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Protein

Zinc finger CCCH domain-containing protein 6

Gene

ZC3H6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri273 – 299C3H1-type 1PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri301 – 328C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri329 – 352C3H1-type 3PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 6
Gene namesi
Name:ZC3H6
Synonyms:KIAA2035, ZC3HDC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000188177.13
HGNCiHGNC:24762 ZC3H6
neXtProtiNX_P61129

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188177
PharmGKBiPA142670510

Polymorphism and mutation databases

BioMutaiZC3H6
DMDMi332278115

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139011 – 1189Zinc finger CCCH domain-containing protein 6Add BLAST1189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1158PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP61129
MaxQBiP61129
PaxDbiP61129
PeptideAtlasiP61129
PRIDEiP61129
ProteomicsDBi57267

PTM databases

iPTMnetiP61129
PhosphoSitePlusiP61129
SwissPalmiP61129

Expressioni

Gene expression databases

BgeeiENSG00000188177
CleanExiHS_ZC3H6
GenevisibleiP61129 HS

Organism-specific databases

HPAiHPA036019
HPA036020
HPA076065

Interactioni

Protein-protein interaction databases

BioGridi132014, 1 interactor
STRINGi9606.ENSP00000386764

Structurei

3D structure databases

ProteinModelPortaliP61129
SMRiP61129
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili27 – 73Sequence analysisAdd BLAST47
Coiled coili353 – 385Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi388 – 545Pro-richAdd BLAST158

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri273 – 299C3H1-type 1PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri301 – 328C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri329 – 352C3H1-type 3PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1040 Eukaryota
COG5084 LUCA
GeneTreeiENSGT00530000063288
HOGENOMiHOG000231733
HOVERGENiHBG063914
InParanoidiP61129
OMAiQKNFDPR
OrthoDBiEOG091G01AA
PhylomeDBiP61129
TreeFamiTF321641

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF00642 zf-CCCH, 2 hits
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 3 hits
SUPFAMiSSF90229 SSF90229, 3 hits
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 3 hits

Sequencei

Sequence statusi: Complete.

P61129-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDSEHAGHD REDGELEDGE IDDAGFEEIQ EKEAKENEKQ KSEKAYRKSR
60 70 80 90 100
KKHKKEREKK KSKRRKREKH KHNSPSSDDS SDYSLDSDVE HTESSHKKRT
110 120 130 140 150
GFYRDYDIPF TQRGHISGSY ITSKKGQHNK KFKSKEYDEY STYSDDNFGN
160 170 180 190 200
YSDDNFGNYG QETEEDFANQ LKQYRQAKET SNIALGSSFS KESGKKQRMK
210 220 230 240 250
GVQQGIEQRV KSFNVGRGRG LPKKIKRKER GGRTNKGPNV FSVSDDFQEY
260 270 280 290 300
NKPGKKWKVM TQEFINQHTV EHKGKQICKY FLEGRCIKGD QCKFDHDAEL
310 320 330 340 350
EKRKEICKFY LQGYCTKGEN CIYMHNEFPC KFYHSGAKCY QGDNCKFSHD
360 370 380 390 400
DLTKETKKLL DKVLNTDEEL INEDERELEE LRKRGITPLP KPPPGVGLLP
410 420 430 440 450
TPPEHFPFSD PEDDFQTDFS DDFRKIPSLF EIVVKPTVDL AHKIGRKPPA
460 470 480 490 500
FYTSASPPGP QFQGSSPHPQ HIYSSGSSPG PGPNMSQGHS SPVMHPGSPG
510 520 530 540 550
HHPCAGPPGL PVPQSPPLPP GPPEIVGPQN QAGVLVQPDT SLTPPSMGGA
560 570 580 590 600
YHSPGFPGHV MKVPRENHCS PGSSYQQSPG EMQLNTNYES LQNPAEFYDN
610 620 630 640 650
YYAQHSIHNF QPPNNSGDGM WHGEFAQQQP PVVQDSPNHG SGSDGSSTRT
660 670 680 690 700
GHGPLPVPGL LPAVQRALFV RLTQRYQEDE EQTSTQPHRA PSKEEDDTVN
710 720 730 740 750
WYSSSEEEEG SSVKSILKTL QKQTETLRNQ QQPSTELSTP TDPRLAKEKS
760 770 780 790 800
KGNQVVDPRL RTIPRQDIRK PSESAPLDLR LAWDPRKLRG NGSGHIGSSV
810 820 830 840 850
GGAKFDLHHA NAGTNVKHKR GDDDDEDTER ELREKAFLIP LDASPGIMLQ
860 870 880 890 900
DPRSQLRQFS HIKMDITLTK PNFAKHIVWA PEDLLPVPLP KPDPVSSINL
910 920 930 940 950
PLPPLIADQR LNRLWNTKSD LHQNTVSIDP KLAAKAKINT TNREGYLEQF
960 970 980 990 1000
GDSHGSGAKL GDPRLQKNFD PRLHRLPNTE SHQVVMKDSH ASKGAPHLPR
1010 1020 1030 1040 1050
SNPGSSQPSG AGTSNSGSGA LPPYAPKLSS SAGLPLGTST SVLSGISLYD
1060 1070 1080 1090 1100
PRDHGSSSTS ELATASSGEN SKNQKKSGGL KSSDKTEPSP GEAILPQKPS
1110 1120 1130 1140 1150
PNVGVTLEGP ADPQADVPRS SGKVQVPAVH SLPVQALTGL IRPQYSDPRQ
1160 1170 1180
ARQPGQGSPT PDNDPGRETD DKSLKEVFKT FDPTASPFC
Length:1,189
Mass (Da):131,670
Last modified:May 3, 2011 - v2
Checksum:i474CCCD8D9E4C466
GO

Sequence cautioni

The sequence BAC85608 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC87128 differs from that shown. Reason: Frameshift at position 1120.Curated
The sequence BAC87128 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti741T → A in BAC85608 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115115 Genomic DNA No translation available.
AB111887 mRNA Translation: BAC98375.1
BC155540 mRNA Translation: AAI55541.1
BC167154 mRNA Translation: AAI67154.1
AK123404 mRNA Translation: BAC85608.1 Different initiation.
AK127776 mRNA Translation: BAC87128.1 Sequence problems.
CCDSiCCDS46393.1
RefSeqiNP_940983.2, NM_198581.2
UniGeneiHs.190477

Genome annotation databases

EnsembliENST00000343936; ENSP00000340298; ENSG00000188177
ENST00000409871; ENSP00000386764; ENSG00000188177
GeneIDi376940
KEGGihsa:376940
UCSCiuc002thq.2 human

Similar proteinsi

Entry informationi

Entry nameiZC3H6_HUMAN
AccessioniPrimary (citable) accession number: P61129
Secondary accession number(s): A9JR71, Q6ZW96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 3, 2011
Last modified: June 20, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM

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