UniProtKB - P61106 (RAB14_HUMAN)
Protein
Ras-related protein Rab-14
Gene
RAB14
Organism
Homo sapiens (Human)
Status
Functioni
Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.By similarity1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 18 – 26 | GTP | 9 | |
Nucleotide bindingi | 66 – 70 | GTP | 5 | |
Nucleotide bindingi | 124 – 127 | GTP | 4 | |
Nucleotide bindingi | 154 – 156 | GTP | 3 |
GO - Molecular functioni
- GDP binding Source: UniProtKB
- GTPase activity Source: UniProtKB
- GTP binding Source: UniProtKB
- myosin V binding Source: UniProtKB
GO - Biological processi
- defense response to bacterium Source: InterPro
- endocytic recycling Source: UniProtKB
- fibroblast growth factor receptor signaling pathway Source: UniProtKB
- Golgi to endosome transport Source: UniProtKB
- intracellular protein transport Source: GO_Central
- intracellular transport Source: UniProtKB
- neutrophil degranulation Source: Reactome
- phagolysosome assembly involved in apoptotic cell clearance Source: GO_Central
- phosphatidylinositol biosynthetic process Source: Reactome
- regulation of embryonic development Source: UniProtKB
- regulation of protein localization Source: UniProtKB
- vesicle-mediated transport Source: UniProtKB
Keywordsi
Biological process | Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P61106 |
Reactomei | R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1660499, Synthesis of PIPs at the plasma membrane R-HSA-6798695, Neutrophil degranulation R-HSA-8873719, RAB geranylgeranylation R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
SignaLinki | P61106 |
SIGNORi | P61106 |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-14 |
Gene namesi | Name:RAB14 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000119396.10 |
HGNCi | HGNC:16524, RAB14 |
MIMi | 612673, gene |
neXtProti | NX_P61106 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Lipid-anchor Curated; Cytoplasmic side Curated
- trans-Golgi network membrane 1 Publication; Lipid-anchor Curated; Cytoplasmic side Curated
Endosome
- Recycling endosome 1 Publication
- Early endosome membrane 1 Publication; Lipid-anchor Curated; Cytoplasmic side Curated
Other locations
- phagosome 1 Publication
Note: Recruited to recycling endosomes by DENND6A (PubMed:22595670). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).2 Publications
Cytosol
- cytosol Source: UniProtKB
Endoplasmic reticulum
- rough endoplasmic reticulum Source: UniProtKB
Endosome
- early endosome Source: UniProtKB
- early endosome membrane Source: Reactome
- late endosome Source: UniProtKB
- recycling endosome Source: UniProtKB
- recycling endosome membrane Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
- Golgi stack Source: UniProtKB
- trans-Golgi network Source: InterPro
Lysosome
- lysosomal membrane Source: UniProtKB
- lysosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- endomembrane system Source: GO_Central
- intracellular membrane-bounded organelle Source: HPA
- nuclear outer membrane-endoplasmic reticulum membrane network Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
- phagocytic vesicle Source: UniProtKB
- tertiary granule membrane Source: Reactome
- trans-Golgi network transport vesicle Source: UniProtKB
Keywords - Cellular componenti
Cytoplasmic vesicle, Endosome, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 51552 |
OpenTargetsi | ENSG00000119396 |
PharmGKBi | PA34104 |
Miscellaneous databases
Pharosi | P61106, Tbio |
Polymorphism and mutation databases
BioMutai | RAB14 |
DMDMi | 85700392 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000121185 | 2 – 215 | Ras-related protein Rab-14Add BLAST | 214 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Lipidationi | 213 | S-geranylgeranyl cysteineBy similarity | 1 | |
Modified residuei | 215 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 215 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Acetylation, Lipoprotein, Methylation, PrenylationProteomic databases
EPDi | P61106 |
jPOSTi | P61106 |
MassIVEi | P61106 |
MaxQBi | P61106 |
PaxDbi | P61106 |
PeptideAtlasi | P61106 |
PRIDEi | P61106 |
ProteomicsDBi | 57265 |
PTM databases
iPTMneti | P61106 |
MetOSitei | P61106 |
PhosphoSitePlusi | P61106 |
SwissPalmi | P61106 |
Expressioni
Gene expression databases
Bgeei | ENSG00000119396, Expressed in upper lobe of lung and 258 other tissues |
ExpressionAtlasi | P61106, baseline and differential |
Genevisiblei | P61106, HS |
Organism-specific databases
HPAi | ENSG00000119396, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with KIF16B (By similarity).
Interacts with ZFYVE20.
By similarity2 PublicationsBinary interactionsi
Hide detailsP61106
With | #Exp. | IntAct |
---|---|---|
EXOC5 [O00471] | 6 | EBI-1056404,EBI-949824 |
FAM71C [Q8NEG0] | 3 | EBI-1056404,EBI-752049 |
OCRL [Q01968] | 3 | EBI-1056404,EBI-6148898 |
SH3BP5L [Q7L8J4] | 3 | EBI-1056404,EBI-747389 |
GO - Molecular functioni
- myosin V binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119605, 80 interactors |
DIPi | DIP-42491N |
IntActi | P61106, 37 interactors |
MINTi | P61106 |
STRINGi | 9606.ENSP00000362946 |
Miscellaneous databases
RNActi | P61106, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P61106 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P61106 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 40 – 48 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0097, Eukaryota |
GeneTreei | ENSGT00940000155178 |
InParanoidi | P61106 |
OMAi | QRDVTFE |
OrthoDBi | 1146851at2759 |
PhylomeDBi | P61106 |
TreeFami | TF300032 |
Family and domain databases
CDDi | cd04122, Rab14, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR030702, Rab14 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
PANTHERi | PTHR24073:SF1098, PTHR24073:SF1098, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P61106-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATAPYNYSY IFKYIIIGDM GVGKSCLLHQ FTEKKFMADC PHTIGVEFGT
60 70 80 90 100
RIIEVSGQKI KLQIWDTAGQ ERFRAVTRSY YRGAAGALMV YDITRRSTYN
110 120 130 140 150
HLSSWLTDAR NLTNPNTVII LIGNKADLEA QRDVTYEEAK QFAEENGLLF
160 170 180 190 200
LEASAKTGEN VEDAFLEAAK KIYQNIQDGS LDLNAAESGV QHKPSAPQGG
210
RLTSEPQPQR EGCGC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketX6RFL8 | X6RFL8_HUMAN | Ras-related protein Rab-14 | RAB14 | 181 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012986 | 4 | A → T3 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF152463 mRNA Translation: AAF00150.1 AF203689 mRNA Translation: AAF19400.1 AY553875 mRNA Translation: AAS64573.1 AF112206 mRNA Translation: AAF17194.1 AL162081 mRNA Translation: CAB82414.1 AK023524 mRNA Translation: BAB14598.1 AK090889 mRNA Translation: BAG52243.1 AF498949 mRNA Translation: AAM21097.1 AL137068 Genomic DNA No translation available. CR457394 mRNA Translation: CAG33675.1 CH471090 Genomic DNA Translation: EAW87487.1 BC006081 mRNA Translation: AAH06081.1 |
CCDSi | CCDS6827.1 |
RefSeqi | NP_057406.2, NM_016322.3 |
Genome annotation databases
Ensembli | ENST00000373840; ENSP00000362946; ENSG00000119396 |
GeneIDi | 51552 |
KEGGi | hsa:51552 |
UCSCi | uc004blc.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF152463 mRNA Translation: AAF00150.1 AF203689 mRNA Translation: AAF19400.1 AY553875 mRNA Translation: AAS64573.1 AF112206 mRNA Translation: AAF17194.1 AL162081 mRNA Translation: CAB82414.1 AK023524 mRNA Translation: BAB14598.1 AK090889 mRNA Translation: BAG52243.1 AF498949 mRNA Translation: AAM21097.1 AL137068 Genomic DNA No translation available. CR457394 mRNA Translation: CAG33675.1 CH471090 Genomic DNA Translation: EAW87487.1 BC006081 mRNA Translation: AAH06081.1 |
CCDSi | CCDS6827.1 |
RefSeqi | NP_057406.2, NM_016322.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1Z0F | X-ray | 2.15 | A | 2-175 | [»] | |
4D0G | X-ray | 2.50 | A | 8-180 | [»] | |
4DRZ | X-ray | 2.30 | A | 1-177 | [»] | |
SMRi | P61106 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119605, 80 interactors |
DIPi | DIP-42491N |
IntActi | P61106, 37 interactors |
MINTi | P61106 |
STRINGi | 9606.ENSP00000362946 |
PTM databases
iPTMneti | P61106 |
MetOSitei | P61106 |
PhosphoSitePlusi | P61106 |
SwissPalmi | P61106 |
Polymorphism and mutation databases
BioMutai | RAB14 |
DMDMi | 85700392 |
Proteomic databases
EPDi | P61106 |
jPOSTi | P61106 |
MassIVEi | P61106 |
MaxQBi | P61106 |
PaxDbi | P61106 |
PeptideAtlasi | P61106 |
PRIDEi | P61106 |
ProteomicsDBi | 57265 |
Protocols and materials databases
Antibodypediai | 15967, 159 antibodies |
DNASUi | 51552 |
Genome annotation databases
Ensembli | ENST00000373840; ENSP00000362946; ENSG00000119396 |
GeneIDi | 51552 |
KEGGi | hsa:51552 |
UCSCi | uc004blc.4, human |
Organism-specific databases
CTDi | 51552 |
DisGeNETi | 51552 |
EuPathDBi | HostDB:ENSG00000119396.10 |
GeneCardsi | RAB14 |
HGNCi | HGNC:16524, RAB14 |
HPAi | ENSG00000119396, Low tissue specificity |
MIMi | 612673, gene |
neXtProti | NX_P61106 |
OpenTargetsi | ENSG00000119396 |
PharmGKBi | PA34104 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0097, Eukaryota |
GeneTreei | ENSGT00940000155178 |
InParanoidi | P61106 |
OMAi | QRDVTFE |
OrthoDBi | 1146851at2759 |
PhylomeDBi | P61106 |
TreeFami | TF300032 |
Enzyme and pathway databases
PathwayCommonsi | P61106 |
Reactomei | R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1660499, Synthesis of PIPs at the plasma membrane R-HSA-6798695, Neutrophil degranulation R-HSA-8873719, RAB geranylgeranylation R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
SignaLinki | P61106 |
SIGNORi | P61106 |
Miscellaneous databases
BioGRID-ORCSi | 51552, 37 hits in 826 CRISPR screens |
ChiTaRSi | RAB14, human |
EvolutionaryTracei | P61106 |
GeneWikii | RAB14 |
GenomeRNAii | 51552 |
Pharosi | P61106, Tbio |
PROi | PR:P61106 |
RNActi | P61106, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000119396, Expressed in upper lobe of lung and 258 other tissues |
ExpressionAtlasi | P61106, baseline and differential |
Genevisiblei | P61106, HS |
Family and domain databases
CDDi | cd04122, Rab14, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR030702, Rab14 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
PANTHERi | PTHR24073:SF1098, PTHR24073:SF1098, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RAB14_HUMAN | |
Accessioni | P61106Primary (citable) accession number: P61106 Secondary accession number(s): B3KR31 Q9UI11 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 181 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations