cascade:FGFR3 R-RNO-5654712, FRS-mediated FGFR4 signaling R-RNO-5654719, SHC-mediated cascade:FGFR4 R-RNO-5654720, PI-3K cascade:FGFR4 R-RNO-5654726, Negative regulation of FGFR1 signaling R-RNO-5654727, Negative regulation of FGFR2 signaling R-RNO-5654732, Negative regulation of FGFR3 signaling R-RNO-5654733, Negative regulation of FGFR4 signaling R-RNO-5673001, RAF/MAP kinase cascade R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Fibroblast growth factor 1Short name: FGF-1 Alternative name(s): Acidic fibroblast growth factor Short name: aFGF Heparin-binding growth factor 1 Short name: HBGF-1 |
Gene namesi | Name:Fgf1 Synonyms:Fgf-1, Fgfa |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2605, Fgf1 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol By similarity
Extracellular region or secreted
- Secreted 1 Publication
Other locations
- Cytoplasm By similarity
- cell cortex By similarity
Note: Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu2+ ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59 (By similarity).By similarity
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- extracellular matrix Source: RGD
- extracellular region Source: UniProtKB
- extracellular space Source: UniProtKB
Nucleus
- nucleolus Source: RGD
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
Other locations
- cell cortex Source: UniProtKB-SubCell
- cytoplasm Source: RGD
Keywords - Cellular componenti
Cytoplasm, Nucleus, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
PropeptideiPRO_0000008916 | 2 – 15 | By similarityAdd BLAST | 14 | |
ChainiPRO_0000008917 | 16 – 155 | Fibroblast growth factor 1Add BLAST | 140 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | P61149 |
PRIDEi | P61149 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000013867, Expressed in heart and 19 other tissues |
Genevisiblei | P61149, RN |
Interactioni
Subunit structurei
Monomer. Homodimer.
Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
Found in a complex with FGFBP1, FGF1 and FGF2.
Interacts with FGFBP1.
Part of a Cu2+-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1.
Interacts with SYT1.
Interacts with S100A13 (By similarity).
Interacts with LRRC59 (By similarity).
Interacts with CSNKA, CSNKB and FIBP (By similarity). While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1.
Forms a ternary complex with FGFR1 and ITGAV:ITGB3 and induces the recruitment of PTPN11 to the complex (By similarity).
By similarityGO - Molecular functioni
- fibroblast growth factor receptor binding Source: UniProtKB
- growth factor activity Source: RGD
- Hsp70 protein binding Source: RGD
- integrin binding Source: UniProtKB
- S100 protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 247356, 1 interactor |
IntActi | P61149, 2 interactors |
MINTi | P61149 |
STRINGi | 10116.ENSRNOP00000018577 |
Structurei
Secondary structure
3D structure databases
BMRBi | P61149 |
SMRi | P61149 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P61149 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 127 – 143 | Heparin-bindingBy similarityAdd BLAST | 17 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3885, Eukaryota |
GeneTreei | ENSGT00940000160557 |
InParanoidi | P61149 |
OMAi | KHADKNW |
OrthoDBi | 1157770at2759 |
PhylomeDBi | P61149 |
TreeFami | TF317805 |
Family and domain databases
CDDi | cd00058, FGF, 1 hit |
InterProi | View protein in InterPro IPR028210, FGF1 IPR002209, Fibroblast_GF_fam IPR008996, IL1/FGF |
PANTHERi | PTHR11486, PTHR11486, 1 hit PTHR11486:SF86, PTHR11486:SF86, 1 hit |
Pfami | View protein in Pfam PF00167, FGF, 1 hit |
PRINTSi | PR00263, HBGFFGF |
SMARTi | View protein in SMART SM00442, FGF, 1 hit |
SUPFAMi | SSF50353, SSF50353, 1 hit |
PROSITEi | View protein in PROSITE PS00247, HBGF_FGF, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAEGEITTFA ALTERFNLPL GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR
60 70 80 90 100
DRSDQHIQLQ LSAESAGEVY IKGTETGQYL AMDTEGLLYG SQTPNEECLF
110 120 130 140 150
LERLEENHYN TYTSKKHAEK NWFVGLKKNG SCKRGPRTHY GQKAILFLPL
PVSSD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14232 mRNA Translation: CAA32448.1 |
PIRi | S04147 |
RefSeqi | NP_036978.1, NM_012846.1 XP_006254712.1, XM_006254650.3 XP_006254713.1, XM_006254651.3 XP_006254714.1, XM_006254652.3 |
Genome annotation databases
Ensembli | ENSRNOT00000018577; ENSRNOP00000018577; ENSRNOG00000013867 ENSRNOT00000087408; ENSRNOP00000070685; ENSRNOG00000013867 |
GeneIDi | 25317 |
KEGGi | rno:25317 |
UCSCi | RGD:2605, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14232 mRNA Translation: CAA32448.1 |
PIRi | S04147 |
RefSeqi | NP_036978.1, NM_012846.1 XP_006254712.1, XM_006254650.3 XP_006254713.1, XM_006254651.3 XP_006254714.1, XM_006254652.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2J3P | X-ray | 1.40 | A/B | 22-155 | [»] | |
2UUS | X-ray | 2.20 | A/B | 22-153 | [»] | |
BMRBi | P61149 | |||||
SMRi | P61149 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 247356, 1 interactor |
IntActi | P61149, 2 interactors |
MINTi | P61149 |
STRINGi | 10116.ENSRNOP00000018577 |
Proteomic databases
PaxDbi | P61149 |
PRIDEi | P61149 |
Genome annotation databases
Ensembli | ENSRNOT00000018577; ENSRNOP00000018577; ENSRNOG00000013867 ENSRNOT00000087408; ENSRNOP00000070685; ENSRNOG00000013867 |
GeneIDi | 25317 |
KEGGi | rno:25317 |
UCSCi | RGD:2605, rat |
Organism-specific databases
CTDi | 2246 |
RGDi | 2605, Fgf1 |
Phylogenomic databases
eggNOGi | KOG3885, Eukaryota |
GeneTreei | ENSGT00940000160557 |
InParanoidi | P61149 |
OMAi | KHADKNW |
OrthoDBi | 1157770at2759 |
PhylomeDBi | P61149 |
TreeFami | TF317805 |
Enzyme and pathway databases
Reactomei | R-RNO-109704, PI3K Cascade R-RNO-1257604, PIP3 activates AKT signaling R-RNO-190322, FGFR4 ligand binding and activation R-RNO-190370, FGFR1b ligand binding and activation R-RNO-190371, FGFR3b ligand binding and activation R-RNO-190372, FGFR3c ligand binding and activation R-RNO-190373, FGFR1c ligand binding and activation R-RNO-190375, FGFR2c ligand binding and activation R-RNO-190377, FGFR2b ligand binding and activation R-RNO-5654219, Phospholipase C-mediated cascade: FGFR1 R-RNO-5654221, Phospholipase C-mediated cascade, FGFR2 R-RNO-5654227, Phospholipase C-mediated cascade, FGFR3 R-RNO-5654228, Phospholipase C-mediated cascade, FGFR4 R-RNO-5654687, Downstream signaling of activated FGFR1 R-RNO-5654688, SHC-mediated cascade:FGFR1 R-RNO-5654689, PI-3K cascade:FGFR1 R-RNO-5654693, FRS-mediated FGFR1 signaling R-RNO-5654695, PI-3K cascade:FGFR2 R-RNO-5654699, SHC-mediated cascade:FGFR2 R-RNO-5654700, FRS-mediated FGFR2 signaling R-RNO-5654704, SHC-mediated cascade:FGFR3 R-RNO-5654706, FRS-mediated FGFR3 signaling R-RNO-5654710, PI-3K cascade:FGFR3 R-RNO-5654712, FRS-mediated FGFR4 signaling R-RNO-5654719, SHC-mediated cascade:FGFR4 R-RNO-5654720, PI-3K cascade:FGFR4 R-RNO-5654726, Negative regulation of FGFR1 signaling R-RNO-5654727, Negative regulation of FGFR2 signaling R-RNO-5654732, Negative regulation of FGFR3 signaling R-RNO-5654733, Negative regulation of FGFR4 signaling R-RNO-5673001, RAF/MAP kinase cascade R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Miscellaneous databases
EvolutionaryTracei | P61149 |
PROi | PR:P61149 |
Gene expression databases
Bgeei | ENSRNOG00000013867, Expressed in heart and 19 other tissues |
Genevisiblei | P61149, RN |
Family and domain databases
CDDi | cd00058, FGF, 1 hit |
InterProi | View protein in InterPro IPR028210, FGF1 IPR002209, Fibroblast_GF_fam IPR008996, IL1/FGF |
PANTHERi | PTHR11486, PTHR11486, 1 hit PTHR11486:SF86, PTHR11486:SF86, 1 hit |
Pfami | View protein in Pfam PF00167, FGF, 1 hit |
PRINTSi | PR00263, HBGFFGF |
SMARTi | View protein in SMART SM00442, FGF, 1 hit |
SUPFAMi | SSF50353, SSF50353, 1 hit |
PROSITEi | View protein in PROSITE PS00247, HBGF_FGF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FGF1_RAT | |
Accessioni | P61149Primary (citable) accession number: P61149 Secondary accession number(s): P10935 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | May 10, 2004 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families