UniProtKB - P61024 (CKS1_HUMAN)
Protein
Cyclin-dependent kinases regulatory subunit 1
Gene
CKS1B
Organism
Homo sapiens (Human)
Status
Functioni
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase activator activity Source: GO_Central
- histone binding Source: GO_Central
- protein kinase binding Source: GO_Central
- ubiquitin binding Source: GO_Central
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- regulation of mitotic cell cycle Source: GO_Central
Keywordsi
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
PathwayCommonsi | P61024 |
Reactomei | R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-69231, Cyclin D associated events in G1 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent kinases regulatory subunit 1Short name: CKS-1 |
Gene namesi | Name:CKS1B Synonyms:CKS1 ORF Names:PNAS-143, PNAS-16 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19083, CKS1B |
MIMi | 116900, gene |
neXtProti | NX_P61024 |
VEuPathDBi | HostDB:ENSG00000173207.12 |
Subcellular locationi
Nucleus
- nucleoplasm Source: Reactome
Other locations
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- SCF ubiquitin ligase complex Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 1163 |
OpenTargetsi | ENSG00000173207 |
PharmGKBi | PA38791 |
Miscellaneous databases
Pharosi | P61024, Tbio |
Chemistry databases
DrugBanki | DB02681, 2,8-bis[oxido(oxo)vanadio]-1,1,1,3,5,5,7,7,9,9,9-undecaoxopentavanadoxane-2,8-diium DB00472, Fluoxetine |
Genetic variation databases
BioMutai | CKS1B |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000206235 | 2 – 79 | Cyclin-dependent kinases regulatory subunit 1Add BLAST | 78 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P61024 |
jPOSTi | P61024 |
MassIVEi | P61024 |
PaxDbi | P61024 |
PeptideAtlasi | P61024 |
PRIDEi | P61024 |
ProteomicsDBi | 57254 |
TopDownProteomicsi | P61024 |
PTM databases
iPTMneti | P61024 |
MetOSitei | P61024 |
PhosphoSitePlusi | P61024 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173207, Expressed in ventricular zone and 115 other tissues |
ExpressionAtlasi | P61024, baseline and differential |
Genevisiblei | P61024, HS |
Organism-specific databases
HPAi | ENSG00000173207, Low tissue specificity |
Interactioni
Subunit structurei
Forms a homohexamer that can probably bind six kinase subunits.
Binary interactionsi
Hide detailsP61024
GO - Molecular functioni
- histone binding Source: GO_Central
- protein kinase binding Source: GO_Central
- ubiquitin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 107582, 86 interactors |
CORUMi | P61024 |
DIPi | DIP-102N |
IntActi | P61024, 72 interactors |
MINTi | P61024 |
STRINGi | 9606.ENSP00000311083 |
Miscellaneous databases
RNActi | P61024, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P61024 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P61024 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CKS family.Curated
Phylogenomic databases
eggNOGi | KOG3484, Eukaryota |
GeneTreei | ENSGT00950000182971 |
HOGENOMi | CLU_140546_2_0_1 |
InParanoidi | P61024 |
OMAi | LMTENEW |
OrthoDBi | 1377855at2759 |
PhylomeDBi | P61024 |
TreeFami | TF101142 |
Family and domain databases
Gene3Di | 3.30.170.10, 1 hit |
IDEALi | IID00309 |
InterProi | View protein in InterPro IPR000789, Cyclin-dep_kinase_reg-sub IPR036858, Cyclin-dep_kinase_reg-sub_sf |
Pfami | View protein in Pfam PF01111, CKS, 1 hit |
PRINTSi | PR00296, CYCLINKINASE |
SMARTi | View protein in SMART SM01084, CKS, 1 hit |
SUPFAMi | SSF55637, SSF55637, 1 hit |
PROSITEi | View protein in PROSITE PS00944, CKS_1, 1 hit PS00945, CKS_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P61024-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ
60 70
SQGWVHYMIH EPEPHILLFR RPLPKKPKK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9BZU3 | Q9BZU3_HUMAN | Cyclin-dependent kinases regulatory... | CKS1B hCG_1739274 | 63 | Annotation score: | ||
Q5T179 | Q5T179_HUMAN | Cyclin-dependent kinases regulatory... | CKS1B | 67 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54941 mRNA Translation: CAA38702.1 AF274941 mRNA Translation: AAK07518.1 AF279897 mRNA Translation: AAK07553.1 BT007196 mRNA Translation: AAP35860.1 BC007751 mRNA Translation: AAH07751.1 BC015629 mRNA Translation: AAH15629.1 BC070319 mRNA Translation: AAH70319.1 BC070320 mRNA Translation: AAH70320.1 |
CCDSi | CCDS1077.1 |
PIRi | A36670 |
RefSeqi | NP_001817.1, NM_001826.2 |
Genome annotation databases
Ensembli | ENST00000308987; ENSP00000311083; ENSG00000173207 |
GeneIDi | 1163 |
KEGGi | hsa:1163 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54941 mRNA Translation: CAA38702.1 AF274941 mRNA Translation: AAK07518.1 AF279897 mRNA Translation: AAK07553.1 BT007196 mRNA Translation: AAP35860.1 BC007751 mRNA Translation: AAH07751.1 BC015629 mRNA Translation: AAH15629.1 BC070319 mRNA Translation: AAH70319.1 BC070320 mRNA Translation: AAH70320.1 |
CCDSi | CCDS1077.1 |
PIRi | A36670 |
RefSeqi | NP_001817.1, NM_001826.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BUH | X-ray | 2.60 | B | 1-79 | [»] | |
1DKS | X-ray | 3.20 | A/B | 1-79 | [»] | |
1DKT | X-ray | 2.90 | A/B | 1-79 | [»] | |
2ASS | X-ray | 3.00 | C | 5-73 | [»] | |
2AST | X-ray | 2.30 | C | 5-73 | [»] | |
4YC6 | X-ray | 2.60 | B/D/F/H | 1-79 | [»] | |
SMRi | P61024 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107582, 86 interactors |
CORUMi | P61024 |
DIPi | DIP-102N |
IntActi | P61024, 72 interactors |
MINTi | P61024 |
STRINGi | 9606.ENSP00000311083 |
Chemistry databases
DrugBanki | DB02681, 2,8-bis[oxido(oxo)vanadio]-1,1,1,3,5,5,7,7,9,9,9-undecaoxopentavanadoxane-2,8-diium DB00472, Fluoxetine |
PTM databases
iPTMneti | P61024 |
MetOSitei | P61024 |
PhosphoSitePlusi | P61024 |
Genetic variation databases
BioMutai | CKS1B |
Proteomic databases
EPDi | P61024 |
jPOSTi | P61024 |
MassIVEi | P61024 |
PaxDbi | P61024 |
PeptideAtlasi | P61024 |
PRIDEi | P61024 |
ProteomicsDBi | 57254 |
TopDownProteomicsi | P61024 |
Protocols and materials databases
Antibodypediai | 47036, 241 antibodies |
DNASUi | 1163 |
Genome annotation databases
Ensembli | ENST00000308987; ENSP00000311083; ENSG00000173207 |
GeneIDi | 1163 |
KEGGi | hsa:1163 |
Organism-specific databases
CTDi | 1163 |
DisGeNETi | 1163 |
GeneCardsi | CKS1B |
HGNCi | HGNC:19083, CKS1B |
HPAi | ENSG00000173207, Low tissue specificity |
MIMi | 116900, gene |
neXtProti | NX_P61024 |
OpenTargetsi | ENSG00000173207 |
PharmGKBi | PA38791 |
VEuPathDBi | HostDB:ENSG00000173207.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3484, Eukaryota |
GeneTreei | ENSGT00950000182971 |
HOGENOMi | CLU_140546_2_0_1 |
InParanoidi | P61024 |
OMAi | LMTENEW |
OrthoDBi | 1377855at2759 |
PhylomeDBi | P61024 |
TreeFami | TF101142 |
Enzyme and pathway databases
PathwayCommonsi | P61024 |
Reactomei | R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-69231, Cyclin D associated events in G1 |
Miscellaneous databases
BioGRID-ORCSi | 1163, 51 hits in 512 CRISPR screens |
ChiTaRSi | CKS1B, human |
EvolutionaryTracei | P61024 |
GeneWikii | CKS1B |
GenomeRNAii | 1163 |
Pharosi | P61024, Tbio |
PROi | PR:P61024 |
RNActi | P61024, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000173207, Expressed in ventricular zone and 115 other tissues |
ExpressionAtlasi | P61024, baseline and differential |
Genevisiblei | P61024, HS |
Family and domain databases
Gene3Di | 3.30.170.10, 1 hit |
IDEALi | IID00309 |
InterProi | View protein in InterPro IPR000789, Cyclin-dep_kinase_reg-sub IPR036858, Cyclin-dep_kinase_reg-sub_sf |
Pfami | View protein in Pfam PF01111, CKS, 1 hit |
PRINTSi | PR00296, CYCLINKINASE |
SMARTi | View protein in SMART SM01084, CKS, 1 hit |
SUPFAMi | SSF55637, SSF55637, 1 hit |
PROSITEi | View protein in PROSITE PS00944, CKS_1, 1 hit PS00945, CKS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CKS1_HUMAN | |
Accessioni | P61024Primary (citable) accession number: P61024 Secondary accession number(s): P33551 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | April 26, 2004 | |
Last modified: | February 10, 2021 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families