UniProtKB - P61073 (CXCR4_HUMAN)
C-X-C chemokine receptor type 4
CXCR4
Functioni
Miscellaneous
Caution
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 171 | Chemokine | 1 | |
Binding sitei | 288 | Chemokine1 Publication1 Publication | 1 |
GO - Molecular functioni
- actin binding Source: UniProtKB
- C-C chemokine binding Source: CAFA
- C-C chemokine receptor activity Source: GO_Central
- chemokine binding Source: GO_Central
- coreceptor activity Source: ProtInc
- C-X-C chemokine receptor activity Source: UniProtKB
- C-X-C motif chemokine 12 receptor activity Source: UniProtKB
- drug binding Source: Ensembl
- G protein-coupled receptor activity Source: ProtInc
- identical protein binding Source: IntAct
- myosin light chain binding Source: UniProtKB
- ubiquitin binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
- virus receptor activity Source: UniProtKB-KW
GO - Biological processi
- activation of MAPK activity Source: ProtInc
- apoptotic process Source: ProtInc
- axon guidance Source: Reactome
- brain development Source: GO_Central
- calcium-mediated signaling Source: MGI
- cardiac muscle contraction Source: Ensembl
- cell chemotaxis Source: GO_Central
- cellular response to cytokine stimulus Source: UniProtKB
- cellular response to drug Source: Ensembl
- chemotaxis Source: GO_Central
- CXCL12-activated CXCR4 signaling pathway Source: UniProtKB
- dendritic cell chemotaxis Source: BHF-UCL
- detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
- detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
- endothelial cell differentiation Source: Ensembl
- endothelial tube morphogenesis Source: Ensembl
- epithelial cell development Source: Ensembl
- fusion of virus membrane with host plasma membrane Source: Reactome
- G protein-coupled receptor signaling pathway Source: UniProtKB
- immune response Source: GO_Central
- inflammatory response Source: ProtInc
- myelin maintenance Source: BHF-UCL
- neurogenesis Source: GO_Central
- neuron migration Source: Ensembl
- neuron recognition Source: Ensembl
- positive regulation of chemotaxis Source: Ensembl
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
- positive regulation of dendrite extension Source: Ensembl
- positive regulation of macrophage migration inhibitory factor signaling pathway Source: ARUK-UCL
- positive regulation of mesenchymal stem cell migration Source: Ensembl
- positive regulation of oligodendrocyte differentiation Source: BHF-UCL
- positive regulation of vascular wound healing Source: Ensembl
- regulation of calcium ion transport Source: Ensembl
- regulation of cell adhesion Source: UniProtKB
- regulation of chemotaxis Source: UniProtKB
- regulation of programmed cell death Source: Ensembl
- regulation of viral process Source: Ensembl
- response to activity Source: Ensembl
- response to hypoxia Source: UniProtKB
- response to morphine Source: Ensembl
- response to ultrasound Source: Ensembl
- response to virus Source: ProtInc
- telencephalon cell migration Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Host cell receptor for virus entry, Receptor, Transducer |
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | P61073 |
Reactomei | R-HSA-173107, Binding and entry of HIV virion R-HSA-376176, Signaling by ROBO receptors R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P61073 |
SIGNORi | P61073 |
Protein family/group databases
TCDBi | 9.A.14.13.17, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: C-X-C chemokine receptor type 4Short name: CXC-R4 Short name: CXCR-4 Alternative name(s): FB22 Fusin HM89 LCR1 Leukocyte-derived seven transmembrane domain receptor Short name: LESTR1 Publication Lipopolysaccharide-associated protein 3 Short name: LAP-3 Short name: LPS-associated protein 3 NPYRL Stromal cell-derived factor 1 receptor Short name: SDF-1 receptor CD_antigen: CD184 |
Gene namesi | Name:CXCR4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000121966.6 |
HGNCi | HGNC:2561, CXCR4 |
MIMi | 162643, gene |
neXtProti | NX_P61073 |
Subcellular locationi
Lysosome
Endosome
Plasma membrane
- Cell membrane 1 Publication1 Publication; Multi-pass membrane protein 1 Publication
Other locations
Note: In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC).
Endosome
- early endosome Source: UniProtKB
- late endosome Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Lysosome
- lysosome Source: UniProtKB
Nucleus
- nucleus Source: Ensembl
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- cell junction Source: UniProtKB-SubCell
- cell leading edge Source: UniProtKB
- cell surface Source: UniProtKB
- cytoplasm Source: ProtInc
- cytoplasmic vesicle Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- protein-containing complex Source: ARUK-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | Extracellular1 PublicationAdd BLAST | 38 | |
Transmembranei | 39 – 63 | Helical; Name=11 PublicationAdd BLAST | 25 | |
Topological domaini | 64 – 77 | Cytoplasmic1 PublicationAdd BLAST | 14 | |
Transmembranei | 78 – 99 | Helical; Name=21 PublicationAdd BLAST | 22 | |
Topological domaini | 100 – 110 | Extracellular1 PublicationAdd BLAST | 11 | |
Transmembranei | 111 – 130 | Helical; Name=31 PublicationAdd BLAST | 20 | |
Topological domaini | 131 – 154 | Cytoplasmic1 PublicationAdd BLAST | 24 | |
Transmembranei | 155 – 174 | Helical; Name=41 PublicationAdd BLAST | 20 | |
Topological domaini | 175 – 195 | Extracellular1 PublicationAdd BLAST | 21 | |
Transmembranei | 196 – 216 | Helical; Name=51 PublicationAdd BLAST | 21 | |
Topological domaini | 217 – 241 | Cytoplasmic1 PublicationAdd BLAST | 25 | |
Transmembranei | 242 – 261 | Helical; Name=61 PublicationAdd BLAST | 20 | |
Topological domaini | 262 – 282 | Extracellular1 PublicationAdd BLAST | 21 | |
Transmembranei | 283 – 302 | Helical; Name=71 PublicationAdd BLAST | 20 | |
Topological domaini | 303 – 352 | Cytoplasmic1 PublicationAdd BLAST | 50 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Endosome, Lysosome, MembranePathology & Biotechi
Involvement in diseasei
WHIM syndrome (WHIMS)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081113 | 334 – 352 | Missing in WHIMS; also found in patients with Waldenstroem macroglobulinemia; somatic mutation. 2 PublicationsAdd BLAST | 19 | |
Natural variantiVAR_081114 | 338 – 352 | Missing in WHIMS; common somatic mutation in patients with Waldenstroem macroglobulinemia; results in decreased CXCL12-triggered receptor internalization; enhanced AKT and MAPK signaling activation; confers resistance to ibrutinib-triggered apoptosis. 4 PublicationsAdd BLAST | 15 | |
Natural variantiVAR_081115 | 343 – 352 | Missing in WHIMS. 1 Publication | 10 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2 – 9 | Missing : Reduced CXCL12 binding. Abolishes signaling. 1 Publication | 8 | |
Mutagenesisi | 4 – 20 | Missing : Reduced CXCL12 binding. Impaired signaling. Reduced coreceptor activity for HIV-1 isolates LAI and NDK. 1 PublicationAdd BLAST | 17 | |
Mutagenesisi | 7 | Y → A: Reduced coreceptor activity for HIV-1 isolates LAI and NDK. Greatly reduced coreceptor activity for HIV-1 isolates LAI and NDK; when associated with A-12. 2 Publications | 1 | |
Mutagenesisi | 7 | Y → F: Sulfate incorporation greatly reduced; when associated with F-12 and F-21. Moderate reduction in sulfate incorporation; when associated with F-12 and A-18. No sulfate incorporation and binding SDF-1alpha greatly reduced; when associated with F-12; A-18 and F-21. 2 Publications | 1 | |
Mutagenesisi | 8 | T → A: No effect on sulfate incorporation; when associated with A-9 and A-13. 1 Publication | 1 | |
Mutagenesisi | 9 | S → A: No effect on sulfate incorporation; when associated with A-8 and A-13. 1 Publication | 1 | |
Mutagenesisi | 10 – 20 | Missing : Reduced CXCL12 binding. No effect on signaling. 1 PublicationAdd BLAST | 11 | |
Mutagenesisi | 11 | N → A: Reduced molecular weight. Enhanced coreceptor activity on R5 HIV-1 isolate Envs. Slight further enhancement of coreceptor activity; when associated with A-13. 1 Publication | 1 | |
Mutagenesisi | 12 | Y → A: Greatly reduced coreceptor activity for HIV-1 isolates LAI and NDK; when associated with A-7. 2 Publications | 1 | |
Mutagenesisi | 12 | Y → F: Sulfate incorporation greatly reduced; when associated with F-7 and F-21. Moderate reduction in sulfate incorporation; when associated with F-7 and A-18. No sulfate incorporation and binding SDF-1alpha greatly reduced; when associated with F-7; A-18 and F-21. 2 Publications | 1 | |
Mutagenesisi | 13 | T → A: Enhanced coreceptor activity on R5 HIV-1 isolate Envs. No effect on sulfate incorporation; when associated with A-8 and A-9. 1 Publication | 1 | |
Mutagenesisi | 14 – 15 | EE → AA: Reduced CXCL12 binding. Reduced coreceptor activity for HIV-1 isolate NDK. 1 Publication | 2 | |
Mutagenesisi | 18 | S → A: Sulfate incorporation greatly reduced; when associated with F-21. Moderate reduction in sulfate incorporation; when associated with F-7 and F-12. No sulfate incorporation and binding SDF-1alpha greatly reduced; when associated with F-7; F-12; and F-21. 1 Publication | 1 | |
Mutagenesisi | 21 | Y → A: Reduced CXCL12 binding. Reduced coreceptor activity for HIV-1 isolates LAI and NDk. 2 Publications | 1 | |
Mutagenesisi | 21 | Y → F: Sulfate incorporation greatly reduced; when associated with F-7 and F-12. Sulfate incorporation greatly reduced; when associated with A-18. No sulfate incorporation and binding SDF-1alpha greatly reduced; when associated with F-7; F-12 and A-18. 2 Publications | 1 | |
Mutagenesisi | 97 | D → N: Reduced CXCL12 binding. Abolishes signaling. Markedly reduced coreceptor activity for HIV-1 isolate LAI. 1 Publication | 1 | |
Mutagenesisi | 119 | N → D: No reduction of agonist-induced G-protein activation. 1 Publication | 1 | |
Mutagenesisi | 119 | N → K: Loss of agonist-induced G-protein activation. 1 Publication | 1 | |
Mutagenesisi | 119 | N → S: Constitutive G-protein activation, with further activation induced by agonist. 1 Publication | 1 | |
Mutagenesisi | 125 | L → W: Increased thermostability. | 1 | |
Mutagenesisi | 133 | D → N: No reduction of agonist-induced G-protein activation. 1 Publication | 1 | |
Mutagenesisi | 134 | R → A: Loss of agonist-induced G-protein activation. 1 Publication | 1 | |
Mutagenesisi | 135 | Y → A: No reduction of agonist-induced G-protein activation. 1 Publication | 1 | |
Mutagenesisi | 171 | D → N: Reduced coreceptor activity for HIV-1 isolate NDK. 1 Publication | 1 | |
Mutagenesisi | 176 | N → A: Enhanced coreceptor activity on R5 HIV-1 isolate Envs; when associated with A-11. 1 Publication | 1 | |
Mutagenesisi | 183 | R → A: Reduced coreceptor activity for several HIV-1 isolates. 1 Publication | 1 | |
Mutagenesisi | 187 | D → A: Reduced CXCL12 binding. Abolishes signaling. 1 Publication | 1 | |
Mutagenesisi | 188 | R → A: Reduced coreceptor activity for several HIV-1 isolates. 1 Publication | 1 | |
Mutagenesisi | 193 | D → A, S or N: Greatly reduced coreceptor activity for HIV-1 isolate NDK. Reduced coreceptor activity for several other HIV-1 isolates. 2 Publications | 1 | |
Mutagenesisi | 193 | D → R: Abolishes coreceptor activity for HIV-1 isolate NDK. Reduced coreceptor activity for several other HIV-1 isolates. 2 Publications | 1 | |
Mutagenesisi | 240 | T → P: Retains ligand-binding affinity but abolishes signaling. | 1 | |
Mutagenesisi | 262 | D → A: Markedly reduced coreceptor activity for HIV-1 isolate LAI. 1 Publication | 1 | |
Mutagenesisi | 268 | E → A: Markedly reduced coreceptor activity for HIV-1 isolate NDK. Less effect for HIV-1 isolate LAI. 1 Publication | 1 | |
Mutagenesisi | 288 | E → Q: Reduced CXCL12 binding. Impaired signaling. Reduced coreceptor activity for HIV-1 isolate LAI. Enhanced coreceptor activity for HIV-1 isolate NDK. 1 Publication | 1 | |
Mutagenesisi | 310 | K → R: No effect on ubiquitination by RNF113A. 1 Publication | 1 | |
Mutagenesisi | 324 | S → A: Moderate degradation. About 60% reduction in binding ITCH and no ubiquitination nor protein degradation; when associated with A-325. 1 Publication | 1 | |
Mutagenesisi | 324 | S → D: Enhanced binding to ITCH. Enhanced binding to ITCH and greatly increased protein degradation; when associated with D-324. 1 Publication | 1 | |
Mutagenesisi | 324 | S → D: Enhanced binding to ITCH. Enhanced binding to ITCH and greatly increased protein degradation; when associated with D-325. 1 Publication | 1 | |
Mutagenesisi | 325 | S → A: Moderate degradation. About 60% reduction in binding ITCH and no ubiquitination nor protein degradation; when associated with A-324. 1 Publication | 1 | |
Mutagenesisi | 330 | S → A: No effect on binding to ITCH. 1 Publication | 1 | |
Mutagenesisi | 331 | K → R: Loss of ubiquitination by RNF113A. 1 Publication | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 7852 |
MalaCardsi | CXCR4 |
MIMi | 193670, phenotype |
OpenTargetsi | ENSG00000121966 |
Orphaneti | 51636, WHIM syndrome |
PharmGKBi | PA27058 |
Miscellaneous databases
Pharosi | P61073, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2107 |
DrugBanki | DB05501, AMD-070 DB00452, Framycetin DB12698, Ibalizumab DB06809, Plerixafor |
DrugCentrali | P61073 |
GuidetoPHARMACOLOGYi | 71 |
Polymorphism and mutation databases
BioMutai | CXCR4 |
DMDMi | 46577576 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069352 | 1 – 352 | C-X-C chemokine receptor type 4Add BLAST | 352 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 7 | Sulfotyrosine; partial1 Publication | 1 | |
Glycosylationi | 11 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 12 | Sulfotyrosine; partial1 Publication | 1 | |
Glycosylationi | 18 | O-linked (Xyl...) (chondroitin sulfate) serine1 Publication | 1 | |
Modified residuei | 21 | Sulfotyrosine3 Publications | 1 | |
Disulfide bondi | 28 ↔ 274 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Disulfide bondi | 109 ↔ 186 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Glycosylationi | 176 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 319 | PhosphoserineCombined sources | 1 | |
Modified residuei | 321 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 324 | Phosphoserine; by PKC and GRK6Combined sources2 Publications | 1 | |
Modified residuei | 325 | Phosphoserine; by PKC and GRK6Combined sources2 Publications | 1 | |
Modified residuei | 330 | Phosphoserine; by GRK61 Publication | 1 | |
Cross-linki | 331 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Modified residuei | 339 | Phosphoserine; by GRK61 Publication | 1 | |
Modified residuei | 348 | PhosphoserineCombined sources | 1 | |
Modified residuei | 351 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Proteoglycan, Sulfation, Ubl conjugationProteomic databases
jPOSTi | P61073 |
MassIVEi | P61073 |
MaxQBi | P61073 |
PaxDbi | P61073 |
PeptideAtlasi | P61073 |
PRIDEi | P61073 |
ProteomicsDBi | 57256 57257 [P61073-2] |
PTM databases
GlyGeni | P61073, 3 sites |
iPTMneti | P61073 |
PhosphoSitePlusi | P61073 |
SwissPalmi | P61073 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000121966, Expressed in oviduct epithelium and 238 other tissues |
Genevisiblei | P61073, HS |
Organism-specific databases
HPAi | ENSG00000121966, Tissue enhanced (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Monomer. Can form homodimers (PubMed:20929726).
Interacts with CD164 (PubMed:17077324).
Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3.
Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization (PubMed:20048153).
Interacts with RNF113A; the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and subsequent degradation (PubMed:28978524).
Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and leads to its degradation.
Interacts with extracellular ubiquitin.
Interacts with DBN1; this interaction is enhanced by antigenic stimulation. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.
15 Publications(Microbial infection) Interacts with HIV-1 surface protein gp120 and Tat.
4 Publications(Microbial infection) Interacts with HHV-8 protein ORF K4 (PubMed:25612609).
1 Publication(Microbial infection) May interact with human cytomegalovirus/HHV-5 protein UL78.
1 Publication(Microbial infection) Interacts with Staphylococcus aureus protein SSL10.
1 PublicationBinary interactionsi
Hide detailsP61073
GO - Molecular functioni
- actin binding Source: UniProtKB
- C-C chemokine binding Source: CAFA
- chemokine binding Source: GO_Central
- identical protein binding Source: IntAct
- myosin light chain binding Source: UniProtKB
- ubiquitin binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113607, 55 interactors |
CORUMi | P61073 |
DIPi | DIP-34773N DIP-46290N |
IntActi | P61073, 40 interactors |
MINTi | P61073 |
STRINGi | 9606.ENSP00000386884 |
Chemistry databases
BindingDBi | P61073 |
Miscellaneous databases
RNActi | P61073, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P61073 |
SMRi | P61073 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P61073 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | Important for chemokine binding, signaling and HIV-1 coreceptor activity1 PublicationAdd BLAST | 21 | |
Regioni | 94 – 97 | Chemokine binding1 Publication1 Publication | 4 | |
Regioni | 113 – 117 | Chemokine binding | 5 | |
Regioni | 135 – 147 | Involved in dimerization; when bound to chemokineAdd BLAST | 13 | |
Regioni | 186 – 190 | Chemokine binding, important for signaling and HIV-1 coreceptor activity | 5 | |
Regioni | 191 – 210 | Involved in dimerizationAdd BLAST | 20 | |
Regioni | 266 – 268 | Involved in dimerization | 3 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 133 – 135 | Important for signaling | 3 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222321 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P61073 |
OMAi | IVHKWIS |
OrthoDBi | 773026at2759 |
PhylomeDBi | P61073 |
TreeFami | TF330966 |
Family and domain databases
DisProti | DP01249 |
InterProi | View protein in InterPro IPR022726, Chemokine_CXCR4_N_dom IPR000355, Chemokine_rcpt IPR001277, CXCR4/ACKR2 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit PF12109, CXCR4_N, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR00645, CXCCHMKINER4 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEGISIYTSD NYTEEMGSGD YDSMKEPCFR EENANFNKIF LPTIYSIIFL
60 70 80 90 100
TGIVGNGLVI LVMGYQKKLR SMTDKYRLHL SVADLLFVIT LPFWAVDAVA
110 120 130 140 150
NWYFGNFLCK AVHVIYTVNL YSSVLILAFI SLDRYLAIVH ATNSQRPRKL
160 170 180 190 200
LAEKVVYVGV WIPALLLTIP DFIFANVSEA DDRYICDRFY PNDLWVVVFQ
210 220 230 240 250
FQHIMVGLIL PGIVILSCYC IIISKLSHSK GHQKRKALKT TVILILAFFA
260 270 280 290 300
CWLPYYIGIS IDSFILLEII KQGCEFENTV HKWISITEAL AFFHCCLNPI
310 320 330 340 350
LYAFLGAKFK TSAQHALTSV SRGSSLKILS KGKRGGHSSV STESESSSFH
SS
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 242 – 244 | VIL → IIP in AAK29630 (Ref. 12) Curated | 3 | |
Sequence conflicti | 278 | N → S in BAG35177 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081112 | 333 – 352 | Missing Found in patients with Waldenstroem macroglobulinemia; somatic mutation. 1 PublicationAdd BLAST | 20 | |
Natural variantiVAR_081113 | 334 – 352 | Missing in WHIMS; also found in patients with Waldenstroem macroglobulinemia; somatic mutation. 2 PublicationsAdd BLAST | 19 | |
Natural variantiVAR_081114 | 338 – 352 | Missing in WHIMS; common somatic mutation in patients with Waldenstroem macroglobulinemia; results in decreased CXCL12-triggered receptor internalization; enhanced AKT and MAPK signaling activation; confers resistance to ibrutinib-triggered apoptosis. 4 PublicationsAdd BLAST | 15 | |
Natural variantiVAR_081115 | 343 – 352 | Missing in WHIMS. 1 Publication | 10 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001890 | 1 – 5 | MEGIS → MSIPLPLLQ in isoform 2. 1 Publication | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L01639 mRNA Translation: AAA16594.1 M99293 mRNA Translation: AAA16617.1 X71635 mRNA Translation: CAA50641.1 L06797 mRNA Translation: AAA03209.1 D10924 mRNA Translation: BAA01722.1 AF005058 Genomic DNA Translation: AAB93982.1 AF052572 Genomic DNA Translation: AAC34581.1 AJ224869 Genomic DNA Translation: CAA12166.1 Sequence problems. AF025375 mRNA Translation: AAB81970.1 Y14739 Genomic DNA Translation: CAA75034.1 AF147204 mRNA Translation: AAF00130.1 AF348491 mRNA Translation: AAK29630.1 AK312244 mRNA Translation: BAG35177.1 AY242129 mRNA Translation: AAO92296.1 BT006660 mRNA Translation: AAP35306.1 AY728138 Genomic DNA Translation: AAU05775.1 AC068492 Genomic DNA Translation: AAY24044.1 CH471058 Genomic DNA Translation: EAX11616.1 BC020968 mRNA Translation: AAH20968.1 |
CCDSi | CCDS33295.1 [P61073-2] CCDS46420.1 |
PIRi | A45747 |
RefSeqi | NP_001008540.1, NM_001008540.2 [P61073-2] NP_001334985.1, NM_001348056.1 NP_001334988.1, NM_001348059.1 NP_001334989.1, NM_001348060.1 NP_003458.1, NM_003467.2 [P61073-1] |
Genome annotation databases
Ensembli | ENST00000241393; ENSP00000241393; ENSG00000121966 [P61073-1] ENST00000409817; ENSP00000386884; ENSG00000121966 [P61073-2] |
GeneIDi | 7852 |
KEGGi | hsa:7852 |
UCSCi | uc002tuy.3, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
CXCR4base CXCR4 mutation db |
Wikipedia CXC chemokine receptors entry |
Wikipedia CXCR4 entry |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L01639 mRNA Translation: AAA16594.1 M99293 mRNA Translation: AAA16617.1 X71635 mRNA Translation: CAA50641.1 L06797 mRNA Translation: AAA03209.1 D10924 mRNA Translation: BAA01722.1 AF005058 Genomic DNA Translation: AAB93982.1 AF052572 Genomic DNA Translation: AAC34581.1 AJ224869 Genomic DNA Translation: CAA12166.1 Sequence problems. AF025375 mRNA Translation: AAB81970.1 Y14739 Genomic DNA Translation: CAA75034.1 AF147204 mRNA Translation: AAF00130.1 AF348491 mRNA Translation: AAK29630.1 AK312244 mRNA Translation: BAG35177.1 AY242129 mRNA Translation: AAO92296.1 BT006660 mRNA Translation: AAP35306.1 AY728138 Genomic DNA Translation: AAU05775.1 AC068492 Genomic DNA Translation: AAY24044.1 CH471058 Genomic DNA Translation: EAX11616.1 BC020968 mRNA Translation: AAH20968.1 |
CCDSi | CCDS33295.1 [P61073-2] CCDS46420.1 |
PIRi | A45747 |
RefSeqi | NP_001008540.1, NM_001008540.2 [P61073-2] NP_001334985.1, NM_001348056.1 NP_001334988.1, NM_001348059.1 NP_001334989.1, NM_001348060.1 NP_003458.1, NM_003467.2 [P61073-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2K03 | NMR | - | B/D | 1-38 | [»] | |
2K04 | NMR | - | B/D | 1-38 | [»] | |
2K05 | NMR | - | B/D | 1-38 | [»] | |
2N55 | NMR | - | B | 1-38 | [»] | |
3ODU | X-ray | 2.50 | A/B | 2-319 | [»] | |
3OE0 | X-ray | 2.90 | A | 2-319 | [»] | |
3OE6 | X-ray | 3.20 | A | 2-325 | [»] | |
3OE8 | X-ray | 3.10 | A/B/C | 2-319 | [»] | |
3OE9 | X-ray | 3.10 | A/B | 2-319 | [»] | |
4RWS | X-ray | 3.10 | A | 2-228 | [»] | |
A | 231-319 | [»] | ||||
BMRBi | P61073 | |||||
SMRi | P61073 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113607, 55 interactors |
CORUMi | P61073 |
DIPi | DIP-34773N DIP-46290N |
IntActi | P61073, 40 interactors |
MINTi | P61073 |
STRINGi | 9606.ENSP00000386884 |
Chemistry databases
BindingDBi | P61073 |
ChEMBLi | CHEMBL2107 |
DrugBanki | DB05501, AMD-070 DB00452, Framycetin DB12698, Ibalizumab DB06809, Plerixafor |
DrugCentrali | P61073 |
GuidetoPHARMACOLOGYi | 71 |
Protein family/group databases
TCDBi | 9.A.14.13.17, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | P61073, 3 sites |
iPTMneti | P61073 |
PhosphoSitePlusi | P61073 |
SwissPalmi | P61073 |
Polymorphism and mutation databases
BioMutai | CXCR4 |
DMDMi | 46577576 |
Proteomic databases
jPOSTi | P61073 |
MassIVEi | P61073 |
MaxQBi | P61073 |
PaxDbi | P61073 |
PeptideAtlasi | P61073 |
PRIDEi | P61073 |
ProteomicsDBi | 57256 57257 [P61073-2] |
Protocols and materials databases
ABCDi | P61073, 37 sequenced antibodies |
Antibodypediai | 4421, 1729 antibodies |
DNASUi | 7852 |
Genome annotation databases
Ensembli | ENST00000241393; ENSP00000241393; ENSG00000121966 [P61073-1] ENST00000409817; ENSP00000386884; ENSG00000121966 [P61073-2] |
GeneIDi | 7852 |
KEGGi | hsa:7852 |
UCSCi | uc002tuy.3, human |
Organism-specific databases
CTDi | 7852 |
DisGeNETi | 7852 |
EuPathDBi | HostDB:ENSG00000121966.6 |
GeneCardsi | CXCR4 |
HGNCi | HGNC:2561, CXCR4 |
HPAi | ENSG00000121966, Tissue enhanced (bone marrow, lymphoid tissue) |
MalaCardsi | CXCR4 |
MIMi | 162643, gene 193670, phenotype |
neXtProti | NX_P61073 |
OpenTargetsi | ENSG00000121966 |
Orphaneti | 51636, WHIM syndrome |
PharmGKBi | PA27058 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222321 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P61073 |
OMAi | IVHKWIS |
OrthoDBi | 773026at2759 |
PhylomeDBi | P61073 |
TreeFami | TF330966 |
Enzyme and pathway databases
PathwayCommonsi | P61073 |
Reactomei | R-HSA-173107, Binding and entry of HIV virion R-HSA-376176, Signaling by ROBO receptors R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P61073 |
SIGNORi | P61073 |
Miscellaneous databases
BioGRID-ORCSi | 7852, 1 hit in 846 CRISPR screens |
ChiTaRSi | CXCR4, human |
EvolutionaryTracei | P61073 |
GeneWikii | CXCR4 |
GenomeRNAii | 7852 |
Pharosi | P61073, Tclin |
PROi | PR:P61073 |
RNActi | P61073, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000121966, Expressed in oviduct epithelium and 238 other tissues |
Genevisiblei | P61073, HS |
Family and domain databases
DisProti | DP01249 |
InterProi | View protein in InterPro IPR022726, Chemokine_CXCR4_N_dom IPR000355, Chemokine_rcpt IPR001277, CXCR4/ACKR2 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit PF12109, CXCR4_N, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR00645, CXCCHMKINER4 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXCR4_HUMAN | |
Accessioni | P61073Primary (citable) accession number: P61073 Secondary accession number(s): B2R5N0 Q9UKN2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | April 26, 2004 | |
Last modified: | December 2, 2020 | |
This is version 186 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries