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Protein

Ras-related protein Rab-5B

Gene

Rab5b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Activity regulationi

Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 35GTPBy similarity9
Nucleotide bindingi46 – 52GTPBy similarity7
Nucleotide bindingi75 – 79GTPBy similarity5
Nucleotide bindingi133 – 136GTPBy similarity4
Nucleotide bindingi163 – 165GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-8856828 Clathrin-mediated endocytosis
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-5B
Gene namesi
Name:Rab5b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:105938 Rab5b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001211082 – 215Ras-related protein Rab-5BAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Lipidationi212S-geranylgeranyl cysteineBy similarity1
Lipidationi213S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Prenylation

Proteomic databases

EPDiP61021
MaxQBiP61021
PaxDbiP61021
PRIDEiP61021

PTM databases

iPTMnetiP61021
PhosphoSitePlusiP61021
SwissPalmiP61021

Expressioni

Gene expression databases

BgeeiENSMUSG00000000711 Expressed in 39 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_RAB5B
ExpressionAtlasiP61021 baseline and differential
GenevisibleiP61021 MM

Interactioni

Subunit structurei

Binds EEA1. Interacts with RIN2 and RIN3, which probably regulate its pathway, possibly by acting as GEFs (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0072EBI-8320093,EBI-5323863From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202548, 18 interactors
IntActiP61021, 27 interactors
MINTiP61021
STRINGi10090.ENSMUSP00000000727

Structurei

3D structure databases

ProteinModelPortaliP61021
SMRiP61021
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi49 – 57Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00760000119101
HOVERGENiHBG009351
InParanoidiP61021
KOiK07888
OMAiRHWVAEL
OrthoDBiEOG091G0HKN
PhylomeDBiP61021
TreeFamiTF300199

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61021-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSRSTARPN GQPQASKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEYQE
60 70 80 90 100
STIGAAFLTQ SVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY
110 120 130 140 150
DITNQETFAR AKTWVKELQR QASPSIVIAL AGNKADLANK RMVEYEEAQA
160 170 180 190 200
YADDNSLLFM ETSAKTAMNV NDLFLAIAKK LPKSEPQNLG GAAGRSRGVD
210
LHEQSQQNKS QCCSN
Length:215
Mass (Da):23,707
Last modified:April 26, 2004 - v1
Checksum:iD47AD834BCF8B591
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56A → G in AAK14835 (PubMed:1555775).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84239 mRNA Translation: CAA59016.1
AK081251 mRNA Translation: BAC38176.1
M79311 mRNA Translation: AAK14835.1
CCDSiCCDS24287.1
PIRiJH0640
S65932
RefSeqiNP_803130.1, NM_177411.4
XP_006513447.1, XM_006513384.3
UniGeneiMm.12815
Mm.490984

Genome annotation databases

EnsembliENSMUST00000000727; ENSMUSP00000000727; ENSMUSG00000000711
GeneIDi19344
KEGGimmu:19344
UCSCiuc007hnv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84239 mRNA Translation: CAA59016.1
AK081251 mRNA Translation: BAC38176.1
M79311 mRNA Translation: AAK14835.1
CCDSiCCDS24287.1
PIRiJH0640
S65932
RefSeqiNP_803130.1, NM_177411.4
XP_006513447.1, XM_006513384.3
UniGeneiMm.12815
Mm.490984

3D structure databases

ProteinModelPortaliP61021
SMRiP61021
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202548, 18 interactors
IntActiP61021, 27 interactors
MINTiP61021
STRINGi10090.ENSMUSP00000000727

PTM databases

iPTMnetiP61021
PhosphoSitePlusiP61021
SwissPalmiP61021

Proteomic databases

EPDiP61021
MaxQBiP61021
PaxDbiP61021
PRIDEiP61021

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000727; ENSMUSP00000000727; ENSMUSG00000000711
GeneIDi19344
KEGGimmu:19344
UCSCiuc007hnv.2 mouse

Organism-specific databases

CTDi5869
MGIiMGI:105938 Rab5b

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00760000119101
HOVERGENiHBG009351
InParanoidiP61021
KOiK07888
OMAiRHWVAEL
OrthoDBiEOG091G0HKN
PhylomeDBiP61021
TreeFamiTF300199

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-8856828 Clathrin-mediated endocytosis
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiRab5b mouse
PROiPR:P61021
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000711 Expressed in 39 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_RAB5B
ExpressionAtlasiP61021 baseline and differential
GenevisibleiP61021 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB5B_MOUSE
AccessioniPrimary (citable) accession number: P61021
Secondary accession number(s): P35239, P35277
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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