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Protein

Proliferating cell nuclear antigen

Gene

PCNA

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi61 – 80Sequence analysisAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA polymerase processivity factor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-PFA-110320 Translesion Synthesis by POLH
R-PFA-174411 Polymerase switching on the C-strand of the telomere
R-PFA-4615885 SUMOylation of DNA replication proteins
R-PFA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-PFA-69091 Polymerase switching
R-PFA-69166 Removal of the Flap Intermediate
R-PFA-69183 Processive synthesis on the lagging strand

Names & Taxonomyi

Protein namesi
Recommended name:
Proliferating cell nuclear antigen
Short name:
PCNA
Alternative name(s):
Cyclin
Gene namesi
Name:PCNA
ORF Names:PF13_0328
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1361900

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: GeneDB
  • PCNA complex Source: GO_Central

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001491731 – 274Proliferating cell nuclear antigenAdd BLAST274

Proteomic databases

PRIDEiP61074

PTM databases

SwissPalmiP61074

Interactioni

Subunit structurei

Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP61074
SMRiP61074
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.Curated

Phylogenomic databases

HOGENOMiHOG000211098
InParanoidiP61074
KOiK04802
OMAiKILRCAG
PhylomeDBiP61074

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit
PS00293 PCNA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P61074-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLEAKLNNAS ILKKLFECIK DLVNDANVDA DESGLKLQAL DGNHVSLVSL
60 70 80 90 100
HLLDSGFSHY RCDRERVLGV NIASLNKVFK LCGANESVVI SSKDDEDNLN
110 120 130 140 150
FVFENNKEDK VTNFSLKLMS IELDSLNIPD CEEGFDAEVE LSSKELTNIF
160 170 180 190 200
RNLSEFSDTV FIEIDSNCIK FTTKGIVGDA EVALKPRDST SEDDIGVTIK
210 220 230 240 250
SKKKIKQSFA IKYLNLFSKS NILADVVVLG LSDSRPIEFK YEIKDTSPDS
260 270
DTLKIGFVKF FLAPKMDDDM DNKD
Length:274
Mass (Da):30,587
Last modified:April 26, 2004 - v1
Checksum:iE3128F7397DD1687
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844509 Genomic DNA Translation: CAD52739.1
RefSeqiXP_001350330.1, XM_001350294.1

Genome annotation databases

EnsemblProtistsiCAD52739; CAD52739; PF3D7_1361900
GeneDBiPF3D7_1361900.1:pep
GeneIDi814288
KEGGipfa:PF3D7_1361900

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844509 Genomic DNA Translation: CAD52739.1
RefSeqiXP_001350330.1, XM_001350294.1

3D structure databases

ProteinModelPortaliP61074
SMRiP61074
ModBaseiSearch...
MobiDBiSearch...

PTM databases

SwissPalmiP61074

Proteomic databases

PRIDEiP61074

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAD52739; CAD52739; PF3D7_1361900
GeneDBiPF3D7_1361900.1:pep
GeneIDi814288
KEGGipfa:PF3D7_1361900

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1361900

Phylogenomic databases

HOGENOMiHOG000211098
InParanoidiP61074
KOiK04802
OMAiKILRCAG
PhylomeDBiP61074

Enzyme and pathway databases

ReactomeiR-PFA-110320 Translesion Synthesis by POLH
R-PFA-174411 Polymerase switching on the C-strand of the telomere
R-PFA-4615885 SUMOylation of DNA replication proteins
R-PFA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-PFA-69091 Polymerase switching
R-PFA-69166 Removal of the Flap Intermediate
R-PFA-69183 Processive synthesis on the lagging strand

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit
PS00293 PCNA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPCNA_PLAF7
AccessioniPrimary (citable) accession number: P61074
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: November 7, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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