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UniProtKB - P61132 (SIAT6_PANTR)
Protein
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
Gene
ST3GAL3
Organism
Pan troglodytes (Chimpanzee)
Status
Functioni
Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc.
By similarityCatalytic activityi
- a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + CMP-N-acetyl-β-neuraminate = an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + CMP + H+By similarityEC:2.4.99.6By similarity
: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
GO - Molecular functioni
- N-acetyllactosaminide alpha-2,3-sialyltransferase activity Source: UniProtKB-EC
- sialyltransferase activity Source: GO_Central
GO - Biological processi
- protein glycosylation Source: GO_Central
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Protein family/group databases
CAZyi | GT29, Glycosyltransferase Family 29 |
Names & Taxonomyi
Protein namesi | Recommended name: CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (EC:2.4.99.6By similarity)Alternative name(s): Beta-galactoside alpha-2,3-sialyltransferase 3 Short name: Alpha 2,3-ST 3 Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase N-acetyllactosaminide alpha-2,3-sialyltransferase ST3Gal III Short name: ST3GalIII ST3N Sialyltransferase 6 |
Gene namesi | Name:ST3GAL3 Synonyms:SIAT6 |
Organismi | Pan troglodytes (Chimpanzee) |
Taxonomic identifieri | 9598 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan |
Proteomesi |
|
Subcellular locationi
Golgi apparatus
- Golgi stack membrane By similarity; Single-pass type II membrane protein By similarity
Extracellular region or secreted
- Secreted By similarity
Note: Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Golgi apparatus
- Golgi cisterna membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 8 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 9 – 28 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 20 | |
Topological domaini | 29 – 375 | LumenalSequence analysisAdd BLAST | 347 |
Keywords - Cellular componenti
Golgi apparatus, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000149268 | 1 – 375 | CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferaseAdd BLAST | 375 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 80 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 160 ↔ 314 | By similarity | ||
Glycosylationi | 171 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
The soluble form derives from the membrane form by proteolytic processing.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinFamily & Domainsi
Sequence similaritiesi
Belongs to the glycosyltransferase 29 family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2692, Eukaryota |
InParanoidi | P61132 |
Family and domain databases
Gene3Di | 3.90.1480.20, 1 hit |
InterProi | View protein in InterPro IPR001675, Glyco_trans_29 IPR038578, GT29-like_sf IPR012163, Sialyl_trans |
Pfami | View protein in Pfam PF00777, Glyco_transf_29, 1 hit |
PIRSFi | PIRSF005557, Sialyl_trans, 1 hit |
i Sequence
Sequence statusi: Complete.
P61132-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLLVFVRNL LLALCLFLVL GFLYYSAWKL HLLQWEEDSN SVVLSFDSAG
60 70 80 90 100
QTLGSEYDRL GFLLNLDSKL PAELATKYAN FSEGACKPGY ASALMTAIFP
110 120 130 140 150
RFSKPAPMFL DDSFRKWARI REFVPPFGIK GQDNLIKAIL SVTKEYRLTP
160 170 180 190 200
ALDSLRCRRC IIVGNGGVLA NKSLGSRIDD YDIVVRLNSA PVKGFEKDVG
210 220 230 240 250
SKTTLRITYP EGAMQRPEQY ERDSLFVLAG FKWQDFKWLK YIVYKERVSA
260 270 280 290 300
SDGFWKSVAT RVPKEPPEIR ILNPYFIQEA AFTLIGLPFN NGLMGRGNIP
310 320 330 340 350
TLGSVAVTMA LHGCDEVAVA GFGYDMSTPN APLHYYETVR MAAIKESWTH
360 370
NIQREKEFLR KLVKARVITD LSSGI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ626819 mRNA Translation: CAF25177.1 |
RefSeqi | NP_001032376.1, NM_001037299.1 XP_016807822.1, XM_016952333.1 |
Genome annotation databases
GeneIDi | 456832 |
KEGGi | ptr:456832 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ626819 mRNA Translation: CAF25177.1 |
RefSeqi | NP_001032376.1, NM_001037299.1 XP_016807822.1, XM_016952333.1 |
3D structure databases
SMRi | P61132 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9598.ENSPTRP00000054125 |
Protein family/group databases
CAZyi | GT29, Glycosyltransferase Family 29 |
Genome annotation databases
GeneIDi | 456832 |
KEGGi | ptr:456832 |
Organism-specific databases
CTDi | 6487 |
Phylogenomic databases
eggNOGi | KOG2692, Eukaryota |
InParanoidi | P61132 |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Family and domain databases
Gene3Di | 3.90.1480.20, 1 hit |
InterProi | View protein in InterPro IPR001675, Glyco_trans_29 IPR038578, GT29-like_sf IPR012163, Sialyl_trans |
Pfami | View protein in Pfam PF00777, Glyco_transf_29, 1 hit |
PIRSFi | PIRSF005557, Sialyl_trans, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SIAT6_PANTR | |
Accessioni | P61132Primary (citable) accession number: P61132 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | May 10, 2004 | |
Last modified: | April 7, 2021 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families