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Protein

Alpha-synuclein

Gene

SNCA

Organism
Pan paniscus (Pygmy chimpanzee) (Bonobo)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May be involved in the regulation of dopamine release and transport.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi2CopperBy similarity1
Metal bindingi50CopperBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-synuclein
Gene namesi
Name:SNCA
OrganismiPan paniscus (Pygmy chimpanzee) (Bonobo)
Taxonomic identifieri9597 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000240080 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane, Nucleus, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840271 – 140Alpha-synucleinAdd BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei87PhosphoserineBy similarity1
Modified residuei125Phosphotyrosine; by FYNBy similarity1
Modified residuei129Phosphoserine; by PLK2By similarity1

Post-translational modificationi

Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress (By similarity).By similarity
Ubiquitinated. The predominant conjugate is the diubiquitinated form (By similarity).By similarity
Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Interactioni

Subunit structurei

Interacts with UCHL1.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP61144
SMRiP61144
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00390000016161
HOVERGENiHBG000481
KOiK04528
OrthoDBiEOG091G11PA

Family and domain databases

InterProiView protein in InterPro
IPR001058 Synuclein
IPR002460 Synuclein_alpha
PANTHERiPTHR13820 PTHR13820, 1 hit
PTHR13820:SF5 PTHR13820:SF5, 1 hit
PfamiView protein in Pfam
PF01387 Synuclein, 1 hit
PRINTSiPR01212 ASYNUCLEIN
PR01211 SYNUCLEIN

Sequencei

Sequence statusi: Complete.

P61144-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH
60 70 80 90 100
GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL
110 120 130 140
GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Length:140
Mass (Da):14,460
Last modified:May 10, 2004 - v1
Checksum:i6BB2F12128931663
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY362299
, AY362295, AY362296, AY362297, AY362298 Genomic DNA Translation: AAQ85068.1
RefSeqiXP_003829936.1, XM_003829888.2
XP_003829937.1, XM_003829889.2
XP_003829938.1, XM_003829890.2
XP_008953542.1, XM_008955294.1

Genome annotation databases

EnsembliENSPPAT00000027770; ENSPPAP00000006465; ENSPPAG00000025110
GeneIDi100984304
KEGGipps:100984304

Similar proteinsi

Entry informationi

Entry nameiSYUA_PANPA
AccessioniPrimary (citable) accession number: P61144
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: July 18, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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