UBE2M

Functionⁱ

Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.2 Publications

Pathwayⁱ: protein neddylation

This protein is involved in the pathway protein neddylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein neddylation and in Protein modification.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	111	Glycyl thioester intermediate		1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
NEDD8 transferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19250909
ubiquitin-protein transferase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15694336

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein modification process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15694336
positive regulation of neuron apoptotic process Source: Ensembl
post-translational protein modification Source: Reactome
protein neddylation
Source: UniProtKB
Inferred from direct assayⁱ
- 19250909

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Ubl conjugation pathway
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS05432-MONOMER
Reactomeⁱ	R-HSA-2173789 TGF-beta receptor signaling activates SMADs R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5676590 NIK-->noncanonical NF-kB signaling R-HSA-8951664 Neddylation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	P61081
UniPathwayⁱ	UPA00885

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: NEDD8-conjugating enzyme Ubc12 (EC:2.3.2.-) Alternative name(s): NEDD8 carrier protein Ubiquitin-conjugating enzyme E2 M
Gene namesⁱ	Name:UBE2M Synonyms:UBC12
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000130725.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12491 UBE2M
MIMⁱ	603173 gene
neXtProtⁱ	NX_P61081

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	1	M → A: No effect on thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	4	L → A: Impairs thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	5	F → A: Strongly impairs thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	6	S → A: Slightly impairs thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	7	L → A: Strongly impairs thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	9	Q → A: Impairs thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	10	Q → A: No effect on thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	11	K → A: No effect on thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	12	K → A: Impairs thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	32	L → A: Strongly impairs thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	35	Q → A: Strongly impairs thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	36	K → A: Strongly impairs thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	38	I → A: Strongly impairs thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	39	N → A: No effect on thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	41	L → A: Strongly impairs thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	51	F → A: Strongly impairs thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	55	D → A: Strongly impairs thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	57	L → A: Strongly impairs thioester intermediate formation. 1 Publication	1
Mutagenesisⁱ	111	C → S: Forms a stable complex with NEDD8, which prevents subsequent NEDD8 conjugation to cullins. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9040
Open Targets More...OpenTargetsⁱ	ENSG00000130725
PharmGKBⁱ	PA37140

Polymorphism and mutation databases

BioMutaⁱ	UBE2M
DMDMⁱ	46577655

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000082488	1 – 183	NEDD8-conjugating enzyme Ubc12Add BLAST		183

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionine2 Publications	1
Modified residueⁱ	3	N6-acetyllysineCombined sources	1
Modified residueⁱ	50	PhosphoserineCombined sources	1
Modified residueⁱ	169	Asymmetric dimethylarginine; alternateBy similarity	1
Modified residueⁱ	169	Omega-N-methylarginine; alternateCombined sources	1

Post-translational modificationⁱ

The acetylation of Met-1 increases affinity for DCUN1D1 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.2 Publications

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	P61081
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P61081
PaxDbⁱ	P61081
PeptideAtlas More...PeptideAtlasⁱ	P61081
PRIDEⁱ	P61081
ProteomicsDBⁱ	57261

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00022597
UCD-2DPAGEⁱ	P61081

PTM databases

iPTMnetⁱ	P61081
PhosphoSitePlusⁱ	P61081
SwissPalmⁱ	P61081

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000130725 Expressed in 208 organ(s), highest expression level in right frontal lobe
CleanExⁱ	HS_UBE2M
ExpressionAtlasⁱ	P61081 baseline and differential
Genevisibleⁱ	P61081 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004993 HPA054551 HPA057800

HPAⁱ

CAB004993
HPA054551
HPA057800

Interactionⁱ

Subunit structureⁱ

Interacts with UBA3 and RBX1. Interacts (acetylated at N-terminal methionine) with DCUN1D1 (via DCUN1 domain) (PubMed:28581483).6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CUL1	Q13616	5	EBI-1041660,EBI-359390
NEDD8	Q15843	5	EBI-1041660,EBI-716247
RBX1	P62877	6	EBI-1041660,EBI-398523
UBA3	Q8TBC4	2	EBI-1041660,EBI-717567

Protein-protein interaction databases

BioGridⁱ	114504, 90 interactors
Database of interacting proteins More...DIPⁱ	DIP-35679N
IntActⁱ	P61081, 23 interactors
Molecular INTeraction database More...MINTⁱ	P61081
STRINGⁱ	9606.ENSP00000253023

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	4 – 14	Combined sources	11
Helixⁱ	29 – 39	Combined sources	11
Beta strandⁱ	47 – 50	Combined sources	4
Beta strandⁱ	59 – 64	Combined sources	6
Beta strandⁱ	67 – 69	Combined sources	3
Turnⁱ	70 – 73	Combined sources	4
Beta strandⁱ	76 – 81	Combined sources	6
Turnⁱ	84 – 88	Combined sources	5
Beta strandⁱ	92 – 95	Combined sources	4
Beta strandⁱ	108 – 110	Combined sources	3
Helixⁱ	113 – 115	Combined sources	3
Turnⁱ	116 – 118	Combined sources	3
Helixⁱ	125 – 137	Combined sources	13
Helixⁱ	147 – 154	Combined sources	8
Helixⁱ	157 – 169	Combined sources	13
Beta strandⁱ	170 – 173	Combined sources	4
Beta strandⁱ	176 – 178	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P61081
SMRⁱ	P61081
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P61081

EvolutionaryTraceⁱ

P61081

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 57	Interaction with UBA3Add BLAST		57

Domainⁱ

Both the N-terminal docking peptide and the catalytic core domain must bind the UBA3-NAE1 complex simultaneously for optimal transfer of NEDD8.

Sequence similaritiesⁱ

Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0420 Eukaryota ENOG410XS81 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00630000089859
HOGENOMⁱ	HOG000233456
HOVERGENⁱ	HBG098591
InParanoidⁱ	P61081
KEGG Orthology (KO) More...KOⁱ	K10579
OMAⁱ	MIKIWSM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N8A
PhylomeDBⁱ	P61081
TreeFamⁱ	TF101125

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00195 UBCc, 1 hit
Gene3Dⁱ	3.10.110.10, 1 hit
InterProⁱ	View protein in InterPro IPR000608 UBQ-conjugat_E2 IPR023313 UBQ-conjugating_AS IPR016135 UBQ-conjugating_enzyme/RWD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00179 UQ_con, 1 hit
SUPFAMⁱ	SSF54495 SSF54495, 1 hit
PROSITEⁱ	View protein in PROSITE PS00183 UBIQUITIN_CONJUGAT_1, 1 hit PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P61081-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIKLFSLKQQ KKEEESAGGT KGSSKKASAA QLRIQKDINE LNLPKTCDIS 
        60         70         80         90        100
FSDPDDLLNF KLVICPDEGF YKSGKFVFSF KVGQGYPHDP PKVKCETMVY 
       110        120        130        140        150
HPNIDLEGNV CLNILREDWK PVLTINSIIY GLQYLFLEPN PEDPLNKEAA 
       160        170        180 
EVLQNNRRLF EQNVQRSMRG GYIGSTYFER CLK

Length:183

Mass (Da):20,900

Last modified:April 26, 2004 - v1

Checksum:ⁱE3C288CA6A98BC5C

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

M0QYI6	M0QYI6_HUMAN	NEDD8-conjugating enzyme Ubc12 NEDD8-conjugating enzyme Ubc12	UBE2M	114	Annotation score:
M0QX69	M0QX69_HUMAN	NEDD8-conjugating enzyme Ubc12 NEDD8-conjugating enzyme Ubc12	UBE2M	69	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB012191 mRNA Translation: BAA33145.1 AF075599 mRNA Translation: AAC26141.1 BT006754 mRNA Translation: AAP35400.1 BC058924 mRNA Translation: AAH58924.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12987.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003960.1, NM_003969.3
UniGeneⁱ	Hs.406068

Genome annotation databases

Ensemblⁱ	ENST00000253023; ENSP00000253023; ENSG00000130725
GeneIDⁱ	9040
KEGGⁱ	hsa:9040
UCSC genome browser More...UCSCⁱ	uc002qtl.5 human

Protein	Similar proteins		Species	Score	Length	Source
P61081	NEDD8-conjugating enzyme Ubc12		BOVIN		183	UniRef100_P61081
NEDD8-conjugating enzyme Ubc12		MOUSE		183
Uncharacterized protein (Fragment)		CEREH		181
Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast), isoform CRA_a		HUMAN		183
NEDD8-conjugating enzyme Ubc12		MACMU		183
+35

Protein	Similar proteins		Species	Score	Length	Source
P61081	NEDD8-conjugating enzyme Ubc12		BOVIN		183	UniRef90_P61081
NEDD8-conjugating enzyme Ubc12		MOUSE		183
Uncharacterized protein (Fragment)		CEREH		181
Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast), isoform CRA_a		HUMAN		183
NEDD8-conjugating enzyme Ubc12		MACMU		183
+39

Protein	Similar proteins		Species	Score	Length	Source
P61081	NEDD8-conjugating enzyme Ubc12		BOVIN		183	UniRef50_P61081
NEDD8-conjugating enzyme Ubc12		MOUSE		183
Uncharacterized protein (Fragment)		CEREH		181
Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast), isoform CRA_a		HUMAN		183
NEDD8-conjugating enzyme Ubc12		MACMU		183
+39

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB012191 mRNA Translation: BAA33145.1 AF075599 mRNA Translation: AAC26141.1 BT006754 mRNA Translation: AAP35400.1 BC058924 mRNA Translation: AAH58924.1
CCDSⁱ	CCDS12987.1
RefSeqⁱ	NP_003960.1, NM_003969.3
UniGeneⁱ	Hs.406068

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1TT5	X-ray	2.60	E/F	1-26	[»]
	1Y8X	X-ray	2.40	A	27-183	[»]
	2NVU	X-ray	2.80	C	1-178	[»]
	3TDU	X-ray	1.50	E/F	1-15	[»]
	3TDZ	X-ray	2.00	E/F	2-12	[»]
	4GAO	X-ray	3.28	C/E/F/H	1-12	[»]
	4P5O	X-ray	3.11	G/I	2-183	[»]
ProteinModelPortalⁱ	P61081
SMRⁱ	P61081
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114504, 90 interactors
DIPⁱ	DIP-35679N
IntActⁱ	P61081, 23 interactors
MINTⁱ	P61081
STRINGⁱ	9606.ENSP00000253023

PTM databases

iPTMnetⁱ	P61081
PhosphoSitePlusⁱ	P61081
SwissPalmⁱ	P61081

Polymorphism and mutation databases

BioMutaⁱ	UBE2M
DMDMⁱ	46577655

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00022597
UCD-2DPAGEⁱ	P61081

Proteomic databases

EPDⁱ	P61081
MaxQBⁱ	P61081
PaxDbⁱ	P61081
PeptideAtlasⁱ	P61081
PRIDEⁱ	P61081
ProteomicsDBⁱ	57261

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9040
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000253023; ENSP00000253023; ENSG00000130725
GeneIDⁱ	9040
KEGGⁱ	hsa:9040
UCSCⁱ	uc002qtl.5 human

Organism-specific databases

CTDⁱ	9040
DisGeNETⁱ	9040
EuPathDBⁱ	HostDB:ENSG00000130725.7
GeneCardsⁱ	UBE2M
HGNCⁱ	HGNC:12491 UBE2M
HPAⁱ	CAB004993 HPA054551 HPA057800
MIMⁱ	603173 gene
neXtProtⁱ	NX_P61081
OpenTargetsⁱ	ENSG00000130725
PharmGKBⁱ	PA37140
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0420 Eukaryota ENOG410XS81 LUCA
GeneTreeⁱ	ENSGT00630000089859
HOGENOMⁱ	HOG000233456
HOVERGENⁱ	HBG098591
InParanoidⁱ	P61081
KOⁱ	K10579
OMAⁱ	MIKIWSM
OrthoDBⁱ	EOG091G0N8A
PhylomeDBⁱ	P61081
TreeFamⁱ	TF101125

Enzyme and pathway databases

UniPathwayⁱ	UPA00885
BioCycⁱ	MetaCyc:HS05432-MONOMER
Reactomeⁱ	R-HSA-2173789 TGF-beta receptor signaling activates SMADs R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5676590 NIK-->noncanonical NF-kB signaling R-HSA-8951664 Neddylation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	P61081

Miscellaneous databases

ChiTaRSⁱ	UBE2M human
EvolutionaryTraceⁱ	P61081
GeneWikiⁱ	UBE2M
GenomeRNAiⁱ	9040
Protein Ontology More...PROⁱ	PR:P61081
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000130725 Expressed in 208 organ(s), highest expression level in right frontal lobe
CleanExⁱ	HS_UBE2M
ExpressionAtlasⁱ	P61081 baseline and differential
Genevisibleⁱ	P61081 HS

Family and domain databases

CDDⁱ	cd00195 UBCc, 1 hit
Gene3Dⁱ	3.10.110.10, 1 hit
InterProⁱ	View protein in InterPro IPR000608 UBQ-conjugat_E2 IPR023313 UBQ-conjugating_AS IPR016135 UBQ-conjugating_enzyme/RWD
Pfamⁱ	View protein in Pfam PF00179 UQ_con, 1 hit
SUPFAMⁱ	SSF54495 SSF54495, 1 hit
PROSITEⁱ	View protein in PROSITE PS00183 UBIQUITIN_CONJUGAT_1, 1 hit PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UBC12_HUMAN
Accessionⁱ	P61081Primary (citable) accession number: P61081 Secondary accession number(s): O76069, Q8VC50
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
	Last sequence update:	April 26, 2004
	Last modified:	November 7, 2018
	This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

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Supporting data

UniProtKB - P61081 (UBC12_HUMAN)

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NEDD8-conjugating enzyme Ubc12

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein neddylation

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: protein neddylation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ