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Protein

Cyclin-dependent kinases regulatory subunit 1

Gene

Cks1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cell proliferation Source: MGI
  • mitotic cell cycle phase transition Source: MGI
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
  • positive regulation of transcription, DNA-templated Source: GO_Central
  • regulation of mitotic cell cycle Source: GO_Central
  • regulation of transcription, DNA-templated Source: MGI

Keywordsi

Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21
R-MMU-69231 Cyclin D associated events in G1

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit 1
Short name:
CKS-1
Alternative name(s):
Sid 1334
Gene namesi
Name:Cks1b
Synonyms:Cks1, Sid1334
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1889208 Cks1b

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002062362 – 79Cyclin-dependent kinases regulatory subunit 1Add BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61025
MaxQBiP61025
PaxDbiP61025
PeptideAtlasiP61025
PRIDEiP61025

PTM databases

iPTMnetiP61025
PhosphoSitePlusiP61025

Expressioni

Gene expression databases

BgeeiENSMUSG00000028044
CleanExiMM_CKS1B
ExpressionAtlasiP61025 baseline and differential
GenevisibleiP61025 MM

Interactioni

Subunit structurei

Forms a homohexamer that can probably bind six kinase subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207564, 1 interactor
STRINGi10090.ENSMUSP00000029679

Structurei

3D structure databases

ProteinModelPortaliP61025
SMRiP61025
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

eggNOGiKOG3484 Eukaryota
ENOG4111UAN LUCA
GeneTreeiENSGT00390000011006
HOVERGENiHBG003626
InParanoidiP61025
KOiK02219
OMAiIHYSSRY
OrthoDBiEOG091G18GQ
PhylomeDBiP61025
TreeFamiTF101142

Family and domain databases

Gene3Di3.30.170.10, 1 hit
InterProiView protein in InterPro
IPR000789 Cyclin-dep_kinase_reg-sub
IPR036858 Cyclin-dep_kinase_reg-sub_sf
PfamiView protein in Pfam
PF01111 CKS, 1 hit
PRINTSiPR00296 CYCLINKINASE
SMARTiView protein in SMART
SM01084 CKS, 1 hit
SUPFAMiSSF55637 SSF55637, 1 hit
PROSITEiView protein in PROSITE
PS00944 CKS_1, 1 hit
PS00945 CKS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61025-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ
60 70
SQGWVHYMIH EPEPHILLFR RPLPKKPKK
Length:79
Mass (Da):9,660
Last modified:April 26, 2004 - v1
Checksum:iE64207B140FA38D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025409 mRNA Translation: BAA84694.1
AK010414 mRNA Translation: BAC25295.1
AK011782 mRNA Translation: BAB27837.1
BC076579 mRNA Translation: AAH76579.1
CCDSiCCDS38493.1
RefSeqiNP_058600.1, NM_016904.1
UniGeneiMm.3049

Genome annotation databases

EnsembliENSMUST00000029679; ENSMUSP00000029679; ENSMUSG00000028044
GeneIDi54124
KEGGimmu:54124
UCSCiuc008pzl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCKS1_MOUSE
AccessioniPrimary (citable) accession number: P61025
Secondary accession number(s): P33551, Q6ZWX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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