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UniProtKB - P61081 (UBC12_HUMAN)

Entry version 173 (02 Jun 2021)
Sequence version 1 (26 Apr 2004)
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Protein

NEDD8-conjugating enzyme Ubc12

Gene

UBE2M

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein neddylation

This protein is involved in the pathway protein neddylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein neddylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei111Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS05432-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.2.34, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P61081

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2173789, TGF-beta receptor signaling activates SMADs
R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5676590, NIK-->noncanonical NF-kB signaling
R-HSA-8951664, Neddylation
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P61081

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00885

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NEDD8-conjugating enzyme Ubc12 (EC:2.3.2.341 Publication)
Alternative name(s):
NEDD8 carrier protein
Ubiquitin-conjugating enzyme E2 M
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBE2M
Synonyms:UBC12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12491, UBE2M

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603173, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P61081

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000130725.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1M → A: No effect on thioester intermediate formation. 1 Publication1
Mutagenesisi4L → A: Impairs thioester intermediate formation. 1 Publication1
Mutagenesisi5F → A: Strongly impairs thioester intermediate formation. 1 Publication1
Mutagenesisi6S → A: Slightly impairs thioester intermediate formation. 1 Publication1
Mutagenesisi7L → A: Strongly impairs thioester intermediate formation. 1 Publication1
Mutagenesisi9Q → A: Impairs thioester intermediate formation. 1 Publication1
Mutagenesisi10Q → A: No effect on thioester intermediate formation. 1 Publication1
Mutagenesisi11K → A: No effect on thioester intermediate formation. 1 Publication1
Mutagenesisi12K → A: Impairs thioester intermediate formation. 1 Publication1
Mutagenesisi32L → A: Strongly impairs thioester intermediate formation. 1 Publication1
Mutagenesisi35Q → A: Strongly impairs thioester intermediate formation. 1 Publication1
Mutagenesisi36K → A: Strongly impairs thioester intermediate formation. 1 Publication1
Mutagenesisi38I → A: Strongly impairs thioester intermediate formation. 1 Publication1
Mutagenesisi39N → A: No effect on thioester intermediate formation. 1 Publication1
Mutagenesisi41L → A: Strongly impairs thioester intermediate formation. 1 Publication1
Mutagenesisi51F → A: Strongly impairs thioester intermediate formation. 1 Publication1
Mutagenesisi55D → A: Strongly impairs thioester intermediate formation. 1 Publication1
Mutagenesisi57L → A: Strongly impairs thioester intermediate formation. 1 Publication1
Mutagenesisi111C → S: Forms a stable complex with NEDD8, which prevents subsequent NEDD8 conjugation to cullins. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		9040

Open Targets

More...OpenTargetsi		ENSG00000130725

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37140

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P61081, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4295787

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UBE2M

Domain mapping of disease mutations (DMDM)

More...DMDMi		46577655

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000824881 – 183NEDD8-conjugating enzyme Ubc12Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine2 Publications1
Modified residuei3N6-acetyllysineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei169Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei169Omega-N-methylarginine; alternateCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The acetylation of Met-1 increases affinity for DCUN1D1 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.2 Publications

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P61081

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P61081

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P61081

MaxQB - The MaxQuant DataBase

More...MaxQBi		P61081

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P61081

PeptideAtlas

More...PeptideAtlasi		P61081

PRoteomics IDEntifications database

More...PRIDEi		P61081

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57261

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00022597

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P61081

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P61081

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P61081

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P61081

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000130725, Expressed in superior frontal gyrus and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P61081, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P61081, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000130725, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with UBA3 and RBX1.

Interacts (N-terminally acetylated form) with (via DCUN1 domain) DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5 (PubMed:23201271, PubMed:28581483).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114504, 589 interactors

Database of interacting proteins

More...DIPi		DIP-35679N

Protein interaction database and analysis system

More...IntActi		P61081, 47 interactors

Molecular INTeraction database

More...MINTi		P61081

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000253023

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P61081

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P61081, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P61081

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P61081

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 173UBC corePROSITE-ProRule annotationAdd BLAST145

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 57Interaction with UBA3Add BLAST57
Regioni1 – 29DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 20Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Both the N-terminal docking peptide and the catalytic core domain must bind the UBA3-NAE1 complex simultaneously for optimal transfer of NEDD8.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0420, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162814

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_030988_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P61081

Identification of Orthologs from Complete Genome Data

More...OMAi		NTNYPHE

Database of Orthologous Groups

More...OrthoDBi		1302735at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P61081

TreeFam database of animal gene trees

More...TreeFami		TF101125

Family and domain databases

Conserved Domains Database

More...CDDi		cd00195, UBCc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000608, UBQ-conjugat_E2
IPR023313, UBQ-conjugating_AS
IPR016135, UBQ-conjugating_enzyme/RWD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00179, UQ_con, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54495, SSF54495, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00183, UBC_1, 1 hit
PS50127, UBC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P61081-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIKLFSLKQQ KKEEESAGGT KGSSKKASAA QLRIQKDINE LNLPKTCDIS 
        60         70         80         90        100
FSDPDDLLNF KLVICPDEGF YKSGKFVFSF KVGQGYPHDP PKVKCETMVY 
       110        120        130        140        150
HPNIDLEGNV CLNILREDWK PVLTINSIIY GLQYLFLEPN PEDPLNKEAA 
       160        170        180 
EVLQNNRRLF EQNVQRSMRG GYIGSTYFER CLK
Length:183
Mass (Da):20,900
Last modified:April 26, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3C288CA6A98BC5C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYI6M0QYI6_HUMAN
NEDD8-conjugating enzyme Ubc12
UBE2M
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX69M0QX69_HUMAN
NEDD8-conjugating enzyme Ubc12
UBE2M
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB012191 mRNA Translation: BAA33145.1
AF075599 mRNA Translation: AAC26141.1
BT006754 mRNA Translation: AAP35400.1
BC058924 mRNA Translation: AAH58924.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12987.1

NCBI Reference Sequences

More...RefSeqi		NP_003960.1, NM_003969.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000253023; ENSP00000253023; ENSG00000130725

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9040

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9040

UCSC genome browser

More...UCSCi		uc002qtl.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012191 mRNA Translation: BAA33145.1
AF075599 mRNA Translation: AAC26141.1
BT006754 mRNA Translation: AAP35400.1
BC058924 mRNA Translation: AAH58924.1
CCDSiCCDS12987.1
RefSeqiNP_003960.1, NM_003969.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TT5X-ray2.60E/F1-26[»]
1Y8XX-ray2.40A27-183[»]
2NVUX-ray2.80C1-178[»]
3TDUX-ray1.50E/F1-15[»]
3TDZX-ray2.00E/F2-12[»]
4GAOX-ray3.28C/E/F/H1-12[»]
4P5OX-ray3.11G/I2-183[»]
SMRiP61081
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114504, 589 interactors
DIPiDIP-35679N
IntActiP61081, 47 interactors
MINTiP61081
STRINGi9606.ENSP00000253023

Chemistry databases

BindingDBiP61081
ChEMBLiCHEMBL4295787

PTM databases

iPTMnetiP61081
PhosphoSitePlusiP61081
SwissPalmiP61081

Genetic variation databases

BioMutaiUBE2M
DMDMi46577655

2D gel databases

REPRODUCTION-2DPAGEiIPI00022597
UCD-2DPAGEiP61081

Proteomic databases

EPDiP61081
jPOSTiP61081
MassIVEiP61081
MaxQBiP61081
PaxDbiP61081
PeptideAtlasiP61081
PRIDEiP61081
ProteomicsDBi57261

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3333, 193 antibodies

The DNASU plasmid repository

More...DNASUi		9040

Genome annotation databases

EnsembliENST00000253023; ENSP00000253023; ENSG00000130725
GeneIDi9040
KEGGihsa:9040
UCSCiuc002qtl.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9040
DisGeNETi9040

GeneCards: human genes, protein and diseases

More...GeneCardsi		UBE2M
HGNCiHGNC:12491, UBE2M
HPAiENSG00000130725, Low tissue specificity
MIMi603173, gene
neXtProtiNX_P61081
OpenTargetsiENSG00000130725
PharmGKBiPA37140
VEuPathDBiHostDB:ENSG00000130725.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0420, Eukaryota
GeneTreeiENSGT00940000162814
HOGENOMiCLU_030988_6_0_1
InParanoidiP61081
OMAiNTNYPHE
OrthoDBi1302735at2759
PhylomeDBiP61081
TreeFamiTF101125

Enzyme and pathway databases

UniPathwayiUPA00885
BioCyciMetaCyc:HS05432-MONOMER
BRENDAi2.3.2.34, 2681
PathwayCommonsiP61081
ReactomeiR-HSA-2173789, TGF-beta receptor signaling activates SMADs
R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5676590, NIK-->noncanonical NF-kB signaling
R-HSA-8951664, Neddylation
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiP61081

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9040, 722 hits in 967 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		UBE2M, human
EvolutionaryTraceiP61081

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		UBE2M

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9040
PharosiP61081, Tbio

Protein Ontology

More...PROi		PR:P61081
RNActiP61081, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000130725, Expressed in superior frontal gyrus and 222 other tissues
ExpressionAtlasiP61081, baseline and differential
GenevisibleiP61081, HS

Family and domain databases

CDDicd00195, UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608, UBQ-conjugat_E2
IPR023313, UBQ-conjugating_AS
IPR016135, UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179, UQ_con, 1 hit
SUPFAMiSSF54495, SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183, UBC_1, 1 hit
PS50127, UBC_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBC12_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61081
Secondary accession number(s): O76069, Q8VC50
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: June 2, 2021
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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