RAB5B

Functionⁱ

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Activity regulationⁱ

Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	27 – 35	GTPCombined sources1 Publication	9
Nucleotide bindingⁱ	46 – 52	GTPCombined sources1 Publication	7
Nucleotide bindingⁱ	75 – 79	GTPBy similarity	5
Nucleotide bindingⁱ	133 – 136	GTPCombined sources1 Publication	4
Nucleotide bindingⁱ	163 – 165	GTPCombined sources1 Publication	3

GO - Molecular functionⁱ

GDP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20937701
GTPase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17562788
GTP binding Source: UniProtKB-KW
GTP-dependent protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10491193

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19717423
endosome organization Source: Ensembl
neutrophil degranulation Source: Reactome
plasma membrane to endosome transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17562788
protein transport Source: UniProtKB-KW
regulation of endocytosis Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation R-HSA-8854214 TBC/RABGAPs R-HSA-8856828 Clathrin-mediated endocytosis R-HSA-8873719 RAB geranylgeranylation R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
SIGNORⁱ	P61020

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein Rab-5B
Gene namesⁱ	Name:RAB5B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000111540.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9784 RAB5B
MIMⁱ	179514 gene
neXtProtⁱ	NX_P61020

Keywords - Cellular componentⁱ

Cell membrane, Endosome, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	34	S → N: Constitutively inactivated. Strongly reduces interaction with RIN2. 1 Publication		1
Mutagenesisⁱ	79	Q → L: Constitutively active. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5869
Open Targets More...OpenTargetsⁱ	ENSG00000111540
PharmGKBⁱ	PA34144

Polymorphism and mutation databases

BioMutaⁱ	RAB5B
DMDMⁱ	46577637

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000121107	2 – 215	Ras-related protein Rab-5BAdd BLAST		214

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylthreonineCombined sources	1
Lipidationⁱ	212	S-geranylgeranyl cysteineBy similarity	1
Lipidationⁱ	213	S-geranylgeranyl cysteineBy similarity	1

Keywords - PTMⁱ

Acetylation, Lipoprotein, Prenylation

Proteomic databases

EPDⁱ	P61020
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P61020
PaxDbⁱ	P61020
PeptideAtlas More...PeptideAtlasⁱ	P61020
PRIDEⁱ	P61020
ProteomicsDBⁱ	57253

PTM databases

iPTMnetⁱ	P61020
PhosphoSitePlusⁱ	P61020
SwissPalmⁱ	P61020

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000111540 Expressed in 234 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_RAB5B
ExpressionAtlasⁱ	P61020 baseline and differential
Genevisibleⁱ	P61020 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB010224 HPA068337

HPAⁱ

CAB010224
HPA068337

Interactionⁱ

Subunit structureⁱ

Binds EEA1. Interacts with RIN2 and RIN3, which probably regulate its pathway, possibly by acting as GEFs.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
EEA1	Q15075	3	EBI-399401,EBI-298113
LRRK2	Q5S007	9	EBI-399401,EBI-5323863

GO - Molecular functionⁱ

GTP-dependent protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10491193

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111807, 66 interactors
IntActⁱ	P61020, 15 interactors
Molecular INTeraction database More...MINTⁱ	P61020
STRINGⁱ	9606.ENSP00000353444

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	19 – 26	Combined sources	8
Helixⁱ	33 – 42	Combined sources	10
Beta strandⁱ	54 – 56	Combined sources	3
Beta strandⁱ	58 – 62	Combined sources	5
Beta strandⁱ	69 – 74	Combined sources	6
Helixⁱ	83 – 85	Combined sources	3
Helixⁱ	86 – 90	Combined sources	5
Beta strandⁱ	95 – 101	Combined sources	7
Helixⁱ	105 – 121	Combined sources	17
Beta strandⁱ	127 – 133	Combined sources	7
Helixⁱ	135 – 140	Combined sources	6
Helixⁱ	145 – 154	Combined sources	10
Beta strandⁱ	158 – 161	Combined sources	4
Turnⁱ	164 – 166	Combined sources	3
Helixⁱ	170 – 180	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	P61020
SMRⁱ	P61020
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P61020

EvolutionaryTraceⁱ

P61020

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	49 – 57	Effector regionSequence analysis		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0092 Eukaryota ENOG410YCCP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119101
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	P61020
KEGG Orthology (KO) More...KOⁱ	K07888
OMAⁱ	QTTVKFE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HKN
PhylomeDBⁱ	P61020
TreeFamⁱ	TF300199

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P61020-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSRSTARPN GQPQASKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEYQE 
        60         70         80         90        100
STIGAAFLTQ SVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY 
       110        120        130        140        150
DITNQETFAR AKTWVKELQR QASPSIVIAL AGNKADLANK RMVEYEEAQA 
       160        170        180        190        200
YADDNSLLFM ETSAKTAMNV NDLFLAIAKK LPKSEPQNLG GAAGRSRGVD 
       210 
LHEQSQQNKS QCCSN

Length:215

Mass (Da):23,707

Last modified:April 26, 2004 - v1

Checksum:ⁱD47AD834BCF8B591

GO

Isoform 2 (identifier: P61020-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
106-146: Missing.

« Hide

        10         20         30         40         50
MTSRSTARPN GQPQASKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEYQE 
        60         70         80         90        100
STIGAAFLTQ SVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY 
       110        120        130        140        150
DITNQEAQAY ADDNSLLFME TSAKTAMNVN DLFLAIAKKL PKSEPQNLGG 
       160        170 
AAGRSRGVDL HEQSQQNKSQ CCSN

Show »

Length:174

Mass (Da):19,090

Checksum:ⁱ90D1C43B99761B6E

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8VVZ0	F8VVZ0_HUMAN	Ras-related protein Rab-5B Ras-related protein Rab-5B	RAB5B	100	Annotation score:
F8VUA5	F8VUA5_HUMAN	Ras-related protein Rab-5B Ras-related protein Rab-5B	RAB5B	115	Annotation score:
F8VWZ7	F8VWZ7_HUMAN	Ras-related protein Rab-5B Ras-related protein Rab-5B	RAB5B	79	Annotation score:
F8VPW9	F8VPW9_HUMAN	Ras-related protein Rab-5B Ras-related protein Rab-5B	RAB5B	73	Annotation score:

Sequence cautionⁱ

The sequence AAH40143 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045301	106 – 146	Missing in isoform 2. 1 PublicationAdd BLAST		41

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X54871 mRNA Translation: CAA38653.1 AF498937 mRNA Translation: AAM21085.1 AK292597 mRNA Translation: BAF85286.1 AK296517 mRNA Translation: BAG59149.1 BX537408 mRNA Translation: CAD97650.1 AC034102 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW96862.1 CH471054 Genomic DNA Translation: EAW96864.1 BC032740 mRNA Translation: AAH32740.1 BC040143 mRNA Translation: AAH40143.1 Different initiation. BC050558 mRNA Translation: AAH50558.2 BC056422 mRNA Translation: AAH56422.2 BC065298 mRNA Translation: AAH65298.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS58244.1 [P61020-2] CCDS8900.1 [P61020-1]
PIRⁱ	A43925
NCBI Reference Sequences More...RefSeqⁱ	NP_001238965.1, NM_001252036.1 [P61020-1] NP_001238966.1, NM_001252037.1 [P61020-2] NP_002859.1, NM_002868.3 [P61020-1] XP_005269108.1, XM_005269051.2 [P61020-1] XP_005269109.1, XM_005269052.2 [P61020-1]
UniGeneⁱ	Hs.157659

Genome annotation databases

Ensemblⁱ	ENST00000360299; ENSP00000353444; ENSG00000111540 [P61020-1] ENST00000448789; ENSP00000391319; ENSG00000111540 [P61020-2] ENST00000553116; ENSP00000450168; ENSG00000111540 [P61020-1]
GeneIDⁱ	5869
KEGGⁱ	hsa:5869
UCSC genome browser More...UCSCⁱ	uc001siv.4 human [P61020-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P61020	Ras-related protein Rab-5B		MOUSE		215	UniRef100_P61020
Ras-related protein Rab-5B		PONAB		215
RAB5B, member RAS oncogene family		OTOGA		161
RAB5B, member RAS oncogene family		SHEEP		227
RAB5B, member RAS oncogene family		PANTR		227
+29
P61020-2	RAB5B, member RAS oncogene family		CALJA		174	UniRef100_U3F4J3
RAB5B isoform 7		PANTR		174
Uncharacterized protein		PROCO		174
ras-related protein Rab-5B isoform X3		ODORO		174
ras-related protein Rab-5B isoform X3		Enhydra lutris kenyoni		174
+6

Protein	Similar proteins		Species	Score	Length	Source
P61020	Ras-related protein Rab-5B		MOUSE		215	UniRef90_P61020
Ras-related protein Rab-5B		PONAB		215
RAB5B, member RAS oncogene family		OTOGA		161
RAB5B, member RAS oncogene family		SHEEP		227
RAB5B, member RAS oncogene family		PANTR		227
+48
P61020-2	Uncharacterized protein		MACMU		174	UniRef90_A0A1D5QLP5
Uncharacterized protein		RHIRO		174
Uncharacterized protein		PAPAN		174
Uncharacterized protein		MANLE		174
Uncharacterized protein		MACFA		174
+26

Protein	Similar proteins		Species	Score	Length	Source
P61020	Ras-related protein Rab-5B		MOUSE		215	UniRef50_P61020
Ras-related protein Rab-5B		PONAB		215
RAB5B, member RAS oncogene family		OTOGA		161
RAB5B, member RAS oncogene family		SHEEP		227
RAB5B, member RAS oncogene family		PANTR		227
+57
P61020-2	RAB5A, member RAS oncogene family		SAIBB		174	UniRef50_A0A2K6TZF5
ras-related protein Rab-5A isoform X2		DELLE		174
ras-related protein Rab-5A isoform X2		Yangtze finless porpoise		174
Uncharacterized protein		CERAT		174
Ras-related protein Rab-5C (Fragment)		OPHHA		168
+44

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X54871 mRNA Translation: CAA38653.1 AF498937 mRNA Translation: AAM21085.1 AK292597 mRNA Translation: BAF85286.1 AK296517 mRNA Translation: BAG59149.1 BX537408 mRNA Translation: CAD97650.1 AC034102 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW96862.1 CH471054 Genomic DNA Translation: EAW96864.1 BC032740 mRNA Translation: AAH32740.1 BC040143 mRNA Translation: AAH40143.1 Different initiation. BC050558 mRNA Translation: AAH50558.2 BC056422 mRNA Translation: AAH56422.2 BC065298 mRNA Translation: AAH65298.2
CCDSⁱ	CCDS58244.1 [P61020-2] CCDS8900.1 [P61020-1]
PIRⁱ	A43925
RefSeqⁱ	NP_001238965.1, NM_001252036.1 [P61020-1] NP_001238966.1, NM_001252037.1 [P61020-2] NP_002859.1, NM_002868.3 [P61020-1] XP_005269108.1, XM_005269051.2 [P61020-1] XP_005269109.1, XM_005269052.2 [P61020-1]
UniGeneⁱ	Hs.157659

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2HEI	X-ray	1.55	A/B	15-191	[»]
ProteinModelPortalⁱ	P61020
SMRⁱ	P61020
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111807, 66 interactors
IntActⁱ	P61020, 15 interactors
MINTⁱ	P61020
STRINGⁱ	9606.ENSP00000353444

PTM databases

iPTMnetⁱ	P61020
PhosphoSitePlusⁱ	P61020
SwissPalmⁱ	P61020

Polymorphism and mutation databases

BioMutaⁱ	RAB5B
DMDMⁱ	46577637

Proteomic databases

EPDⁱ	P61020
MaxQBⁱ	P61020
PaxDbⁱ	P61020
PeptideAtlasⁱ	P61020
PRIDEⁱ	P61020
ProteomicsDBⁱ	57253

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5869
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000360299; ENSP00000353444; ENSG00000111540 [P61020-1] ENST00000448789; ENSP00000391319; ENSG00000111540 [P61020-2] ENST00000553116; ENSP00000450168; ENSG00000111540 [P61020-1]
GeneIDⁱ	5869
KEGGⁱ	hsa:5869
UCSCⁱ	uc001siv.4 human [P61020-1]

Organism-specific databases

CTDⁱ	5869
DisGeNETⁱ	5869
EuPathDBⁱ	HostDB:ENSG00000111540.15
GeneCardsⁱ	RAB5B
HGNCⁱ	HGNC:9784 RAB5B
HPAⁱ	CAB010224 HPA068337
MIMⁱ	179514 gene
neXtProtⁱ	NX_P61020
OpenTargetsⁱ	ENSG00000111540
PharmGKBⁱ	PA34144
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0092 Eukaryota ENOG410YCCP LUCA
GeneTreeⁱ	ENSGT00760000119101
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	P61020
KOⁱ	K07888
OMAⁱ	QTTVKFE
OrthoDBⁱ	EOG091G0HKN
PhylomeDBⁱ	P61020
TreeFamⁱ	TF300199

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation R-HSA-8854214 TBC/RABGAPs R-HSA-8856828 Clathrin-mediated endocytosis R-HSA-8873719 RAB geranylgeranylation R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
SIGNORⁱ	P61020

Miscellaneous databases

ChiTaRSⁱ	RAB5B human
EvolutionaryTraceⁱ	P61020
GeneWikiⁱ	RAB5B
GenomeRNAiⁱ	5869
Protein Ontology More...PROⁱ	PR:P61020
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000111540 Expressed in 234 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_RAB5B
ExpressionAtlasⁱ	P61020 baseline and differential
Genevisibleⁱ	P61020 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAB5B_HUMAN
Accessionⁱ	P61020Primary (citable) accession number: P61020 Secondary accession number(s): A8K982 Q8IXL2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
	Last sequence update:	April 26, 2004
	Last modified:	October 10, 2018
	This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P61020 (RAB5B_HUMAN)

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Ras-related protein Rab-5B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Plasma membrane

Other locations

Endosome

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ