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Protein

Ras-related protein Rab-14

Gene

Rab14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26GTPCurated9
Nucleotide bindingi66 – 70GTPCurated5
Nucleotide bindingi124 – 127GTPCurated4
Nucleotide bindingi154 – 156GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-14
Gene namesi
Name:Rab14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620881 Rab14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi25S → N: Mimicks the GTP-bound state and is enriched in the Golgi region. 1 Publication1
Mutagenesisi70Q → L: Mimicks the GDP-bound state. 1 Publication1
Mutagenesisi124N → I: Enriched in the Golgi region. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001211872 – 215Ras-related protein Rab-14Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Lipidationi213S-geranylgeranyl cysteineBy similarity1
Modified residuei215Cysteine methyl esterBy similarity1
Lipidationi215S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP61107
PRIDEiP61107

PTM databases

iPTMnetiP61107
PhosphoSitePlusiP61107
SwissPalmiP61107

Expressioni

Tissue specificityi

Widely expressed (at protein level). Highest levels found in whole brain, spinal cord, heart, kidney and lung.

Interactioni

Subunit structurei

Interacts with KIF16B. Interacts with ZFYVE20 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NISCHQ9Y2I19EBI-917845,EBI-2688731From Homo sapiens.

Protein-protein interaction databases

BioGridi250177, 3 interactors
IntActiP61107, 6 interactors
MINTiP61107
STRINGi10116.ENSRNOP00000025649

Structurei

3D structure databases

ProteinModelPortaliP61107
SMRiP61107
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 48Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0097 Eukaryota
COG1100 LUCA
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP61107
KOiK07881
PhylomeDBiP61107

Family and domain databases

CDDicd04122 Rab14, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR030702 Rab14
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PANTHERiPTHR24073:SF654 PTHR24073:SF654, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P61107-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATTPYNYSY IFKYIIIGDM GVGKSCLLHQ FTEKKFMADC PHTIGVEFGT
60 70 80 90 100
RIIEVSGQKI KLQIWDTAGQ ERFRAVTRSY YRGAAGALMV YDITRRSTYN
110 120 130 140 150
HLSSWLTDAR NLTNPNTVII LIGNKADLEA QRDVTYEEAK QFAEENGLLF
160 170 180 190 200
LEASAKTGEN VEDAFLEAAK KIYQNIQDGS LDLNAAESGV QHKPSAPQGG
210
RLTSEPQPQR EGCGC
Length:215
Mass (Da):23,927
Last modified:January 23, 2007 - v3
Checksum:iB435AAC6F562B007
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0BMW0B0BMW0_RAT
RAB14, member RAS oncogene family
Rab14 rCG_45389
215Annotation score:
A0A1B0GWR3A0A1B0GWR3_RAT
Ras-related protein Rab-14
Rab14
88Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83680 mRNA Translation: AAA41994.1
PIRiE42148
RefSeqiNP_446041.1, NM_053589.1
UniGeneiRn.163656
Rn.6008

Genome annotation databases

GeneIDi94197
KEGGirno:94197
UCSCiRGD:620881 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83680 mRNA Translation: AAA41994.1
PIRiE42148
RefSeqiNP_446041.1, NM_053589.1
UniGeneiRn.163656
Rn.6008

3D structure databases

ProteinModelPortaliP61107
SMRiP61107
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250177, 3 interactors
IntActiP61107, 6 interactors
MINTiP61107
STRINGi10116.ENSRNOP00000025649

PTM databases

iPTMnetiP61107
PhosphoSitePlusiP61107
SwissPalmiP61107

Proteomic databases

PaxDbiP61107
PRIDEiP61107

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi94197
KEGGirno:94197
UCSCiRGD:620881 rat

Organism-specific databases

CTDi51552
RGDi620881 Rab14

Phylogenomic databases

eggNOGiKOG0097 Eukaryota
COG1100 LUCA
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP61107
KOiK07881
PhylomeDBiP61107

Miscellaneous databases

PROiPR:P61107

Family and domain databases

CDDicd04122 Rab14, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR030702 Rab14
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PANTHERiPTHR24073:SF654 PTHR24073:SF654, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB14_RAT
AccessioniPrimary (citable) accession number: P61107
Secondary accession number(s): P35287, Q969L0, Q9UI11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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